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List of works by Lucio Miele

17β-estradiol enhances signalling mediated by VEGF-A-delta-like ligand 4-notch1 axis in human endothelial cells

scientific article

A magnifying glass on glioblastoma stem cell signaling pathways.

scientific article

A novel patient-derived xenograft model for claudin-low triple-negative breast cancer.

scientific article published in February 2018

AKT and 14-3-3 regulate Notch4 nuclear localization.

scientific article

Aberrant activation of canonical Notch1 signaling in the mouse uterus decreases progesterone receptor by hypermethylation and leads to infertility

scientific article

Activation of Notch-1 signaling maintains the neoplastic phenotype in human Ras-transformed cells

scientific article published on 19 August 2002

Activation of an endothelial Notch1-Jagged1 circuit induces VCAM1 expression, an effect amplified by interleukin-1β.

scientific article published on 3 December 2015

Activation of the A2B adenosine receptor in B16 melanomas induces CXCL12 expression in FAP-positive tumor stromal cells, enhancing tumor progression

scientific article

Advancing the Science of Health Disparities Through Research on the Social Determinants of Health

scientific article published on January 2017

An Integrative Genomics Approach for Associating GWAS Information with Triple-Negative Breast Cancer.

scientific article

An Integrative Genomics Approach for Associating Genome-Wide Association Studies Information With Localized and Metastatic Prostate Cancer Phenotypes

scientific article

An integrative genomics approach to biomarker discovery in breast cancer ⬇️

scientific article published on July 25, 2011

Analysis of Patterns of Gene Expression Variation within and between Ethnic Populations in Pediatric B-ALL

scientific article published on 27 August 2013

Ancestry as a potential modifier of gene expression in breast tumors from Colombian women.

scientific article published on 23 August 2017

Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance.

scientific article

Arachidonic acid release from NIH 3T3 cells by group‐I phospholipase A2: Involvement of a receptor‐mediated mechanism ⬇️

scientific article published on December 1, 1995

Assessing needs and assets for building a regional network infrastructure to reduce cancer related health disparities

scientific article

Assessing the Racial and Ethnic Disparities in Breast Cancer Mortality in the United States

scientific article

Associating GWAS Information with the Notch Signaling Pathway Using Transcription Profiling.

scientific article

Association of Abdominal Visceral Adiposity and Total Fat Mass with Cancer Incidence and Mortality in White and Black Adults

scientific article published in 2022

Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skin

scientific article (publication date: 2010)

Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma.

scientific article published on December 2013

Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status

scientific article published on 9 September 2015

Boronic prodrug of endoxifen as an effective hormone therapy for breast cancer

scientific article published on 14 June 2015

Characterization of tissue specific expression of Notch-1 in human tissues

scientific article published on May 2004

Chemoresistance to gemcitabine in hepatoma cells induces epithelial-mesenchymal transition and involves activation of PDGF-D pathway

scientific article published on November 2013

Comprehensive assessment and network analysis of the emerging genetic susceptibility landscape of prostate cancer

scientific article published on 28 August 2013

Contribution of Notch signaling activation to human glioblastoma multiforme.

scientific article published on March 2007

Crosstalk between PKCα and Notch-4 in endocrine-resistant breast cancer cells.

scientific article published on 05 August 2013

Cystic fibrosis and phosphatidylcholine biosynthesis

scientific article published on 01 October 1994

Deadly crosstalk: Notch signaling at the intersection of EMT and cancer stem cells.

scientific article published on 21 August 2013

Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization.

scientific article

Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study

scientific article published on 4 May 2017

Diverse and converging roles of ERK1/2 and ERK5 pathways on mesenchymal to epithelial transition in breast cancer

scientific article published on 21 March 2021

Down-regulation of Notch-1 is associated with Akt and FoxM1 in inducing cell growth inhibition and apoptosis in prostate cancer cells

scientific article published on January 2011

Elevated expression of notch1 is associated with metastasis of human malignancies.

scientific article published on 24 July 2013

Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications

scientific article

Epoxyazadiradione suppresses breast tumor growth through mitochondrial depolarization and caspase-dependent apoptosis by targeting PI3K/Akt pathway

scientific article published on 8 January 2018

ErbB-2 inhibition activates Notch-1 and sensitizes breast cancer cells to a gamma-secretase inhibitor

scientific article published on 12 May 2008

Estrogen receptor β-dependent Notch1 activation protects vascular endothelium against tumor necrosis factor α (TNFα)-induced apoptosis

scientific article published on 11 September 2017

Expression and distribution of notch protein members in human placenta throughout pregnancy.

scientific article published in February 2007

Expression and significance of notch signaling pathway in salivary adenoid cystic carcinoma.

scientific article published on 10 October 2013

Farmers' Market Utilization among Supplemental Nutrition Assistance Program Recipients in New Orleans, Louisiana: Preliminary Findings.

scientific article

Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD).

scientific article

Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells

scientific article published in September 2005

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke.

scientific article published on 7 May 2006

HPV16 E6 and E7 oncoproteins regulate Notch-1 expression and cooperate to induce transformation.

scientific article published on March 2003

Hedgehog signaling in hepatocellular carcinoma: novel therapeutic strategy targeting hedgehog signaling in HCC

scientific article published on 07 February 2006

High prevalence of luminal B breast cancer intrinsic subtype in Colombian women

scientific article published on 16 April 2016

Hyper-activation of Notch3 amplifies the proliferative potential of rhabdomyosarcoma cells.

scientific article

Hypoxic Induction of Vasorin Regulates Notch1 Turnover to Maintain Glioma Stem-like Cells

scientific article

Increased plasma levels of soluble vascular endothelial growth factor receptor 1 (sFlt-1) in women by moderate exercise and increased plasma levels of vascular endothelial growth factor in overweight/obese women.

scientific article

Inhibition of HER2 Increases JAGGED1-dependent Breast Cancer Stem Cells: Role for Membrane JAGGED1

Inhibition of Notch3 signalling induces rhabdomyosarcoma cell differentiation promoting p38 phosphorylation and p21(Cip1) expression and hampers tumour cell growth in vitro and in vivo.

scientific article

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

scientific article published in July 2005

Integrative Analysis of Response to Tamoxifen Treatment in ER-Positive Breast Cancer Using GWAS Information and Transcription Profiling ⬇️

scientific article published on February 20, 2012

Involvement of notch signaling in wound healing

scientific article

Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma

scientific article

Lys 43 and Asp 46 in alpha-helix 3 of uteroglobin are essential for its phospholipase A2 inhibitory activity

scientific article (publication date: 26 July 2002)

Manic fringe promotes a claudin-low breast cancer phenotype through notch-mediated PIK3CG induction.

scientific article published on 25 March 2015

MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality

scientific article published on 24 September 2011

Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia.

scientific article published on 14 March 2016

Myeloid-derived suppressor cells contribute to A2B adenosine receptor-induced VEGF production and angiogenesis in a mouse melanoma model

scientific article

NOTCH-1 and NOTCH-4 are novel gene targets of PEA3 in breast cancer: novel therapeutic implications.

scientific article published on 14 June 2011

NOTCH1 Can Initiate NF-κB Activation via Cytosolic Interactions with Components of the T Cell Signalosome

scientific article published on 26 May 2014

New weapons against inflammation: dual inhibitors of phospholipase A2 and transglutaminase.

scientific article

Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4(+) T Cells.

scientific article published on 12 February 2014

Nonradiometric ELISA-based quantitation and validation of polymerase chain reaction-amplified DNA, including detection of point mutations, without allele-specific amplification, or ligation.

scientific article published on December 1994

Notch Signaling in Myeloid Cells as a Regulator of Tumor Immune Responses.

scientific article

Notch Signaling in Neuroendocrine Tumors

scientific article

Notch and NOXA-related pathways in melanoma cells.

scientific article

Notch and the immune system.

scientific article

Notch inhibition in Kaposi's sarcoma tumor cells leads to mitotic catastrophe through nuclear factor-kappaB signaling.

scientific article

Notch regulates cytolytic effector function in CD8+ T cells.

scientific article

Notch signaling in pediatric soft tissue sarcomas

scientific article

Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiation

scientific article

Notch signaling is necessary but not sufficient for differentiation of dendritic cells.

scientific article published on 7 August 2003

Notch signaling regulates mouse and human Th17 differentiation

scientific article

Notch signaling.

scientific article

Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition

scientific article published on 06 September 2013

Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy.

scientific article

Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.

scientific article published on 19 October 2009

Notch-1 associates with IKKalpha and regulates IKK activity in cervical cancer cells.

scientific article

Notch-1 induces epithelial-mesenchymal transition consistent with cancer stem cell phenotype in pancreatic cancer cells

scientific article

Notch-1 inhibits apoptosis in murine erythroleukemia cells and is necessary for differentiation induced by hybrid polar compounds

scientific article published on 01 May 1999

Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.

scientific article

Notch-1-PTEN-ERK1/2 signaling axis promotes HER2+ breast cancer cell proliferation and stem cell survival.

scientific article published on 10 May 2018

Notch-associated microRNAs in cancer.

scientific article published on September 2013

Notch-independent regulation of Hes-1 expression by c-Jun N-terminal kinase signaling in human endothelial cells

Notch1 is regulated by chorionic gonadotropin and progesterone in endometrial stromal cells and modulates decidualization in primates

scientific article

Notch1 mediates uterine stromal differentiation and is critical for complete decidualization in the mouse.

scientific article published on 11 October 2011

Notch1 phenotype and clinical stage progression in non-small cell lung cancer

scientific article

Notch1 primes CD4 T cells for T helper type I differentiation through its early effects on miR-29

scientific article published on 26 May 2018

Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells

scientific article

Novel Integrative Genomics Approach for Associating GWAS Information with Intrinsic Subtypes of Breast Cancer.

scientific article published on 15 May 2013

Novel putative drivers revealed by targeted exome sequencing of advanced solid tumors.

scientific article published on 23 March 2018

Off the beaten pathway: the complex cross talk between Notch and NF-kappaB

scientific article published on 03 December 2007

Over-expression of FoxM1 leads to epithelial-mesenchymal transition and cancer stem cell phenotype in pancreatic cancer cells

scientific article

Overexpression of the NOTCH ligand JAG2 in malignant plasma cells from multiple myeloma patients and cell lines.

scientific article

Oxygen concentration determines the biological effects of NOTCH-1 signaling in adenocarcinoma of the lung.

scientific article published in September 2007

PKCα Attenuates Jagged-1-Mediated Notch Signaling in ErbB-2-Positive Breast Cancer to Reverse Trastuzumab Resistance

scientific article

Phospholipase A2 enzymes: regulation and physiological role.

scientific article published on July 1994

Plants as bioreactors for biopharmaceuticals: regulatory considerations.

scientific article published on February 1997

Postmenopausal obesity promotes tumor angiogenesis and breast cancer progression in mice

scientific article published on 15 May 2011

Proteasome inhibitors trigger NOXA-mediated apoptosis in melanoma and myeloma cells

scientific article published on July 2005

Racial Disparities and Preventive Measures to Renal Cell Carcinoma.

scientific article published on 28 May 2018

Rational targeting of Notch signaling in breast cancer

scientific article published on 01 August 2008

Recombinant human uteroglobin suppresses cellular invasiveness via a novel class of high-affinity cell surface binding site.

scientific article published on April 1996

Recombinant human uteroglobin/CC10 inhibits the adhesion and migration of primary human endothelial cells via specific and saturable binding to fibronectin

scientific article published on 01 May 2006

Resonance assignment and secondary structure determination and stability of the recombinant human uteroglobin with heteronuclear multidimensional NMR.

scientific article published in January 1997

Retracted: Activated K-ras and INK4a/Arf Deficiency Cooperate During the Development of Pancreatic Cancer by Activation of Notch and NF-κB Signaling Pathways

retracted article

SU11248, A selective tyrosine kinases inhibitor suppresses breast tumor angiogenesis and growth via targeting both tumor vasculature and breast cancer cells ⬇️

scientific article published on October 1, 2010

SV40 and human brain tumors

scientific article published on 01 August 2003

Serum From Advanced Heart Failure Patients Promotes Angiogenic Sprouting and Affects the Notch Pathway in Human Endothelial Cells

scientific article

Sirt2 deacetylase is a novel AKT binding partner critical for AKT activation by insulin

scientific article published on 20 January 2014

Sunitinib significantly suppresses the proliferation, migration, apoptosis resistance, tumor angiogenesis and growth of triple-negative breast cancers but increases breast cancer stem cells

scientific article

Systems Biology Approaches in Identifying the Targets of Natural Compounds for Cancer Therapy ⬇️

scientific article published on June 1, 2013

Targeting Met and Notch in the Lfng-deficient, Met-amplified triple-negative breast cancer.

scientific article

Targeting Notch in oncology: the path forward

scientific article published on 08 December 2020

Targeting Notch to target cancer stem cells.

scientific article published on 08 June 2010

Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update

scientific article published on 7 April 2015

Targeting pancreatic cancer stem cells for cancer therapy ⬇️

scientific article published on June 20, 2012

Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

scientific article published on 17 December 2006

Targeting the adenosine A2b receptor in the tumor microenvironment overcomes local immunosuppression by myeloid-derived suppressor cells.

scientific article published on 14 February 2014

The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendritic cells

scientific article published on 01 October 2002

The Notch pathway: a crossroad between the life and death of the endothelium ⬇️

scientific article published on May 29, 2012

The Polycomb group (PcG) protein EZH2 supports the survival of PAX3-FOXO1 alveolar rhabdomyosarcoma by repressing FBXO32 (Atrogin1/MAFbx).

scientific article published on 11 November 2013

The role of chorionic gonadotropin and Notch1 in implantation

scientific article

The sphingosine kinase 2 inhibitor ABC294640 displays anti-non-small cell lung cancer activities in vitro and in vivo.

scientific article published on 26 December 2017

Therapeutic targeting of NOTCH signaling ameliorates immune-mediated bone marrow failure of aplastic anemia

scientific article published on 03 June 2013

Transcription factor RBPJ/CSL: A genome-wide look at transcriptional regulation ⬇️

scientific article published on August 24, 2011

Uteroglobin, a possible ligand of the lipoxin receptor inhibits serum amyloid A-driven inflammation.

scientific article published on 23 March 2014

Whole Genome Transcriptome Analysis of the Association between Obesity and Triple-Negative Breast Cancer in Caucasian Women

scientific article published on 23 October 2018

ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models.

scientific article published on 8 January 2018

p53 Modulates Notch Signaling in MCF-7 Breast Cancer Cells by Associating With the Notch Transcriptional Complex Via MAML1

scientific article

γ-Secretase inhibitors in cancer clinical trials are pharmacologically and functionally distinct

scientific article published on 24 May 2017

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