List of works - Jean-François Brunet

A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics.

scientific article

A differential molecular biology search for genes preferentially expressed in functional T lymphocytes: the CTLA genes

scientific article

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.

scientific article

A medullary centre for lapping in mice

scientific article published on 02 November 2021

A molecular biology approach to the mechanism of T-cell-mediated cytotoxicity

scientific article published on 01 March 1987

A new member of the immunoglobulin superfamily--CTLA-4

scientific article

A possible link between cell adhesion receptors, homeodomain proteins and neuronal identity.

scientific article published in November 1993

A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture

scientific journal article

Ancient origin of somatic and visceral neurons

scientific article (publication date: 30 April 2013)

Ascl1/Mash1 is required for the development of central serotonergic neurons

scientific journal article

Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression

scientific article

Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach

scientific article published on May 1995

Breathing with phox2b

scientific article published on September 2009

Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

scientific article published in September 2011

CTLA-1 and CTLA-3 serine esterase transcripts are detected mostly in cytotoxic T cells, but not only and not always

scientific article published on 01 June 1987

Central chemoreception: lessons from mouse and human genetics

scientific article published on 20 March 2010

Centralization of the deuterostome nervous system predates chordates

scientific article

Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.

scientific article published in April 2000

Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system

scientific article published in February 1998

Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.

scientific article

Deconstructing cell determination: proneural genes and neuronal identity

scientific article

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons

scientific article

Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a

scientific journal article

Delays in neuronal differentiation in Mash1/Ascl1 mutants

scientific article published on 4 May 2006

Developmentally regulated expression of the neural cell adhesion molecule (NCAM) by mouse thymocytes

scientific article published on 01 May 1989

Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons.

scientific article

Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest.

scientific article

Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b.

scientific article published in November 2003

Epibranchial ganglia orchestrate the development of the cranial neurogenic crest

scientific article

Essential role of Gata transcription factors in sympathetic neuron development

scientific journal article

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

scientific journal article

Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat.

scientific article

Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype.

scientific article published on 15 December 2006

Generation and characterization of Rgs4 mutant mice

scientific article

Genetic identification of a hindbrain nucleus essential for innate vocalization

scientific article

Haploinsufficiency for Phox2b in mice causes dilated pupils and atrophy of the ciliary ganglion: mechanistic insights into human congenital central hypoventilation syndrome.

scientific article published on 18 May 2004

Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways

scientific article

Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling

scientific article

Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening

scientific article published in May 1991

In Vitro studies of non poly alanine PHOX2B mutations argue against a loss-of-function mechanism for congenital central hypoventilation

scientific article

Induction of the epibranchial placodes

scientific article published on 01 February 1999

Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction

scientific article

Mouse Otlx2/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenance.

scientific article published in September 1997

Mutation in precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice

article published in the Proceedings of the National Academy of Sciences of the United States of America

Mutations of the RET gene in isolated and syndromic Hirschsprung's disease in human disclose major and modifier alleles at a single locus

scientific article published on 27 January 2006

NCAM: structural diversity, function and regulation of expression

scientific article

Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors.

scientific article published on 12 June 2014

Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites.

scientific article published on October 1998

Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions

scientific article

Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation

scientific journal article

Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain

scientific article

P815 mastocytoma cells, classical targets for cytotoxic T lymphocytes, exert natural cytotoxicity

scientific article published on 01 January 1987

PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models.

scientific article published on 21 March 2009

Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene

scientific article published on 01 November 1998

Phox2 genes - from patterning to connectivity

scientific article (publication date: August 2002)

Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.

scientific article published on 19 November 2003

Phox2b expression in the taste centers of fish.

scientific article

Phox2b, congenital central hypoventilation syndrome and the control of respiration

scientific article published on 04 August 2010

Precraniate origin of cranial motoneurons.

scholarly article

Proceedings of the fourth international conference on central hypoventilation

scientific article

Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.

scientific article published on 17 July 2008

Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus

scientific journal article

Role of the target in the pathfinding of facial visceral motor axons.

scientific article published in July 2000

Self-sparing of long-term in vitro-cloned or uncloned cytotoxic T lymphocytes

scientific article

Spatiotemporal structure of cell fate decisions in murine neural crest

scientific article

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

scientific journal article

Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells

scientific article published on April 1999

Specification of the central noradrenergic phenotype by the homeobox gene Phox2b.

scientific article published in March 2000

Task2 potassium channels set central respiratory CO2 and O2 sensitivity.

scientific article

Taste bud formation depends on taste nerves

scientific article published on 01 October 2019

The "sacral parasympathetic": ontogeny and anatomy of a myth

scientific article published on 4 November 2017

The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity

scientific article published on 01 December 2000

The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system

scientific article published on 01 December 1996

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

scientific journal article

The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans

scientific article published in August 2000

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14.

scientific article

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.

scientific article

The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂

scientific article published on 13 April 2015

The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis.

scientific article published in November 2002

The sacral autonomic outflow is sympathetic.

scientific article

Transcriptional control of neurotransmitter phenotype

scientific article

List of works by Jean-François Brunet

A Phox2b::FLPo transgenic mouse line suitable for intersectional genetics.

A differential molecular biology search for genes preferentially expressed in functional T lymphocytes: the CTLA genes

A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.

A medullary centre for lapping in mice

A molecular biology approach to the mechanism of T-cell-mediated cytotoxicity

A new member of the immunoglobulin superfamily--CTLA-4

A possible link between cell adhesion receptors, homeodomain proteins and neuronal identity.

A single rostrocaudal colonization of the rodent intestine by enteric neuron precursors is revealed by the expression of Phox2b, Ret, and p75 and by explants grown under the kidney capsule or in organ culture

Ancient origin of somatic and visceral neurons

Ascl1/Mash1 is required for the development of central serotonergic neurons

Autonomic neurocristopathy-associated mutations in PHOX2B dysregulate Sox10 expression

Barx1, a new mouse homeodomain transcription factor expressed in cranio-facial ectomesenchyme and the stomach

Breathing with phox2b

Breathing without CO(2) chemosensitivity in conditional Phox2b mutants.

CTLA-1 and CTLA-3 serine esterase transcripts are detected mostly in cytotoxic T cells, but not only and not always

Central chemoreception: lessons from mouse and human genetics

Centralization of the deuterostome nervous system predates chordates

Control of hindbrain motor neuron differentiation by the homeobox gene Phox2b.

Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system

Coordinated temporal and spatial control of motor neuron and serotonergic neuron generation from a common pool of CNS progenitors.

Deconstructing cell determination: proneural genes and neuronal identity

Defective respiratory rhythmogenesis and loss of central chemosensitivity in Phox2b mutants targeting retrotrapezoid nucleus neurons

Defects in sensory and autonomic ganglia and absence of locus coeruleus in mice deficient for the homeobox gene Phox2a

Delays in neuronal differentiation in Mash1/Ascl1 mutants

Developmentally regulated expression of the neural cell adhesion molecule (NCAM) by mouse thymocytes

Differential regulation of transcription factor gene expression and phenotypic markers in developing sympathetic neurons.

Dual origin of enteric neurons in vagal Schwann cell precursors and the sympathetic neural crest.

Dynamic expression of RGS4 in the developing nervous system and regulation by the neural type-specific transcription factor Phox2b.

Epibranchial ganglia orchestrate the development of the cranial neurogenic crest

Essential role of Gata transcription factors in sympathetic neuron development

Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis

Expression of Phox2b by brainstem neurons involved in chemosensory integration in the adult rat.

Forced expression of Phox2 homeodomain transcription factors induces a branchio-visceromotor axonal phenotype.

Generation and characterization of Rgs4 mutant mice

Genetic identification of a hindbrain nucleus essential for innate vocalization

Haploinsufficiency for Phox2b in mice causes dilated pupils and atrophy of the ciliary ganglion: mechanistic insights into human congenital central hypoventilation syndrome.

Homeoprotein Phox2b commands a somatic-to-visceral switch in cranial sensory pathways

Hox paralog group 2 genes control the migration of mouse pontine neurons through slit-robo signaling

Identification of a peptide specific for Aplysia sensory neurons by PCR-based differential screening

In Vitro studies of non poly alanine PHOX2B mutations argue against a loss-of-function mechanism for congenital central hypoventilation

Induction of the epibranchial placodes

Molecular consequences of PHOX2B missense, frameshift and alanine expansion mutations leading to autonomic dysfunction

Mouse Otlx2/RIEG expression in the odontogenic epithelium precedes tooth initiation and requires mesenchyme-derived signals for its maintenance.

Mutation in precludes transcription factor cooperativity and causes congenital hypoventilation in humans and mice

Mutations of the RET gene in isolated and syndromic Hirschsprung's disease in human disclose major and modifier alleles at a single locus

NCAM: structural diversity, function and regulation of expression

Neurodevelopment. Parasympathetic ganglia derive from Schwann cell precursors.

Noradrenergic-specific transcription of the dopamine beta-hydroxylase gene requires synergy of multiple cis-acting elements including at least two Phox2a-binding sites.

Novel structures CTLA-2 alpha and CTLA-2 beta expressed in mouse activated T cells and mast cells and homologous to cysteine proteinase proregions

Ongoing roles of Phox2 homeodomain transcription factors during neuronal differentiation

Otlx2, an Otx-related homeobox gene expressed in the pituitary gland and in a restricted pattern in the forebrain

P815 mastocytoma cells, classical targets for cytotoxic T lymphocytes, exert natural cytotoxicity

PHOX2B in respiratory control: lessons from congenital central hypoventilation syndrome and its mouse models.

Paired-like homeodomain proteins, Phox2a and Phox2b, are responsible for noradrenergic cell-specific transcription of the dopamine beta-hydroxylase gene

Phox2 genes - from patterning to connectivity

Phox2b controls the development of peripheral chemoreceptors and afferent visceral pathways.

Phox2b expression in the taste centers of fish.

Phox2b, congenital central hypoventilation syndrome and the control of respiration

Precraniate origin of cranial motoneurons.

Proceedings of the fourth international conference on central hypoventilation

Regulator of G protein signaling-4 controls fatty acid and glucose homeostasis.

Role of Phox2b and Mash1 in the generation of the vestibular efferent nucleus

Role of the target in the pathfinding of facial visceral motor axons.

Self-sparing of long-term in vitro-cloned or uncloned cytotoxic T lymphocytes

Spatiotemporal structure of cell fate decisions in murine neural crest

Specific and integrated roles of Lmx1a, Lmx1b and Phox2a in ventral midbrain development

Specification of neurotransmitter identity by Phox2 proteins in neural crest stem cells

Specification of the central noradrenergic phenotype by the homeobox gene Phox2b.

Task2 potassium channels set central respiratory CO2 and O2 sensitivity.

Taste bud formation depends on taste nerves

The "sacral parasympathetic": ontogeny and anatomy of a myth

The Phox2b transcription factor coordinately regulates neuronal cell cycle exit and identity

The expression pattern of the transcription factor Phox2 delineates synaptic pathways of the autonomic nervous system

The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

The homeodomain protein CePHOX2/CEH-17 controls antero-posterior axonal growth in C. elegans

The inducible cytotoxic T-lymphocyte-associated gene transcript CTLA-1 sequence and gene localization to mouse chromosome 14.

The mouse homeodomain protein Phox2 regulates Ncam promoter activity in concert with Cux/CDP and is a putative determinant of neurotransmitter phenotype.

The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO₂

The role of Phox2b in synchronizing pan-neuronal and type-specific aspects of neurogenesis.