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List of works by Paul S. Frenette

2011 - ENGINEERING A HEMATOPOIETIC STEM CELL NICHE BY REVITALIZING MESENCHYMAL STEM CELLS

scholarly article

A Time Bomb for Leukemia

scientific article published in April 2016

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche.

scientific article published on 4 January 2018

A novel model for lymphocytic infiltration of the thyroid gland generated by transgenic expression of the CC chemokine CCL21

scientific article published on 01 October 2004

A novel role for factor VIII and thrombin/PAR1 in regulating hematopoiesis and its interplay with the bone structure

scientific article published on 27 August 2013

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017

article

Activated Neutrophils Are Associated with Pediatric Cerebral Malaria Vasculopathy in Malawian Children

scientific article published on January 2015

Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche

scientific article

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

scientific article published on 07 May 2018

Adrenergic nerves activate an angio-metabolic switch in prostate cancer.

scientific article

Adrenergic nerves govern circadian leukocyte recruitment to tissues.

scientific article

An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis

scientific article

Arteriolar niches maintain haematopoietic stem cell quiescence.

scientific article published on 09 October 2013

Artery-Associated Sympathetic Innervation Drives Rhythmic Vascular Inflammation of Arteries and Veins

scientific article published on 12 August 2019

Author Correction: Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

scientific article published on 01 April 2019

Author Correction: The bone marrow microenvironment at single-cell resolution

scientific article published on 01 August 2019

Autonomic nerve development contributes to prostate cancer progression

scientific article published on July 2013

B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

scientific article

Bad blood: a trigger for TRALI

scientific article published on 01 April 2010

Beneficial Effects of Soluble Guanylyl Cyclase Stimulation and Activation in Sickle Cell Disease are Amplified by Hydroxyurea: In Vitro and In Vivo Studies

scientific article published on 06 July 2020

Bone Marrow Arteriolar Niches Maintain Hematopoietic Stem Cell Quiescence ⬇️

scholarly article

Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

scientific article

Bone marrow NG2<sup>+</sup>/Nestin<sup>+</sup> mesenchymal stem cells drive DTC dormancy <i>via</i> TGFβ2

scientific article published on 11 March 2021

Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands

scientific article published on 31 March 2011

Brain motor and fear circuits regulate leukocytes during acute stress

scientific article published on 30 May 2022

CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine

scientific article published on 15 February 2018

CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress

scientific article published on 17 March 2013

CD44 is a physiological E-selectin ligand on neutrophils

scientific article

CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions

scientific article

Chemotherapy-induced bone marrow nerve injury impairs hematopoietic regeneration.

scientific article published on 05 May 2013

Cholinergic Signals from the CNS Regulate G-CSF-Mediated HSC Mobilization from Bone Marrow via a Glucocorticoid Signaling Relay.

scientific article

Circadian Adrenergic Regulation of Bone Marrow Endothelial Adhesion Molecule Expression Impacts Progenitor Recruitment and Engraftment Efficiency ⬇️

scholarly article

Circadian control of the immune system

scientific article

Circadian rhythms influence hematopoietic stem cells

scientific article

Clinically Actional Strategies for Studying Neural Influences in Cancer

scientific article published on 09 June 2020

Complete identification of E-selectin ligands on neutrophils reveals distinct functions of PSGL-1, ESL-1, and CD44

scientific article

Complexity of bone marrow hematopoietic stem cell niche

scientific article

Contributions of Immune Cells to Vascular Occlusion in Sickle Cell Disease. ⬇️

scholarly article

Cooperation of beta(2)- and beta(3)-adrenergic receptors in hematopoietic progenitor cell mobilization

scientific article

Coordinated Regulation of Hematopoietic and Mesenchymal Stem Cells in a Bone Marrow Niche. ⬇️

scholarly article

Cross talk between neutrophils and the microbiota

scientific article published on 21 March 2019

Deciphering the transcriptional network of the dendritic cell lineage

scientific article published on 15 July 2012

Diabetes impairs hematopoietic stem cell mobilization by altering niche function

scientific article

Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool

scientific article published on 22 August 2019

Differential cytokine contributions of perivascular haematopoietic stem cell niches

scientific article published on 20 February 2017

Distinct Contributions By Perivascular Niche Cells in Hematopoietic Stem Cell Maintenance ⬇️

scholarly article

Endothelial Jagged-1 is necessary for homeostatic and regenerative hematopoiesis

scientific article published on 05 September 2013

Enforced fucosylation of neonatal CD34+ cells generates selectin ligands that enhance the initial interactions with microvessels but not homing to bone marrow

scientific article published on 14 September 2004

Engineering a haematopoietic stem cell niche by revitalizing mesenchymal stromal cells

scientific article published on 15 April 2019

F4/80 Identifies a Subset of Non-Mobilizable Bone Marrow HSCs Involved in Stress-Induced Hematopoiesis ⬇️

scholarly article

Fetal liver hematopoietic stem cell niches associate with portal vessels

scientific article

Functional selectin ligands mediating human CD34(+) cell interactions with bone marrow endothelium are enhanced postnatally.

scientific article

GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells

scientific article

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

scientific article

Galactocerebrosides are required postnatally for stromal-dependent bone marrow lymphopoiesis

scientific article published on 01 June 2003

Galpha(s) uncouples hematopoietic stem cell homing and mobilization.

scientific article published in May 2009

Granulocyte-derived TNFα promotes vascular and hematopoietic regeneration in the bone marrow.

scientific article published on 20 November 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies

scientific article published on October 2017

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

scientific article published on 01 October 2019

HSC Contribution in Making Steady-State Blood

scientific article

Haematopoietic stem cell activity and interactions with the niche

scientific article published on 01 May 2019

Haematopoietic stem cell release is regulated by circadian oscillations

scientific article

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

scientific article

Hematopoietic stem cell trafficking

scientific article published on 9 July 2010

Hematopoietic stem cell trafficking: regulated adhesion and attraction to bone marrow microenvironment

scientific article

Heme-Induced Neutrophil Extracellular Traps (NETs) Formation Contributes To Sickle Cell Disease Pathogenesis ⬇️

scholarly article

Heme-induced neutrophil extracellular traps contribute to the pathogenesis of sickle cell disease

scientific article

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

scientific article

Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice

scientific article

Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men.

scientific article

Identification of the Circulating Langerhans Cell Precursor. ⬇️

scholarly article

Imaging receptor microdomains on leukocyte subsets in live mice

scientific article published on 25 February 2007

In Situ Hematopoietic Stem Cell Imaging

scientific article published on 01 January 2021

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging

scientific article published in 2022

Influences of vascular niches on hematopoietic stem cell fate

scientific article published on 23 April 2014

Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene.

scientific article

Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation

scientific article published on 25 May 2004

Intravenous immune globulin prevents venular vaso-occlusion in sickle cell mice by inhibiting leukocyte adhesion and the interactions between sickle erythrocytes and adherent leukocytes

scientific article published on 20 November 2003

Intravenous immunoglobulins modulate neutrophil activation and vascular injury through FcγRIII and SHP-1.

scientific article

Intravenous immunoglobulins reverse acute vaso-occlusive crises in sickle cell mice through rapid inhibition of neutrophil adhesion.

scientific article

Leukocyte podosomes sense their way through the endothelium

scientific article published on 01 June 2007

Lineage-Biased Hematopoietic Stem Cells Are Regulated by Distinct Niches

scientific article

Local Adrenergic Nerves Regulate Diurnal Leukocyte Adhesion: Impact In Sickle Cell Disease ⬇️

scholarly article

Loss of Adrenergic Nerves in the Bone Marrow Microenvironment Drives an Aging HSC Niche Phenotype ⬇️

scholarly article

MAEA is an E3 ubiquitin ligase promoting autophagy and maintenance of haematopoietic stem cells

scientific article published on 04 May 2021

Macrophage Erythroblast Attacher (MAEA), but Not VCAM1, Is Required for the Bone Marrow Erythroblastic Niche ⬇️

scholarly article

Macrophages, not neutrophils, infiltrate skeletal muscle in mice deficient in P/E selectins after mechanical reloading

scientific article published on 26 June 2003

Maea expressed by macrophages, but not erythroblasts, maintains postnatal murine bone marrow erythroblastic islands

scientific article published on 23 January 2019

Making sense of hematopoietic stem cell niches

scientific article published on 11 March 2015

Megakaryocytes Regulate Hematopoietic Stem Cell Quiescence Via PF4 Secretion ⬇️

scholarly article

Megakaryocytes regulate hematopoietic stem cell quiescence through CXCL4 secretion.

scientific article

Mesenchymal stem cell: keystone of the hematopoietic stem cell niche and a stepping-stone for regenerative medicine

scientific article published on 03 January 2013

Mobilized hematopoietic stem cell yield depends on species-specific circadian timing.

scientific article

Muscarinic Receptor Type-1 Regulates Centrally Hematopoietic Stem Cell Mobilization By Granulocyte-Colony Stimulating Factor Via the Hypothalamic-Pituitary Axis ⬇️

scholarly article

Nerves in cancer

scientific article published on 23 January 2020

Nestin+ Pericytes In The Fetal Liver Are Necessary To Maintain HSCs ⬇️

scholarly article

Nestin+NG2+ Cells Form a Reserve Stem Cell Population in the Mouse Prostate

scientific article published on 23 May 2019

Neural Regulation of Bone and Bone Marrow

scientific article published on 2 March 2018

Neural regulation of hematopoiesis, inflammation, and cancer

scientific article published on April 2015

Neutrophil Aging, Regulated By Microbiota-Derived Signals, Promotes Sickle Cell Vaso-Occlusion ⬇️

scholarly article

Neutrophil ageing is regulated by the microbiome

scientific article published on 16 September 2015

Neutrophil microdomains: linking heterocellular interactions with vascular injury

scientific article

Neutrophils, platelets, and inflammatory pathways at the nexus of sickle cell disease pathophysiology

scientific article published on 12 January 2016

Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1

scientific article published on 27 January 2021

Niche heterogeneity in the bone marrow

scientific article

Niches for Hematopoietic Stem Cells and Their Progeny

scientific article published in April 2018

No "Kindlin," it's all about HSC balance

scientific article

Nociceptive nerves regulate haematopoietic stem cell mobilization

scientific article published on 23 December 2020

Nociceptors protect sickle cell disease mice from vaso-occlusive episodes and chronic organ damage

scientific article published on 01 January 2021

Norepinephrine reuptake inhibition promotes mobilization in mice: potential impact to rescue low stem cell yields

scientific article

Osteoblasts: yes, they can

scientific article published on 01 August 2008

Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development.

scientific article

PDGFRα and CD51 mark human Nestin+ sphere-forming mesenchymal stem cells capable of hematopoietic progenitor cell expansion ⬇️

scientific article published on June 17, 2013

PSGL-1 participates in E-selectin-mediated progenitor homing to bone marrow: evidence for cooperation between E-selectin ligands and alpha4 integrin.

scientific article published on 22 May 2003

Physiological contribution of CD44 as a ligand for E-Selectin during inflammatory T-cell recruitment.

scientific article

Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation

scientific article

Primary role for adherent leukocytes in sickle cell vascular occlusion: a new paradigm

scientific article

Prospective cohort study of the circadian rhythm pattern in allogeneic sibling donors undergoing standard granulocyte colony-stimulating factor mobilization

scientific article published on 20 March 2013

Randomized phase 2 trial of Intravenous Gamma Globulin (IVIG) for the treatment of acute vaso-occlusive crisis in patients with sickle cell disease: Lessons learned from the midpoint analysis

scientific article published on 09 June 2020

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

scientific article

Regulation of leucocyte homeostasis in the circulation.

scientific article

Rhythmic modulation of the hematopoietic niche through neutrophil clearance.

scientific article

Roadmap for the Emerging Field of Cancer Neuroscience

scientific article published on 01 April 2020

Seasonal manifestations of sickle cell disease activity

scientific article published on 01 April 2019

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance.

scientific article

Sickle cell disease: old discoveries, new concepts, and future promise

scientific article published on April 2007

Sickle cell vaso-occlusion

scientific article

Sickle cell vaso-occlusion: multistep and multicellular paradigm

scientific article

Sickle cell vasoocclusion: heterotypic, multicellular aggregations driven by leukocyte adhesion

scientific article published in March 2004

Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow

scientific article

Single-dose intravenous gammaglobulin can stabilize neutrophil Mac-1 activation in sickle cell pain crisis

scientific article published on April 2015

Small RNAs derived from lncRNA RNase MRP have gene-silencing activity relevant to human cartilage-hair hypoplasia

scientific article published on 05 September 2013

Snai2 Maintains Bone Marrow Niche Cells by Repressing Osteopontin Expression

scientific article published on 03 May 2020

Stem cell factor is selectively secreted by arterial endothelial cells in bone marrow.

scientific article

Stem cells: Reprogramming finds its niche

scientific article published on 2 July 2014

Stimulation of Adrenergic Activity By Desipramine Enhances Hematopoietic Stem and Progenitor Cell Mobilization Along with G-CSF in Multiple Myeloma - a Pilot Study of Safety and Efficacy ⬇️

scholarly article

Stimulation of adrenergic activity by desipramine enhances hematopoietic stem and progenitor cell mobilization along with G-CSF in multiple myeloma: A pilot study

scientific article

T-Regulating Hair Follicle Stem Cells

scientific article published in June 2017

Targeting CXCR4, SDF1 and Beta-Adrenergic Receptors In the AML Microenvironment by Novel Antagonist POL6326, G-CSF and Isoproterenol ⬇️

scholarly article

Targeting Mac-1-mediated leukocyte-RBC interactions uncouples the benefits for acute vaso-occlusion and chronic organ damage

scientific article published on 5 July 2016

Targeting Neutrophil Aging and the Microbiota for the Treatment of Sickle Cell Disease ⬇️

scholarly article

Tet-mediated DNA demethylation regulates specification of hematopoietic stem and progenitor cells during mammalian embryogenesis

scientific article published on 02 March 2022

The Gut Microbiome Regulates Psychological-Stress-Induced Inflammation

scientific article published on 24 July 2020

The Majority of CD45 Ter119 CD31 Bone Marrow Cell Fraction Is of Hematopoietic Origin and Contains Erythroid and Lymphoid Progenitors

scientific article published on 09 October 2018

The bone marrow microenvironment at single-cell resolution

scientific article published on 10 April 2019

The good side of inflammation: Staphylococcus aureus proteins SpA and Sbi contribute to proper abscess formation and wound healing during skin and soft tissue infections

scientific article published on 09 July 2019

The hematopoietic stem cell niche: from embryo to adult.

scientific article

The integrin alphaMbeta2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization

scientific article published on 20 April 2004

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine ⬇️

scientific article published on 07 January 2013

The secrets of the bone marrow niche: Enigmatic niche brings challenge for HSC expansion ⬇️

scientific article published on June 6, 2012

The vessel wall and its interactions

scientific article published on June 2008

This Niche Is a Maze; An Amazing Niche ⬇️

scientific article published on April 4, 2013

Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes

scientific article

Trafficking of stem cells.

scientific article published on January 2011

Use of beta-blocker types and risk of incident prostate cancer in a multiethnic population

scientific article published on 16 April 2020

Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage

scientific article

Vaso-Occlusion-Promoting Neutrophil Mac-1 Integrin Activation in Human Sickle Cell Crises Is Stabilized By a Single Dose of Intravenous Gammaglobulin ⬇️

scholarly article

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

scientific article published on 19 September 2013

Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

scientific article published on January 2013

Vcam1 Is a "Don't-Eat-Me" Signal on Healthy Hematopoietic and Leukemic Stem Cells ⬇️

scholarly article

Very low incidence of <i>Clostridioides difficile</i> infection in pediatric sickle cell disease patients

scientific article published on 14 September 2020

When integrins fail to integrate

scientific article published on March 2009

Whole bone subcutaneous transplantation as a strategy to study precisely the bone marrow niche

scientific article published in 2022

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