List of works - Razq Hakem

A role for Brca1 in chromosome end maintenance

scientific article published on 30 January 2006

AID and caspase 8 shape the germinal center response through apoptosis

scientific article published on 15 November 2013

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

scientific article

Animal models of tumor-suppressor genes.

scientific article

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

scientific journal article

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

scientific article

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

scientific article

Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.

scientific article published in March 2004

Brca2 is required for embryonic cellular proliferation in the mouse

scientific journal article

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

scientific article

CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8.

scientific article

Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells

scientific article published in April 2007

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

scientific article published on May 2005

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

scientific journal article

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

scientific article

Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression

scientific article published on 26 May 2014

Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific.

scientific article

Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.

scholarly article

DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration

scientific article

Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models

scientific article published on 11 June 2007

Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

scientific article published on 19 March 2007

Essential role for Bclaf1 in lung development and immune system function

scientific article published on 14 November 2008

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

scientific article (publication date: 29 March 2001)

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

scientific article

Genome Integrity - a new open access journal.

scientific article published on 26 May 2010

LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.

scientific article

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

scientific article

Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9

scientific article published on 01 March 2003

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

scientific journal article

RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation

scientific article published on 22 August 2013

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

scientific article (publication date: 17 March 2011)

Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation

scientific article published on 15 February 2016

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

scientific article

Serological and structural analysis of HLA class I molecules: beta 2-microglobulin interacts with the two external domains of the HLA class I heavy chain

scientific article published in January 1987

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

scientific article

Systemic ceramide accumulation leads to severe and varied pathological consequences.

scientific article published on 16 May 2013

Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.

scientific article

The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover

scientific article

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

scientific article

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

scientific article published on 04 September 2018

The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets

scientific article published on 19 January 2014

List of works by Razq Hakem

A role for Brca1 in chromosome end maintenance

AID and caspase 8 shape the germinal center response through apoptosis

Absence of caspase-3 protects pancreatic {beta}-cells from c-Myc-induced apoptosis without leading to tumor formation.

Animal models of tumor-suppressor genes.

Apaf1 is required for mitochondrial pathways of apoptosis and brain development

Apoptosis caused by p53-induced protein with death domain (PIDD) depends on the death adapter protein RAIDD.

BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore

Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.

Brca2 is required for embryonic cellular proliferation in the mouse

CD28-dependent activation of protein kinase B/Akt blocks Fas-mediated apoptosis by preventing death-inducing signaling complex assembly.

CD95 apoptosis resistance in certain cells can be overcome by noncanonical activation of caspase-8.

Caspase-12 compensates for lack of caspase-2 and caspase-3 in female germ cells

Caspase-3-dependent beta-cell apoptosis in the initiation of autoimmune diabetes mellitus.

Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis

Cellular FLICE-inhibitory protein is required for T cell survival and cycling

Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression

Coupling of caspase-9 to Apaf1 in response to loss of pRb or cytotoxic drugs is cell-type-specific.

Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.

DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration

Distinct in vivo roles of caspase-8 in beta-cells in physiological and diabetes models

Endoplasmic reticulum stress-induced death of mouse embryonic fibroblasts requires the intrinsic pathway of apoptosis.

Essential role for Bclaf1 in lung development and immune system function

Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

Fatal hepatitis mediated by tumor necrosis factor TNFalpha requires caspase-8 and involves the BH3-only proteins Bid and Bim.

Genome Integrity - a new open access journal.

LATS2 suppresses oncogenic Wnt signaling by disrupting β-catenin/BCL9 interaction.

Partial rescue of Brca1 (5-6) early embryonic lethality by p53 or p21 null mutation.

Perforin-dependent activation-induced cell death acts through caspase 3 but not through caspases 8 or 9

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

RIP3 inhibits inflammatory hepatocarcinogenesis but promotes cholestasis by controlling caspase-8- and JNK-dependent compensatory cell proliferation

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation

Requirement for caspase-8 in NF-kappaB activation by antigen receptor.

Serological and structural analysis of HLA class I molecules: beta 2-microglobulin interacts with the two external domains of the HLA class I heavy chain

Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3

Systemic ceramide accumulation leads to severe and varied pathological consequences.

Th-MYCN mice with caspase-8 deficiency develop advanced neuroblastoma with bone marrow metastasis.

The E3 ligase PIRH2 polyubiquitylates CHK2 and regulates its turnover

The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis

The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

The role of caspase-8 in amyloid-induced beta cell death in human and mouse islets

Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis