List of works by Michel De Waard

A Ca(v)3.2/syntaxin-1A signaling complex controls T-type channel activity and low-threshold exocytosis

scientific article

A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway.

scientific article published on 14 October 2015

A cell-penetrating peptide derived from human lactoferrin with conformation-dependent uptake efficiency.

scientific article published on 26 October 2009

A maurotoxin with constrained standard disulfide bridging: innovative strategy of chemical synthesis, pharmacology, and docking on K+ channels.

scientific article

A miniaturized planar patch-clamp system for transportable use.

scientific article

A retro-biosynthetic approach to the prediction of biosynthetic pathways from position-specific isotope analysis as shown for tramadol

scientific article published on 23 June 2015

A store-operated Ca2+ influx activated in response to the depletion of thapsigargin-sensitive Ca2+ stores is developmentally regulated in embryonic cortical neurons from mice.

scientific article published in September 2005

Actiflagelin, a new sperm activator isolated from Walterinnesia aegyptia venom using phenotypic screening.

scientific article published on 23 January 2018

Analysis of the interacting surface of maurotoxin with the voltage-gated Shaker B K(+) channel

scientific article published on 11 January 2011

Antibodies against the beta subunit of voltage-dependent calcium channels in Lambert-Eaton myasthenic syndrome.

scientific article published in April 1999

Anticancer properties of lipid and poly(ε-caprolactone) nanocapsules loaded with ferrocenyl-tamoxifen derivatives

scientific article published on 23 August 2018

Anticonvulsant activity of an active fraction extracted from Crinum jagus L. (Amaryllidaceae), and its possible effects on fully kindled seizures, depression-like behaviour and oxidative stress in experimental rodent models.

scientific article

Anticonvulsant effects of iridoid glycosides fraction purified from Feretia apodanthera Del. (Rubiaceae) in experimental mice models of generalized tonic-clonic seizures.

scientific article

Antipsychotic and sedative effects of the leaf extract of Crassocephalum bauchiense (Hutch.) Milne-Redh (Asteraceae) in rodents.

scientific article published on 27 June 2012

Antipyretic and antinociceptive effects of Nauclea latifolia root decoction and possible mechanisms of action.

scientific article published on 7 September 2010

Autism throughout genetics: Perusal of the implication of ion channels

publication published on 22 June 2018

Biodistribution, Stability, and Blood Distribution of the Cell Penetrating Peptide Maurocalcine in Mice.

scientific article

Biomimetic synthesis of Tramadol

scientific article published in 2015

Biophysical and pharmacological characterization of spermatogenic T-type calcium current in mice lacking the CaV3.1 (alpha1G) calcium channel: CaV3.2 (alpha1H) is the main functional calcium channel in wild-type spermatogenic cells.

scientific article

BotAF, a new Buthus occitanus tunetanus scorpion toxin, produces potent analgesia in rodents.

scientific article published on 11 January 2018

C-terminal splice variants of P/Q-type Ca2+ channel CaV2.1 α1 subunits are differentially regulated by Rab3-interacting molecule proteins.

scientific article published on 4 April 2017

CD38-dependent ADP-ribosyl cyclase activity in developing and adult mouse brain

scientific journal article

Ca2+ channel regulation by a conserved beta subunit domain

scientific article published on 01 August 1994

Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy

scientific journal article

Calcium channel β-subunit binds to a conserved motif in the I–II cytoplasmic linker of the α1-subunit

scientific article published in Nature

Cell penetration properties of a highly efficient mini maurocalcine Peptide

scientific article published on 18 March 2013

Cell penetration properties of maurocalcine, a natural venom peptide active on the intracellular ryanodine receptor.

scientific article published on 3 March 2006

Cell-penetrating nanobiosensors for pointillistic intracellular Ca2+-transient detection.

scientific article published on 7 May 2014

Cell-permeable Ln(III) chelate-functionalized InP quantum dots as multimodal imaging agents.

scientific article published on 16 September 2011

Characteristics of calcium channels responsible for voltage-activated calcium entry in rat cerebellar granule cells.

scientific article

Characterization of the purified N-type Ca2+ channel and the cation sensitivity of omega-conotoxin GVIA binding.

scientific article published on November 1993

Chlorotoxin: a helpful natural scorpion peptide to diagnose glioma and fight tumor invasion

scientific article

Cobatoxin 1 from Centruroides noxius scorpion venom: chemical synthesis, three-dimensional structure in solution, pharmacology and docking on K+ channels

scientific article

Combining Ca2+ and membrane potential imaging in single neurons

scientific article (publication date: December 2013)

Combining Ca2+ imaging with -glutamate photorelease.

scientific article published on December 2013

Combining calcium imaging with other optical techniques

scientific article (publication date: December 2013)

Compact and highly stable quantum dots through optimized aqueous phase transfer

Conjugation of doxorubicin to cell penetrating peptides sensitizes human breast MDA-MB 231 cancer cells to endogenous TRAIL-induced apoptosis

scientific article published on 01 November 2009

Contribution of the functional dyad of animal toxins acting on voltage-gated Kv1-type channels.

scientific article

Contribution of the kinetics of G protein dissociation to the characteristic modifications of N-type calcium channel activity.

scientific article published on 12 September 2006

Design of a disulfide-less, pharmacologically inert, and chemically competent analog of maurocalcine for the efficient transport of impermeant compounds into cells.

scientific article published on 11 July 2008

Diagnostic and Therapeutic Value of Aptamers in Envenomation Cases ⬇️

scientific article published on 18 May 2020

Differential down-regulation of voltage-gated calcium channel currents by glutamate and BDNF in embryonic cortical neurons.

scientific article published in August 2006

Differential effects of maurocalcine on Ca2+ release events and depolarization-induced Ca2+ release in rat skeletal muscle.

scientific article published on 14 April 2005

Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel

scientific article

Disulfide bridge reorganization induced by proline mutations in maurotoxin.

scientific article

Diversity of folds in animal toxins acting on ion channels.

scientific article

Downregulation of the Wnt/β-catenin signaling pathway by Cacnb4.

scientific article published on 11 October 2017

Doxorubicin coupled to penetratin promotes apoptosis in CHO cells by a mechanism involving c-Jun NH2-terminal kinase.

scientific article published on 10 May 2010

Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction.

scientific article published in February 1996

Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K+ channels.

scientific article published in June 2000

Efficient functional neutralization of lethal peptide toxins in vivo by oligonucleotides

scientific article

Efficient induction of apoptosis by doxorubicin coupled to cell-penetrating peptides compared to unconjugated doxorubicin in the human breast cancer cell line MDA-MB 231.

scientific article

Estrogenic and anti-estrogenic activity of 23 commercial textile dyes.

scientific article published in September 2012

Evaluation of antinociceptive effects of Crassocephalum bauchiense Hutch (Asteraceae) leaf extract in rodents.

scientific article published on 17 February 2012

Evidence for an intracellular ADP-ribosyl cyclase/NAD+-glycohydrolase in brain from CD38-deficient mice.

scientific article published on 8 August 2003

Evidence for domain-specific recognition of SK and Kv channels by MTX and HsTx1 scorpion toxins.

scientific article

Evolution of maurotoxin conformation and blocking efficacy towards Shaker B channels during the course of folding and oxidation in vitro

scientific article

Expression, localization and functions in acrosome reaction and sperm motility of CaV3.1 and CaV3.2 channels in sperm cells: An evaluation from CaV3.1 and CaV3.2 deficient mice

FRET-Based Nanobiosensors for Imaging Intracellular Ca²⁺ and H⁺ Microdomains

scientific article

Familial hemiplegic migraine type 1 mutations W1684R and V1696I alter G protein-mediated regulation of Ca(V)2.1 voltage-gated calcium channels

scientific article

Fractionation and proteomic analysis of the Walterinnesia aegyptia snake venom using OFFGEL and MALDI-TOF-MS techniques.

scientific article published on 14 July 2015

Functional Impact of BeKm-1, a High-Affinity hERG Blocker, on Cardiomyocytes Derived from Human-Induced Pluripotent Stem Cells

scientific article published on 28 September 2020

Functional characterization of cell-free expressed Kv1.3 channel using a voltage-sensitive fluorescent dye.

scientific article published on 20 January 2018

Functional coupling of Rab3-interacting molecule 1 (RIM1) and L-type Ca2+ channels in insulin release

scientific article

Functional interaction between mouse spermatogenic LVA and thapsigargin-modulated calcium channels.

scientific article published in December 2002

Functional reconstitution of cell-free synthesized purified Kv channels.

scientific article published on 6 September 2017

Gene regulation by voltage-dependent calcium channels

scientific article (publication date: June 2009)

Group X phospholipase A2 is released during sperm acrosome reaction and controls fertility outcome in mice

scientific article

Group X secreted phospholipase A2 specifically decreases sperm motility in mice

scientific article published on 01 October 2011

H-Rubies, a new family of red emitting fluorescent pH sensors for living cells.

scientific article

Hemicalcin, a new toxin from the Iranian scorpion Hemiscorpius lepturus which is active on ryanodine-sensitive Ca2+ channels

scientific article published on May 2007

How do G proteins directly control neuronal Ca2+ channel function?

scientific article

How do T-type calcium channels control low-threshold exocytosis?

scientific article published on July 2012

Identification, Characterization and Synthesis of Walterospermin, a Sperm Motility Activator from the Egyptian Black Snake Walterinnesia aegyptia Venom

scientific article published on 21 October 2020

Importance of voltage-dependent inactivation in N-type calcium channel regulation by G-proteins

scientific article published on 14 December 2006

In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide

scientific article published on 11 April 2016

In vivo expression of G-protein beta1gamma2 dimer in adult mouse skeletal muscle alters L-type calcium current and excitation-contraction coupling.

scientific article

In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

scientific article published on 20 January 2022

Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity.

scientific article

Inhibition of voltage-gated calcium channels by sequestration of beta subunits.

scientific article published in November 2003

Inositol phosphate regulation of voltage-dependent calcium channels in cerebellar granule neurons

scientific article published on September 1, 1992

Interaction of cysteine string proteins with the alpha1A subunit of the P/Q-type calcium channel

scientific article published on 01 May 1998

Introducing an alternative biophysical method to analyze direct G protein regulation of voltage-dependent calcium channels.

scientific article published on 20 September 2006

Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels.

scientific article

K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom.

scientific article

Liposomal encapsulation enhances antiviral efficacy of SPC3 against human immunodeficiency virus type-1 infection in human lymphocytes.

scientific article

MAP6 interacts with Tctex1 and Cav 2.2/N-type calcium channels to regulate calcium signalling in neurons.

scientific article published on 2 November 2017

Maurocalcine and domain A of the II-III loop of the dihydropyridine receptor Cav 1.1 subunit share common binding sites on the skeletal ryanodine receptor.

scientific article published on 9 December 2004

Maurocalcine and peptide A stabilize distinct subconductance states of ryanodine receptor type 1, revealing a proportional gating mechanism.

scientific article published on 13 February 2003

Maurocalcine as a non toxic drug carrier overcomes doxorubicin resistance in the cancer cell line MDA-MB 231

scientific article

Maurocalcine interacts with the cardiac ryanodine receptor without inducing channel modification

scientific article published on September 2007

Maurotoxin versus Pi1/HsTx1 scorpion toxins. Toward new insights in the understanding of their distinct disulfide bridge patterns.

scientific article published in December 2000

Modelling of the III-IV loop, a domain involved in calcium channel Ca(v)2.1 inactivation, highlights a structural homology with the gamma subunit of G proteins.

scientific article published in July 2002

Molecular modeling and docking simulations of scorpion toxins and related analogs on human SKCa2 and SKCa3 channels

scientific article published on 19 April 2005

Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum

scientific article published on 01 September 2002

Na(+) channel regulation by calmodulin kinase II in rat cerebellar granule cells

scientific article published on 01 August 2000

Nauclea latifolia Smith (Rubiaceae) exerts antinociceptive effects in neuropathic pain induced by chronic constriction injury of the sciatic nerve.

scientific article published on 18 November 2013

Nauclea latifolia: biological activity and alkaloid phytochemistry of a West African tree

scientific article published on 27 June 2016

Nitric oxide augments voltage-gated P/Q-type Ca(2+) channels constituting a putative positive feedback loop.

scientific article

Nuclear life of the voltage-gated Cacnb4 subunit and its role in gene transcription regulation.

scientific article

Occurrence of the synthetic analgesic tramadol in an African medicinal plant

scientific article

PTEN-regulated AKT/FoxO3a/Bim signaling contributes to Human cell glioblastoma apoptosis by platinum-maurocalcin conjugate

scientific article published on 19 May 2016

Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogs with a trimmed N-terminal domain

scientific article

Profiling the biological effects of wastewater samples via bioluminescent bacterial biosensors combined with estrogenic assays.

scientific article

Protein partners of the calcium channel β subunit highlight new cellular functions.

scientific article published on July 2016

Proteolytic cleavage of the voltage-gated Ca2+ channel alpha2delta subunit: structural and functional features

scientific article published on March 2007

Quantitative evaluation of the cell penetrating properties of an iodinated Tyr-L-maurocalcine analog.

scientific article published on 22 March 2014

RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels.

scientific article published on 13 May 2007

Redox-sensitive stimulation of type-1 ryanodine receptors by the scorpion toxin maurocalcine.

scientific article

Rim1 modulates direct G-protein regulation of Ca(v)2.2 channels

scientific article

Rôle du canal calcique P/Q dans la migraine hémiplégique familiale

article by Norbert Weiss et al published January 2007 in Médecine/sciences

SRP-27 is a novel component of the supramolecular signalling complex involved in skeletal muscle excitation-contraction coupling.

scientific article

Scorpion alpha-like toxins, toxic to both mammals and insects, differentially interact with receptor site 3 on voltage-gated sodium channels in mammals and insects.

scientific article

Snake venoms as a source of compounds modulating sperm physiology: Secreted phospholipases A2 from Oxyuranus scutellatus scutellatus impact sperm motility, acrosome reaction and in vitro fertilization in mice

scientific article published on 11 March 2010

Spermaurin, an La1-like peptide from the venom of the scorpion Scorpio maurus palmatus, improves sperm motility and fertilization in different mammalian species.

scientific article

Subunit interaction sites in voltage-dependent Ca2+ channels: role in channel function.

scientific article published on April 1998

Synthesis and characterization of Pi4, a scorpion toxin from Pandinus imperator that acts on K+ channels.

scientific article published in September 2003

Synthesis, 1H NMR structure, and activity of a three-disulfide-bridged maurotoxin analog designed to restore the consensus motif of scorpion toxins

scientific article published on 01 May 2000

The 'functional' dyad of scorpion toxin Pi1 is not itself a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels.

scientific article published on January 2004

The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.

scientific article published on April 2006

The I-II loop of the Ca2+ channel alpha1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit.

scientific article

The S218L familial hemiplegic migraine mutation promotes deinhibition of Ca(v)2.1 calcium channels during direct G-protein regulation

scientific article published on 26 June 2008

The development of high quality seals for silicon patch-clamp chips.

scientific article

The impact of the fourth disulfide bridge in scorpion toxins of the α-KTx6 subfamily

scientific article published on 01 December 2005

The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner.

scientific article published on 14 January 2002

Trafficking of L-type calcium channels mediated by the postsynaptic scaffolding protein AKAP79

scientific article published on 11 July 2002

Transient loss of voltage control of Ca2+ release in the presence of maurocalcine in skeletal muscle.

scientific article

Triadin (Trisk 95) overexpression blocks excitation-contraction coupling in rat skeletal myotubes

scientific journal article

Triadins are not triad-specific proteins: two new skeletal muscle triadins possibly involved in the architecture of sarcoplasmic reticulum

scientific article published on 31 May 2005

Two PEST-like motifs regulate Ca2+/calpain-mediated cleavage of the CaVbeta3 subunit and provide important determinants for neuronal Ca2+ channel activity

scientific article published on May 2006

Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues.

scientific article published on 3 April 2014

[Potential of cell penetrating peptides for cell drug delivery]

scientific article published on 25 May 2011

[Voltage-dependent calcium channels at the heart of pain perception]

scientific article published on 01 April 2006

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