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List of works by Sami Haddad

A PBPK modeling-based approach to account for interactions in the health risk assessment of chemical mixtures.

scientific article

A case study addressing the reliability of polychlorinated biphenyl levels measured at the time of breast cancer diagnosis in representing early-life exposure

scientific article published on 21 December 2010

A method for quantification of volatile organic compounds in blood by SPME-GC-MS/MS with broader application: From non-occupational exposure population to exposure studies.

scientific article published on 20 April 2015

A methodology for solving physiologically based pharmacokinetic models without the use of simulation softwares.

scientific article published in May 1996

A modeling approach to account for toxicokinetic interactions in the calculation of biological hazard index for chemical mixtures.

scientific article published in September 1999

A physiologically based pharmacokinetic model for the assessment of infant exposure to persistent organic pollutants in epidemiologic studies

scientific article

Advancing prediction of tissue distribution and volume of distribution of highly lipophilic compounds from a simplified tissue-composition-based model as a mechanistic animal alternative method

scientific article published on 02 March 2012

Albumin and Uptake of Drugs in Cells: Additional Validation Exercises of a Recently Published Equation that Quantifies the Albumin-Facilitated Uptake Mechanism(s) in Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling Research.

scientific article published on 12 October 2015

An assessment of the impact of multi-route co-exposures on human variability in toxicokinetics: A case study with binary and quaternary mixtures of volatile drinking water contaminants

scientific article published on 05 March 2019

Assessing human variability in kinetics for exposures to multiple environmental chemicals: a physiologically based pharmacokinetic modeling case study with dichloromethane, benzene, toluene, ethylbenzene, and m-xylene.

scientific article published in January 2015

Assessment of air and water contamination by disinfection by-products at 41 indoor swimming pools

scientific article published on 28 April 2016

Breast Cancer and Exposure to Organochlorines in the CECILE Study: Associations with Plasma Levels Measured at the Time of Diagnosis and Estimated during Adolescence

scientific article published on 18 January 2019

Characterization of Aerosols of Titanium Dioxide Nanoparticles Following Three Generation Methods Using an Optimized Aerosolization System Designed for Experimental Inhalation Studies

scientific article published on July 2017

Characterization of age-related changes in body weight and organ weights from birth to adolescence in humans.

scientific article

Comparative Assessment Of Extrapolation Methods Based On The Conventional Free Drug Hypothesis And Plasma Protein-Mediated Hepatic Uptake Theory For The Hepatic Clearance Predictions Of Two Drugs Extensively Bound To Both The Albumin And Alpha-1-Aci

scientific article published on 17 November 2020

Comparative assessment of In Vitro-In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs

scientific article published on 13 August 2012

Derivation of exposure factors for infant lactational exposure to persistent organic pollutants (POPs)

scientific article published on 12 December 2014

Deriving A Drinking Water Guideline for A Non-Carcinogenic Contaminant: The Case of Manganese

scientific article published on 20 June 2018

Development and Validation of a Method for the Simultaneous Quantification of 21 Microbial Volatile Organic Compounds in Ambient and Exhaled Air by Thermal Desorption and Gas Chromatography–Mass Spectrometry

scientific article published in 2022

Development of physiologically based toxicokinetic models for improving the human indoor exposure assessment to water contaminants: trichloroethylene and trihalomethanes.

scientific article published in December 2006

ESTIMATION OF TOLUENE EXPOSURE IN AIR FROM BMA (S-BENZYLMERCAPTURIC ACID) URINARY MEASURES USING A REVERSE DOSIMETRY APPROACH BASED ON PHYSIOLOGICALLY PHARMACOKINETIC MODELING

scientific article published on 03 January 2021

Effects of chronic exposure to octylphenol on the male rat reproductive system.

scientific article published in January 2009

Ethanol toxicokinetics resulting from inhalation exposure in human volunteers and toxicokinetic modeling

scientific article published on 01 February 2014

Evaluating the neurotoxic effects of lactational exposure to persistent organic pollutants (POPs) in Spanish children.

scientific article published on 18 October 2012

Evaluation and modeling of the impact of coexposures to VOC mixtures on urinary biomarkers.

scientific article published on 6 April 2016

Extrapolating in vitro metabolic interactions to isolated perfused liver: predictions of metabolic interactions between R-bufuralol, bunitrolol, and debrisoquine

scientific article

Extrapolation of the Hepatic Clearance of Drugs in the Absence of Albumin In Vitro to That in the Presence of Albumin In Vivo: Comparative Assessement of 2 Extrapolation Models Based on the Albumin-Mediated Hepatic Uptake Theory and Limitations and

scientific article published on 20 March 2018

Hepatocyte composition-based model as a mechanistic tool for predicting the cell suspension: aqueous phase partition coefficient of drugs in in vitro metabolic studies

scientific article published on 13 May 2013

High concentrations of commonly used drugs can inhibit the in vitro glucuronidation of bisphenol A and nonylphenol in rats.

scientific article

Human inhalation exposures to toluene, ethylbenzene, and m-xylene and physiologically based pharmacokinetic modeling of exposure biomarkers in exhaled air, blood, and urine.

scientific article published on 19 January 2015

Impact of extensive plasma protein binding on the in situ hepatic uptake and clearance of perampanel and fluoxetine in Sprague Dawley rats

scientific article published on 07 July 2020

Improving the risk assessment of lipophilic persistent environmental chemicals in breast milk

scientific article

In vitro neurotoxicity data in human risk assessment of polybrominated diphenyl ethers (PBDEs): overview and perspectives.

scientific article

In vitro-in vivo extrapolation of clearance: modeling hepatic metabolic clearance of highly bound drugs and comparative assessment with existing calculation methods.

scientific article published on 18 October 2011

In vivo effects of naproxen, salicylic acid, and valproic acid on the pharmacokinetics of trichloroethylene and metabolites in rats

scientific article published on January 2015

Microsome composition-based model as a mechanistic tool to predict nonspecific binding of drugs in liver microsomes

scientific article published on 13 May 2011

Modulation of trichloroethylene in vitro metabolism by different drugs in human.

scientific article published on 14 March 2014

Modulation of trichloroethylene in vitro metabolism by different drugs in rats.

scientific article published on 23 October 2012

Oral p-tert-octylphenol exposures induce minimal toxic or estrogenic effects in adult female Sprague-Dawley rats

scientific article published on January 2010

Physiological daily inhalation rates for health risk assessment in overweight/obese children, adults, and elderly.

scientific article published on 22 October 2013

Physiological modeling and extrapolation of pharmacokinetic interactions from binary to more complex chemical mixtures

scientific article

Physiological modeling of age-specific changes in the pharmacokinetics of organic chemicals in children

scientific article

Physiological modeling of the toxicokinetic interactions in a quaternary mixture of aromatic hydrocarbons

scientific article published on 01 December 1999

Physiologically based modeling of p-tert-octylphenol kinetics following intravenous, oral or subcutaneous exposure in male and female Sprague-Dawley rats.

scientific article published in July 2010

Physiologically based pharmacokinetic modeling of persistent organic pollutants for lifetime exposure assessment: a new tool in breast cancer epidemiologic studies

scientific article

Physiologically-Based Pharmacokinetic (PBPK) Models in Toxicity Testing and Risk Assessment ⬇️

scientific article published on January 1, 2012

Predictions of bisphenol A hepatic clearance in the isolated perfused rat liver (IPRL): impact of albumin binding and of co-administration with naproxen

scientific article

Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers.

scientific article

Rate of pyrene metabolism in rat liver post-mitochondrial fractions

scientific article published on 01 December 1997

Relative lipid content as the sole mechanistic determinant of the adipose tissue:blood partition coefficients of highly lipophilic organic chemicals

scientific article published on 01 April 2000

Reverse dosimetry modeling of toluene exposure concentrations based on biomonitoring levels from the Canadian health measures survey

article

Supplemental Analysis of the Prediction of Hepatic Clearance of Binary Mixtures of Bisphenol A and Naproxen Determined in an Isolated Perfused Rat Liver Model to Promote the Understanding of Potential Albumin-Facilitated Hepatic Uptake Mechanism

scientific article

The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative In Vitro-to-In Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research.

scientific article published on 14 July 2015

The potential protein-mediated hepatic uptake: discussion on the molecular interactions between albumin and the hepatocyte cell surface and their implications for the in vitro-to-in vivo extrapolations of hepatic clearance of drugs

scientific article published on 18 July 2019

Toward a new paradigm for the efficient in vitro-in vivo extrapolation of metabolic clearance in humans from hepatocyte data

scientific article

Toxic effects of PCDD/Fs mixtures on Eisenia andrei earthworms

scientific article published on 06 March 2012

Toxicokinetic modeling of persistent organic pollutant levels in blood from birth to 45 months of age in longitudinal birth cohort studies

scientific article published on 17 October 2012

Toxicokinetics of titanium dioxide (TiO2) nanoparticles after inhalation in rats.

scientific article published on 21 November 2016

Utility of physiologically based pharmacokinetic models to drug development and rational drug discovery candidate selection.

scientific article

Validation of a physiological modeling framework for simulating the toxicokinetics of chemicals in mixtures

scientific article published on 01 September 2000

ÉquiNanos: innovative team for nanoparticle risk management.

scientific article published on 06 September 2012

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