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List of works by Matthew R Pratt

A dual small-molecule rheostat for precise control of protein concentration in Mammalian cells

scientific article published on 11 March 2014

A full-length group 1 bacterial sigma factor adopts a compact structure incompatible with DNA binding

scientific article published on October 2008

An alkyne-aspirin chemical reporter for the detection of aspirin-dependent protein modification in living cells

scientific article published on 18 September 2013

Anthrax lethal toxin induced lysosomal membrane permeabilization and cytosolic cathepsin release is Nlrp1b/Nalp1b-dependent

scientific article

Asking more from metabolic oligosaccharide engineering

Azide- and Alkyne-Bearing Metabolic Chemical Reporters of Glycosylation Show Structure-Dependent Feedback Inhibition of the Hexosamine Biosynthetic Pathway

scientific article published on 10 August 2018

Bioorthogonal Profiling of a Cancer Cell Proteome Identifies a Large Set of 3-Bromopyruvate Targets beyond Glycolysis

Bioorthogonal Profiling of a Cancer Cell Proteome Identifies a Large Set of 3-Bromopyruvate Targets beyond Glycolysis

scholarly article by Narek Darabedian et al published 5 November 2018 in ACS Chemical Biology

Changes in metabolic chemical reporter structure yield a selective probe of O-GlcNAc modification

scientific article

Chemical Methods for Encoding and Decoding of Posttranslational Modifications

scientific article published on January 2016

Chemical methods for the proteome-wide identification of posttranslationally modified proteins

scientific article

Chemical reporter for visualizing metabolic cross-talk between carbohydrate metabolism and protein modification

scientific article published on 29 July 2014

Chemical reporters for fluorescent detection and identification of O-GlcNAc-modified proteins reveal glycosylation of the ubiquitin ligase NEDD4-1 ⬇️

scientific article published on May 3, 2011

Chemistry-enabled methods for the visualization of cell-surface glycoproteins in Metazoans

scientific article published on 28 April 2015

Chemoproteomics reveals Toll-like receptor fatty acylation.

scientific article

Chemoselective ligation applied to the synthesis of a biantennary N-linked glycoform of CD52.

scientific article published in May 2003

Click Chemistry in Proteomic Investigations

scientific article published on 13 February 2020

Comparison of <i>N</i>-Acetyl-Glucosamine to Other Monosaccharides Reveals Structural Differences for the Inhibition of α-Synuclein Aggregation

scientific article published on 05 January 2021

Correction to “An Alkyne–Aspirin Chemical Reporter for the Detection of Aspirin-Dependent Protein Modification in Living Cells”

scientific article published on 28 March 2018

Covalent capture of phospho-dependent protein oligomerization by site-specific incorporation of a diazirine photo-cross-linker

scientific article

Deconvoluting the functions of polypeptide N-alpha-acetylgalactosaminyltransferase family members by glycopeptide substrate profiling

scientific article

Direct measurement of cathepsin B activity in the cytosol of apoptotic cells by an activity-based probe

scientific article

Extent of inhibition of α-synuclein aggregation in vitro by SUMOylation is conjugation site- and SUMO isoform-selective

scientific article published on 21 January 2015

Formation of 1,1-alpha,alpha-glycosidic bonds by intramolecular aglycone delivery. A convergent synthesis of trehalose

scientific article published on 01 September 2003

Homogeneous glycopeptides and glycoproteins for biological investigation.

scientific article

Identification of O-GlcNAc modification targets in mouse retinal pericytes: implication of p53 in pathogenesis of diabetic retinopathy

scientific article

Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis

scientific journal article

Identifying potentially O-GlcNAcylated proteins using metabolic labeling, bioorthogonal enrichment, and Western blotting

scientific article published on 06 March 2019

Incorporation of Unnatural Sugars for the Identification of Glycoproteins ⬇️

scientific article published on January 1, 2013

Inhibiting the Hexosamine Biosynthetic Pathway Lowers O-GlcNAcylation Levels and Sensitizes Cancer to Environmental Stress

scientific article published on 18 November 2019

Investigating the Effects of O-GlcNAc Modifications in Parkinson's Disease Using Semisynthetic α-Synuclein

scientific article published on 01 January 2020

MYPT1 O-GlcNAc modification regulates sphingosine-1-phosphate mediated contraction

scientific article published on 14 September 2020

Metabolic Chemical Reporters of Glycans Exhibit Cell-Type-Selective Metabolism and Glycoprotein Labeling

scientific article published on 23 February 2017

Metabolic Labeling for the Visualization and Identification of Potentially O-GlcNAc-Modified Proteins

scientific article published on 01 June 2020

Methods for Studying Site-Specific O-GlcNAc Modifications: Successes, Limitations, and Important Future Goals

scientific article published in 2021

N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation ⬇️

scientific article published on December 12, 2012

O-Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent Background Labeling of Proteins but Are Generally Reliable Tools for the Identification of Glycoproteins

scientific article published on 28 April 2020

O-GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity

scientific article published on 16 August 2019

O-GlcNAc modification blocks the aggregation and toxicity of the protein α-synuclein associated with Parkinson's disease

scientific article

O-GlcNAc modification inhibits the calpain-mediated cleavage of α-synuclein.

scientific article published on 29 April 2017

O-GlcNAc modification prevents peptide-dependent acceleration of α-synuclein aggregation

scientific article published on November 9, 2012

O-GlcNAcylation of α-Synuclein at Serine 87 Reduces Aggregation without Affecting Membrane Binding.

scientific article published on 14 February 2017

Optimization of Chemoenzymatic Mass Tagging by Strain-Promoted Cycloaddition (SPAAC) for the Determination of O-GlcNAc Stoichiometry by Western Blotting

scientific article published on 24 September 2018

Precise Control of Protein Concentration in Living Cells ⬇️

scientific article published on November 2, 2010

Probing glycosyltransferase activities with the Staudinger ligation

scientific article

Revolutionizing Our Understanding of Amyloidogenic Proteins by Cryo-Electron Microscopy.

scientific article

Robust in-gel fluorescence detection of mucin-type O-linked glycosylation ⬇️

scientific article published on April 14, 2011

Semisynthetic, Site-Specific Ubiquitin Modification of α-Synuclein Reveals Differential Effects on Aggregation ⬇️

scientific article published on March 14, 2012

Simple and Efficient Preparation of O- and S-GlcNAcylated Amino Acids through InBr-Catalyzed Synthesis of β- N-Acetylglycosides from Commercially Available Reagents

scientific article published in 2018

Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein.

scientific article published on October 2013

Small-Molecule Reprogramming of Cancer Metabolism ⬇️

scientific article published on September 21, 2012

Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt

scholarly article

Structure-activity analysis of semisynthetic nucleosomes: mechanistic insights into the stimulation of Dot1L by ubiquitylated histone H2B.

scientific article

Syntheses of 6-sulfo sialyl Lewis X glycans corresponding to the L-selectin ligand "sulfoadhesin"

scientific article published on 01 July 2004

Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.

scientific article published on 4 January 2016

Synthesis of thioether-linked analogues of the 2,3-sialyl-TF and MECA-79 antigens: mucin-type glycopeptides associated with cancer and inflammation

scientific article

Synthetic Proteins and Peptides for the Direct Interrogation of α-Synuclein Posttranslational Modifications

scientific article

Synthetic glycopeptides and glycoproteins as tools for biology.

scientific article

The Metabolic Chemical Reporter 6-Azido-6-deoxy-glucose Further Reveals the Substrate Promiscuity of O-GlcNAc Transferase and Catalyzes the Discovery of Intracellular Protein Modification by O-Glucose.

scientific article

The New Chemical Reporter 6-Alkynyl-6-deoxy-GlcNAc Reveals O-GlcNAc Modification of the Apoptotic Caspases That Can Block the Cleavage/Activation of Caspase-8.

scientific article published on 22 May 2017

The Small Molecule 2-Azido-2-deoxy-glucose Is a Metabolic Chemical Reporter of O-GlcNAc Modifications in Mammalian Cells, Revealing an Unexpected Promiscuity of O-GlcNAc Transferase.

scientific article published on 30 January 2017

The Sulfur-Linked Analogue of O-GlcNAc (S-GlcNAc) Is an Enzymatically Stable and Reasonable Structural Surrogate for O-GlcNAc at the Peptide and Protein Levels

scientific article published on 19 June 2017

Traceless native chemical ligation of lipid-modified peptide surfactants by mixed micelle formation

scientific article published on 03 June 2020

Translation of Microbiota Short-Chain Fatty Acid Mechanisms Affords Anti-infective Acyl-Salicylic Acid Derivatives

scientific article published on 02 March 2020

Trehalose is required for growth of Mycobacterium smegmatis

scientific article published on 21 April 2004

Ubiquitination Can Change the Structure of the α-Synuclein Amyloid Fiber in a Site Selective Fashion

scientific article published on 19 December 2019

Using chemistry to investigate the molecular consequences of protein ubiquitylation

scientific article published on 27 June 2014

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potential inhibitors of Parkinson's disease

scientific article published on 16 January 2019

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