List of works - Nicholas C.O. Tomkinson

A General Method for the α-Acyloxylation of Carbonyl Compounds

scientific article published on 01 December 2005

A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family

scientific article published on 31 October 2019

A Scalable Metal-, Azide-, and Halogen-Free Method for the Preparation of Triazoles

scientific article published on 10 March 2020

A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis.

scientific article published on 31 January 2017

A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy

scientific article published on 16 July 2020

A simple method for the alpha-oxygenation of aldehydes.

scientific article

Advancements in the Development of non-BET Bromodomain Chemical Probes

scientific article published on 04 February 2019

Alkene Dioxygenation with Malonoyl Peroxides: Synthesis of γ-Lactones, Isobenzofuranones, and Tetrahydrofurans

scientific article published on 17 June 2016

Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines

scientific article published on 29 May 2018

Alkene Syn- and Anti-Oxyamination with Malonoyl Peroxides

scientific article published on 30 January 2020

Alkene anti-Dihydroxylation with Malonoyl Peroxides

scientific article published on 01 October 2015

Alkene syn dihydroxylation with malonoyl peroxides.

scientific article published on October 2010

Aminocatalytic preparation of bisindolylalkanes

scientific article published on 12 October 2005

Arene oxidation with malonoyl peroxides

scientific article published on 12 May 2015

Asymmetric α-oxyacylation of cyclic ketones

scientific article published on 02 April 2012

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.

scientific article published on 13 March 2018

Clinical progress and pharmacology of small molecule bromodomain inhibitors.

scientific article

Computational study of iminium ion formation: effects of amine structure

scientific article published on 01 June 2006

Copper-catalysed C-H functionalisation gives access to 2-aminobenzimidazoles

scientific article published on 01 August 2019

Copper-catalyzed coupling of hydroxylamines with aryl iodides.

scientific article

Differential activity of rosiglitazone enantiomers at PPAR gamma

scientific article published on 01 December 1998

Direct alpha-oxytosylation of carbonyl compounds: one-pot synthesis of heterocycles

scientific article published on 08 September 2007

Enhanced pi ... pi interactions in alpha,beta-unsaturated carbonyls.

scientific article published in February 2003

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

scientific article published on 24 September 2018

Further studies on the synthesis of 24(S),25-epoxycholesterol. A new, efficient preparation of desmosterol

scientific article published on 01 April 2000

Identification of key features required for efficient S-acylation and plasma membrane targeting of Sprouty-2

scientific article published on 09 October 2020

Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.

scientific article published in December 1997

Iminium ion catalysis: direct comparison of imidazolidinone and diarylprolinol ether reactivity

Iminium ion catalysis: use of the alpha-effect in the acceleration of the Diels-Alder reaction

scientific article published on 01 March 2003

Improving catalyst activity in secondary amine catalysed transformations

scientific article published on 01 January 2015

Inhibition of the ULK1 protein complex suppresses Staphylococcus-induced autophagy and cell death

scientific article published on 06 August 2019

Kinetics of iminium ion catalysis.

scientific article

Metal Triflate-Promoted Allylic Substitution Reactions of Cinnamyl Alcohol in the Presence of Orthoesters and Acetals

scientific article published on 23 September 2019

Metal-free dihydroxylation of alkenes using cyclobutane malonoyl peroxide.

scientific article

Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.

scientific article

Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH

scientific article published in 2021

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.

scientific article published on 06 February 2017

On the roles of protic solvents in imidazolidinone-catalyzed transformations

scientific article published on 05 January 2011

Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides

scientific article published on 01 January 2009

Progress in the Development of non-BET Bromodomain Chemical Probes

scientific article

Ratiometric sensing of fluoride ions using Raman spectroscopy

scientific article published on 04 November 2020

Readily accessible chiral at nitrogen cage structures

scientific article published on 01 April 2013

Rearrangement strategy for the synthesis of 2-aminoanilines.

scientific article published in April 2010

Regioselective Reaction of Heterocyclic N-Oxides, an Acyl Chloride, and Cyclic Thioethers.

scientific article published on 18 January 2018

Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers.

scientific article published on 16 June 2017

Secondary and primary amine catalysts for iminium catalysis.

scientific article published on January 2010

Solution phase, solid state, and theoretical investigations on the MacMillan imidazolidinone.

scientific article

Stereoselective Synthesis of Alkylidene Phthalides

scientific article published on 17 June 2016

Stimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug–cell interactions

scientific article published in 2022

Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers

scientific article published on 01 January 2016

Temporal imaging of drug dynamics in live cells using stimulated Raman scattering microscopy and a perfusion cell culture system

scientific article published in 2022

The α-effect in cyclic secondary amines: new scaffolds for iminium ion accelerated transformations

article

The α-effect in iminium ion catalysis

Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy

scientific article published on 7 March 2018

List of works by Nicholas C.O. Tomkinson

A General Method for the α-Acyloxylation of Carbonyl Compounds

A Photoaffinity Displacement Assay and Probes to Study the Cyclin-Dependent Kinase Family

A Scalable Metal-, Azide-, and Halogen-Free Method for the Preparation of Triazoles

A cluster of palmitoylated cysteines are essential for aggregation of cysteine-string protein mutants that cause neuronal ceroid lipofuscinosis.

A new class of ratiometric small molecule intracellular pH sensors for Raman microscopy

A simple method for the alpha-oxygenation of aldehydes.

Advancements in the Development of non-BET Bromodomain Chemical Probes

Alkene Dioxygenation with Malonoyl Peroxides: Synthesis of γ-Lactones, Isobenzofuranones, and Tetrahydrofurans

Alkene Oxyamination Using Malonoyl Peroxides: Preparation of Pyrrolidines and Isoxazolidines

Alkene Syn- and Anti-Oxyamination with Malonoyl Peroxides

Alkene anti-Dihydroxylation with Malonoyl Peroxides

Alkene syn dihydroxylation with malonoyl peroxides.

Aminocatalytic preparation of bisindolylalkanes

Arene oxidation with malonoyl peroxides

Asymmetric α-oxyacylation of cyclic ketones

Circadian clock component REV-ERBα controls homeostatic regulation of pulmonary inflammation.

Clinical progress and pharmacology of small molecule bromodomain inhibitors.

Computational study of iminium ion formation: effects of amine structure

Copper-catalysed C-H functionalisation gives access to 2-aminobenzimidazoles

Copper-catalyzed coupling of hydroxylamines with aryl iodides.

Differential activity of rosiglitazone enantiomers at PPAR gamma

Direct alpha-oxytosylation of carbonyl compounds: one-pot synthesis of heterocycles

Enhanced pi ... pi interactions in alpha,beta-unsaturated carbonyls.

Fam49/CYRI interacts with Rac1 and locally suppresses protrusions

Further studies on the synthesis of 24(S),25-epoxycholesterol. A new, efficient preparation of desmosterol

Identification of key features required for efficient S-acylation and plasma membrane targeting of Sprouty-2

Identification of peroxisome proliferator-activated receptor ligands from a biased chemical library.

Iminium ion catalysis: direct comparison of imidazolidinone and diarylprolinol ether reactivity

Iminium ion catalysis: use of the alpha-effect in the acceleration of the Diels-Alder reaction

Improving catalyst activity in secondary amine catalysed transformations

Inhibition of the ULK1 protein complex suppresses Staphylococcus-induced autophagy and cell death

Kinetics of iminium ion catalysis.

Metal Triflate-Promoted Allylic Substitution Reactions of Cinnamyl Alcohol in the Presence of Orthoesters and Acetals

Metal-free dihydroxylation of alkenes using cyclobutane malonoyl peroxide.

Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors.

Mitokyne: A Ratiometric Raman Probe for Mitochondrial pH

Molecular basis of fatty acid selectivity in the zDHHC family of S-acyltransferases revealed by click chemistry.

On the roles of protic solvents in imidazolidinone-catalyzed transformations

Palladium-catalyzed coupling of hydroxylamines with aryl bromides, chlorides, and iodides

Progress in the Development of non-BET Bromodomain Chemical Probes

Ratiometric sensing of fluoride ions using Raman spectroscopy

Readily accessible chiral at nitrogen cage structures

Rearrangement strategy for the synthesis of 2-aminoanilines.

Regioselective Reaction of Heterocyclic N-Oxides, an Acyl Chloride, and Cyclic Thioethers.

Regioselective Three-Component Reaction of Pyridine N-Oxides, Acyl Chlorides, and Cyclic Ethers.

Secondary and primary amine catalysts for iminium catalysis.

Solution phase, solid state, and theoretical investigations on the MacMillan imidazolidinone.

Stereoselective Synthesis of Alkylidene Phthalides

Stimulated Raman scattering microscopy with spectral phasor analysis: applications in assessing drug–cell interactions

Synthesis of dibenzylamino-1-methylcyclohexanol and dibenzylamino-1-trifluoromethylcyclohexanol isomers

Temporal imaging of drug dynamics in live cells using stimulated Raman scattering microscopy and a perfusion cell culture system

The α-effect in cyclic secondary amines: new scaffolds for iminium ion accelerated transformations

The α-effect in iminium ion catalysis

Tracking intracellular uptake and localisation of alkyne tagged fatty acids using Raman spectroscopy