List of works - Tsunehiko Higuchi

3-Hydroxycoumarins: first direct preparation from coumarins using a Cu2(+)-ascorbic acid-O2 system, and their potent bioactivities

scientific article published on 01 April 1990

A new thioether-ligated iron porphyrin as a model of a protonated form of P450 active site

scientific article published on 01 November 2000

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.

scientific article published on 10 July 2018

A versatile strategy for the synthesis of crown ether-bearing heterocycles: discovery of calcium-selective fluoroionophore

scientific article published on 22 August 2007

Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker.

scientific article published on 23 December 2016

Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine

scientific article published on 7 September 2017

Application of chemical P-450 model systems to study drug metabolism. III. Metabolism of 3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine

scientific article published on 01 February 1990

Application of chemical cytochrome P-450 model systems to studies on drug metabolism--VIII. Novel metabolism of carboxylic acids via oxidative decarboxylation

scientific article published on 01 January 1995

Biogenic triamine and tetraamine activate core catalytic ability of Tetrahymena group I ribozyme in the absence of its large activator module

scientific article published on 12 January 2018

Branched-Chain Polyamine Found in Hyperthermophiles Induces Unique Temperature-Dependent Structural Changes in Genome-Size DNA

scientific article published on 10 July 2018

Design and Synthesis of Intramolecular Resonance-Energy Transfer Probes for Use in Ratiometric Measurements in Aqueous Solution

scientific article published on 01 October 2000

Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer

scientific article published on 31 August 2018

Design of New Extraction Surfactants for Membrane Proteins from Peptide Gemini Surfactants.

scientific article

Design, synthesis, and evaluation of new type of L-amino acids containing pyridine moiety as nitric oxide synthase inhibitor.

scientific article published on 8 February 2006

Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.

scientific article

Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol

scientific article published on 29 January 2020

Development of a time-resolved fluorometric detection system using diffusion-enhanced energy transfer

scientific article published on 01 October 2000

Dipeptides containing L-arginine analogs: new isozyme-selective inhibitors of nitric oxide synthase

scientific article published on 01 September 1999

Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator: DAF-2 DA.

scientific article published in October 1998

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

scientific article published on 6 February 2013

Effect of the o-Acetamido Group on pH-Dependent Light Emission of a 3-Hydroxyphenyl-Substituted Dioxetane Luminophore

scientific article published on 15 February 2019

Enhanced catalase-like activity of manganese salen complexes in water: effect of a three-dimensionally fixed auxiliary

scientific article published on 09 October 2006

Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.

scientific article published on 25 April 2005

Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

scientific article published on 01 January 2008

Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase.

scientific article published on 19 July 2010

Fluorescent Indicators for Imaging Nitric Oxide Production.

scientific article

Hydrogen sulfide bypasses the rate-limiting oxygen activation of heme oxygenase

scientific article published in Journal of Biological Chemistry

Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles.

scientific article

Identification of a novel sugar, 4-amino-4,6-dideoxy-2-O-methylmannose in the lipopolysaccharide of Vibrio cholerae O1 serotype Ogawa

scientific article published on 01 March 1994

Imaging of caspase-3 activation in HeLa cells stimulated with etoposide using a novel fluorescent probe

scientific article published on 01 June 1999

Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors

scientific article published on 01 December 1998

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

scientific article published in June 2009

Intramolecular fluorescence resonance energy transfer system with coumarin donor included in beta-cyclodextrin

scientific article published in March 2001

Manganese salen complexes with acid-base catalytic auxiliary: functional mimetics of catalase

scientific article published on 12 March 2013

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst

scientific article published on 24 June 2019

Naturally occurring branched-chain polyamines induce a crosslinked meshwork structure in a giant DNA.

scientific article published on December 2016

Nitrous oxide reduction-coupled alkene-alkene coupling catalysed by metalloporphyrins.

scientific article published in October 2013

Novel probes showing specific fluorescence enhancement on binding to a hexahistidine tag.

scientific article published in January 2008

On-bead fluorescence assay for serine/threonine kinases

scientific article published on 01 December 2005

Photocontrol of Peptide function: backbone cyclization strategy with photocleavable amino Acid.

scientific article published on 7 June 2011

Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme

scientific article published on 24 September 2018

Rational design of fluorescein-based fluorescence probes. Mechanism-based design of a maximum fluorescence probe for singlet oxygen.

scientific article published in March 2001

Remarkable axial thiolate ligand effect on the oxidation of hydrocarbons by active intermediate of iron porphyrin and cytochrome P450

scientific article published on 01 November 2000

Role of Thiolate Ligand in Spin State and Redox Switching in the Cytochrome P450 Catalytic Cycle.

scientific article published on 28 March 2017

Selective recognition and detection of biomacromolecules utilizing chemical property of amino Acid or Peptide

scientific article published in December 2007

Spectroscopic and mechanistic studies on oxidation reactions catalyzed by the functional Model SR complex for cytochrome P450: influence of oxidant, substrate, and solvent

scientific article published on 01 November 2009

Stable Iron Porphyrin Intramolecularly Coordinated by Alcoholate Anion: Synthesis and Evaluation of Axial Ligand Effect of Alcoholate on Spectroscopy and Catalytic Activity

scientific article published on 21 March 2019

Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA

scientific article published on 16 July 2015

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

scientific article

Superoxide dismutase activity of iron(II)TPEN complex and its derivatives.

scientific article published in October 2000

Synthesis of 5,10,15,20-tetrakis(4-tert- butyl-2,6-dicarboxyphenyl)porphyrin: a versatile bis-faced porphyrin synthon for D4-symmetric chiral porphyrins

scientific article published on 01 June 2001

Synthesis of the carbon framework of scholarisine A by intramolecular oxidative coupling.

scientific article published on 11 February 2013

Unique oxidation reaction of amides with pyridine-N-oxide catalyzed by ruthenium porphyrin: direct oxidative conversion of N-acyl-L-proline to N-acyl-L-glutamate.

scientific article published in January 2005

Unusual substituent effects in the hydroxylation of phenols by a Cu(2+)-ascorbic acid-O2 system, gamma-radiolysis, and microsomes

scientific article published on 01 April 1993

List of works by Tsunehiko Higuchi

3-Hydroxycoumarins: first direct preparation from coumarins using a Cu2(+)-ascorbic acid-O2 system, and their potent bioactivities

A new thioether-ligated iron porphyrin as a model of a protonated form of P450 active site

A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model.

A versatile strategy for the synthesis of crown ether-bearing heterocycles: discovery of calcium-selective fluoroionophore

Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker.

Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine

Application of chemical P-450 model systems to study drug metabolism. III. Metabolism of 3-isobutyryl-2-isopropylpyrazolo[1,5-alpha]pyridine

Application of chemical cytochrome P-450 model systems to studies on drug metabolism--VIII. Novel metabolism of carboxylic acids via oxidative decarboxylation

Biogenic triamine and tetraamine activate core catalytic ability of Tetrahymena group I ribozyme in the absence of its large activator module

Branched-Chain Polyamine Found in Hyperthermophiles Induces Unique Temperature-Dependent Structural Changes in Genome-Size DNA

Design and Synthesis of Intramolecular Resonance-Energy Transfer Probes for Use in Ratiometric Measurements in Aqueous Solution

Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer

Design of New Extraction Surfactants for Membrane Proteins from Peptide Gemini Surfactants.

Design, synthesis, and evaluation of new type of L-amino acids containing pyridine moiety as nitric oxide synthase inhibitor.

Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1.

Development of Cell-Penetration PG-Surfactants and Its Application in External Peptide Delivery to Cytosol

Development of a time-resolved fluorometric detection system using diffusion-enhanced energy transfer

Dipeptides containing L-arginine analogs: new isozyme-selective inhibitors of nitric oxide synthase

Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator: DAF-2 DA.

Effect of helical conformation and side chain structure on γ-secretase inhibition by β-peptide foldamers: insight into substrate recognition.

Effect of the o-Acetamido Group on pH-Dependent Light Emission of a 3-Hydroxyphenyl-Substituted Dioxetane Luminophore

Enhanced catalase-like activity of manganese salen complexes in water: effect of a three-dimensionally fixed auxiliary

Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes.

Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin

Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase.

Fluorescent Indicators for Imaging Nitric Oxide Production.

Hydrogen sulfide bypasses the rate-limiting oxygen activation of heme oxygenase

Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles.

Identification of a novel sugar, 4-amino-4,6-dideoxy-2-O-methylmannose in the lipopolysaccharide of Vibrio cholerae O1 serotype Ogawa

Imaging of caspase-3 activation in HeLa cells stimulated with etoposide using a novel fluorescent probe

Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors

Inhibition of gamma-secretase activity by helical beta-peptide foldamers.

Intramolecular fluorescence resonance energy transfer system with coumarin donor included in beta-cyclodextrin

Manganese salen complexes with acid-base catalytic auxiliary: functional mimetics of catalase

Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst

Naturally occurring branched-chain polyamines induce a crosslinked meshwork structure in a giant DNA.

Nitrous oxide reduction-coupled alkene-alkene coupling catalysed by metalloporphyrins.

Novel probes showing specific fluorescence enhancement on binding to a hexahistidine tag.

On-bead fluorescence assay for serine/threonine kinases

Photocontrol of Peptide function: backbone cyclization strategy with photocleavable amino Acid.

Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme

Rational design of fluorescein-based fluorescence probes. Mechanism-based design of a maximum fluorescence probe for singlet oxygen.

Remarkable axial thiolate ligand effect on the oxidation of hydrocarbons by active intermediate of iron porphyrin and cytochrome P450

Role of Thiolate Ligand in Spin State and Redox Switching in the Cytochrome P450 Catalytic Cycle.

Selective recognition and detection of biomacromolecules utilizing chemical property of amino Acid or Peptide

Spectroscopic and mechanistic studies on oxidation reactions catalyzed by the functional Model SR complex for cytochrome P450: influence of oxidant, substrate, and solvent

Stable Iron Porphyrin Intramolecularly Coordinated by Alcoholate Anion: Synthesis and Evaluation of Axial Ligand Effect of Alcoholate on Spectroscopy and Catalytic Activity

Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA

Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

Superoxide dismutase activity of iron(II)TPEN complex and its derivatives.

Synthesis of 5,10,15,20-tetrakis(4-tert- butyl-2,6-dicarboxyphenyl)porphyrin: a versatile bis-faced porphyrin synthon for D4-symmetric chiral porphyrins

Synthesis of the carbon framework of scholarisine A by intramolecular oxidative coupling.

Unique oxidation reaction of amides with pyridine-N-oxide catalyzed by ruthenium porphyrin: direct oxidative conversion of N-acyl-L-proline to N-acyl-L-glutamate.

Unusual substituent effects in the hydroxylation of phenols by a Cu(2+)-ascorbic acid-O2 system, gamma-radiolysis, and microsomes