List of works - Geoff P Horsman

A glutathione S-transferase catalyzes the dehalogenation of inhibitory metabolites of polychlorinated biphenyls.

scientific article published on June 2006

An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters

scientific article published on 14 August 2019

Characterization of a C-C bond hydrolase from Sphingomonas wittichii RW1 with novel specificities towards polychlorinated biphenyl metabolites.

scientific article published on 6 April 2007

Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol Metabolism

scientific article

Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster

scientific article

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. ⬇️

scientific article published on 29 January 2013

Evaporative light scattering quantification of natural products possessing a carbon-phosphorus bond

scientific article published on 20 May 2015

Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans

scientific article

Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad

scientific article

Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus ⬇️

scientific article

Iterative type I polyketide synthases for enediyne core biosynthesis.

scientific article published in January 2009

Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway.

scientific article published on September 2006

Mapping the substrate selectivity of new hydrolases using colorimetric screening: lipases from Bacillus thermocatenulatus and Ophiostoma piliferum, esterases from Pseudomonas fluorescens and Streptomyces diastatochromogenes

Mutations in distant residues moderately increase the enantioselectivity of Pseudomonas fluorescens esterase towards methyl 3bromo-2-methylpropanoate and ethyl 3phenylbutyrate

scientific article published in May 2003

Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids

scientific article (publication date: 7 October 2016)

Phosphonate Biochemistry

scientific article

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates

scientific article published on 17 January 2018

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

scientific article

Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics.

scientific article published on 23 July 2013

Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.

scientific article published on 20 April 2012

Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase

scientific article

The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage.

scientific article published on 11 July 2012

The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization

scientific article

The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis

scientific article published on 16 August 2019

The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad

scientific article

Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces.

scientific article published on 29 February 2016

Whole-Cell Detection of C-P Bonds in Bacteria.

scientific article published on 25 October 2017

List of works by Geoff P Horsman

A glutathione S-transferase catalyzes the dehalogenation of inhibitory metabolites of polychlorinated biphenyls.

An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters

Characterization of a C-C bond hydrolase from Sphingomonas wittichii RW1 with novel specificities towards polychlorinated biphenyl metabolites.

Characterization of a Carbon-Carbon Hydrolase from Mycobacterium tuberculosis Involved in Cholesterol Metabolism

Characterization of the epoxide hydrolase NcsF2 from the neocarzinostatin biosynthetic gene cluster

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics. ⬇️

Evaporative light scattering quantification of natural products possessing a carbon-phosphorus bond

Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans

Identification of an acyl-enzyme intermediate in a meta-cleavage product hydrolase reveals the versatility of the catalytic triad

Improvement of the enediyne antitumor antibiotic C-1027 production by manipulating its biosynthetic pathway regulation in Streptomyces globisporus ⬇️

Iterative type I polyketide synthases for enediyne core biosynthesis.

Kinetic and structural insight into the mechanism of BphD, a C-C bond hydrolase from the biphenyl degradation pathway.

Mapping the substrate selectivity of new hydrolases using colorimetric screening: lipases from Bacillus thermocatenulatus and Ophiostoma piliferum, esterases from Pseudomonas fluorescens and Streptomyces diastatochromogenes

Mutations in distant residues moderately increase the enantioselectivity of Pseudomonas fluorescens esterase towards methyl 3bromo-2-methylpropanoate and ethyl 3phenylbutyrate

Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids

Phosphonate Biochemistry

PokMT1 from the Polyketomycin Biosynthetic Machinery of Streptomyces diastatochromogenes Tü6028 Belongs to the Emerging Family of C-Methyltransferases That Act on CoA-Activated Aromatic Substrates

Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes

Predictive model for epoxide hydrolase-generated stereochemistry in the biosynthesis of nine-membered enediyne antitumor antibiotics.

Specificity of the ester bond forming condensation enzyme SgcC5 in C-1027 biosynthesis.

Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase

The catalytic serine of meta-cleavage product hydrolases is activated differently for C-O bond cleavage than for C-C bond cleavage.

The molecular basis for inhibition of BphD, a C-C bond hydrolase involved in polychlorinated biphenyls degradation: large 3-substituents prevent tautomerization

The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis

The tautomeric half-reaction of BphD, a C-C bond hydrolase. Kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad

Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces.

Whole-Cell Detection of C-P Bonds in Bacteria.