List of works - Yun-Ru Chen

A novel method for expression and purification of authentic amyloid-β with and without (15)N labels

scientific article published on 9 May 2015

Alzheimer's Amyloid-β Sequesters Caspase-3 in Vitro via Its C-Terminal Tail.

scientific article

Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity

scientific article

Amyloid oligomer conformation in a group of natively folded proteins

scientific article

Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies ⬇️

scientific article published on April 30, 2012

Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study.

scientific article

Discovery of dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study

scientific article (publication date: 2013)

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

scientific article published on 29 June 2006

Effects of Dissolved Gases on the Amyloid Fibril Morphology

scientific article published on 22 December 2020

Folding stability of amyloid-beta 40 monomer is an important determinant of the nucleation kinetics in fibrillization

scientific article published on 05 January 2011

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

scientific article published on 12 September 2014

In vitro prion-like behaviour of TDP-43 in ALS.

scientific article published on 30 August 2016

Kinetic traps in the folding/unfolding of procaspase-1 CARD domain.

scientific article published in August 2004

Lipid-Modified Graphene-Transistor Biosensor for Monitoring Amyloid-β Aggregation.

scientific article published on 3 April 2018

Molecular structure of amyloid fibrils formed by residues 127 to 147 of the human prion protein.

scientific article published in May 2010

Negatively charged gold nanoparticles inhibit Alzheimer's amyloid-β fibrillization, induce fibril dissociation, and mitigate neurotoxicity.

scientific article published on 23 August 2012

Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer.

scientific article published in November 2001

TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease

scientific article published on 23 November 2020

Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization

scientific article

The Glycine-Alanine Dipeptide Repeat from C9orf72 Hexanucleotide Expansions Forms Toxic Amyloids Possessing Cell-to-Cell Transmission Properties

scientific article published on 14 January 2016

The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

scientific article

The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates

scientific article published on 31 January 2013

Using optical profilometry to characterize cell membrane roughness influenced by amyloid-beta 42 aggregates and electric fields.

scientific article published on January 2014

List of works by Yun-Ru Chen

A novel method for expression and purification of authentic amyloid-β with and without (15)N labels

Alzheimer's Amyloid-β Sequesters Caspase-3 in Vitro via Its C-Terminal Tail.

Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity

Amyloid oligomer conformation in a group of natively folded proteins

Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies ⬇️

Discovery of DNA dyes Hoechst 34580 and 33342 as good candidates for inhibiting amyloid beta formation: in silico and in vitro study.

Discovery of dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study

Distinct early folding and aggregation properties of Alzheimer amyloid-beta peptides Abeta40 and Abeta42: stable trimer or tetramer formation by Abeta42.

Effects of Dissolved Gases on the Amyloid Fibril Morphology

Folding stability of amyloid-beta 40 monomer is an important determinant of the nucleation kinetics in fibrillization

Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients.

In vitro prion-like behaviour of TDP-43 in ALS.

Kinetic traps in the folding/unfolding of procaspase-1 CARD domain.

Lipid-Modified Graphene-Transistor Biosensor for Monitoring Amyloid-β Aggregation.

Molecular structure of amyloid fibrils formed by residues 127 to 147 of the human prion protein.

Negatively charged gold nanoparticles inhibit Alzheimer's amyloid-β fibrillization, induce fibril dissociation, and mitigate neurotoxicity.

Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer.

TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease

Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization

The Glycine-Alanine Dipeptide Repeat from C9orf72 Hexanucleotide Expansions Forms Toxic Amyloids Possessing Cell-to-Cell Transmission Properties

The coexistence of an equal amount of Alzheimer's amyloid-β 40 and 42 forms structurally stable and toxic oligomers through a distinct pathway

The truncated C-terminal RNA recognition motif of TDP-43 protein plays a key role in forming proteinaceous aggregates

Using optical profilometry to characterize cell membrane roughness influenced by amyloid-beta 42 aggregates and electric fields.