List of works - Wan Wan Lin

15-deoxy-Δ12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription

article

5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.

scientific article published on May 2007

A comprehensive investigation of anti-inflammatory diarylheptanoids from the leaves of Alnus formosana

scientific article published on 07 March 2011

A study on the cause of death due to waglerin-I, a toxin from Trimeresurus wagleri.

scientific article

AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

scientific article published on 20 November 2018

Activation of metabotropic glutamate receptor 5 is associated with effect of amphetamine on brain neurons ⬇️

scientific article published on December 15, 2003

Agonist-induced desensitization of ATP receptor-mediated phosphoinositide turnover in C6 glioma cells: comparison with the negative-feedback regulation by protein kinase C.

scientific article published in July 1993

Anti-obesity action of INDUS810, a natural compound from Trigonella foenum-graecum: AMPK-dependent lipolysis effect in adipocytes

scientific article published on 11 September 2018

Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IkappaB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kina

scientific article

BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation

scientific article published on 31 August 2018

Biphasic effects of endothelin in the guinea-pig ileum

scientific article published on 01 January 1990

Celecoxib induces heme oxygenase-1 expression in macrophages and vascular smooth muscle cells via ROS-dependent signaling pathway.

scientific article published on 22 December 2010

Characterization of signaling pathways of P2Y and P2U purinoceptors in bovine pulmonary artery endothelial cells.

scientific article

Chronic Viral Hepatitis Signifies the Association of Premixed Insulin Analogues with Liver Cancer Risks: A Nationwide Population-Based Study

scientific article published on 13 June 2019

Correction to: Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

scientific article published on 04 September 2019

Cycloheximide-induced cPLA2 activation is via the MKP-1 down-regulation and ERK activation

scientific article published on 01 July 2000

Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer.

scientific article published on 02 February 2011

Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions.

scientific article

Dual roles of NOD2 in TLR4-mediated signal transduction and -induced inflammatory gene expression in macrophages.

scientific article

EGFR-driven up-regulation of decoy receptor 3 in keratinocytes contributes to the pathogenesis of psoriasis ⬇️

scientific article published on May 23, 2013

Effect of sea nettle (Chrysaora quinquecirrha) venom on isolated rat aorta

scientific article published on 01 January 1988

Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids.

scientific article published on January 2001

Endothelin-1 stimulates the release of preloaded [3H]D-aspartate from cultured cerebellar granule cells.

scientific article published in March 1990

Erratum to ‘Effects of protein kinase A activation on endothelin and ATP-induced signal transduction’

scholarly article published in European Journal of Pharmacology

HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation ⬇️

scientific article published on November 16, 2012

HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.

scientific article

HMG-CoA reductase inhibitors induce COX-2 gene expression in murine macrophages: role of MAPK cascades and promoter elements for CREB and C/EBPbeta.

scientific article

HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways.

scientific article published on 20 April 2005

High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway.

scientific article published on 13 January 2005

High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway

scientific article published on 20 June 2005

Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism.

scientific article

Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid

scientific article

Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.

scientific article published on 19 September 2005

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase

article

Inhibition of the sodium channel by SK&F 96365, an inhibitor of the receptor-operated calcium channel, in mouse diaphragm

scientific article published on 01 June 1994

Involvement of protein kinase C in the UTP-mediated potentiation of cyclic AMP accumulation in mouse J774 macrophages.

scientific article

Mechanism of LIGHT/interferon-?-induced cell death in HT-29 cells

scientific article published on 01 December 2004

Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction.

scientific article

Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.

scientific article published on January 2003

Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase ⬇️

scientific article published on January 31, 2013

Opposite effects of high glucose on MMP-2 and TIMP-2 in human endothelial cells

scientific article published on 01 May 2007

Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death.

scientific article

PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP.

scientific article published on May 2004

PKC-Dependent Human Monocyte Adhesion Requires AMPK and Syk Activation ⬇️

scientific article published on July 25, 2012

Pharmacological comparison of UTP‐ and thapsigargin‐induced arachidonic acid release in mouse RAW 264.7 macrophages ⬇️

scientific article published on March 1, 1998

Potentiation by Ca2+ ionophores and inhibition by extracellular KCl of endothelin-induced phosphoinositide turnover in C6 glioma cells.

scientific article published on September 1992

Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs

scientific article published on 9 August 2005

Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.

scientific article published on August 2002

Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-kappaB (nuclear factor kappaB) inhibition.

scientific article published on May 2004

Protein kinase C β and δ isoenzymes mediate cholesterol accumulation in PMA-activated macrophages

scientific article published on 11 August 2006

Pyrimidinoceptor-mediated potentiation of inducible nitric-oxide synthase induction in J774 macrophages. Role of intracellular calcium.

scientific article

Reactive oxygen species are involved in FasL-induced caspase-independent cell death and inflammatory responses.

scientific article published in 2008

Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

scientific article published on 22 May 2019

Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells

scientific article

STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death.

scientific article

Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells

scientific article (publication date: 4 July 1997)

Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages

scientific article

Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation

scientific article published on 01 December 2006

Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation.

scientific article published in December 2002

Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation.

scientific article published in January 2016

Spleen tyrosine kinase mediates the actions of EPO and GM-CSF and coordinates with TGF-β in erythropoiesis.

scientific article published on 25 January 2017

Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity.

scientific article published on 16 July 2015

TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production.

scientific article

TRAIL-Induced Keratinocyte Differentiation Requires Caspase Activation and p63 Expression

scientific article published on 20 January 2011

The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization

scientific article published on 06 June 2018

The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells

scientific article published on 07 April 2007

The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages.

scientific article

Two subtypes of acetylcholinesterase isoenzymes distinguishable by Angusticeps-type toxin F7

scientific article published on 01 January 1989

Upregulation of FcγRIIB by resveratrol via NF-κB activation reduces B-cell numbers and ameliorates lupus.

scientific article published on 29 September 2017

List of works by Wan Wan Lin

15-deoxy-Δ12,14-prostaglandin J2 up-regulates death receptor 5 gene expression in HCT116 cells: involvement of reactive oxygen species and C/EBP homologous transcription factor gene transcription

5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling.

A comprehensive investigation of anti-inflammatory diarylheptanoids from the leaves of Alnus formosana

A study on the cause of death due to waglerin-I, a toxin from Trimeresurus wagleri.

AMPK-dependent and independent actions of P2X7 in regulation of mitochondrial and lysosomal functions in microglia

Activation of metabotropic glutamate receptor 5 is associated with effect of amphetamine on brain neurons ⬇️

Agonist-induced desensitization of ATP receptor-mediated phosphoinositide turnover in C6 glioma cells: comparison with the negative-feedback regulation by protein kinase C.

Anti-obesity action of INDUS810, a natural compound from Trigonella foenum-graecum: AMPK-dependent lipolysis effect in adipocytes

Aurintricarboxylic acid protects against cell death caused by lipopolysaccharide in macrophages by decreasing inducible nitric-oxide synthase induction via IkappaB kinase, extracellular signal-regulated kinase, and p38 mitogen-activated protein kina

BLIMP1 transcriptionally induced by EGFR activation and post-translationally regulated by proteasome and lysosome is involved in keratinocyte differentiation, migration and inflammation

Biphasic effects of endothelin in the guinea-pig ileum

Celecoxib induces heme oxygenase-1 expression in macrophages and vascular smooth muscle cells via ROS-dependent signaling pathway.

Characterization of signaling pathways of P2Y and P2U purinoceptors in bovine pulmonary artery endothelial cells.

Chronic Viral Hepatitis Signifies the Association of Premixed Insulin Analogues with Liver Cancer Risks: A Nationwide Population-Based Study

Correction to: Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

Cycloheximide-induced cPLA2 activation is via the MKP-1 down-regulation and ERK activation

Decoy receptor 3: a pleiotropic immunomodulator and biomarker for inflammatory diseases, autoimmune diseases and cancer.

Decoy receptor 3: an endogenous immunomodulator in cancer growth and inflammatory reactions.

Dual roles of NOD2 in TLR4-mediated signal transduction and -induced inflammatory gene expression in macrophages.

EGFR-driven up-regulation of decoy receptor 3 in keratinocytes contributes to the pathogenesis of psoriasis ⬇️

Effect of sea nettle (Chrysaora quinquecirrha) venom on isolated rat aorta

Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids.

Endothelin-1 stimulates the release of preloaded [3H]D-aspartate from cultured cerebellar granule cells.

Erratum to ‘Effects of protein kinase A activation on endothelin and ATP-induced signal transduction’

HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation ⬇️

HMG-CoA reductase inhibitors activate the unfolded protein response and induce cytoprotective GRP78 expression.

HMG-CoA reductase inhibitors induce COX-2 gene expression in murine macrophages: role of MAPK cascades and promoter elements for CREB and C/EBPbeta.

HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways.

High glucose induces human endothelial cell apoptosis through a phosphoinositide 3-kinase-regulated cyclooxygenase-2 pathway.

High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway

Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism.

Inhibition of cytokine-induced JAK-STAT signalling pathways by an endonuclease inhibitor aurintricarboxylic acid

Inhibition of iNOS gene expression by quercetin is mediated by the inhibition of IkappaB kinase, nuclear factor-kappa B and STAT1, and depends on heme oxygenase-1 induction in mouse BV-2 microglia.

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase

Inhibition of the sodium channel by SK&F 96365, an inhibitor of the receptor-operated calcium channel, in mouse diaphragm

Involvement of protein kinase C in the UTP-mediated potentiation of cyclic AMP accumulation in mouse J774 macrophages.

Mechanism of LIGHT/interferon-?-induced cell death in HT-29 cells

Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction.

Negative regulation of phosphatidylinositol 3-kinase and Akt signalling pathway by PKC.

Nutrient deprivation induces the Warburg effect through ROS/AMPK-dependent activation of pyruvate dehydrogenase kinase ⬇️

Opposite effects of high glucose on MMP-2 and TIMP-2 in human endothelial cells

Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death.

PKA-dependent activation of PKC, p38 MAPK and IKK in macrophage: implication in the induction of inducible nitric oxide synthase and interleukin-6 by dibutyryl cAMP.

PKC-Dependent Human Monocyte Adhesion Requires AMPK and Syk Activation ⬇️

Pharmacological comparison of UTP‐ and thapsigargin‐induced arachidonic acid release in mouse RAW 264.7 macrophages ⬇️

Potentiation by Ca2+ ionophores and inhibition by extracellular KCl of endothelin-induced phosphoinositide turnover in C6 glioma cells.

Preparation and anti-inflammatory activities of diarylheptanoid and diarylheptylamine analogs

Proteasome inhibitors stimulate activator protein-1 pathway via reactive oxygen species production.

Proteasome inhibitors up-regulate haem oxygenase-1 gene expression: requirement of p38 MAPK (mitogen-activated protein kinase) activation but not of NF-kappaB (nuclear factor kappaB) inhibition.

Protein kinase C β and δ isoenzymes mediate cholesterol accumulation in PMA-activated macrophages

Pyrimidinoceptor-mediated potentiation of inducible nitric-oxide synthase induction in J774 macrophages. Role of intracellular calcium.

Reactive oxygen species are involved in FasL-induced caspase-independent cell death and inflammatory responses.

Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death

Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells

STI571 reduces TRAIL-induced apoptosis in colon cancer cells: c-Abl activation by the death receptor leads to stress kinase-dependent cell death.

Serine/threonine kinase activity associated with the cytoplasmic domain of the lymphotoxin-beta receptor in HepG2 cells

Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages

Signaling pathways of LIGHT induced macrophage migration and vascular smooth muscle cell proliferation

Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation.

Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation.

Spleen tyrosine kinase mediates the actions of EPO and GM-CSF and coordinates with TGF-β in erythropoiesis.

Synthesis of Diverse N-Substituted Muramyl Dipeptide Derivatives and Their Use in a Study of Human NOD2 Stimulation Activity.

TAK1 inhibition-induced RIP1-dependent apoptosis in murine macrophages relies on constitutive TNF-α signaling and ROS production.

TRAIL-Induced Keratinocyte Differentiation Requires Caspase Activation and p63 Expression

The Mycobacterial Adjuvant Analogue TDB Attenuates Neuroinflammation via Mincle-Independent PLC-γ1/PKC/ERK Signaling and Microglial Polarization

The anti-inflammatory actions of LCY-2-CHO, a carbazole analogue, in vascular smooth muscle cells

The anti-inflammatory carbazole, LCY-2-CHO, inhibits lipopolysaccharide-induced inflammatory mediator expression through inhibition of the p38 mitogen-activated protein kinase signaling pathway in macrophages.

Two subtypes of acetylcholinesterase isoenzymes distinguishable by Angusticeps-type toxin F7

Upregulation of FcγRIIB by resveratrol via NF-κB activation reduces B-cell numbers and ameliorates lupus.