List of works - Jean-François Brunet

A new member of the immunoglobulin superfamily--CTLA-4

scientific article

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

scientific journal article

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

scientific journal article

Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a

scientific journal article

Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat.

scientific article

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.

scientific article

Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.

scientific article published on 19 November 2003

The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system

scientific article published on 01 December 1996

Essential role of Gata transcription factors in sympathetic neuron development

scientific journal article

Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.

scientific article

Phox2 genes - from patterning to connectivity

scientific article (publication date: August 2002)

A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture

scientific journal article

Specification of the central noradrenergic phenotype by the homeobox gene Phox2b.

scientific article published in March 2000

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14.

scientific article

Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach

scientific article published on May 1995

Mouse Otlx2/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenance.

scientific article published in September 1997

Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells

scientific article published on April 1999

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons

scientific article

Ascl1/Mash1 is required for the development of central serotonergic neurons

scientific journal article

Task2 potassium channels set central respiratory CO2 and O2 sensitivity.

scientific article

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.

scientific article

Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors

scientific article published on 12 June 2014

Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system

scientific article published in February 1998

Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene

scientific article published on 01 November 1998

Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling

scientific article

Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.

scientific article published in April 2000

Precraniate origin of cranial motoneurons.

scholarly article

Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

scientific article published in September 2011

Transcriptional control of neurotransmitter phenotype

scientific article

Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction

scientific article

Deconstructing cell determination: proneural genes and neuronal identity

scientific article

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

scientific journal article

Centralization of the deuterostome nervous system predates chordates

scientific article

Generation and characterization of Rgs4 mutant mice

scientific article

Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain

scientific article

Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening

scientific article published in May 1991

Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites.

scientific article published on October 1998

Delays in neuronal differentiation in Mash1/Ascl1 mutants

scientific article published on 4 May 2006

Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression

scientific article

Epibranchial ganglia orchestrate the development of the cranial neurogenic crest

scientific article

The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity

scientific article published on 01 December 2000

Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways

scientific article

Induction of the epibranchial placodes

scientific article published on 01 February 1999

The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂

scientific article published on 13 April 2015

Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions

scientific article

The sacral autonomic outflow is sympathetic.

scientific article

Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b.

scientific article published in November 2003

Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus

scientific journal article

Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation

scientific journal article

PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models.

scientific article published on 21 March 2009

List of works by Jean-François Brunet

A new member of the immunoglobulin superfamily--CTLA-4

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a

Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat.

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.

Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.

The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system

Essential role of Gata transcription factors in sympathetic neuron development

Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.

Phox2 genes - from patterning to connectivity

A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture

Specification of the central noradrenergic phenotype by the homeobox gene Phox2b.

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14.

Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach

Mouse Otlx2/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenance.

Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons

Ascl1/Mash1 is required for the development of central serotonergic neurons

Task2 potassium channels set central respiratory CO2 and O2 sensitivity.

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.

Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors

Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system

Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene

Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling

Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.

Precraniate origin of cranial motoneurons.

Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

Transcriptional control of neurotransmitter phenotype

Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction

Deconstructing cell determination: proneural genes and neuronal identity

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

Centralization of the deuterostome nervous system predates chordates

Generation and characterization of Rgs4 mutant mice

Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain

Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening

Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites.

Delays in neuronal differentiation in Mash1/Ascl1 mutants

Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression

Epibranchial ganglia orchestrate the development of the cranial neurogenic crest

The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity

Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways

Induction of the epibranchial placodes

The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂

Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions

The sacral autonomic outflow is sympathetic.

Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b.

Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus

Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation

PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models.