List of works by Massimo Broggini

Absence of deletions but frequent loss of expression of p16INK4 in human ovarian tumours ⬇️

scientific article published on January 1, 1997

Across the universe of K-RAS mutations in non-small-cell-lung cancer.

scientific article published on January 2014

Activity and distribution of iv and oral 4-demethoxydaunorubicin in murine experimental tumors

scientific article published on 01 May 1984

Adriamycin distribution in plasma and blood cells of cancer patients with altered hematocrit

scientific article published on 01 October 1981

Allelic expression of p73 in human ovarian cancers

scientific article published on 01 August 1999

Alpha-bromoacryloyl derivative of distamycin A (PNU 151807): a new non-covalent minor groove DNA binder with antineoplastic activity.

scientific article published on June 1999

Analysis of gene expression in early-stage ovarian cancer.

scientific article

Anti-Influenza Effect of Nanosilver in a Mouse Model

scientific article published on 13 November 2020

Antiangiogenic activity of aplidine, a new agent of marine origin

scientific article published on June 2004

Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 (flt-1) autocrine loop in human leukemia cells MOLT-4.

scientific article published on January 2003

Available evidence and new biological perspectives on medical treatment of advanced thymic epithelial tumors

scientific article published on 19 November 2014

Base excision repair-mediated resistance to cisplatin in KRAS(G12C) mutant NSCLC cells.

scientific article published on 2 September 2015

Benzylidenetetralones, cyclic chalcone analogues, induce cell cycle arrest and apoptosis in HCT116 colorectal cancer cells.

scientific article published on 10 July 2014

Biochemical studies on the ability of pentamethylmelamine to interact in vivo with DNA and proteins in a sensitive murine ovarian reticular cell sarcoma

scientific article published on 01 September 1984

Biodegradable microcarriers as cell delivery vehicle for in vivo transplantation and magnetic resonance monitoring.

scientific article published in April 2011

Brassinin and its derivatives as potential anticancer agents

scientific article published on 18 April 2014

Breast cancer-derived bone metastasis can be effectively reduced through specific c-MET inhibitor tivantinib (ARQ 197) and shRNA c-MET knockdown

scientific article

Brostallicin, a novel anticancer agent whose activity is enhanced upon binding to glutathione.

scientific article

CHK1 frameshift mutations in genetically unstable colorectal and endometrial cancers

scientific article published on 01 October 1999

CRISP-R/Cas9 Mediated Deletion of Copper Transport Genes CTR1 and DMT1 in NSCLC Cell Line H1299. Biological and Pharmacological Consequences

scientific article published on 06 April 2019

Can the response to a platinum-based therapy be predicted by the DNA repair status in non-small cell lung cancer?

scientific article published on 24 May 2016

Cancer and the cell cycle. Lausanne, Switzerland, January 17-20, 1996

scientific article published on 01 April 1996

Cancer-derived p53 mutants suppress p53-target gene expression--potential mechanism for gain of function of mutant p53.

scientific article published on 7 March 2007

Capturing the metabolomic diversity of KRAS mutants in non-small-cell lung cancer cells.

scientific article

Cell cycle checkpoint proteins and cellular response to treatment by anticancer agents.

scientific article published on January 2004

Central side effects of pentamethylmelamine: biochemical and behavioural studies.

scientific article published in December 1984

Changes in cyclins and cyclin-dependent kinases induced by DNA damaging agents in a human ovarian cancer cell line expressing mutated or wild-type P53.

scientific article published on September 1996

Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines

scientific article published on 11 January 2016

Characterization of the 5'flanking region of the human Chk1 gene: identification of E2F1 functional sites

scientific article published on November 1, 2003

Checkpoint kinase 1 down-regulation by an inducible small interfering RNA expression system sensitized in vivo tumors to treatment with 5-fluorouracil.

scientific article

Chemotherapy versus tyrosine kinase inhibitor in EGFR unselected population advanced non-small cell lung cancer still matter of debate?-An update incorporating the DELTA trial data

scientific article

Chk1, but not Chk2, is involved in the cellular response to DNA damaging agents: differential activity in cells expressing or not p53.

scientific article published on 13 September 2004

Circulating plasma vascular endothelial growth factor in mice bearing human ovarian carcinoma xenograft correlates with tumor progression and response to therapy

scientific article published on 01 May 2005

Class II phosphoinositide 3-kinase C2β regulates a novel signaling pathway involved in breast cancer progression.

scientific article published on 26 February 2016

Combination of the c-Met inhibitor tivantinib and zoledronic acid prevents tumor bone engraftment and inhibits progression of established bone metastases in a breast xenograft model

scientific article (publication date: 2013)

Comparative metabolism of daunorubicin and 4-demethoxydaunorubicin in mice and rabbits

scientific article published on 01 June 1986

Comparative metabolomics profiling of isogenic KRAS wild type and mutant NSCLC cells in vitro and in vivo.

scientific article published on 22 June 2016

Comparison between VP 16 and VM 26 in Lewis lung carcinoma of the mouse

scientific article published on 01 February 1986

DDP-induced cytotoxicity is not influenced by p53 in nine human ovarian cancer cell lines with different p53 status.

scientific article

DNA damage induces transcriptional activation of p73 by removing C-EBP repression on E2F1 ⬇️

scientific article published on November 15, 2003

DNA damage, cytotoxic effect and cell-cycle perturbation of Hoechst 33342 on L1210 cells in vitro ⬇️

scientific article published on January 1, 1988

DNA interstrand cross-links induced by cis-dichlorodiammine platinum in ovarian cancer cells growing in primary culture

scientific article published on 01 May 1988

DNA-topoisomerase I activity and content in epithelial ovarian cancer

scientific article published on 01 March 1998

DRAGO (KIAA0247), a new DNA damage-responsive, p53-inducible gene that cooperates with p53 as oncosuppressor. [Corrected]

scientific article

Decreased cytotoxic effects of doxorubicin in a human ovarian cancer-cell line expressing wild-type p53 and WAF1/CIP1 genes.

scientific article published on May 1995

Detailed genetic and physical mapping of tumor suppressor loci on chromosome 3p in ovarian cancer

scientific article published on 01 September 1999

Development of distamycin-related DNA binding anticancer drugs.

scientific article

Different metabolic responses to PI3K inhibition in NSCLC cells harboring wild-type and G12C mutant KRAS.

scientific article published on 6 June 2016

Differential adriamycin distribution to blood components

scientific article published on 01 January 1981

Differential distribution of antitumor agents in primary and secondary tumors

scientific article published on October 1, 1977

Differential expression of c-fos proto-oncogene in two subclones derived from a human ovarian cancer cell line.

scientific article published on March 1995

Differential inhibition of the DNA binding of transcription factors NF kappa B and OTF-1 by nitrogen mustard and quinacrine mustard: transcriptional implications.

scientific article published on September 1993

Direct but not indirect co-culture with osteogenically differentiated human bone marrow stromal cells increases RANKL/OPG ratio in human breast cancer cells generating bone metastases

scientific article

Distribution and antitumor activity of adriamycin given in a high-dose and a repeated low-dose schedule to mice

scientific article published on 01 May 1978

Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells

scientific article

Driving p53 response to Bax activation greatly enhances sensitivity to taxol by inducing massive apoptosis.

scientific article

EGFR mutations and EGFR tyrosine kinase inhibitors.

scientific article

Early DNA damage induced in cells exposed to N10-propargyl 5,8-dideazafolic acid (CB 3717) or methotrexate

scientific article published on 01 May 1988

Early phase pharmacokinetics of doxorubicin (adriamycin) in plasma of cancer patients during single- or multiple-drug therapy

scientific article published on 01 August 1980

Effect of Aplidin in acute lymphoblastic leukaemia cells.

scientific article published on August 2003

Effect of G:C-->A:T transition, potentially arising from O6-guanine alkylation, in the transcription regulation of c-fos serum response element

scientific article published on May 1, 1997

Effects of DNA damaging agents on gene expression in two human cancer cell lines

scientific article published on 01 December 1993

Effects of inducible overexpression of DNp73alpha on cancer cell growth and response to treatment in vitro and in vivo.

scientific article

Enhancement of in vivo antitumor activity of classical anticancer agents by combination with the new, glutathione-interacting DNA minor groove-binder, brostallicin.

scientific article published in November 2003

Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer.

scientific article

Epithelial-mesenchymal transition and breast cancer: role, molecular mechanisms and clinical impact.

scientific article

Establishment and Characterization of Patient-Derived Xenografts (PDXs) of Different Histology from Malignant Pleural Mesothelioma Patients

scientific article published on 20 December 2020

Establishment of L1210 leukemia cells resistant to the distamycin-A derivative (FCE 24517): characterization and cross-resistance studies.

scientific article published on January 1993

Evaluation of safety and efficacy of tivantinib in the treatment of inoperable or recurrent non-small-cell lung cancer

scientific article published on 17 January 2013

Experimental switching of copper status in laboratory rodents.

scientific article published on 20 October 2010

Exploiting FAsting-mimicking Diet and MEtformin to Improve the Efficacy of Platinum-pemetrexed Chemotherapy in Advanced LKB1-inactivated Lung Adenocarcinoma: The FAME Trial

scientific article published on 19 December 2018

Expression of genes of potential importance in the response to chemotherapy and DNA repair in patients with ovarian cancer

scientific article published on 01 April 1997

Flow-cytometric analysis of DNA distribution after VP16-213 treatment of Lewis lung carcinoma

scientific article published on 01 January 1983

G48A, a New KRAS Mutation Found in Lung Adenocarcinoma.

scientific article published on 4 April 2016

Generation and characterization of MEK and ERK inhibitors- resistant non-small-cells-lung-cancer (NSCLC) cells

scientific article published on 23 October 2018

Genetic alterations in ovarian cancer cells that might account for sensitivity to chemotherapy in patients.

scientific article

Genetic markers for prediction of treatment outcomes in ovarian cancer.

scientific article published on 08 July 2014

Germ cell tumors overexpress the candidate therapeutic target cyclin B1 independently of p53 function.

scientific article published on 22 July 2015

Glutaminase Inhibition on NSCLC Depends on Extracellular Alanine Exploitation

scientific article published on 23 July 2020

Hepatobiliary metabolism and urinary excretion of 4-demethoxydaunorubicin as compared to daunorubicin in rats

scientific article published on 01 July 1988

Human ovarian tumors in primary culture: growth, characterization and initial evaluation of the response to cis platinum treatment in vitro

scientific article published on 01 June 1988

Improving the selectivity of cancer treatments by interfering with cell response pathways.

scientific article

In vitro and in vivo methazolastone-induced DNA damage and repair in L-1210 leukemia sensitive and resistant to chloroethylnitrosoureas.

scientific article

In vivo evaluation of the role of DNp73alpha protein in regulating the p53-dependent apoptotic pathway after treatment with cytotoxic drugs

scientific article published on 01 February 2007

In vivo studies with the novel anticancer agent mitozolomide (NSC 353451) on Lewis lung carcinoma

scientific article published on 01 January 1986

Influence of tumor on adriamycin concentration in blood cells

scientific article published on 01 January 1980

Inhibition of the Lysophosphatidylinositol Transporter ABCC1 Reduces Prostate Cancer Cell Growth and Sensitizes to Chemotherapy

scientific article published on 23 July 2020

Interaction between human-breast cancer metastasis and bone microenvironment through activated hepatocyte growth factor/Met and beta-catenin/Wnt pathways.

scientific article published on 29 March 2010

Interference of transcriptional activation by the antineoplastic drug ecteinascidin-743.

scientific article published on June 2000

Intracellular doxorubicin concentrations and drug-induced DNA damage in a human colon adenocarcinoma cell line and in a drug-resistant subline.

scientific article published in December 1988

It's Got Too Greedy. New Therapeutic Options for Metabolic[ally] Addicted NSCLC?

scientific article published on 01 November 2020

KRAS mutations affect prognosis of non-small-cell lung cancer patients treated with first-line platinum containing chemotherapy

scientific article published on 15 September 2015

KRas-LCS6 polymorphism does not impact on outcomes in ovarian cancer.

scientific article published on 21 April 2012

L1210 cells selected for resistance to methoxymorpholinyl doxorubicin appear specifically resistant to this class of morpholinyl derivatives

scientific article

Lack of Efficacy: When Opioids Do Not Achieve Analgesia from the Beginning of Treatment in Cancer Patients

scientific article published on 10 December 2019

Microsatellite instability and frameshift mutations in genes involved in cell cycle progression or apoptosis in ovarian cancer.

scientific article

Microsatellite instability and genetic alterations in ovarian cancer.

scientific article

Microsatellite instability and mutational analysis of transforming growth factor beta receptor type II gene (TGFBR2) in sporadic ovarian cancer.

scientific article

Modulation of transcription factor--DNA interactions by anticancer drugs.

scientific article published on August 1994

Molecular characterisation of a panel of human ovarian carcinoma xenografts

scientific article published on 01 August 1998

Nemorubicin

scientific article published on 01 January 2008

New Omics Information for Clinical Trial Utility in the Primary Setting

scientific article published on 01 January 2011

New molecules and strategies in the field of anticancer agents.

scientific article published on May 2004

Non-hepatic tumors change the activity of genes encoding copper trafficking proteins in the liver.

scientific article published on 10 May 2013

Notes on the use of in vitro systems to investigate the activity and the mechanism of action of antineoplastic agents

scientific article published on 01 February 1991

Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker.

scientific article

Ovarian carcinoma tumor-initiating cells have a mesenchymal phenotype

scientific article published on 15 May 2012

P73a overexpression is associated with resistance to treatment with DNA-damaging agents in a human ovarian cancer cell line.

scientific article

PI3K/AKT/mTOR inhibitors in ovarian cancer.

scientific article published on January 2010

PRL-3 phosphatase is implicated in ovarian cancer growth

scientific article

Pharmacokinetics of hexamethylmelamine and pentamethylmelamine in mice

scientific article published on 01 July 1981

Phospholipase Cgamma1 is required for metastasis development and progression

scientific article

Platinum Resistance in Ovarian Cancer: Role of DNA Repair

scientific article published on 20 January 2019

Preclinical colorectal cancer chemopreventive efficacy and p53-modulating activity of 3',4',5'-trimethoxyflavonol, a quercetin analogue.

scientific article

Predicting the Role of DNA Polymerase β Alone or with KRAS Mutations in Advanced NSCLC Patients Receiving Platinum-Based Chemotherapy

scientific article published on 30 July 2020

Prostaglandin and thromboxane synthesis by Lewis lung carcinoma during growth

scientific article published on 01 August 1985

Questioning the oncogenic role of DeltaNp73alpha in different cell lines expressing p53 or not.

scientific article published on 28 July 2006

RANBP9 affects cancer cells response to genotoxic stress and its overexpression is associated with worse response to platinum in NSCLC patients

scientific article published on 3 August 2018

Role of Cetuximab in the Treatment of Patients With NSCLC: Are We Throwing Out the Baby With the Bath Water?

scientific article published on 28 June 2010

Role of Chk1 in the differentiation program of hematopoietic stem cells

scientific article published on 10 February 2010

Role of KRAS-LCS6 polymorphism in advanced NSCLC patients treated with erlotinib or docetaxel in second line treatment (TAILOR)

scientific article

Role of glutathione transferases in the mechanism of brostallicin activation.

scientific article

Routes of elimination of hexamethylmelamine and pentamethylmelamine in the rat

scientific article published on 01 May 1982

Seminars in clinical pharmacology: an introduction to MET inhibitors for the medical oncologist.

scientific article published on 30 October 2012

Sensitivity and cellular response to different anticancer agents of a human ovarian cancer cell line expressing wild-type, mutated or no p53.

scientific article

Sequence-specific DNA interactions by novel alkylating anthracycline derivatives

scientific article published on 01 December 1995

Serum depletion of holo-ceruloplasmin induced by silver ions in vivo reduces uptake of cisplatin.

scientific article published on 8 July 2012

Silver Ions as a Tool for Understanding Different Aspects of Copper Metabolism

scientific article published on 17 June 2019

Special conference on 'growth factors, development and cancer

scientific article published on 01 September 1994

Spectrum of cellular responses to pyriplatin, a monofunctional cationic antineoplastic platinum(II) compound, in human cancer cells

scientific article

Structure-based discovery of the first allosteric inhibitors of cyclin-dependent kinase 2.

scientific article

Studies of the mode of action of antitumour triazenes and triazines-III. Metabolism studies on hexamethylmelamine

scientific article published on 01 March 1982

Studies on the comparative distribution and biliary excretion of doxorubicin and 4'-epi-doxorubicin in mice and rats

scientific article published on 01 August 1980

Subcellular distribution of adriamycin in the liver and tumor of 3LL-bearing mice

scientific article published on 01 March 1983

The effect of silver ions on copper metabolism and expression of genes encoding copper transport proteins in rat liver

scientific article published on 01 January 2008

The expression of the DeltaNp73beta isoform of p73 leads to tetraploidy.

scientific article

The inhibition of supercoiling activity of DNA gyrase from Micrococcus luteus caused by rufloxacin (MF 934) and MF 961

scientific article published on 01 May 1991

The integrated stress response is tumorigenic and constitutes a therapeutic liability in KRAS-driven lung cancer

scientific article published on 30 July 2021

To target or not to target, that is the question.

scientific article

Transplacental passage of doxorubicin

scientific article published on 01 January 1983

Triple negative breast cancers have a reduced expression of DNA repair genes

scientific article

Value of KRAS as prognostic or predictive marker in NSCLC: results from the TAILOR trial.

scientific article

Wee1 inhibitor MK1775 sensitizes KRAS mutated NSCLC cells to sorafenib.

scientific article published on 17 January 2018

Zebularine partially reverses GST methylation in prostate cancer cells and restores sensitivity to the DNA minor groove binder brostallicin.

scientific article published on 14 June 2013

[Prospects of molecular pharmacology in oncology]

scientific article published on 01 February 2001

hMLH1 and hMSH2 expression and BAX frameshift mutations in ovarian cancer cell lines and tumors.

scientific article published in April 1998

p21WAF1-derived peptides linked to an internalization peptide inhibit human cancer cell growth

scientific article published on 01 April 1997

p53Transfectants in Ovarian Cancer

scientific article published on 01 January 2001

p73 competes with p53 and attenuates its response in a human ovarian cancer cell line.

scientific article

p73 overexpression increases VEGF and reduces thrombospondin-1 production: implications for tumor angiogenesis

scientific article published on 01 November 2001

p73: a chiaroscuro gene in cancer.

scientific article

ΔNp63 expression is associated with poor survival in ovarian cancer

scientific article published on 12 November 2007

∆Np73beta induces caveolin-1 in human non-small cell lung cancer cell line H1299.

scientific article published on 4 September 2015

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