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List of works by Stephanus Malherbe

119. Prospective Validation of a 3-Gene Signature for Tuberculosis Diagnosis, Predicting Progression and Evaluating Treatment Response

article

121. Improving Predictive Value of Phase 2a TB Drug Development Models Through PET/CT Imaging (NexGen EBA)

article

A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

scientific article published in Nature

A semi-automatic technique to quantify complex tuberculous lung lesions on 18F-fluorodeoxyglucose positron emission tomography/computerised tomography images.

scientific article published on 25 June 2018

Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa

scholarly article

Africa-wide evaluation of host biomarkers in QuantiFERON supernatants for the diagnosis of pulmonary tuberculosis.

scientific article published on 8 February 2018

Author Correction: A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes

scientific article published in Nature

Cardiovascular risk and endothelial function in people living with HIV/AIDS: design of the multi-site, longitudinal EndoAfrica study in the Western Cape Province of South Africa

scientific article

Combining host-derived biomarkers with patient characteristics improves signature performance in predicting tuberculosis treatment outcomes

scientific article published on 09 July 2020

Correction to "Elucidation of a Novel Human Urine Metabolite as a Seryl-Leucine Glycopeptide and as a Biomarker of Effective Anti-Tuberculosis Therapy"

scientific article published on 13 March 2019

Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

scientific article published in December 2017

Corrigendum: Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

article

Diabetes Mellitus Among Pulmonary Tuberculosis Patients From 4 Tuberculosis-endemic Countries: The TANDEM Study

scientific article published on 01 February 2020

Diabetes screen during tuberculosis contact investigations highlights opportunity for new diabetes diagnosis and reveals metabolic differences between ethnic groups

scientific article published on 18 August 2018

Diagnostic Challenge of Tuberculosis Heterogeneity

scientific article published on 01 June 2018

Diagnostic Potential of Novel Salivary Host Biomarkers as Candidates for the Immunological Diagnosis of Tuberculosis Disease and Monitoring of Tuberculosis Treatment Response

scientific article

Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB.

scientific article published on 4 May 2016

Disease characteristics and treatment of patients with diabetes mellitus attending government health services in Indonesia, Peru, Romania and South Africa

article

Elucidation of a Human Urine Metabolite as a Seryl-Leucine Glycopeptide and as a Biomarker of Effective Anti-Tuberculosis Therapy.

scientific article

Establishment of a Patient-Derived, Magnetic Levitation-Based, Three-Dimensional Spheroid Granuloma Model for Human Tuberculosis

scientific article published on 21 July 2021

Expression and production of the SERPING1-encoded endogenous complement regulator C1-inhibitor in multiple cohorts of tuberculosis patients

scientific article published on 13 March 2020

Host biomarkers detected in saliva show promise as markers for the diagnosis of pulmonary tuberculosis disease and monitoring of the response to tuberculosis treatment.

scientific article published on 12 February 2016

Host blood RNA signatures predict the outcome of tuberculosis treatment.

scientific article published on 12 August 2017

Host urine immunological biomarkers as potential candidates for the diagnosis of tuberculosis

scientific article published on 12 August 2020

Identification of novel host biomarkers in plasma as candidates for the immunodiagnosis of tuberculosis disease and monitoring of tuberculosis treatment response

scientific article published on 19 August 2016

Immune profiling enables stratification of patients with active TB disease or M. tuberculosis infection

scientific article published on 16 October 2020

Impact of intermediate hyperglycaemia as well as diabetes on immune dysfunction in tuberculosis

scientific article published on 13 June 2020

Investigating Non-sterilizing Cure in TB Patients at the End of Successful Anti-TB Therapy

scientific article published on 25 August 2020

Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis

scientific article published on 01 December 2021

Persisting positron emission tomography lesion activity and Mycobacterium tuberculosis mRNA after tuberculosis cure

scientific article

Prospective evaluation of host biomarkers other than interferon gamma in QuantiFERON Plus supernatants as candidates for the diagnosis of tuberculosis in symptomatic individuals

scientific article published on 15 July 2019

Quantitative 18F-FDG PET-CT scan characteristics correlate with tuberculosis treatment response

scientific article published on 10 February 2020

RISK6, a 6-gene transcriptomic signature of TB disease risk, diagnosis and treatment response

scientific article published on 25 May 2020

Screening diabetes mellitus patients for pulmonary tuberculosis: a multisite study in Indonesia, Peru, Romania and South Africa

scientific article published on 28 October 2020

Targeted Gene Expression Profiling of Human Myeloid Cells From Blood and Lung Compartments of Patients With Tuberculosis and Other Lung Diseases

scientific article published on 08 March 2022

The Functional Response of B Cells to Antigenic Stimulation: A Preliminary Report of Latent Tuberculosis

scientific article

The Peripheral Blood Transcriptome Is Correlated With PET Measures of Lung Inflammation During Successful Tuberculosis Treatment

scientific article published on 10 February 2021

The potential of imaging tools as correlates of infection and disease for new TB vaccine development

article

Transcriptional profiles predict treatment outcome in patients with tuberculosis and diabetes at diagnosis and at two weeks after initiation of anti-tuberculosis treatment

scientific article published in 2022

Understanding the biology, morbidity and social contexts of adolescent tuberculosis: a prospective observational cohort study protocol (Teen TB)

scientific article published in 2022

Using biomarkers to predict TB treatment duration (Predict TB): a prospective, randomized, noninferiority, treatment shortening clinical trial

article

Validation and Optimization of Host Immunological Bio-Signatures for a Point-of-Care Test for TB Disease

scientific article published on 26 February 2021

Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study

scientific article published on 13 April 2021

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