List of works - Sonia Séverin

A confocal-based morphometric analysis shows a functional crosstalk between the actin filament system and microtubules in thrombin-stimulated platelets

scientific article published on 01 January 2013

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

scientific article

A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples

scientific article

ATP-binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces thromboxane A2 production independently of hematopoietic ABCA1.

scientific article published on 17 February 2016

Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions

scientific article published on 01 December 2019

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

scientific article

Class I PI 3-kinases signaling in platelet activation and thrombosis: PDK1/Akt/GSK3 axis and impact of PTEN and SHIP1.

scientific article published on 18 September 2013

Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation

scientific article published on 18 July 2009

Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth

scientific article

Different roles of SHIP1 according to the cell context: the example of blood platelets.

scientific article

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation

scientific article published on 01 July 2020

Distinct and overlapping functional roles of Src family kinases in mouse platelets

scientific article

Effects of Estrogens on Platelets and Megakaryocytes

scientific article published on 25 June 2019

Essential role of class II PI3K-C2α in platelet membrane morphology

scientific article

Expression of myotubularins in blood platelets: Characterization and potential diagnostic of X-linked myotubular myopathy.

scientific article published on 4 May 2016

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia

scientific article published on October 2013

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

scientific article

Phosphatidylinositol 3 monophosphate metabolizing enzymes in blood platelet production and in thrombosis

scientific article published on 07 October 2019

Phosphoinositides: Important lipids in the coordination of cell dynamics

scientific article published on 18 September 2015

Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate.

scientific article published on 14 November 2014

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation

scientific article published on 12 June 2018

Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.

scientific article

Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions

scientific article published on 11 August 2009

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation

scientific journal article

Src family kinases are essential for primary aggregation by G(i) -coupled receptors

scientific article published on October 2010

Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling

scientific article published on 22 November 2010

Targeting Kinases in Cancer Therapies: Adverse Effects on Blood Platelets.

scientific article published on 26 February 2016

The importance of blood platelet lipid signaling in thrombosis and in sepsis.

scientific article published on 29 September 2017

The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation

scientific article published on 23 October 2009

The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis

scientific article published on 02 December 2015

List of works by Sonia Séverin

A confocal-based morphometric analysis shows a functional crosstalk between the actin filament system and microtubules in thrombin-stimulated platelets

A dual role for the class III PI3K, Vps34, in platelet production and thrombus growth.

A novel mass assay to quantify the bioactive lipid PtdIns3P in various biological samples

ATP-binding cassette transporter 1 (ABCA1) deficiency decreases platelet reactivity and reduces thromboxane A2 production independently of hematopoietic ABCA1.

Catalytic dysregulation of SHP2 leading to Noonan syndromes affects platelet signaling and functions

Cdc42-dependent F-actin dynamics drive structuration of the demarcation membrane system in megakaryocytes

Class I PI 3-kinases signaling in platelet activation and thrombosis: PDK1/Akt/GSK3 axis and impact of PTEN and SHIP1.

Critical role for ERK1/2 in bone marrow and fetal liver-derived primary megakaryocyte differentiation, motility, and proplatelet formation

Deficiency of Src homology 2 domain-containing inositol 5-phosphatase 1 affects platelet responses and thrombus growth

Different roles of SHIP1 according to the cell context: the example of blood platelets.

Disrupting the platelet internal membrane via PI3KC2α inhibition impairs thrombosis independently of canonical platelet activation

Distinct and overlapping functional roles of Src family kinases in mouse platelets

Effects of Estrogens on Platelets and Megakaryocytes

Essential role of class II PI3K-C2α in platelet membrane morphology

Expression of myotubularins in blood platelets: Characterization and potential diagnostic of X-linked myotubular myopathy.

JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

Phosphatidylinositol 3 monophosphate metabolizing enzymes in blood platelet production and in thrombosis

Phosphoinositides: Important lipids in the coordination of cell dynamics

Platelet PI3Kβ and GSK3 regulate thrombus stability at a high shear rate.

Profiling of phosphoinositide molecular species in human and mouse platelets identifies new species increasing following stimulation

Protein kinase Cε and protein kinase Cθ double-deficient mice have a bleeding diathesis.

Proteomic analysis of integrin alphaIIbbeta3 outside-in signaling reveals Src-kinase-independent phosphorylation of Dok-1 and Dok-3 leading to SHIP-1 interactions

Roles of the C-terminal tyrosine residues of LAT in GPVI-induced platelet activation: insights into the mechanism of PLC gamma 2 activation

Src family kinases are essential for primary aggregation by G(i) -coupled receptors

Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling

Targeting Kinases in Cancer Therapies: Adverse Effects on Blood Platelets.

The importance of blood platelet lipid signaling in thrombosis and in sepsis.

The mitogen-activated protein kinase signaling pathways: role in megakaryocyte differentiation

The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis