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List of works by Jacek Sapa

(2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands

scientific article published on 10 August 2015

7-3-Chlorophenypiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione as a serotonin receptor ligands with potential antidepressant activity

scientific article published on 13 April 2014

A Comparison of the Anorectic Effect and Safety of the Alpha2-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity

scientific article

ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF 8-METHOXY-1,3-DIMETHYL-2,6-DIOXO-PURIN-7-YL DERIVATIVES WITH TERMINAL CARBOXYLIC, ESTER OR AMIDE MOIETIES IN ANIMAL MODELS.

scientific article published on May 2016

Alpha lipoic acid protects the heart against myocardial post ischemia-reperfusion arrhythmias via KATP channel activation in isolated rat hearts

scientific article published on 03 April 2014

Analgesic activity of new 8-methoxy-1,3-dimethyl-2,6-dioxo-purin-7-yl derivatives with carboxylic, ester or amide moieties

scientific article published on 13 August 2014

Analgesic and anti-inflammatory activity of 7-substituted purine-2,6-diones

scientific article published on 28 June 2014

Anti-inflammatory activity of lipoic acid in mice peritonitis model

Anti-inflammatory, antioxidant, and antiparkinsonian effects of adenosine A2A receptor antagonists.

scientific article

Antiarrhythmic activity in occlusion-reperfusion model of 1-(1H-indol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino} propan-2-ol and its enantiomers.

scientific article published on 19 September 2015

Antiarrhythmic activity of new 2-methoxyphenylpiperazine xanthone derivatives after ischemia/reperfusion in rats

scientific article published on 01 April 2015

Antiarrhythmic activity of novel S-enantiomers of pyrrolidin-2-one derivatives with adrenolytic properties

scientific article published on September 1, 2010

Antiarrhythmic activity of some xanthone derivatives with β1-adrenoceptor affinities in rats.

scientific article published on 27 May 2014

Antiarrhythmic and antioxidant activity of novel pyrrolidin-2-one derivatives with adrenolytic properties.

scientific article published on 15 October 2010

Antiarrhythmic and hypotensive activities of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one (MG-1(R,S)) and its enantiomers

scientific article published on 01 March 2011

Antiarrhythmic and α-Adrenoceptor Antagonistic Properties of Novel Arylpiperazine Derivatives of Pyrrolidin-2-one.

scientific article published on 2 November 2015

Antiarrhythmic, hypotensive and α1-adrenolytic properties of new 2-methoxyphenylpiperazine derivatives of xanthone

scientific article published on 18 April 2014

Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT₁A and 5-HT₇ Antagonists in Animal Models

scientific article

Antidepressant-like activity of a new piperazine derivative of xanthone in the forced swim test in mice: The involvement of serotonergic system.

scientific article

Antidepressant-like activity of the phenylpiperazine pyrrolidin-2-one derivatives in mice.

scientific article published in January 2011

Antidepressant-like properties of (R,S)-HBK-1 and its isomers, new xanthone derivatives, in mice

Antiparkinsonian Effects of Novel Adenosine A2A Receptor Antagonists

scientific article published on 18 November 2010

Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?

scientific article published in January 2013

Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands.

scientific article

Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity.

scientific article published on 10 September 2016

Biofunctional studies of new 2-methoxyphenylpiperazine xanthone derivatives with α₁-adrenolytic properties

scientific article published on 28 October 2014

Bioresearch of New 1<i>H</i>-pyrrolo[3,4-c]pyridine-1,3(2<i>H</i>)-diones

scientific article published on 12 December 2020

Characterization and antidiabetic activity of salicylhydrazone Schiff base vanadium(IV) and (V) complexes

scientific article published on 24 December 2020

Chemically Homogenous Compounds with Antagonistic Properties at All α1-Adrenoceptor Subtypes but not β1-Adrenoceptor Attenuate Adrenaline-Induced Arrhythmia in Rats

scientific article published on 3 August 2016

Correlation of Paraoxonase-1 with the Severity of Crohn's Disease

scientific article published on 11 October 2018

Design, synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxy-propyl]-3,3-diphenylpyrrolidin-2-one derivatives with antiarrhythmic, antihypertensive, and alpha-adrenolytic activity.

scientific article published on 22 April 2009

Design, synthesis, anticonvulsant, and antiarrhythmic properties of novel N-Mannich base and amide derivatives of β-tetralinohydantoin

scientific article published on 21 May 2016

Ergotamine and nicergoline - facts and myths

scientific article

Evaluation of anticonvulsant activity of novel pyrrolidin-2-one derivatives

scientific article published on 06 March 2014

Evaluation of antidepressant-like and anxiolytic-like activity of purinedione-derivatives with affinity for adenosine A2A receptors in mice

scientific article

H3 histamine receptor antagonist pitolisant reverses some subchronic disturbances induced by olanzapine in mice.

scientific article published on 24 May 2016

HBK-17, a 5-HT Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling

scientific article published on 16 October 2018

HBK-7 - A new xanthone derivative and a 5-HT1A receptor antagonist with antidepressant-like properties.

scientific article published on 27 April 2016

Hypotensive effect of alpha-lipoic acid after a single administration in rats.

scientific article published on 30 June 2015

In vivo anti-inflammatory activity of lipoic acid derivatives in mice.

scientific article published on 24 April 2013

Investigations on the synthesis and pharmacological properties of N-substituted derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones

scientific article (publication date: 2005)

KD-64-A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist-Caffeine does not reduce diet-induced obesity in mice

scientific article published on 18 June 2020

KSK19 - Novel histamine H3 receptor ligand reduces body weight in diet induced obese mice

scientific article published on 08 July 2019

Ligand role on insulin-mimetic properties of vanadium complexes. Structural and biological studies

scientific article published in February 2021

Methylprednisolone- acute spinal cord injury, benefits or risks?

scientific article published on 26 June 2013

Muscle relaxants--the current position in the treatment of spasticity in orthopedics.

scientific article published on September 2015

PRELIMINARY EVALUATION OF CENTRAL NERVOUS SYSTEM ACTIVITY OF (E)-N-2-METHYL-3-PHENYLPROP-2-ENYL ((E)-N- α-METHYLCINNAMYL) DERIVATIVES OF SELECTED AMINOALKANOLS.

scientific article

PSB 603 - a known selective adenosine A2B receptor antagonist - has anti-inflammatory activity in mice

scientific article published on 29 December 2020

Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model

scientific article published on 18 June 2020

Preparation of novel derivatives of pyridothiazine-1,1-dioxide and their CNS and antioxidant properties.

scientific article published in September 2002

Pyrrolidin-2-one derivatives may reduce body weight in rats with diet-induced obesity

scientific article published on 16 February 2016

Search for new antiarrhythmic and hypotensive compounds. Synthesis, antiarrhythmic, antihypertensive, and alpha-adrenoceptor blocking activity of novel 1-[(2-hydroxy-3-amino)]-propylpyrrolidin-2-one derivatives

scientific article published on 01 July 1997

Serotonin receptors in depression and anxiety: Insights from animal studies

scientific article published on 23 August 2018

Synthesis and Analgesic Activity of Annelated Xanthine Derivatives in Experimental Models in Rodents.

scientific article published on 6 August 2015

Synthesis and Evaluation of Antidepressant-like Activity of Some 4-Substituted 1-(2-methoxyphenyl)Piperazine Derivatives

scientific article published on 14 August 2014

Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors

scientific article published on 29 July 2021

Synthesis and Pharmacological Activity of a New Series of 1-(1H-Indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol Analogs

scientific article published on 08 February 2016

Synthesis and Pharmacological Evaluation of Novel Silodosin-Based Arylsulfonamide Derivatives as α/α-Adrenergic Receptor Antagonist with Potential Uroselective Profile

scientific article published on 29 August 2018

Synthesis and analgesic action of N-(substituted-ethyl)pyrrole-3,4-dicarboximides

scientific article published on 22 December 2004

Synthesis and antinociceptive activity of four 1 H ‐isoindolo‐1,3(2 H )‐diones

scientific article published on 9 April 2022

Synthesis and biological evaluation of N-arylpiperazine derivatives of 4,4-dimethylisoquinoline-1,3(2H,4H)-dione as potential antiplatelet agents.

scientific article published in December 2018

Synthesis and development of new 2-substituted 1-[3-(4-arylpiperazin-1-yl)propyl]-pyrrolidin-2-one derivatives with antiarrhythmic, hypotensive, and alpha-adrenolytic activity

scientific article published on 21 September 2005

Synthesis and pharmacological evaluation of new 1-[3-(4-arylpiperazin-1-yl)-2-hydroxypropyl]-pyrrolidin-2-one derivatives with anti-arrhythmic, hypotensive, and alpha-adrenolytic activity

scientific article published on 01 September 2007

Synthesis and pharmacological evaluation of new 1-[3-(4-phenylpiperazin-1-yl)-propyl]- and 1-[3-(4-phenylpiperidine)-propyl]- 3-aryl-3-alkyl-pyrrolidin-2-one derivatives with antiarrhythmic and antihypertensive activity

scientific article published in November 2009

Synthesis and pharmacological evaluation of pyrrolidin-2-one derivatives as antiarrhythmic, antihypertensive and alpha-adrenolytic agents

scientific article published in January 2010

Synthesis and pharmacological properties of 1-[2-hydroxy-3-(4-o,m,p-halogenophenyl)- and 3-(4-m-chlorophenyl)-1-piperazinyl]propyl derivatives of amides of 7-methyl-3-phenyl-2,4-dioxo-1,2,3,4-tetrahydropyrido [2,3-d]pyrimidine-5-carboxylic acid with

scientific article published in July 2007

Synthesis and pharmacological properties of new derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-diones.

scientific article published in January 2009

Synthesis and properties of 4-alkoxy-2-[2-hydroxy-3-(4-o,m,p-halogenoaryl-1 -piperazinyl)propyl]-6-methyl-1H-pyrrolo-[3,4-c]pyridine-1,3(2H)-diones with analgesic and sedative activities

scientific article

Synthesis and properties of N-methyl and N-phenyl derivatives of 1,4-dioxo-1,2,3,4-tetrahydropyrido[3,4-d]pyridazines.

scientific article published in June 2004

Synthesis and properties of some aminoalkanolic derivatives of xanthone

scientific article published on 01 January 1997

Synthesis and properties of tetra(hexa)hydropyrazolo [1,2-a]pyrido[3,4-d]pyridazine derivatives.

scientific article published in January 2003

Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity.

scientific article published in March 2002

Synthesis, coordination properties and biological activity of vanadium complexes with hydrazone Schiff base ligands

scientific article published in July 2020

Synthesis, structure and antiarrhythmic properties evaluation of new basic derivatives of 5,5-diphenylhydantoin

scientific article published in June 2003

THE EFFECT OF SEROTONIN 5-HT1A, 5-HT2 RECEPTOR LIGANDS, KETOPROFEN AND THEIR COMBINATION IN MODELS OF INDUCED PAIN IN MICE

The Antiarrhythmic Activity of Novel Pyrrolidin-2-one Derivative S-75 in Adrenaline-Induced Arrhythmia

scientific article published on 20 October 2021

The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products ⬇️

article

The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice.

scientific article published on May 2016

The antidepressant-like activity of 6-methoxy-2-[4-(2-methoxyphenyl)piperazin-1-yl]-9H-xanthen-9-one involves serotonergic 5-HT(1A) and 5-HT(2A/C) receptors activation

scientific article published on 22 July 2015

The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling

scientific article published on 24 October 2020

The histamine H3 receptor inverse agonist pitolisant reduces body weight in obese mice

scientific article published on 25 May 2018

The influence of the route of administration of gold nanoparticles on their tissue distribution and basic biochemical parameters: In vivo studies

scientific article published on 08 November 2014

The nitric oxide/soluble cyclic guanylase/cyclic guanosine monophosphate pathway is involved in the cardiovascular effects of a novel α1- and β-adrenoceptor antagonist

scientific article published on 17 December 2014

The possible mechanism of hypotensive activity of some pyrrolidin-2-one derivatives with antagonist properties at alpha1-adrenoceptors ⬇️

scientific article published on May 18, 2011

The role of glutamatergic, GABA-ergic, and cholinergic receptors in depression and antidepressant-like effect.

scientific article published on 31 October 2015

The role of melatonin, neurokinin, neurotrophic tyrosine kinase and glucocorticoid receptors in antidepressant-like effect

scientific article published on 29 January 2017

The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect

scientific article published on 25 August 2015

Tissue distribution of gold nanoparticles after single intravenous administration in mice.

scientific article published in January 2013

Tridentate ONO ligands in vanadium(III-V) complexes - synthesis, characterization and biological activity

scientific article published in January 2021

α-Adrenoceptor antagonistic and hypotensive properties of novel arylpiperazine derivatives of pyrrolidin-2-one

scientific article published on 09 March 2015

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