List of works - Pierre Maechler

216. Glutamate Dehydrogenase-Deficient Mice: A Novel Mouse Model of Schizophrenia-Like Phenotypes.

scientific article published on 20 March 2017

A high carbohydrate diet does not induce hyperglycaemia in a mitochondrial glycerol-3-phosphate dehydrogenase-deficient mouse.

scientific article published on 13 September 2003

A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets

scientific article published on 27 November 2013

A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes

scientific article

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress

scientific article published on 01 June 2020

Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets

scientific article published on 29 July 2016

Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia

scientific article published on 5 August 2009

Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion

scientific journal article

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

scientific article published on February 2005

Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

scientific article

Beta-cell mitochondrial carriers and the diabetogenic stress response.

scientific article published on 12 March 2016

Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression

scientific article published on 7 July 2017

ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells

scientific article

Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids

scientific article

Channels and transporters in cell metabolism.

scientific article published on 2 June 2016

Chronic fructose renders pancreatic β-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling

scientific article published on 26 March 2019

Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions

scientific article published in October 2017

Circulating 1,5-Anhydroglucitol as a Biomarker of ß-cell Mass Independent of a Diabetes Phenotype in Human Subjects

scientific article published in 2022

Connexin-36 contributes to control function of insulin-producing cells.

scientific article published on 22 May 2003

Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase ⬇️

scientific article published on February 6, 1998

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

scientific article published on 17 November 2008

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenase ⬇️

scientific article published on August 8, 2012

Desensitization of Mitochondrial Ca2+ and Insulin Secretion Responses in the Beta Cell ⬇️

scientific article published on August 14, 1998

Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.

scientific article published on 18 April 2013

Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function.

scientific article published on 31 May 2006

Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets.

scientific article

Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα

scientific article published in 2021

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

scientific article

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors

scientific article

Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.

scientific article

Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells.

scientific article published on 7 March 2011

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

scientific article

From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis

scientific article published on 12 May 2011

Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease.

scientific article published on April 1999

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells.

scientific article published on 3 April 2008

GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.

scientific article

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

scientific article published on 30 September 2015

Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells ⬇️

scientific article published on October 30, 2003

Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction.

scientific article published on 20 February 2018

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

scientific article published in January 2017

Glutamate pathways of the beta-cell and the control of insulin secretion.

scientific article published on 12 July 2017

Hepatic glucose sensing is required to preserve β cell glucose competence

scientific article published on 15 March 2013

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion

scientific article published on 01 November 2000

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

scientific article published on September 1999

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia

scientific article

Importance of exogenous cholesterol in diabetic rats: effects of treatment with insulin or with an acyl-CoA:cholesterol acyltransferase inhibitor

scientific article published on 01 January 1993

In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way

scientific article published on 08 July 2019

Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.

scientific article published in November 2002

Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.

scientific article published on 20 December 2003

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes

scientific article published on 10 June 2015

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes.

scientific article published on 12 May 2015

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells

scientific article published on 17 August 2016

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production

scientific article published in November 2017

Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

scientific article published in April 2003

Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis

scientific article published on 12 July 2018

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

scientific article published on 17 July 2013

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

scientific article published on 28 October 2020

Metabolomics Identifies a Biomarker Revealing In Vivo Loss of Functional β-Cell Mass Before Diabetes Onset

scientific article published on 19 September 2019

Minireview: New Roles for Peripheral Dopamine on Metabolic Control and Tumor Growth: Let’s Seek the Balance ⬇️

scientific article published on November 3, 2010

Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells.

scientific article

Mitochondria in endocrinology ⬇️

scientific article published on 03 September 2012

Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion

scientific article

Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress

scientific article published on 12 November 2020

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.

scientific article

Mitochondrial damages and the regulation of insulin secretion

scientific article published on 01 November 2006

Mitochondrial function and insulin secretion.

scientific article published on 20 June 2013

Mitochondrial function in normal and diabetic β-cells ⬇️

scientific article published on December 13, 2001

Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?

scientific article

Mitochondrial signal transduction in pancreatic β-cells.

scientific article published on 18 August 2012

NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.

scientific article

New insights into amino acid metabolism, beta-cell function and diabetes

scientific article

Non-Invasive Imaging of Ferucarbotran Labeled INS-1E Cells and Rodent Islets in Vitro and in Transplanted Diabetic Rats ⬇️

scientific article published on April 1, 2011

Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

scientific article published on 14 October 2021

Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells

scientific article published on 01 November 2011

Novel regulation of insulin secretion: the role of mitochondria.

scientific article published on October 2003

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

scientific article published on September 2009

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

scientific journal article

Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.

scientific article published on 8 November 2014

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells

scientific article

Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism

scientific article published on 12 November 2009

Preventing mitochondrial fission impairs mitochondrial function and leads to loss of mitochondrial DNA

scientific article

Procyanidins modify insulinemia by affecting insulin production and degradation

scientific article published on 22 March 2012

Reactive oxygen metabolites increase mitochondrial calcium in endothelial cells: implication of the Ca2+/Na+ exchanger.

scientific article published on April 1999

Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase

scientific article

Reply to Mishra: Prohibitin heterodimers-a complex time dependence for carcinogenesis

scientific article published on 01 October 2019

Resveratrol long-term treatment differentiates INS-1E beta-cell towards improved glucose response and insulin secretion

scientific article published on 11 October 2018

Resveratrol potentiates glucose-stimulated insulin secretion in INS-1E beta-cells and human islets through a SIRT1-dependent mechanism.

scientific article

Resveratrol-activated SIRT1 in liver and pancreatic β-cells: a Janus head looking to the same direction of metabolic homeostasis

scientific article

Role of mitochondria in beta-cell function and dysfunction.

scientific article published on January 2010

Role of mitochondria in metabolism-secretion coupling of insulin release in the pancreatic beta-cell

scientific article published on 01 January 1998

Role of the intestinal acyl-CoA:cholesterol acyltransferase activity in the hyperresponse of diabetic rats to dietary cholesterol

scientific article published on 01 October 1992

Saturated fatty acid-induced insulin resistance is associated with mitochondrial dysfunction in skeletal muscle cells.

scientific article

Sclerocarya birrea (Anacardiaceae) stem-bark extract corrects glycaemia in diabetic rats and acts on beta-cells by enhancing glucose-stimulated insulin secretion.

scientific article

Silencing of the mitochondrial NADH shuttle component aspartate-glutamate carrier AGC1/Aralar1 in INS-1E cells and rat islets.

scientific article published on 10 December 2009

Small molecule kaempferol modulates PDX-1 protein expression and subsequently promotes pancreatic β-cell survival and function via CREB ⬇️

scientific article published on July 21, 2012

Studies on the human plasma kallikrein-kinin system: alpha-kallikrein does not directly activate blood neutrophils

scientific article published on 01 July 1989

Sustained glucose-stimulated insulin secretion in mouse islets is not culture-dependent.

scientific article published on 22 October 2004

The Amplifying Pathway of the β-Cell Contributes to Diet-induced Obesity

scientific article published on 02 May 2016

The antiepileptic drug topiramate preserves metabolism-secretion coupling in insulin secreting cells chronically exposed to the fatty acid oleate.

scientific article

The dopamine receptor D2 agonist bromocriptine inhibits glucose-stimulated insulin secretion by direct activation of the alpha2-adrenergic receptors in beta cells.

scientific article

The importance of redox shuttles to pancreatic β-cell energy metabolism and function

scientific article published on 01 November 2006

The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells

scientific article

The sensitivity of pancreatic beta-cells to mitochondrial injuries triggered by lipotoxicity and oxidative stress.

scientific article published on October 2008

Transglutaminase 2 transamidation activity during first-phase insulin secretion: natural substrates in INS-1E.

scientific article

Transient oxidative stress damages mitochondrial machinery inducing persistent beta-cell dysfunction

scientific article published on 22 June 2009

Upregulation of UCP2 in beta-cells confers partial protection against both oxidative stress and glucotoxicity.

scientific article published on 21 July 2017

Vesicular storage and secretion of L-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells.

scientific article

List of works by Pierre Maechler

216. Glutamate Dehydrogenase-Deficient Mice: A Novel Mouse Model of Schizophrenia-Like Phenotypes.

A high carbohydrate diet does not induce hyperglycaemia in a mitochondrial glycerol-3-phosphate dehydrogenase-deficient mouse.

A possible role of transglutaminase 2 in the nucleus of INS-1E and of cells of human pancreatic islets

A role for pancreatic beta-cell secretory hyperresponsiveness in catch-up growth hyperinsulinemia: Relevance to thrifty catch-up fat phenotype and risks for type 2 diabetes

AMPK Profiling in Rodent and Human Pancreatic Beta-Cells under Nutrient-Rich Metabolic Stress

Activation of Nicotinic Acetylcholine Receptors Decreases Apoptosis in Human and Female Murine Pancreatic Islets

Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia

Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion

Alteration of the malonyl-CoA/carnitine palmitoyltransferase I interaction in the beta-cell impairs glucose-induced insulin secretion.

Beta cell glutamate receptor antagonists: novel oral antidiabetic drugs?

Beta-cell mitochondrial carriers and the diabetogenic stress response.

Bone Regulates Browning and Energy Metabolism Through Mature Osteoblast/Osteocyte PPARγ Expression

ChREBP mediates glucose repression of peroxisome proliferator-activated receptor alpha expression in pancreatic beta-cells

Changes in mitochondrial carriers exhibit stress-specific signatures in INS-1Eβ-cells exposed to glucose versus fatty acids

Channels and transporters in cell metabolism.

Chronic fructose renders pancreatic β-cells hyper-responsive to glucose-stimulated insulin secretion through extracellular ATP signaling

Chronic orexin-A (hypocretin-1) treatment of type 2 diabetic rats improves glucose control and beta-cell functions

Circulating 1,5-Anhydroglucitol as a Biomarker of ß-cell Mass Independent of a Diabetes Phenotype in Human Subjects

Connexin-36 contributes to control function of insulin-producing cells.

Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase ⬇️

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

Delineation of glutamate pathways and secretory responses in pancreatic islets with β-cell–specific abrogation of the glutamate dehydrogenase ⬇️

Desensitization of Mitochondrial Ca2+ and Insulin Secretion Responses in the Beta Cell ⬇️

Development of mice with brain-specific deletion of floxed glud1 (glutamate dehydrogenase 1) using cre recombinase driven by the nestin promoter.

Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function.

Diabetogenic milieus induce specific changes in mitochondrial transcriptome and differentiation of human pancreatic islets.

Dietary excess regulates absorption and surface of gut epithelium through intestinal PPARα

Dominant-negative suppression of HNF-1alpha function results in defective insulin gene transcription and impaired metabolism-secretion coupling in a pancreatic beta-cell line.

Dopamine modulates von Willebrand factor secretion in endothelial cells via D2-D4 receptors

Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.

Effects of olive leaf polyphenols against H₂O₂ toxicity in insulin secreting β-cells.

Epigallocatechin-3-gallate (EGCG) activates AMPK through the inhibition of glutamate dehydrogenase in muscle and pancreatic ß-cells: A potential beneficial effect in the pre-diabetic state?

From pancreatic islets to central nervous system, the importance of glutamate dehydrogenase for the control of energy homeostasis

Functional and morphological abnormalities of mitochondria harbouring the tRNA(Leu)(UUR) mutation in mitochondrial DNA derived from patients with maternally inherited diabetes and deafness (MIDD) and progressive kidney disease.

Functional significance of repressor element 1 silencing transcription factor (REST) target genes in pancreatic beta cells.

GAD65-mediated glutamate decarboxylation reduces glucose-stimulated insulin secretion in pancreatic beta cells.

GDH-Dependent Glutamate Oxidation in the Brain Dictates Peripheral Energy Substrate Distribution.

Glucose Sensitivity and Metabolism-Secretion Coupling Studied during Two-Year Continuous Culture in INS-1E Insulinoma Cells ⬇️

Glutamate Dehydrogenase-Deficient Mice Display Schizophrenia-Like Behavioral Abnormalities and CA1-Specific Hippocampal Dysfunction.

Glutamate dehydrogenase is essential to sustain neuronal oxidative energy metabolism during stimulation.

Glutamate pathways of the beta-cell and the control of insulin secretion.

Hepatic glucose sensing is required to preserve β cell glucose competence

Hepatocyte nuclear factor 4alpha regulates the expression of pancreatic beta -cell genes implicated in glucose metabolism and nutrient-induced insulin secretion

Hydrogen peroxide alters mitochondrial activation and insulin secretion in pancreatic beta cells.

Identification of the molecular dysfunction caused by glutamate dehydrogenase S445L mutation responsible for hyperinsulinism/hyperammonemia

Importance of exogenous cholesterol in diabetic rats: effects of treatment with insulin or with an acyl-CoA:cholesterol acyltransferase inhibitor

In vivo stabilization of OPA1 in hepatocytes potentiates mitochondrial respiration and gluconeogenesis in a prohibitin-dependent way

Increase in cellular glutamate levels stimulates exocytosis in pancreatic beta-cells.

Insulin secretion profiles are modified by overexpression of glutamate dehydrogenase in pancreatic islets.

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes

Integrated analysis of mRNA and miRNA expression in response to interleukin-6 in hepatocytes.

Integrative Genomics Outlines a Biphasic Glucose Response and a ChREBP-RORγ Axis Regulating Proliferation in β Cells

Interleukin-33-Activated Islet-Resident Innate Lymphoid Cells Promote Insulin Secretion through Myeloid Cell Retinoic Acid Production

Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

Liver Glutamate Dehydrogenase Controls Whole-Body Energy Partitioning Through Amino Acid-Derived Gluconeogenesis and Ammonia Homeostasis

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

Macrophage-derived glutamine boosts satellite cells and muscle regeneration

Metabolomics Identifies a Biomarker Revealing In Vivo Loss of Functional β-Cell Mass Before Diabetes Onset

Minireview: New Roles for Peripheral Dopamine on Metabolic Control and Tumor Growth: Let’s Seek the Balance ⬇️

Mitochondria as the conductor of metabolic signals for insulin exocytosis in pancreatic beta-cells.

Mitochondria in endocrinology ⬇️

Mitochondria-derived glutamate at the interplay between branched-chain amino acid and glucose-induced insulin secretion

Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress

Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells.

Mitochondrial damages and the regulation of insulin secretion

Mitochondrial function and insulin secretion.

Mitochondrial function in normal and diabetic β-cells ⬇️

Mitochondrial hormesis in pancreatic β cells: does uncoupling protein 2 play a role?

Mitochondrial signal transduction in pancreatic β-cells.

NADPH oxidase NOX2 defines a new antagonistic role for reactive oxygen species and cAMP/PKA in the regulation of insulin secretion.

New insights into amino acid metabolism, beta-cell function and diabetes

Non-Invasive Imaging of Ferucarbotran Labeled INS-1E Cells and Rodent Islets in Vitro and in Transplanted Diabetic Rats ⬇️

Non-canonical glutamine transamination sustains efferocytosis by coupling redox buffering to oxidative phosphorylation

Novel hexahydropyridoindole derivative as prospective agent against oxidative damage in pancreatic β cells

Novel regulation of insulin secretion: the role of mitochondria.

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal beta-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism.

PPARdelta is a fatty acid sensor that enhances mitochondrial oxidation in insulin-secreting cells and protects against fatty acid-induced dysfunction

Pancreatic polypeptide regulates glucagon release through PPYR1 receptors expressed in mouse and human alpha-cells.

Peroxisome proliferator-activated receptor alpha (PPARalpha) potentiates, whereas PPARgamma attenuates, glucose-stimulated insulin secretion in pancreatic beta-cells