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List of works by Wioletta Makuch

A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis

scientific article published in May 2015

Analgesic effects of antidepressants alone and after their local co-administration with morphine in a rat model of neuropathic pain

scientific article

Antinociceptive effects of novel histamine H3 R and H4 R receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse.

scientific article published on 27 February 2018

Attenuation of morphine tolerance by minocycline and pentoxifylline in naive and neuropathic mice

scientific article

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats

scientific article published on 16 July 2015

Bidirectional Action of Cenicriviroc, a CCR2/CCR5 Antagonist, Results in Alleviation of Pain-Related Behaviors and Potentiation of Opioid Analgesia in Rats With Peripheral Neuropathy

scientific article published on 21 December 2020

Bifunctional opioid/nociceptin hybrid KGNOP1 effectively attenuates pain-related behaviour in a rat model of neuropathy

scientific article

Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners.

scientific article

Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine

scientific article published on 5 January 2016

Blockade of P2X4 Receptors Inhibits Neuropathic Pain-Related Behavior by Preventing MMP-9 Activation and, Consequently, Pronociceptive Interleukin Release in a Rat Model

scientific article published on 16 February 2017

Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model

scientific article

Botulinum neurotoxin type A counteracts neuropathic pain and facilitates functional recovery after peripheral nerve injury in animal models

scientific article published on 6 September 2010

CCR4 antagonist (C021) influences the level of nociceptive factors and enhances the analgesic potency of morphine in a rat model of neuropathic pain

scientific article published in August 2020

Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia

scientific article published on 16 April 2019

Comparison of the beneficial effects of RS504393, maraviroc and cenicriviroc on neuropathic pain-related symptoms in rodents: behavioral and biochemical analyses

scientific article published on 10 May 2020

Dataset of (±)-NBI-74330 (CXCR3 antagonist) influence on chemokines under neuropathic pain

Dataset of botulinum toxin A influence on interleukins under neuropathy

scientific article

Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain

scientific article

Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain - In vivo and in vitro evidence

scientific article published on 3 May 2016

Dual Alleviation of Acute and Neuropathic Pain by Fused Opioid Agonist-Neurokinin 1 Antagonist Peptidomimetics

scientific article published on 31 October 2015

Effects of Glycogen Synthase Kinase 3beta and Cyclin-Dependent Kinase 5 Inhibitors on Morphine-Induced Analgesia and Tolerance in Rats

scientific article published on 10 August 2006

Effects of chronic doxepin and amitriptyline administration in naïve mice and in neuropathic pain mice model

scientific article published on 10 March 2015

Effects of selective and non-selective inhibitors of nitric oxide synthase on morphine- and endomorphin-1-induced analgesia in acute and neuropathic pain in rats

scientific article published on 10 September 2013

Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism

scientific article

Functional characterization of a novel opioid, PZM21, and its effects on the behavioural responses to morphine

scientific article published on 08 December 2019

Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain

scientific article published on 25 September 2009

Glutamate receptor ligands attenuate allodynia and hyperalgesia and potentiate morphine effects in a mouse model of neuropathic pain

scientific article published on 28 April 2008

IL-1 receptor antagonist improves morphine and buprenorphine efficacy in a rat neuropathic pain model.

scientific article published in June 2015

Inhibition of intracellular signaling pathways NF-κB and MEK1/2 attenuates neuropathic pain development and enhances morphine analgesia.

scientific article

Interleukin-1 alpha has antiallodynic and antihyperalgesic activities in a rat neuropathic pain model

scientific journal article

Involvement of microglial cells in the antinociceptive effects of metamizol in a mouse model of neuropathic pain

scientific article published on 26 September 2018

Involvement of pro- and antinociceptive factors in minocycline analgesia in rat neuropathic pain model

scientific article published on 02 October 2014

Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors.

scientific article published in December 2018

Local peripheral antinociceptive effects of 14-O-methyloxymorphone derivatives in inflammatory and neuropathic pain in the rat.

scientific article published on 25 November 2006

Local peripheral opioid effects and expression of opioid genes in the spinal cord and dorsal root ganglia in neuropathic and inflammatory pain

scientific article

Maraviroc reduces neuropathic pain through polarization of microglia and astroglia – Evidence from in vivo and in vitro studies

article

Metamizole relieves pain by influencing cytokine levels in dorsal root ganglia in a rat model of neuropathic pain

scientific article published on 20 July 2020

Minocycline and pentoxifylline attenuate allodynia and hyperalgesia and potentiate the effects of morphine in rat and mouse models of neuropathic pain

scientific article published on 19 January 2007

Minocycline enhances the effectiveness of nociceptin/orphanin FQ during neuropathic pain

scientific article published on 3 September 2014

Minocycline prevents dynorphin-induced neurotoxicity during neuropathic pain in rats

scientific article published on 27 August 2014

Minocycline reduces the injury-induced expression of prodynorphin and pronociceptin in the dorsal root ganglion in a rat model of neuropathic pain

scientific article published in December 2009

Neuronal and immunological basis of action of antidepressants in chronic pain - clinical and experimental studies

scientific article published on January 2013

Novel bifunctional hybrid compounds designed to enhance the effects of opioids and antagonize the pronociceptive effects of non-opioid peptides as potent analgesics in a rat model of neuropathic pain

scientific article published on 20 August 2020

Novel hybrid compounds, opioid agonist+melanocortin 4 receptor antagonist, as efficient analgesics in mouse neuropathic pain model

scientific article published on 01 August 2020

PD98059 Influences Immune Factors and Enhances Opioid Analgesia in Model of Neuropathy

scientific article published on October 2015

Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy

scientific article published on 18 May 2015

Participation of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia in a rat model of neuropathic pain

scientific article published on 9 September 2016

Peripheral versus central antinociceptive actions of 6-amino acid-substituted derivatives of 14-O-methyloxymorphone in acute and inflammatory pain in the rat.

scientific article published on 21 September 2004

Pharmacological Blockade of Spinal CXCL3/CXCR2 Signaling by NVP CXCR2 20, a Selective CXCR2 Antagonist, Reduces Neuropathic Pain Following Peripheral Nerve Injury

scientific article published on 26 September 2019

Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model

scholarly article by Ewelina Rojewska et al published 2018 in Frontiers in Pharmacology

Pharmacological blockade of CXCR3 by (±)-NBI-74330 reduces neuropathic pain and enhances opioid effectiveness - Evidence from in vivo and in vitro studies

scientific article published on 01 August 2018

Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model

scientific article published on 30 October 2015

Spinal anandamide produces analgesia in neuropathic rats: Possible CB1- and TRPV1-mediated mechanisms

scientific article published on 08 December 2011

Synthesis and biological evaluation of compact, conformationally constrained bifunctional opioid agonist - neurokinin-1 antagonist peptidomimetics

scientific article

The RS504393 Influences the Level of Nociceptive Factors and Enhances Opioid Analgesic Potency in Neuropathic Rats

scientific article published on 23 March 2017

The blockade of CC chemokine receptor type 1 influences the level of nociceptive factors and enhances opioid analgesic potency in a rat model of neuropathic pain

scientific article published on 05 February 2020

The effect of botulinum neurotoxin A on sciatic nerve injury-induced neuroimmunological changes in rat dorsal root ganglia and spinal cord.

scientific article

The effects of early-life adversity on fear memories in adolescent rats and their persistence into adulthood

scientific article

The influence of microglia activation on the efficacy of amitriptyline, doxepin, milnacipran, venlafaxine and fluoxetine in a rat model of neuropathic pain

article

The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain

scientific article published on 17 June 2016

Treatment with a carbon monoxide-releasing molecule (CORM-2) inhibits neuropathic pain and enhances opioid effectiveness in rats

scientific article published on 11 September 2015

Zaprinast diminished pain and enhanced opioid analgesia in a rat neuropathic pain model

scientific article published on 10 September 2018

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