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List of works by Tim Friede

A Bayesian time-to-event pharmacokinetic model for phase I dose-escalation trials with multiple schedules

scientific article published on 14 August 2020

A Comparison of Methods for Adaptive Treatment Selection

article published in 2008

A comparison of methods for adaptive sample size adjustment ⬇️

scientific article published on December 30, 2001

A comparison of methods for treatment selection in seamless phase II/III clinical trials incorporating information on short-term endpoints

scientific article published on January 2015

A comparison of subgroup identification methods in clinical drug development: Simulation study and regulatory considerations

scientific article published on 03 July 2019

A conditional error function approach for adaptive enrichment designs with continuous endpoints

scientific article published on 07 May 2019

A conditional error function approach for subgroup selection in adaptive clinical trials ⬇️

scientific article published on August 3, 2012

A design-by-treatment interaction model for network meta-analysis and meta-regression with integrated nested Laplace approximations.

scientific article published on 29 November 2017

A group-sequential design for clinical trials with treatment selection

article by Nigel Stallard & Tim Friede published 20 December 2008 in Statistics in Medicine

A note on testing for intervention effects on binary responses.

scientific article

A novel adaptive design strategy increases the efficiency of clinical trials in secondary progressive multiple sclerosis

scientific article published on 26 August 2010

A standardised frankincense extract reduces disease activity in relapsing-remitting multiple sclerosis (the SABA phase IIa trial).

scientific article published on 16 December 2017

A studentized permutation test for three-arm trials in the 'gold standard' design ⬇️

scientific article

A systematic review identifies shortcomings in the reporting of crossover trials in chronic painful conditions

scientific article published on 30 April 2015

Adaptive designs for confirmatory clinical trials with subgroup selection.

scientific article published on January 2014

Adaptive seamless clinical trials using early outcomes for treatment or subgroup selection: Methods, simulation model and their implementation in R

scientific article published on 02 March 2020

Adaptive trial designs in diagnostic accuracy research

scientific article published on 27 November 2019

Adhesion maturation of neutrophils on nanoscopically presented platelet glycoprotein Ibα.

scientific article

Advances and unmet needs in genetic, basic and clinical science in Alport syndrome: report from the 2015 International Workshop on Alport Syndrome

scientific article

An R package for implementing simulations for seamless phase II/III clinical trials using early outcomes for treatment selection

An Unconditional Test for Change Point Detection in Binary Sequences with Applications to Clinical Registries.

scientific article published on 13 July 2016

Anticholinergics for urinary symptoms in multiple sclerosis

scientific article

Anticholinergics for urinary symptoms in multiple sclerosis

scientific article (publication date: 21 January 2009)

Assess, compare and enhance the status of Persons with Multiple Sclerosis (MS) in Europe: a European Register for MS.

scientific article published on January 2012

Assessment of statistical significance and clinical relevance

scientific article published on 28 September 2012

Authors’ response: on the role of data, statistics and decisions in a pandemic

scientific article published in 2022

Automated electronic reminders to facilitate primary cardiovascular disease prevention: randomised controlled trial

scientific article

Back schools for the treatment of chronic low back pain: possibility of benefit but no convincing evidence after 47 years of research-systematic review and meta-analysis

scientific article published on June 2016

Baseline CSF/Serum-Ratio of Apolipoprotein E and Rate of Differential Decline in Alzheimer's Disease

scientific article published in August 2015

Biometrical Journal and Reproducible Research

scientific article published on 01 August 2009

Bladder symptoms in multiple sclerosis: a review of pathophysiology and management

scientific article

Blinded and unblinded internal pilot study designs for clinical trials with count data

scientific article

Blinded continuous information monitoring of recurrent event endpoints with time trends in clinical trials

scientific article published on 19 August 2020

Blinded sample size re-estimation for recurrent event data with time trends

scientific article

Blinded sample size re-estimation in three-arm trials with 'gold standard' design.

scientific article published on 12 June 2017

Blinded sample size recalculation for clinical trials with normal data and baseline adjusted analysis

scientific article

Blinded sample size reestimation for negative binomial regression with baseline adjustment

scientific article published on 23 March 2020

Blinded sample size reestimation in event-driven clinical trials: Methods and an application in multiple sclerosis

scientific article published on 16 January 2019

Blinded sample size reestimation with count data: methods and applications in multiple sclerosis

scientific article

Blinded sample size reestimation with negative binomial counts in superiority and non-inferiority trials

scientific article published on August 5, 2010

Blinded sample size re‐estimation in superiority and noninferiority trials: bias versus variance in variance estimation ⬇️

scientific article published on March 19, 2013

Blinded versus unblinded estimation of a correlation coefficient to inform interim design adaptations.

scientific article published on 25 November 2016

CR1 is potentially associated with rate of decline in sporadic Alzheimer's disease.

scientific article published on 4 July 2014

Calcineurin inhibitor sparing with mycophenolate mofetil in liver transplantion: a systematic review of randomized controlled trials.

scientific article published on 19 July 2012

Causal inference methods for small non-randomized studies: Methods and an application in COVID-19

scientific article published on 11 November 2020

Cerebrospinal fluid apolipoprotein E concentration and progression of Alzheimer's disease.

scientific article published on January 2015

Changing EDSS Progression in Placebo Cohorts in Relapsing MS: A Systematic Review and Meta-Regression

scientific article published on September 2015

Clinical Trials in Oncology

Clinical presentation of pediatric multiple sclerosis before puberty.

scientific article published on 16 December 2013

Clinical trials with nested subgroups: Analysis, sample size determination and internal pilot studies.

scientific article published in January 2017

Considerations on what constitutes a 'qualified statistician' in regulatory guidelines

scientific article published on 21 September 2011

Contribution to the discussion of “When should meta-analysis avoid making hidden normality assumptions?” A Bayesian perspective

scientific article published on 01 August 2018

Control conditions for randomised trials of behavioural interventions in psychiatry: a decision framework

scientific article (publication date: 7 April 2017)

Correction

scholarly article published in Statistics in Medicine

Correction: study protocol: improving patient choice in treating Low back pain (IMPACT - LBP): a randomised controlled trial of a decision support package for use in physical therapy.

scientific article published on 3 May 2013

Correction: ‘A conditional error function approach for subgroup selection in adaptive clinical trials’

Cross cultural evaluation of the Warwick-Edinburgh Mental Well-being Scale (WEMWBS) --a mixed methods study

scientific article

Data-driven treatment selection for seamless phase II/III trials incorporating early-outcome data

scientific article

Decreasing longitudinal use of glucocorticosteroids in multiple sclerosis

scientific article published on 24 July 2018

Design and analysis of three-arm trials with negative binomially distributed endpoints.

scientific article

Design and development of a decision support package for low back pain.

scientific article

Design and semiparametric analysis of non-inferiority trials with active and placebo control for censored time-to-event data

scientific article

Designing a seamless phase II/III clinical trial using early outcomes for treatment selection: an application in multiple sclerosis

scientific article

Development and external validation of prediction models to predict implantable cardioverter-defibrillator efficacy in primary prevention of sudden cardiac death

scientific article published on 01 June 2021

Development of oral immunomodulatory agents in the management of multiple sclerosis

scientific article

Differences in the Reponses to Apheresis Therapy of Patients With 3 Histopathologically Classified Immunopathological Patterns of Multiple Sclerosis

scientific article published on 5 February 2018

Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy

article

Discrete Approximation of a Mixture Distribution via Restricted Divergence ⬇️

Do we consent to rules of consent and confidentiality?

scientific article

Dose-finding methods for Phase I clinical trials using pharmacokinetics in small populations

scientific article published on 21 March 2017

Doxycycline in early CJD: a double-blinded randomised phase II and observational study.

scientific article

Dynamically borrowing strength from another study through shrinkage estimation

scientific article published on 01 March 2019

EFSPI/PSI working group on data sharing: accessing and working with pharmaceutical clinical trial patient level datasets - a primer for academic researchers

scientific article

Early angiotensin-converting enzyme inhibition in Alport syndrome delays renal failure and improves life expectancy

scientific article

Economic Analysis of a Telemedicine Intervention to Improve Glycemic Control in Patients with Diabetes Mellitus

article

Educating orally anticoagulated patients in drug safety: a cluster-randomized study in general practice

scientific article

Effect and Feasibility of Controlled Rewarming After Moderate Hypothermia in Stroke Patients With Malignant Infarction of the Middle Cerebral Artery

scientific article published on 01 December 2001

Effect of the left internal mammary artery to the left anterior descending artery on mortality and morbidity after combined coronary and valve operations.

scientific article published in July 2005

Efficacy of Ambroxol lozenges for pharyngitis: a meta-analysis.

scientific article published on 13 March 2014

Evaluation of dysphagia by novel real-time MRI.

scientific article published on 21 October 2016

Evidence synthesis for count distributions based on heterogeneous and incomplete aggregated data.

scientific article

Exact change point detection with improved power in small-sample binomial sequences

scientific article published on 05 November 2020

Explaining temporal trends in annualised relapse rates in placebo groups of randomised controlled trials in relapsing multiple sclerosis: systematic review and meta-regression.

scientific article published on 07 March 2013

Exploring changes in treatment effects across design stages in adaptive trials.

scientific article published on January 2009

Factors Influencing the Frequency of Airway Infections in Underage Refugees: A Retrospective, Cross Sectional Study

scientific article published on 18 September 2020

Ferric carboxymaltose for iron deficiency at discharge after acute heart failure: a multicentre, double-blind, randomised, controlled trial

scientific article published on 12 November 2020

First international meeting of early career investigators: Current opportunities, challenges and horizon in critical care nutrition research

scientific article published on 22 September 2020

Flexible selection of a single treatment incorporating short-term endpoint information in a phase II/III clinical trial

scientific article

Gender Differences in Appropriate Shocks and Mortality among Patients with Primary Prophylactic Implantable Cardioverter-Defibrillators: Systematic Review and Meta-Analysis

scientific article

Group sequential designs for negative binomial outcomes

scientific article published on 17 May 2018

Group sequential designs with robust semiparametric recurrent event models

scientific article published on 11 June 2018

Guest Editors' Introduction

scientific article published on 01 December 2014

Hartung-Knapp-Sidik-Jonkman approach and its modification for random-effects meta-analysis with few studies ⬇️

scientific article published on 14 November 2015

Impact of COVID-19 outbreak on regional STEMI care in Germany

scientific article published on 16 July 2020

Impact of community neonatal services: a multicentre survey.

scientific article

Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial.

scientific article published on 14 February 2018

Improving clinical trials for cardiovascular diseases: a position paper from the Cardiovascular Round Table of the European Society of Cardiology

scientific article published on 15 June 2015

Independent academic Data Monitoring Committees for clinical trials in cardiovascular and cardiometabolic diseases

scientific article

Insights into permanent pacemaker implantation following TAVR in a real-world cohort

scientific article published in PLoS ONE

Interleukin-2 receptor antagonists for pediatric liver transplant recipients: a systematic review and meta-analysis of controlled studies.

scientific article published on 04 October 2014

Intervention effects in observational survival studies with an application in total hip replacements.

scientific article published in December 2003

Is there a role for statistics in artificial intelligence?

scientific article published in 2021

Memorandum "Open Metadata". Open Access to Documentation Forms and Item Catalogs in Healthcare

scientific article

Meta-analysis of few small studies in orphan diseases ⬇️

scientific article published on 30 June 2016

Meta-analysis of two studies in the presence of heterogeneity with applications in rare diseases.

scientific article

Methods for evidence synthesis in the case of very few studies

article

Methods for identification and confirmation of targeted subgroups in clinical trials: A systematic review

scientific article

Modeling the recovery from depressive illness by an exponential model with mixed effects.

scientific article published in March 2000

Modelling and sample size reestimation for longitudinal count data with incomplete follow up.

scientific article

Monitoring of 30 marker candidates in early Parkinson disease as progression markers

scientific article

Multifocal ERG with confocal scanning laser ophthalmoscope. Comparison with monitor simulation

scientific article

Multiple sclerosis registries in Europe – results of a systematic survey

scientific article published on 28 April 2014

On estimands and the analysis of adverse events in the presence of varying follow-up times within the benefit assessment of therapies

scientific article published on 20 November 2018

On the inappropriateness of an EM algorithm based procedure for blinded sample size re‐estimation ⬇️

scientific article published on January 30, 2002

On weakly informative prior distributions for the heterogeneity parameter in Bayesian random‐effects meta‐analysis

scientific article

Optimal choice of the number of treatments to be included in a clinical trial

scientific article published in April 2009

Over three decades study populations in progressive multiple sclerosis have become older and more disabled, but have lower on-trial progression rates: A systematic review and meta-analysis of 43 randomised placebo-controlled trials

scientific article published on 24 August 2018

Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale-29.

scientific article

Patients characteristics influencing the longitudinal utilization of steroids in multiple sclerosis--an observational study

scientific article published on 09 May 2015

Peripheral Nerve Dysfunction in Middle-Aged Subjects Born with Thalidomide Embryopathy

scientific article

Perspectives on the Use of Adaptive Designs in Clinical Trials. Part II. Panel Discussion

scientific article published on 01 November 2010

Pharmacological Approaches to the Management of Secondary Progressive Multiple Sclerosis

scientific article

Pilot of "Families for Health": community-based family intervention for obesity

scientific article published on 7 May 2008

Plasma prion protein concentration and progression of Alzheimer disease

scientific article

Point and Interval Estimators of the Target Dose in Clinical Dose-Finding Studies with Active Control.

scientific article published on 11 June 2014

Practice nursed-based, individual and video-assisted patient education in oral anticoagulation--protocol of a cluster-randomized controlled trial

scientific article

Precise variant interpretation, phenotype ascertainment and genotype-phenotype correlation of children in the EARLY PRO-TECT Alport trial

scientific article published on 11 October 2020

Predicting menstrual bleeding patterns with levonorgestrel-releasing intrauterine systems

scientific article published on 03 December 2020

Predictors of mortality and ICD shock therapy in primary prophylactic ICD patients-A systematic review and meta-analysis

scientific article published on 17 October 2017

Primum non nocere: shared informed decision making in low back pain--a pilot cluster randomised trial

scientific article

Pro-active call center treatment support (PACCTS) to improve glucose control in type 2 diabetes: a randomized controlled trial

scientific article

Quantitative approaches underpinning decision making

scientific article published on 28 July 2019

Random-effects meta-analysis of few studies involving rare events

scientific article published on 22 August 2019

Randomised controlled trial of a self-guided online fatigue intervention in multiple sclerosis.

scientific article published on 16 March 2018

Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis

scientific article

Rationale and design of the EU-CERT-ICD prospective study: comparative effectiveness of prophylactic ICD implantation

article

Rationale, objectives, and design of the EUTrigTreat clinical study: a prospective observational study for arrhythmia risk stratification and assessment of interrelationships among repolarization markers and genotype

scientific article published on 23 November 2011

Reclassifying Acute Respiratory Distress Syndrome.

scientific article published on 18 January 2018

Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with uva-ursi (REGATTA) - a double-blind, randomized, controlled comparative effectiveness trial.

scientific article published on 3 July 2018

Refinement of the Clinical Scenario Evaluation Framework for Assessment of Competing Development Strategies with an Application to Multiple Sclerosis

article

Regression to the mean and predictors of MRI disease activity in RRMS placebo cohorts--is there a place for baseline-to-treatment studies in MS?

scientific article

Repeating noninvasive risk stratification improves prediction of outcome in ICD patients

scientific article published on 17 August 2020

Reporting FDR analogous confidence intervals for the log fold change of differentially expressed genes. ⬇️

scientific article

Reporting and interpretation of subgroup analyses in heart failure randomized controlled trials

scientific article published on 30 November 2020

Results of medial patellofemoral ligament reconstruction compared with trochleoplasty plus individual extensor apparatus balancing in patellar instability caused by severe trochlear dysplasia: a systematic review and meta-analysis

scientific article published on 27 October 2016

Robustness of methods for blinded sample size re-estimation with overdispersed count data.

scientific article

Robustness of testing procedures for confirmatory subpopulation analyses based on a continuous biomarker

scientific article published on 11 June 2018

Safety relevant knowledge of orally anticoagulated patients without self-monitoring: a baseline survey in primary care.

scientific article

Sample size re-estimation for clinical trials with longitudinal negative binomial counts including time trends

scientific article published on 21 December 2018

Sample size re-estimation incorporating prior information on a nuisance parameter

scientific article published on 27 November 2017

Sample size reassessment in non-inferiority trials. Internal pilot study designs with ANCOVA.

scientific article published on 8 March 2010

Sample size recalculation in multicenter randomized controlled clinical trials based on noncomparative data

scientific article published on 04 March 2020

Scientific Versus Experiential Evidence: Discourse Analysis of the Chronic Cerebrospinal Venous Insufficiency Debate in a Multiple Sclerosis Forum

scientific article published on July 2015

Semi-parametric analysis of overdispersed count and metric data with varying follow-up times: Asymptotic theory and small sample approximations

scientific article published on 05 December 2018

Serum peptide reactivities may distinguish neuromyelitis optica subgroups and multiple sclerosis

scientific article published on 2 February 2016

Sex differences in outcomes of primary prevention implantable cardioverter defibrillator therapy: combined registry data from eleven European countries.

scientific article published on 28 June 2017

Simvastatin add-on to escitalopram in patients with comorbid obesity and major depression (SIMCODE): study protocol of a multicentre, randomised, double-blind, placebo-controlled trial

scientific article published on 01 December 2020

Software tools for implementing simulation studies in adaptive seamless designs: introducing R package ASD.

scientific article published on 13 December 2011

Sources of information and behavioral patterns in online health forums: observational study

scientific article (publication date: 14 January 2014)

Spline-based procedures for dose-finding studies with active control.

scientific article published on 16 October 2014

Strategies to reduce antibiotic use in women with uncomplicated urinary tract infection in primary care: protocol of a systematic review and meta-analysis including individual patient data

scientific article published on 01 October 2020

Study protocol: improving patient choice in treating low back pain (IMPACT-LBP): a randomised controlled trial of a decision support package for use in physical therapy

scientific article

Survival analysis for AdVerse events with VarYing follow-up times (SAVVY): Rationale and statistical concept of a meta-analytic study

scientific article published on 04 November 2020

Symptomatology and symptomatic treatment in multiple sclerosis: Results from a nationwide MS registry

scientific article published on 19 September 2018

Systematic review of randomized controlled trials of clinical prediction rules for physical therapy in low back pain.

scientific article

Systematic review of sonographic chronic cerebrospinal venous insufficiency findings in multiple sclerosis.

scientific article published on 23 October 2011

Systematic reviews in paediatric multiple sclerosis and Creutzfeldt-Jakob disease exemplify shortcomings in methods used to evaluate therapies in rare conditions

scientific article

T-wave loop area from a pre-implant 12-lead ECG is associated with appropriate ICD shocks

scientific article

Telephone peer-delivered intervention for diabetes motivation and support: the telecare exploratory RCT.

scientific article published on 14 November 2008

The impact of smoking cessation on multiple sclerosis disease progression

scientific article published on 01 May 2022

Therapeutic Apheresis in Pediatric Patients with Acute CNS Inflammatory Demyelinating Disease

scientific article published on 07 September 2013

Time-patterns of annualized relapse rates in randomized placebo-controlled clinical trials in relapsing multiple sclerosis: a systematic review and meta-analysis.

scientific article published on 15 March 2012

Toward evidence-based diagnosis of myocarditis in children and adolescents: Rationale, design, and first baseline data of MYKKE, a multicenter registry and study platform

scientific article

Treatment for fatigue in amyotrophic lateral sclerosis/motor neuron disease (ALS/MND)

scientific article

Treatment of fatigue in amyotrophic lateral sclerosis/motor neuron disease

scientific article published on 2 January 2018

Trends in annualized relapse rates in relapsing-remitting multiple sclerosis and consequences for clinical trial design.

scientific article published on 17 May 2011

Trochleoplasty versus MPFL-Reconstruction in Severe Trochlear Dysplasia. A Systematic Review and Meta-Analysis.

scientific article published on 23 March 2016

Using phase II data for the analysis of phase III studies: An application in rare diseases. ⬇️

scientific article

Validation and Reliability of the Neuropathic Pain Scale (NPS) in Multiple Sclerosis

scientific article published on 01 July 2007

Warwick-Edinburgh Mental Well-being Scale (WEMWBS): validated for teenage school students in England and Scotland. A mixed methods assessment

scientific article

Work-related outcomes in randomised placebo-controlled pain trials: a systematic review and meta-analysis

scientific article

dfpk: An R-package for Bayesian dose-finding designs using pharmacokinetics (PK) for phase I clinical trials

scientific article published on 31 January 2018

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