List of works - Shawn Williams

2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists.

scientific article published on 23 July 2009

A characterisation of dark-field imaging of colloidal gold labels in a scanning transmission X-ray microscope.

scientific article published on February 1996

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

scientific article

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator

scientific article

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model

scientific article published on 5 April 2018

Atomic structure of progesterone complexed with its receptor ⬇️

scientific article published on May 28, 1998

Chemical contrast in X-ray microscopy and spatially resolved XANES spectroscopy of organic specimens

scientific article published on November 6, 1992

Chromatin fibers are left-handed double helices with diameter and mass per unit length that depend on linker length.

scientific article

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

scientific article

Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene

scientific article

Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene

scientific article

Crystallization of protein-ligand complexes.

scientific article published on 13 December 2006

Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains ⬇️

scientific article published on May 26, 1998

Diffraction-limited imaging in a scanning transmission x-ray microscope

scientific article published in November 1991

Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase ⬇️

scientific article published on May 29, 2013

Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists.

scientific article published on 25 June 2009

FXR agonist activity of conformationally constrained analogs of GW 4064

scientific article

Helix 1/8 interactions influence the activity of nuclear receptor ligand-binding domains.

scientific article published on 19 June 2003

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

scientific article

Micro-XANES: Chemical contrast in the scanning transmission X-ray microscope

scientific article published in August 1994

New results in soft X-ray microscopy

scientific article published in April 1994

Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.

scientific article

Recent applications of protein crystallography and structure-guided drug design.

scientific article

Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

scientific article

Soft x‐ray microscopy with coherent x rays (invited)

scientific article published in January 1992

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

scientific article published on February 2005

Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction

scientific article

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity

scientific article

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064

scientific article

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

scientific article

The Drosophila nuclear receptor e75 contains heme and is gas responsive

scientific article

The evolution of progesterone receptor ligands.

scientific article published on May 2007

The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist

scientific article

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch

scientific article (publication date: 18 July 2003)

List of works by Shawn Williams

2-Amino-9-aryl-3-cyano-4-methyl-7-oxo-6,7,8,9-tetrahydropyrido[2',3':4,5]thieno[2,3-b]pyridine derivatives as selective progesterone receptor agonists.

A characterisation of dark-field imaging of colloidal gold labels in a scanning transmission X-ray microscope.

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator

An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model

Atomic structure of progesterone complexed with its receptor ⬇️

Chemical contrast in X-ray microscopy and spatially resolved XANES spectroscopy of organic specimens

Chromatin fibers are left-handed double helices with diameter and mass per unit length that depend on linker length.

Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064

Conformationally constrained farnesoid X receptor (FXR) agonists: alternative replacements of the stilbene

Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene

Crystallization of protein-ligand complexes.

Crystallographic comparison of the estrogen and progesterone receptor’s ligand binding domains ⬇️

Diffraction-limited imaging in a scanning transmission x-ray microscope

Discovery of a Potent Boronic Acid Derived Inhibitor of the HCV RNA-Dependent RNA Polymerase ⬇️

Discovery of orally active, pyrrolidinone-based progesterone receptor partial agonists.

FXR agonist activity of conformationally constrained analogs of GW 4064

Helix 1/8 interactions influence the activity of nuclear receptor ligand-binding domains.

Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids

Micro-XANES: Chemical contrast in the scanning transmission X-ray microscope

New results in soft X-ray microscopy

Progesterone receptor ligand binding pocket flexibility: crystal structures of the norethindrone and mometasone furoate complexes.

Recent applications of protein crystallography and structure-guided drug design.

Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2)

Soft x‐ray microscopy with coherent x rays (invited)

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

Structure of Rev-erbα bound to N-CoR reveals a unique mechanism of nuclear receptor–co-repressor interaction

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity

Substituted isoxazole analogs of farnesoid X receptor (FXR) agonist GW4064

Synthesis of 3-alkyl naphthalenes as novel estrogen receptor ligands

The Drosophila nuclear receptor e75 contains heme and is gas responsive

The evolution of progesterone receptor ligands.

The first X-ray crystal structure of the glucocorticoid receptor bound to a non-steroidal agonist

X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch