List of works - Santiago Ramón-Maiques

A crystallographic glimpse of a nucleotide triphosphate (AMPPNP) bound to a protein surface: external and internal AMPPNP molecules in crystalline N-acetyl-L-glutamate kinase.

scientific article published on 28 September 2002

Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy

scientific article published on 28 May 2020

Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD

scientific article published in Journal of Biological Chemistry

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD.

scientific article

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD.

scientific article

Functional and structural deficiencies of Gemin5 variants associated with neurological disorders

scientific article published on 07 April 2022

Gain-of-function mutations in DNMT3A in patients with paraganglioma

scientific article published on 08 May 2018

Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

scientific article published on 11 February 2021

Molecular physiology of phosphoryl group transfer from carbamoyl phosphate by a hyperthermophilic enzyme at low temperature.

scientific article published in March 2002

MuB gives a new twist to target DNA selection.

scientific article published on September 2013

MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition ⬇️

scientific article published on June 17, 2013

N-Acetyl-L-glutamate kinase from Escherichia coli: cloning of the gene, purification and crystallization of the recombinant enzyme and preliminary X-ray analysis of the free and ligand-bound forms

article

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

scientific article

Site-directed mutagenesis of Escherichia coli acetylglutamate kinase and aspartokinase III probes the catalytic and substrate-binding mechanisms of these amino acid kinase family enzymes and allows three-dimensional modelling of aspartokinase.

scientific article published in November 2003

Site-directed mutagenesis of the regulatory domain of escherichia coli carbamoyl phosphate synthetase identifies crucial residues for allosteric regulation and for transduction of the regulatory signals 1 1Edited by A. R. Fersht

scholarly article by Vicente Fresquet et al published June 2000 in Journal of Molecular Biology

Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis

scientific article published on 19 May 2017

Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosa

scientific article published on 12 December 2005

Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA

scientific article

Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair

scientific article published on 07 October 2004

Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD

scientific article

Substrate binding and catalysis in carbamate kinase ascertained by crystallographic and site-directed mutagenesis studies: movements and significance of a unique globular subdomain of this key enzyme for fermentative ATP production in bacteria

scientific article

The 1.5 A resolution crystal structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic Archaeon pyrococcus furiosus, bound to ADP, confirms that this thermostable enzyme is a carbamate kinase, and provides [...]

scientific article

The Carbamoyl-phosphate Synthetase of Pyrococcus furiosus Is Enzymologically and Structurally a Carbamate Kinase

scientific article published in Journal of Biological Chemistry

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

scientific article published on 25 June 2020

The N-terminal domain of MuB protein has striking structural similarity to DNA-binding domains and mediates MuB filament-filament interactions

scientific article published on 10 July 2015

The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers

scientific article

Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant

scientific article published on 29 May 2002

Two crystal structures of Escherichia coli N-acetyl-L-glutamate kinase demonstrate the cycling between open and closed conformations

scientific article

List of works by Santiago Ramón-Maiques

A crystallographic glimpse of a nucleotide triphosphate (AMPPNP) bound to a protein surface: external and internal AMPPNP molecules in crystalline N-acetyl-L-glutamate kinase.

Cell-based analysis of CAD variants identifies individuals likely to benefit from uridine therapy

Characterization of the catalytic flexible loop in the dihydroorotase domain of the human multi-enzymatic protein CAD

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the aspartate transcarbamoylase domain of human CAD.

Expression, purification, crystallization and preliminary X-ray diffraction analysis of the dihydroorotase domain of human CAD.

Functional and structural deficiencies of Gemin5 variants associated with neurological disorders

Gain-of-function mutations in DNMT3A in patients with paraganglioma

Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase

Molecular physiology of phosphoryl group transfer from carbamoyl phosphate by a hyperthermophilic enzyme at low temperature.

MuB gives a new twist to target DNA selection.

MuB is an AAA+ ATPase that forms helical filaments to control target selection for DNA transposition ⬇️

N-Acetyl-L-glutamate kinase from Escherichia coli: cloning of the gene, purification and crystallization of the recombinant enzyme and preliminary X-ray analysis of the free and ligand-bound forms

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

Site-directed mutagenesis of Escherichia coli acetylglutamate kinase and aspartokinase III probes the catalytic and substrate-binding mechanisms of these amino acid kinase family enzymes and allows three-dimensional modelling of aspartokinase.

Site-directed mutagenesis of the regulatory domain of escherichia coli carbamoyl phosphate synthetase identifies crucial residues for allosteric regulation and for transduction of the regulatory signals 1 1Edited by A. R. Fersht

Structural Insight into the Core of CAD, the Multifunctional Protein Leading De Novo Pyrimidine Biosynthesis

Structural bases of feed-back control of arginine biosynthesis, revealed by the structures of two hexameric N-acetylglutamate kinases, from Thermotoga maritima and Pseudomonas aeruginosa

Structure and Functional Characterization of Human Aspartate Transcarbamoylase, the Target of the Anti-tumoral Drug PALA

Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair

Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD

Substrate binding and catalysis in carbamate kinase ascertained by crystallographic and site-directed mutagenesis studies: movements and significance of a unique globular subdomain of this key enzyme for fermentative ATP production in bacteria

The 1.5 A resolution crystal structure of the carbamate kinase-like carbamoyl phosphate synthetase from the hyperthermophilic Archaeon pyrococcus furiosus, bound to ADP, confirms that this thermostable enzyme is a carbamate kinase, and provides [...]

The Carbamoyl-phosphate Synthetase of Pyrococcus furiosus Is Enzymologically and Structurally a Carbamate Kinase

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

The N-terminal domain of MuB protein has striking structural similarity to DNA-binding domains and mediates MuB filament-filament interactions

The PHD Finger of Human UHRF1 Reveals a New Subgroup of Unmethylated Histone H3 Tail Readers

Towards structural understanding of feedback control of arginine biosynthesis: cloning and expression of the gene for the arginine-inhibited N-acetyl-L-glutamate kinase from Pseudomonas aeruginosa, purification and crystallization of the recombinant

Two crystal structures of Escherichia coli N-acetyl-L-glutamate kinase demonstrate the cycling between open and closed conformations