Search filters

List of works by Daniel H Bedinger

A fully human, allosteric monoclonal antibody that activates the insulin receptor and improves glycemic control

scientific article published on 8 March 2012

A natively paired antibody library yields drug leads with higher sensitivity and specificity than a randomly paired antibody library.

scientific article published on 29 January 2018

Acute Treatment With XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice.

scientific article published on 23 March 2015

Assessing the binding properties of the anti-PD-1 antibody landscape using label-free biosensors

scientific article published on 05 March 2020

Chickens with humanized immunoglobulin genes generate antibodies with high affinity and broad epitope coverage to conserved targets

scientific article published on 16 October 2017

Development and characterization of human monoclonal antibodies that neutralize multiple TGFβ isoforms.

scientific article published on 13 November 2015

Differential pathway coupling of the activated insulin receptor drives signaling selectivity by XMetA, an allosteric partial agonist antibody

scientific article published on 22 January 2015

Discovery of diverse and functional antibodies from large human repertoire antibody libraries.

scientific article

Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity

scientific article

Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: a potential new approach for the treatment of hyperinsulinemic hypoglycemia.

scientific article published on January 2014

Kinetic approach to pathway attenuation using XOMA 052, a regulatory therapeutic antibody that modulates interleukin-1beta activity.

scientific article

Metabolic, anabolic, and mitogenic insulin responses: A tissue-specific perspective for insulin receptor activators

scientific article published on 12 August 2015

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

scientific article published on 19 March 2013

Selective allosteric antibodies to the insulin receptor for the treatment of hyperglycemic and hypoglycemic disorders

scientific article published on 07 April 2014

Thermodynamic benchmark study using Biacore technology

scientific article published on 26 January 2007

Paulina is supported by:

About Paulina

Help