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List of works by C. Oliver Kappe

5-aroyl-3,4-dihydropyrimidin-2-one library generation via automated sequential and parallel microwave-assisted synthesis techniques.

scientific article

A Facile and Efficient Synthesis of Thieno[2,3-c]furans and Furo[3,4-b]indoles via a Pummerer-Induced Cyclization Reaction ⬇️

scientific article published on September 6, 1996

A Reexamination of the Mechanism of the Biginelli Dihydropyrimidine Synthesis. Support for an N-Acyliminium Ion Intermediate1 ⬇️

scientific article published on October 17, 1997

A TRPC3 Blocker, Ethyl-1-(4-(2,3,3-Trichloroacrylamide)Phenyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate (Pyr3), Prevents Stent-Induced Arterial Remodeling

scientific article published on 25 September 2012

A continuous-flow protocol for light-induced benzylic fluorinations

scientific article published on 26 August 2014

A critical assessment of the specific role of microwave irradiation in the synthesis of ZnO micro- and nanostructured materials

scientific article published on 27 March 2012

A high-throughput platform for low-volume high-temperature/pressure sealed vessel solvent extractions

scientific article published on 17 September 2011

A novel pathway for the thermolysis of N-nitrosoanthranilates using flash vacuum pyrolysis leading to 7-aminophthalides

scientific article published on 16 October 2020

A scalable procedure for light-induced benzylic brominations in continuous flow

scientific article published on 27 November 2013

A sequential Ugi multicomponent/Cu-catalyzed azide-alkyne cycloaddition approach for the continuous flow generation of cyclic peptoids.

scientific article published on 13 April 2015

A three step continuous flow synthesis of the biaryl unit of the HIV protease inhibitorAtazanavir

scientific article published on 14 August 2013

A two-step continuous-flow synthesis of N-(2-aminoethyl)acylamides through ring-opening/hydrogenation of oxazolines

scientific article published on 14 October 2011

A unified mechanistic view on the Morita-Baylis-Hillman reaction: computational and experimental investigations.

scientific article published on 17 November 2010

Activation and deactivation of a chemical transformation by an electromagnetic field: evidence for specific microwave effects in the formation of Grignard reagents

scientific article published on 07 June 2011

Amphiphilic polymers based on higher alkylene oxides Synthesis and characterization by different chromatographic techniques.

scientific article published on 27 December 2008

An algorithm for the deconvolution of mass spectroscopic patterns in isotope labeling studies. Evaluation for the hydrogen-deuterium exchange reaction in ketones.

scientific article published on 20 June 2007

An evaluation of microwave-assisted derivatization procedures using hyphenated mass spectrometric techniques.

scientific article published on 17 June 2009

An experimental and computational assessment of acid-catalyzed azide-nitrile cycloadditions

scientific article published on 13 November 2012

An investigation of wall effects in microwave-assisted ring-closing metathesis and cyclotrimerization reactions.

scientific article published on August 2010

Anthropogenic reaction parameters--the missing link between chemical intuition and the available chemical space.

scientific article published in August 2014

Automated library generation using sequential microwave-assisted chemistry. Application toward the Biginelli multicomponent condensation.

scientific article

Batch- and Continuous-Flow Aerobic Oxidation of 14-Hydroxy Opioids to 1,3-Oxazolidines-A Concise Synthesis of Noroxymorphone.

scientific article published on 12 May 2016

Bis(diethylamino)(pentafluorophenyl)phosphane – a Push–Pull Phosphane Available for Coordination.

scientific article published on 27 April 2011

Can electromagnetic fields influence the structure and enzymatic digest of proteins? A critical evaluation of microwave-assisted proteomics protocols.

scientific article

Catalyst Free Oxytrifluoromethylation of Alkenes via Paired Electrolysis in Organic-Aqueous Media

scientific article published on 30 October 2018

Cathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex

scientific article published on 12 September 2019

Chiral Chlorohydrins from the Biocatalyzed Reduction of Chloroketones: Chiral Building Blocks for Antiretroviral Drugs

Click chemistry under non-classical reaction conditions.

scientific article published on 27 July 2009

Combinatorial synthesis of functionalized 1,3-thiazine libraries using a combined polymer-supported reagent/catch-and-release strategy.

scientific article

Combined batch and continuous flow procedure to the chemo-enzymatic synthesis of biaryl moiety of Odanacatib

Continuous Flow Homolytic Aromatic Substitution with Electrophilic Radicals: A Fast and Scalable Protocol for Trifluoromethylation.

scientific article published on 24 October 2016

Continuous Flow Synthesis of Terminal Epoxides from Ketones Using in Situ Generated Bromomethyl Lithium

scientific article published on 03 December 2019

Continuous flow generation and reactions of anhydrous diazomethane using a Teflon AF-2400 tube-in-tube reactor.

scientific article

Continuous flow organic synthesis under high-temperature/pressure conditions.

scientific article published on June 2010

Continuous flow ozonolysis in a laboratory scale reactor

scientific article published on 26 January 2011

Continuous flow reduction of artemisinic acid utilizing multi-injection strategies-closing the gap towards a fully continuous synthesis of antimalarial drugs

scientific article published on 05 February 2015

Continuous flow synthesis of arylhydrazines via nickel/photoredox coupling of tert-butyl carbazate with aryl halides

scientific article published on 05 November 2020

Continuous flow synthesis of α-halo ketones: essential building blocks of antiretroviral agents.

scientific article

Continuous flow α-trifluoromethylation of ketones by metal-free visible light photoredox catalysis

scientific article published on 16 January 2014

Continuous multistep synthesis of 2-(azidomethyl)oxazoles.

scientific article published on 23 February 2018

Continuous-Flow Amide and Ester Reductions Using Neat Borane Dimethylsulfide Complex

scientific article published on 20 February 2020

Continuous-Flow Electrophilic Amination of Arenes and Schmidt Reaction of Carboxylic Acids Utilizing the Superacidic Trimethylsilyl Azide/Triflic Acid Reagent System.

scientific article published on 20 September 2016

Continuous-Flow Pd-Catalyzed Carbonylation of Aryl Chlorides with Carbon Monoxide at Elevated Temperature and Pressure

scientific article published on 15 January 2019

Continuous-Flow Synthesis of ZIF-8 Biocomposites with Tunable Particle Size

scientific article published on 14 February 2020

Continuous-flow Synthesis of Aryl Aldehydes by Pd-catalyzed Formylation of Aryl Bromides Using Carbon Monoxide and Hydrogen

scientific article published on 13 November 2018

Continuous-flow synthesis of CdSe quantum dots: a size-tunable and scalable approach.

scientific article published on 15 July 2013

Continuous-flow synthesis of adipic acid from cyclohexene using hydrogen peroxide in high-temperature explosive regimes

scientific article published on 16 April 2013

Continuous-flow technology—a tool for the safe manufacturing of active pharmaceutical ingredients.

scientific article published on 18 May 2015

Controlled microwave heating in modern organic synthesis.

scientific article

Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

scientific article published on 21 April 2009

Copper-catalyzed C-C coupling of thiol esters and boronic acids under aerobic conditions

scientific article published on 01 January 2008

Copper-catalyzed formation of C-O bonds by direct α-C-H bond activation of ethers using stoichiometric amounts of peroxide in batch and continuous-flow formats

scientific article published on 11 April 2012

Correction to: The Use of Molecular Oxygen for Liquid Phase Aerobic Oxidations in Continuous Flow

scientific article published on 07 February 2019

Design and Performance Validation of a Conductively Heated Sealed-Vessel Reactor for Organic Synthesis

scientific article published on 18 November 2016

Design and construction of an open source-based photometer and its applications in flow chemistry

scientific article published in 2018

Design and evaluation of improved magnetic stir bars for single-mode microwave reactors

scientific article published on 25 June 2013

Diazo Strategy for the Synthesis of Pyridazines: Pivotal Impact of the Configuration of the Diazo Precursor on the Process.

scientific article published on 25 November 2015

Dipolar Cycloaddition Reactions of Dihydropyrimidine-Fused Mesomeric Betaines. An Approach toward Conformationally Restricted Dihydropyrimidine Derivatives1 ⬇️

scientific article published on May 16, 1997

Direct Arylation of Benzene with Aryl Bromides using High‐Temperature/High‐Pressure Process Windows: Expanding the Scope of CH Activation Chemistry ⬇️

scientific article published on 07 March 2012

Direct preparation of nitriles from carboxylic acids in continuous flow

scientific article published on 08 October 2013

Direct solid-phase synthesis of the beta-amyloid (1-42) peptide using controlled microwave heating.

scientific article

Diversity-oriented synthesis of dibenzoazocines and dibenzoazepines via a microwave-assisted intramolecular A(3)-coupling reaction

scientific article published on 01 June 2010

Effect of configuration of 2-vinyldiazocarbonyl compounds on their reactivity: experimental and computational study

scientific article published on 01 January 2014

Electrochemical N-Demethylation of 14-Hydroxy Morphinans: Sustainable Access to Opioid Antagonists

scientific article published on 13 August 2020

Electromagnetic simulations of microwave heating experiments using reaction vessels made out of silicon carbide

scientific article published on 12 July 2010

Enantioseparation of racemic 4-aryl-3,4-dihydro-2(1H)-pyrimidones on chiral stationary phases based on 3,5-dimethylanilides of N-(4-alkylamino-3,5-dinitro)benzoyl L-alpha-amino acids.

scientific article published in June 2003

Flash flow pyrolysis: mimicking flash vacuum pyrolysis in a high-temperature/high-pressure liquid-phase microreactor environment

scientific article published on 22 February 2012

Generation and Synthetic Application of Trifluoromethyl Diazomethane Utilizing Continuous Flow Technologies

scientific article published on 23 February 2016

HCN on Tap: On-Demand Continuous Production of Anhydrous HCN for Organic Synthesis

scientific article published on 19 June 2019

Heterogeneous catalytic hydrogenation reactions in continuous-flow reactors.

scientific article published on 17 February 2011

Heterogeneous hydrogenation reactions using a continuous flow high pressure device.

scientific article published in September 2005

Heterogeneous versus homogeneous palladium catalysts for ligandless mizoroki-heck reactions: a comparison of batch/microwave and continuous-flow processing.

scientific article

High-speed microwave-assisted synthesis of the trifluoromethylpyrazol-derived canonical transient receptor potential (TRPC) channel inhibitor Pyr3.

scientific article published in November 2009

High-throughput experimentation platform: parallel microwave chemistry in HPLC/GC vials

scientific article published on 01 May 2009

How to measure reaction temperature in microwave-heated transformations.

scientific article published on June 2013

Hydrazine-mediated reduction of nitro and azide functionalities catalyzed by highly active and reusable magnetic iron oxide nanocrystals.

scientific article published on 15 April 2013

Iminopropadienethiones, Ar=N=C=C=C=S

scientific article published on 01 March 2001

Immobilized iron oxide nanoparticles as stable and reusable catalysts for hydrazine-mediated nitro reductions in continuous flow.

scientific article published on 10 September 2014

In situ generated iron oxide nanocrystals as efficient and selective catalysts for the reduction of nitroarenes using a continuous flow method

In situ preparation of silver nanocomposites on cellulosic fibers – Microwave vs. conventional heating ⬇️

scientific article published on February 7, 2013

Integration of Bromine and Cyanogen Bromide Generators for the Continuous-Flow Synthesis of Cyclic Guanidines.

scientific article published on 6 September 2017

Investigating the existence of nonthermal/specific microwave effects using silicon carbide heating elements as power modulators

scientific article published on 10 July 2008

Investigation of the Formation of CuInS2Nanoparticles by the Oleylamine Route: Comparison of Microwave-Assisted and Conventional Syntheses

scientific article published on 3 January 2011

Lab-scale production of anhydrous diazomethane using membrane separation technology.

scientific article

Laboratory-Scale Membrane Reactor for the Generation of Anhydrous Diazomethane.

scientific article published on 30 June 2016

Light-Induced C-H Arylation of (Hetero)arenes by In Situ Generated Diazo Anhydrides

scientific article published on 03 August 2015

Mechanistic Insights into Copper(I)-Catalyzed Azide-Alkyne Cycloadditions using Continuous Flow Conditions

scholarly article by Michael Fuchs et al published 15 February 2010 in Advanced Synthesis & Catalysis

Mechanistic insights on azide-nitrile cycloadditions: on the dialkyltin oxide-trimethylsilyl azide route and a new Vilsmeier-Haack-type organocatalyst

scientific article published on 07 March 2011

Microwave chemistry in silicon carbide reaction vials: separating thermal from nonthermal effects

scientific article published on 01 January 2009

Microwave effects in organic synthesis: myth or reality?

scientific article published on 07 December 2012

Microwave-assisted Negishi and Kumada cross-coupling reactions of aryl chlorides

scientific article published on 30 January 2004

Microwave-assisted and continuous flow multistep synthesis of 4-(pyrazol-1-yl)carboxanilides

scientific article published on 13 July 2011

Microwave-assisted asymmetric organocatalysis. A probe for nonthermal microwave effects and the concept of simultaneous cooling

scientific article published on 01 February 2007

Microwave-assisted cross-coupling and hydrogenation chemistry by using heterogeneous transition-metal catalysts: an evaluation of the role of selective catalyst heating

scientific article published on 01 November 2009

Microwave-assisted forced degradation using high-throughput microtiter platforms

scientific article published on 04 August 2011

Microwave-assisted high-throughput acid hydrolysis in silicon carbide microtiter platforms--a rapid and low volume sample preparation technique for total amino acid analysis in proteins and peptides

scientific article published on 21 October 2010

Microwave-assisted ring-closing metathesis revisited. On the question of the nonthermal microwave effect

scientific article published on 01 November 2003

Microwave-assisted solution- and solid-phase synthesis of 2-amino-4-arylpyrimidine derivatives

scientific article published on 01 March 2007

Microwave-assisted synthesis in water as solvent.

scientific article published on 24 April 2007

Microwave-assisted synthesis involving immobilized catalysts.

scientific article published on January 2004

Microwave-assisted synthesis of CdSe quantum dots: can the electromagnetic field influence the formation and quality of the resulting nanocrystals?

scientific article published on 01 December 2012

Microwave-assisted synthesis of colloidal inorganic nanocrystals.

scientific article

Microwave-assisted three-component synthesis of 7-aryl-2-alkylthio-4,7-dihydro-1,2,4-triazolo[1,5-a]-pyrimidine-6-carboxamides and their selective reduction.

scientific article published in May 2006

Microwave-enhanced and metal-catalyzed functionalizations of the 4-aryl-dihydropyrimidone template.

scientific article published in July 2005

Multigram-scale flow synthesis of the chiral key intermediate of (-)-paroxetine enabled by solvent-free heterogeneous organocatalysis

scientific article published on 18 October 2019

Nonthermal microwave effects revisited: on the importance of internal temperature monitoring and agitation in microwave chemistry.

scientific article published on 7 December 2007

Novel pyrazole compounds for pharmacological discrimination between receptor-operated and store-operated Ca(2+) entry pathways

scientific article

On the energy efficiency of microwave-assisted organic reactions.

scientific article published in January 2008

On the importance of simultaneous infrared/fiber-optic temperature monitoring in the microwave-assisted synthesis of ionic liquids.

scientific article published on 24 November 2009

On the mechanism of the Dakin-West reaction

scientific article published on 15 October 2012

One-pot, multicomponent route to pyrazoloquinolizinones

scientific article published on 27 March 2007

Organomagnesium Based Flash Chemistry: Continuous Flow Generation and Utilization of Halomethylmagnesium Intermediates

scientific article published on 11 September 2020

Palladium(0)-catalyzed, copper(I)-mediated coupling of boronic acids with cyclic thioamides. selective carbon-carbon bond formation for the functionalization of heterocycles

scientific article published on 11 May 2007

Palladium(0)-catalyzed, copper(i)-mediated coupling of cyclic thioamides with alkenylboronic acids, organostannanes, and siloxanes.

scientific article

Palladium-catalyzed direct arylation of heteroaromatic compounds: improved conditions utilizing controlled microwave heating

scientific article published on 26 August 2011

Parallel microwave chemistry in silicon carbide microtiter platforms: a review ⬇️

scientific article published on November 30, 2011

Parallel microwave chemistry in silicon carbide reactor platforms: an in-depth investigation into heating characteristics

scientific article published on 23 June 2009

Parallel microwave synthesis of 2-styrylquinazolin-4(3H)-ones in a high-throughput platform using HPLC/GC vials as reaction vessels.

scientific article

Parallel synthesis of an amide library based on the 6,8-dioxa-3-azabicyclo[3.2.1]octane scaffold by direct aminolysis of methyl esters.

scientific article

Pericyclic versus Pseudopericyclic 1,5-Electrocyclization of Iminodiazomethanes. An ab Initio and Density Functional Theory Study ⬇️

scientific article published on August 21, 1998

Rapid formation of triarylphosphines by microwave-assisted transition metal-catalyzed C-p cross-coupling reactions

scientific article published on 01 October 2002

Rapid nickel-catalyzed Suzuki-Miyaura cross-couplings of aryl carbamates and sulfamates utilizing microwave heating.

scientific article

Rapid preparation of the mitotic kinesin Eg5 inhibitor monastrol using controlled microwave-assisted synthesis

scientific article published on 01 January 2007

Rapid solid-phase peptide synthesis using thermal and controlled microwave irradiation

scientific article published on 01 October 2006

Rapid solid-phase synthesis of a calmodulin-binding peptide using controlled microwave irradiation

scientific article published on 01 January 2007

Recent advances in the Biginelli dihydropyrimidine synthesis. New tricks from an old dog.

scientific article

Shifting chemical equilibria in flow--efficient decarbonylation driven by annular flow regimes.

scientific article

Silicon carbide passive heating elements in microwave-assisted organic synthesis

scientific article published on 01 June 2006

Simulating microwave chemistry in a resistance-heated autoclave made of semiconducting silicon carbide ceramic.

scientific article

Singlet-oxygen oxidation of 5-hydroxymethylfurfural in continuous flow.

scientific article published on 11 December 2014

Sintered Silicon Carbide: A New Ceramic Vessel Material for Microwave Chemistry in Single‐Mode Reactors ⬇️

scientific article published on October 25, 2010

Solid-phase synthesis of difficult peptide sequences at elevated temperatures: a critical comparison of microwave and conventional heating technologies

scientific article published on 27 August 2008

Stereoconservative Negishi arylation and alkynylation as an efficient approach to enantiopure 2,2'-diarylated 1,1'-binaphthyls

scientific article published on 01 October 2004

Structure-activity relationships and molecular docking of novel dihydropyrimidine-based mitotic Eg5 inhibitors.

scientific article published in October 2010

Studies Dealing with the Cycloaddition/Ring Opening/Elimination Sequence of 2-Amino-Substituted Isobenzofurans ⬇️

scientific article published on 01 May 1997

Symmetrical bisquinolones via metal-catalyzed cross-coupling and homocoupling reactions.

scientific article published in February 2006

Synthesis of 5-substituted 1H-tetrazoles from nitriles and hydrazoic acid by using a safe and scalable high-temperature microreactor approach.

scientific article published on September 2010

Synthesis of bisquinolone-based mono- and diphosphine ligands of the Aza-BINAP type.

scientific article published on 29 May 2008

TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1.

scientific article

Tandem Pummerer−Diels−Alder Reaction Sequence. A Novel Cascade Process for the Preparation of 1-Arylnaphthalene Lignans ⬇️

scientific article published on May 31, 1996

Telescoped Continuous Flow Synthesis of Optically Active γ-Nitrobutyric Acids as Key Intermediates of Baclofen, Phenibut, and Fluorophenibut

scientific article published on 07 October 2020

The Concept of Chemical Generators: On-Site On-Demand Production of Hazardous Reagents in Continuous Flow

scientific article published on 16 June 2020

The Liebeskind-Srogl C-C cross-coupling reaction.

scientific article

The Use of Molecular Oxygen for Liquid Phase Aerobic Oxidations in Continuous Flow

scientific article published on 11 December 2018

The Use of Molecular Oxygen in Pharmaceutical Manufacturing: Is Flow the Way to Go?

scientific article

The application of "click chemistry" for the decoration of 2(1H)-pyrazinone scaffold: generation of templates.

scientific article published in May 2005

The effect of pressure on microwave-enhanced Diels-Alder reactions. A case study

scientific article published on 04 December 2003

The impact of microwave synthesis on drug discovery.

scientific article

The microwave-to-flow paradigm: translating high-temperature batch microwave chemistry to scalable continuous-flow processes

scientific article published on 20 September 2011

Towards a Scalable Synthesis of 2-Oxabicyclo[2.2.0]hex-5-en-3-one Using Flow Photochemistry

scientific article published on 18 February 2019

Traceless solid-phase synthesis of bicyclic dihydropyrimidones using multidirectional cyclization cleavage.

scientific article published in September 2002

Tunable carbon-carbon and carbon-sulfur cross-coupling of boronic acids with 3,4-dihydropyrimidine-2-thiones

scientific article published on 01 March 2004

Understanding microwave heating effects in single mode type cavities—theory and experiment

article

Unraveling the mysteries of microwave chemistry using silicon carbide reactor technology.

scientific article published on 06 March 2013

Unusual behavior in the reactivity of 5-substituted-1H-tetrazoles in a resistively heated microreactor.

scientific article published on 21 April 2011

Utilization of fluoroform for difluoromethylation in continuous flow: a concise synthesis of α-difluoromethyl-amino acids

Visible Light-Promoted Beckmann Rearrangements: Separating Sequential Photochemical and Thermal Phenomena in a Continuous Flow Reactor

scientific article published on 08 March 2019

Visible-Light-Mediated Iodoperfluoroalkylation of Alkenes in Flow and Its Application to the Synthesis of a Key Fulvestrant Intermediate

scientific article published on 21 June 2019

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