Search filters

List of works by Osamu Kurasawa

2-Aminomethylthieno[3,2-d]pyrimidin-4(3H)-ones bearing 3-methylpyrazole hinge binding moiety: Highly potent, selective, and time-dependent inhibitors of Cdc7 kinase.

scientific article published on 2 May 2017

CCR5 antagonists as anti-HIV-1 agents. 1. Synthesis and biological evaluation of 5-oxopyrrolidine-3-carboxamide derivatives.

scientific article

Discovery of Novel Allosteric Inhibitors of Deoxyhypusine Synthase

scientific article published on 16 March 2020

Discovery of a Novel, Highly Potent, and Selective Thieno[3,2-d]pyrimidinone-Based Cdc7 Inhibitor with a Quinuclidine Moiety (TAK-931) as an Orally Active Investigational Antitumor Agent

scientific article published on 14 January 2020

Discovery of a novel pyrrole derivative 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine fumarate (TAK-438) as a potassium-competitive acid blocker (P-CAB)

scientific article published on 30 April 2012

Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents

scientific article published on 4 April 2018

Discovery, synthesis, and biological evaluation of novel pyrrole derivatives as highly selective potassium-competitive acid blockers

scientific article published on 14 April 2012

Identification of Novel, Potent, and Orally Available GCN2 Inhibitors with Type I Half Binding Mode

scientific article published on 19 September 2019

Identification of a new class of potent Cdc7 inhibitors designed by putative pharmacophore model: Synthesis and biological evaluation of 2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-ones.

scientific article published on 16 February 2017

Inhibition of GCN2 sensitizes ASNS-low cancer cells to asparaginase by disrupting the amino acid response

article published in the Proceedings of the National Academy of Sciences of the United States of America

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

scientific article published on 22 May 2019

Synthesis and Properties of Conformationally Rigid Cyclouridylic Acids Having Covalent Bonding Linkers Between the Uracil 5-Position and the 5′-Phosphate Group

Synthesis and properties of oligodeoxynucleotides incorporating a conformationally rigid uridine unit having a cyclic structure at the 5'-terminal site.

scientific article published in June 2000

Synthesis and properties of oligonucleotides having a phosphorus chiral center by incorporation of conformationally rigid 5'-cyclouridylic acid derivatives

scientific article published on 01 October 2000

Using a biologically annotated library to analyze the anticancer mechanism of serine palmitoyl transferase (SPT) inhibitors.

scientific article

Paulina is supported by:

About Paulina

Help