List of works - Joseph Zabner

A common mutation in paraoxonase-2 results in impaired lactonase activity.

scientific article published on December 2009

A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia ⬇️

scientific article published on November 1, 1997

A mouse model for the delta F508 allele of cystic fibrosis.

scientific article published on October 1995

A novel host defense system of airways is defective in cystic fibrosis

scientific article

A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth

scientific article

A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia.

scientific article

Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism

scientific article published on 01 December 1999

Abundant DNase I-Sensitive Bacterial DNA in Healthy Porcine Lungs and Its Implications for the Lung Microbiome ⬇️

scientific article published on July 19, 2013

Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model

scientific article

Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo.

scientific article

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

scientific article published in March 2010

Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape

scientific article

Adenovirus-mediated gene therapy for head and neck squamous cell carcinomas.

scientific article published on July 1996

Adenovirus-mediated gene transfer for cystic fibrosis: Part A. Safety of dose and repeat administration in the nasal epithelium. Part B. Clinical efficacy in the maxillary sinus

scientific article published on 01 February 1995

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis.

scientific article published on October 1993

Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathologic observations

scientific article

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

scientific article published on January 2016

Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance.

scientific article published on 10 March 2018

Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia.

scientific article

Apical localization of the coxsackie-adenovirus receptor by glycosyl-phosphatidylinositol modification is sufficient for adenovirus-mediated gene transfer through the apical surface of human airway epithelia

scientific article published on August 2001

Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene ⬇️

scientific article published on October 1, 1998

Bronchoalveolar fluid is not a major hindrance to virus-mediated gene therapy in cystic fibrosis.

scientific article

Bronchoscopic assessment of airway retention time of aerosolized xylitol.

scientific article

CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia

scientific article published on 3 June 2005

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes

scientific article published on 08 September 2016

CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia

scientific article

Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors.

scientific article published on February 2006

Cationic lipid mediated gene transfer of CFTR: safety of a single administration to the nasal epithelia

scientific article published on 01 June 1999

Cationic lipid-mediated transfer of the hIL-10 gene prolongs survival of allogeneic hepatocytes in Nagase analbuminemic rats

scientific article published on 01 December 1996

Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid ⬇️

scientific article published on August 11, 1995

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

scientific article

Characterization of fusion genes and the significantly expressed fusion isoforms in breast cancer by hybrid sequencing.

scientific article

Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs.

scientific article published on 4 January 2018

Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo ⬇️

scientific article published on September 15, 1997

Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo.

scientific article published on March 1997

Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions

scientific article published on 18 February 2011

Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: efficiency of adenovirus-mediated gene transfer in vitro

article

Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs.

scientific article

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth

scientific article

DEVELOPMENT OF A POLARIZED PANCREATIC DUCTULAR CELL EPITHELIA FOR PHYSIOLOGICAL STUDIES.

scientific article published on 8 March 2018

Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia.

scientific article

Differentiation of human airway epithelia is dependent on erbB2

scientific article published on 17 February 2006

Directed evolution of adeno-associated virus to an infectious respiratory virus

scientific article

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

scientific article published on September 2008

Do cell junction protein mutations cause an airway phenotype in mice or humans?

scientific article published on 04 February 2011

Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.

scientific article published on September 2008

Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.

scientific article published in December 2004

Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial.

scientific article published on 4 June 2017

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid

scientific article published on 5 July 2017

Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense

scientific article published on 22 January 2016

Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model

scientific article

Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus

scientific article

Evaluation of in vivo total and regional air content and distribution in primate lungs with high-resolution CT.

scientific article published in October 1997

Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma

scientific article (publication date: February 2001)

Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect

scientific article published on December 1999

Foxj1 is required for apical localization of ezrin in airway epithelial cells

scientific journal article

Functional effects of coxsackievirus and adenovirus receptor glycosylation on homophilic adhesion and adenoviral infection.

scientific article published on 21 March 2007

Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR.

scientific article

Gene transfer to airway epithelia using feline immunodeficiency virus-based lentivirus vectors

scientific article published in January 2002

Glucose depletion in the airway surface liquid is essential for sterility of the airways

scientific article (publication date: 2011)

Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25-75/FVC) in COPD

scientific article

Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability.

scientific article published on July 2003

Hoechst increases adeno-associated virus-mediated transgene expression in airway epithelia by inducing the cytomegalovirus promoter

scientific article

Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance.

scientific article

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.

scientific article published on August 2014

In Situ Quantification of Glucose Concentration in Airway Surface Liquid With Functionalized ZnO Nanorod-Coated Microelectrodes ⬇️

scientific article published on August 12, 2011

Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia.

scholarly article

Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo ⬇️

scientific article published on July 1, 1998

Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo.

scientific article published in February 2000

Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis.

scientific article

Integrin α6β4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung disease

scientific article (publication date: 2013)

Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport.

scientific article published on 31 March 2005

Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia

scientific article published on 01 March 2003

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs

scientific article published on 8 May 2013

Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function

scientific article

Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epithelia

scientific article

Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis

scientific article published on 09 August 2018

Keratinocyte growth factor induced epithelial proliferation facilitates retroviral–mediated gene transfer to distal lung epithelia in vivo

article

Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection

scientific article published on September 1997

Large-scale gene discovery in human airway epithelia reveals novel transcripts

scientific article published on 12 March 2004

Loss of CFTR chloride channels alters salt absorption by cystic fibrosis airway epithelia in vitro.

scientific article published in September 1998

Loss of carbonic anhydrase XII function in individuals with elevated sweat chloride concentration and pulmonary airway disease

scientific article

Loss of cystic fibrosis transmembrane conductance regulator function produces abnormalities in tracheal development in neonatal pigs and young children

scientific article

Lysozyme secretion by submucosal glands protects the airway from bacterial infection.

scientific article published on 3 March 2005

MMP9 modulates tight junction integrity and cell viability in human airway epithelia

scientific article

Medical reversal of chronic sinusitis in a cystic fibrosis patient with ivacaftor

scientific article

Mitochondrial-targeted antioxidant therapy decreases transforming growth factor-β-mediated collagen production in a murine asthma model

scientific article

Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study

scientific article

Newborn Cystic Fibrosis Pigs Have a Blunted Early Response to an Inflammatory Stimulus

scientific article

Nominal carbonic anhydrase activity minimizes airway-surface liquid pH changes during breathing.

scientific article published in January 2018

Patterns and density of early tracheal colonization in intensive care unit patients.

scientific article published on March 2009

Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth

scientific article

Postnatal airway growth in cystic fibrosis piglets

scientific article published on 15 June 2017

Practical reconstruction method for bioluminescence tomography

scientific article published in September 2005

Precision Genomic Medicine in Cystic Fibrosis

scientific article

Protein Kinase Cζ Inhibitor Promotes Resolution of Bleomycin-Induced Acute Lung Injury.

scientific article published on 3 August 2016

Protein composition of bronchoalveolar lavage fluid and airway surface liquid from newborn pigs

scientific article published on 24 May 2013

Recombinant adeno-associated virus type 2, 4, and 5 vectors: transduction of variant cell types and regions in the mammalian central nervous system.

scholarly article

Reduced airway surface pH impairs bacterial killing in the porcine cystic fibrosis lung

scientific article

Repurposing tromethamine as inhaled therapy to treat CF airway disease.

scientific article published on June 2016

Requirements for ion and solute transport, and pH regulation during enamel maturation.

scientific article

Role of PON in anoxia-reoxygenation injury: a Drosophila melanogaster transgenic model

scientific article published on 06 January 2014

Safety and efficacy of repetitive adenovirus-mediated transfer of CFTR cDNA to airway epithelia of primates and cotton rats.

scientific article published in January 1994

Safety assessment of inhaled xylitol in mice and healthy volunteers

scientific article

Safety assessment of inhaled xylitol in subjects with cystic fibrosis.

scientific article published on 15 June 2006

Safety assessment of nebulized xylitol in beagle dogs

scientific article published on 01 May 2012

Secreted and transmembrane mucins inhibit gene transfer with AAV4 more efficiently than AAV5.

scientific article

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

scientific article

Sinus hypoplasia precedes sinus infection in a porcine model of cystic fibrosis

scientific article

Starting a lung transplant program: a roadmap for long-term excellence

scientific article

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

scientific article

Targeting the urokinase plasminogen activator receptor enhances gene transfer to human airway epithelia.

scientific article

The Coxsackievirus and Adenovirus Receptor: a new adhesion protein in cochlear development

scientific journal article

The Effects of Timed Light Exposure in Critically Ill Patients: A Randomized Controlled Pilot Clinical Trial

scientific article published on 01 July 2018

The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia

scientific article

The indirect effect of Tityus discrepans on rabbit pulmonary vasculature.

scientific article published in February 2003

The porcine lung as a potential model for cystic fibrosis

scientific article published on 16 May 2008

The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs

scientific article

Thixotropic solutions enhance viral-mediated gene transfer to airway epithelia.

scientific article published in August 2002

Transepithelial migration of neutrophils into the lung requires TREM-1

scientific journal article

Tryptase does not alter transepithelial conductance or paracellular permeability in human airway epithelial cells.

scientific article published in March 2010

Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis.

scientific article published on 8 February 2007

Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility

scientific article

pH modulates the activity and synergism of the airway surface liquid antimicrobials β-defensin-3 and LL-37

scientific article

List of works by Joseph Zabner

A common mutation in paraoxonase-2 results in impaired lactonase activity.

A low rate of cell proliferation and reduced DNA uptake limit cationic lipid-mediated gene transfer to primary cultures of ciliated human airway epithelia ⬇️

A mouse model for the delta F508 allele of cystic fibrosis.

A novel host defense system of airways is defective in cystic fibrosis

A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth

A shortened adeno-associated virus expression cassette for CFTR gene transfer to cystic fibrosis airway epithelia.

Absence of amiloride-sensitive sodium absorption in the airway of an infant with pseudohypoaldosteronism

Abundant DNase I-Sensitive Bacterial DNA in Healthy Porcine Lungs and Its Implications for the Lung Microbiome ⬇️

Adenoviral gene transfer corrects the ion transport defect in the sinus epithelia of a porcine CF model

Adenoviral-mediated gene transfer to fetal pulmonary epithelia in vitro and in vivo.

Adenovirus 5-fiber 35 chimeric vector mediates efficient apical correction of the cystic fibrosis transmembrane conductance regulator defect in cystic fibrosis primary airway epithelia.

Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape

Adenovirus-mediated gene therapy for head and neck squamous cell carcinomas.

Adenovirus-mediated gene transfer for cystic fibrosis: Part A. Safety of dose and repeat administration in the nasal epithelium. Part B. Clinical efficacy in the maxillary sinus

Adenovirus-mediated gene transfer transiently corrects the chloride transport defect in nasal epithelia of patients with cystic fibrosis.

Aggregates of mutant CFTR fragments in airway epithelial cells of CF lungs: new pathologic observations

Airway acidification initiates host defense abnormalities in cystic fibrosis mice.

Airway surface liquid from smokers promotes bacterial growth and biofilm formation via iron-lactoferrin imbalance.

Alveolar macrophages inhibit retrovirus-mediated gene transfer to airway epithelia.

Apical localization of the coxsackie-adenovirus receptor by glycosyl-phosphatidylinositol modification is sufficient for adenovirus-mediated gene transfer through the apical surface of human airway epithelia

Augmentation of lung liquid clearance via adenovirus-mediated transfer of a Na,K-ATPase beta1 subunit gene ⬇️

Bronchoalveolar fluid is not a major hindrance to virus-mediated gene therapy in cystic fibrosis.

Bronchoscopic assessment of airway retention time of aerosolized xylitol.

CFTR DeltaF508 mutation has minimal effect on the gene expression profile of differentiated human airway epithelia

CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes

CFTR is required for maximal transepithelial liquid transport in pig alveolar epithelia

Canine adenovirus vectors for lung-directed gene transfer: efficacy, immune response, and duration of transgene expression using helper-dependent vectors.

Cationic lipid mediated gene transfer of CFTR: safety of a single administration to the nasal epithelia

Cationic lipid-mediated transfer of the hIL-10 gene prolongs survival of allogeneic hepatocytes in Nagase analbuminemic rats

Cellular and Molecular Barriers to Gene Transfer by a Cationic Lipid ⬇️

Cellular localization and activity of Ad-delivered GFP-CFTR in airway epithelial and tracheal cells.

Characterization of fusion genes and the significantly expressed fusion isoforms in breast cancer by hybrid sequencing.

Chest wall strapping increases expiratory airflow and detectable airway segments in computer tomographic scans of normal and obstructed lungs.

Comparison of DNA-lipid complexes and DNA alone for gene transfer to cystic fibrosis airway epithelia in vivo ⬇️

Complexes of adenovirus with polycationic polymers and cationic lipids increase the efficiency of gene transfer in vitro and in vivo.

Concentration of the antibacterial precursor thiocyanate in cystic fibrosis airway secretions

Correction of cAMP-stimulated fluid secretion in cystic fibrosis airway epithelia: efficiency of adenovirus-mediated gene transfer in vitro

Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs.

Cystic fibrosis pigs develop lung disease and exhibit defective bacterial eradication at birth

DEVELOPMENT OF A POLARIZED PANCREATIC DUCTULAR CELL EPITHELIA FOR PHYSIOLOGICAL STUDIES.

Differential expression of sheep beta-defensin-1 and -2 and interleukin 8 during acute Mannheimia haemolytica pneumonia.

Differentiation of human airway epithelia is dependent on erbB2

Directed evolution of adeno-associated virus to an infectious respiratory virus

Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs

Do cell junction protein mutations cause an airway phenotype in mice or humans?

Drosophila are protected from Pseudomonas aeruginosa lethality by transgenic expression of paraoxonase-1.

Dual therapeutic utility of proteasome modulating agents for pharmaco-gene therapy of the cystic fibrosis airway.

Effect of vitamin D3 on the antimicrobial activity of human airway surface liquid: preliminary results of a randomised placebo-controlled double-blind trial.

Effects of Coal Fly Ash Particulate Matter on the Antimicrobial Activity of Airway Surface Liquid

Electrolyte transport properties in distal small airways from cystic fibrosis pigs with implications for host defense

Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model

Enhanced sialic acid-dependent endocytosis explains the increased efficiency of infection of airway epithelia by a novel adeno-associated virus

Evaluation of in vivo total and regional air content and distribution in primate lungs with high-resolution CT.

Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma

Feline immunodeficiency virus vectors persistently transduce nondividing airway epithelia and correct the cystic fibrosis defect

Foxj1 is required for apical localization of ezrin in airway epithelial cells

Functional effects of coxsackievirus and adenovirus receptor glycosylation on homophilic adhesion and adenoviral infection.

Gene transfer of CFTR to airway epithelia: low levels of expression are sufficient to correct Cl- transport and overexpression can generate basolateral CFTR.

Gene transfer to airway epithelia using feline immunodeficiency virus-based lentivirus vectors

Glucose depletion in the airway surface liquid is essential for sterility of the airways

Higher BMI is associated with higher expiratory airflow normalised for lung volume (FEF25-75/FVC) in COPD

Histamine alters E-cadherin cell adhesion to increase human airway epithelial permeability.

Hoechst increases adeno-associated virus-mediated transgene expression in airway epithelia by inducing the cytomegalovirus promoter

Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance.

Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis.

In Situ Quantification of Glucose Concentration in Airway Surface Liquid With Functionalized ZnO Nanorod-Coated Microelectrodes ⬇️

Inactivation of a Pseudomonas aeruginosa quorum-sensing signal by human airway epithelia.

Incorporation of adenovirus in calcium phosphate precipitates enhances gene transfer to airway epithelia in vitro and in vivo ⬇️

Increasing epithelial junction permeability enhances gene transfer to airway epithelia In vivo.

Inflammatory response in airway epithelial cells isolated from patients with cystic fibrosis.

Integrin α6β4 identifies human distal lung epithelial progenitor cells with potential as a cell-based therapy for cystic fibrosis lung disease

Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport.

Interleukin-9 induces goblet cell hyperplasia during repair of human airway epithelia

Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs

Iron oxide nanoparticles induce Pseudomonas aeruginosa growth, induce biofilm formation, and inhibit antimicrobial peptide function

Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epithelia

Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis

Keratinocyte growth factor induced epithelial proliferation facilitates retroviral–mediated gene transfer to distal lung epithelia in vivo

Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection