List of works - Kwok-Fai Lau

A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia

scientific article published in September 2014

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

scientific article published on 2 January 2018

Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers

scientific article published on 14 August 2018

Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

scientific article published on 24 February 2010

An Enhanced Green Fluorescence Protein-based Assay for Studying Neurite Outgrowth in Primary Neurons

scientific article published on 19 October 2019

An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter

scientific article

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

scientific article published on 2 February 2016

Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35

scientific article published on 05 August 2019

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

scientific article

Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task.

scientific article published on 11 September 2009

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

scientific article

DNA microarray expression analysis of baicalin-induced differentiation of C17.2 neural stem cells.

scientific article published on 3 May 2012

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.

scientific article

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription

scientific journal article

Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress

scientific article published on 01 August 2018

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

scientific article

Emerging roles of the neural adaptor FE65 in neurite outgrowth

scientific article published on 01 December 2018

Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.

scientific article published on 7 February 2011

Expression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in breast cancers.

scientific article published on 2 November 2013

Expression of the Fe65 adapter protein in adult and developing mouse brain.

scientific article published in January 2002

Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease

scientific article published on January 2010

FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth

scientific journal article

FE65 serine-610 phosphorylation and its functional implications in Alzheimer disease amyloid precursor protein processing

scientific article published on 01 October 2019

FE65: Roles beyond amyloid precursor protein processing

scientific article published on March 2015

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

scientific article published on 28 August 2007

Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene

article

Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein

scientific article (publication date: 9 November 2000)

GULP1 is a novel APP-interacting protein that alters APP processing.

scientific article published in June 2011

GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease

scientific article published on 8 August 2017

Genomic organization and promoter cloning of the human X11α gene APBA1.

scientific article published on 2 December 2011

Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines

scientific article published in February 2003

Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase

scientific article

Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.

scientific article

Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages.

scientific article

Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo

scientific article published on 26 September 2011

Molecular cloning and expression analysis of human glycogen synthase kinase-3 alpha promoter.

scientific article

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.

scientific article published on 3 April 2018

Neuronal differentiation of C17.2 neural stem cells induced by a natural flavonoid, baicalin.

scientific article

Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity

scientific article

Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

scientific article published on 17 July 2015

Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing

scientific article published on 29 September 2017

Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models

scientific article published on 19 July 2018

Promoter characterization and genomic organization of the human X11β gene APBA2.

scientific article published in February 2012

Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer.

scientific article

Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis.

scientific article

The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

scientific article published on 03 September 2004

The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.

scientific article published on December 2014

The X11 proteins, Abeta production and Alzheimer's disease.

scientific article

The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling

scientific article published on 18 March 2004

The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

scientific article published in December 2003

The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice

scientific article published on 11 September 2003

The potency of allospecific Tregs cells appears to correlate with T cell receptor functional avidity.

scientific article published in August 2011

The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?

scientific article published on 01 August 2020

Three SpoA-domain proteins interact in the creation of the flagellar type III secretion system in Helicobacter pylori

scientific article published on 10 July 2018

Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1

scientific article

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

scientific article

X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice

scientific article published on 10 September 2009

List of works by Kwok-Fai Lau

A novel missense mutation in CCDC88C activates the JNK pathway and causes a dominant form of spinocerebellar ataxia

A peptidylic inhibitor for neutralizing expanded CAG RNA-induced nucleolar stress in polyglutamine diseases

Amyloid Precursor Protein Is Associated with Aggressive Behavior in Nonluminal Breast Cancers

Amyotrophic lateral sclerosis mutant vesicle-associated membrane protein-associated protein-B transgenic mice develop TAR-DNA-binding protein-43 pathology.

An Enhanced Green Fluorescence Protein-based Assay for Studying Neurite Outgrowth in Primary Neurons

An X11alpha/FSBP complex represses transcription of the GSK3beta gene promoter

Assessing a peptidylic inhibitor-based therapeutic approach that simultaneously suppresses polyglutamine RNA- and protein-mediated toxicities in patient cells and Drosophila

Attenuation of amyloid-β generation by atypical protein kinase C-mediated phosphorylation of engulfment adaptor PTB domain containing 1 threonine 35

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task.

Cyclin-dependent kinase-5/p35 phosphorylates Presenilin 1 to regulate carboxy-terminal fragment stability.

DNA microarray expression analysis of baicalin-induced differentiation of C17.2 neural stem cells.

Degradation of mutant huntingtin via the ubiquitin/proteasome system is modulated by FE65.

Dexras1 interacts with FE65 to regulate FE65-amyloid precursor protein-dependent transcription

Drosophila Exo70 Is Essential for Neurite Extension and Survival under Thermal Stress

ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43.

Emerging roles of the neural adaptor FE65 in neurite outgrowth

Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1.

Expression and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 6 in breast cancers.

Expression of the Fe65 adapter protein in adult and developing mouse brain.

Expression of the neuronal adaptor protein X11alpha protects against memory dysfunction in a transgenic mouse model of Alzheimer's disease

FE65 interacts with ADP-ribosylation factor 6 to promote neurite outgrowth

FE65 serine-610 phosphorylation and its functional implications in Alzheimer disease amyloid precursor protein processing

FE65: Roles beyond amyloid precursor protein processing

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content

Familial ataxia, tremor, and dementia in a polish family with a novel mutation in the CCDC88C gene

Fe65 and X11beta co-localize with and compete for binding to the amyloid precursor protein

GULP1 is a novel APP-interacting protein that alters APP processing.

GULP1/CED-6 ameliorates amyloid-β toxicity in a Drosophila model of Alzheimer's disease

Genomic organization and promoter cloning of the human X11α gene APBA1.

Glycogen synthase kinase-3 beta-mediated tau phosphorylation in cultured cell lines

Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase

Influenza polymerase activity correlates with the strength of interaction between nucleoprotein and PB2 through the host-specific residue K/E627.

Inhibition of TGF-β signaling in combination with TLR7 ligation re-programs a tumoricidal phenotype in tumor-associated macrophages.

Lemur tyrosine kinase-2 signalling regulates kinesin-1 light chain-2 phosphorylation and binding of Smad2 cargo

Molecular cloning and expression analysis of human glycogen synthase kinase-3 alpha promoter.

Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.

Neuronal differentiation of C17.2 neural stem cells induced by a natural flavonoid, baicalin.

Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity

Phosphorylation of FE65 Ser610 by serum- and glucocorticoid-induced kinase 1 modulates Alzheimer's disease amyloid precursor protein processing.

Phosphorylation of FE65 at threonine 579 by GSK3β stimulates amyloid precursor protein processing

Planar cell polarity gene Fuz triggers apoptosis in neurodegenerative disease models

Promoter characterization and genomic organization of the human X11β gene APBA2.

Proteolytic cleavage of amyloid precursor protein by ADAM10 mediates proliferation and migration in breast cancer.

Structural basis of the PE-PPE protein interaction in Mycobacterium tuberculosis.

The Neuronal Adaptor Protein X11β Reduces Amyloid β-Protein Levels and Amyloid Plaque Formation in the Brains of Transgenic Mice

The SARS-coronavirus membrane protein induces apoptosis via interfering with PDK1-PKB/Akt signalling.

The X11 proteins, Abeta production and Alzheimer's disease.

The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling

The neuronal adaptor protein Fe65 is phosphorylated by mitogen-activated protein kinase (ERK1/2).

The neuronal adaptor protein X11alpha reduces Abeta levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice

The potency of allospecific Tregs cells appears to correlate with T cell receptor functional avidity.

The roles of atypical protein kinase Cs (aPKCs) in the nervous system: targets for neuroregeneration?

Three SpoA-domain proteins interact in the creation of the flagellar type III secretion system in Helicobacter pylori

Transcriptional regulation of human FE65, a ligand of Alzheimer's disease amyloid precursor protein, by Sp1

VAPB interacts with the mitochondrial protein PTPIP51 to regulate calcium homeostasis

X11beta rescues memory and long-term potentiation deficits in Alzheimer's disease APPswe Tg2576 mice