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List of works by Dolores Gonzalez-Pacanowska

2-alkylaminoethyl-1,1-bisphosphonic acids are potent inhibitors of the enzymatic activity of Trypanosoma cruzi squalene synthase.

scientific article

3-D QSAR investigations of the inhibition of Leishmania major farnesyl pyrophosphate synthase by bisphosphonates.

scientific article published in November 2003

3-Hydroxy-3-methyl-glutaryl-CoA reductase in Trypanosoma (Schizotrypanum) cruzi: subcellular localization and kinetic properties

scientific article published on 01 April 1998

A Mitochondrial Orthologue of the dNTP Triphosphohydrolase SAMHD1 Is Essential and Controls Pyrimidine Homeostasis in <i>Trypanosoma brucei</i>

scientific article published on 08 January 2021

A mutant dihydrofolate reductase-thymidylate synthase from Leishmania major as a selectable marker in transfection experiments

scientific article published on 01 July 1996

A novel calcium-dependent soluble inorganic pyrophosphatase from the trypanosomatid Leishmania major.

scientific article published in February 2004

Acyclic Nucleoside Analogues as Inhibitors ofPlasmodiumfalciparumdUTPase

scientific article published on 01 July 2006

Amplification of the H locus in Leishmania infantum.

scientific article published on November 1994

Antimalarial activity of imidazo[2,1-a]isoindol-5-ol derivatives and related compounds.

scientific article published on 8 September 2011

Apurinic/apyrimidinic endonuclease genes from the trypanosomatidae leishmania major and Trypanosoma cruzi confer resistance to oxidizing agents in DNA repair-deficient Escherichia coli

scientific article published on February 1999

Azasterols as inhibitors of sterol 24-methyltransferase in Leishmania species and Trypanosoma cruzi.

scientific article published in October 2003

Carbohydrate-Binding Non-Peptidic Pradimicins for the Treatment of Acute Sleeping Sickness in Murine Models

scientific article

Carbohydrate‐binding agents act as potent trypanocidals that elicit modifications in VSG glycosylation and reduced virulence in Trypanosoma brucei ⬇️

scientific article published on October 14, 2013

Cell cycle regulation and novel structural features of thymidine kinase, an essential enzyme in Trypanosoma brucei

scientific article

Changes in chick liver and brain mevalonate kinase, mevalonate-5-phosphate kinase and mevalonate-5-pyrophosphate decarboxylase during development

scientific article published in January 1984

Characterization and regulation of Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase.

scientific article published on July 2000

Characterization of deoxyuridine 5'-triphosphate nucleotidohydrolase from Trypanosoma cruzi.

scientific article

Cholesterol synthesis and esterification in isolated enterocytes: regulation by cholesterol and cholestyramine feeding

scientific article published on 01 June 1993

Cloning and expression of the dihydrofolate reductase-thymidylate synthase gene from Trypanosoma cruzi

scientific article published on June 1994

Co-existence of circular and multiple linear amplicons in methotrexate-resistantLeishmania ⬇️

scientific article published on August 11, 1995

Crystal structure and DNA repair activities of the AP endonuclease from Leishmania major

scientific article

Crystallization and preliminary X-ray diffraction of Trypanosoma cruzi dUTPase

scientific article published on 01 February 1999

DCTPP1 prevents a mutator phenotype through the modulation of dCTP, dTTP and dUTP pools

scientific article published on 03 August 2019

Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme.

scientific article published on 8 April 2008

Depletion of dimeric all-alpha dUTPase induces DNA strand breaks and impairs cell cycle progression in Trypanosoma brucei.

scientific article published on 5 July 2008

Design, synthesis and evaluation of 2,4-diaminoquinazolines as inhibitors of trypanosomal and leishmanial dihydrofolate reductase.

scientific article

Design, synthesis, and evaluation of 5'-diphenyl nucleoside analogues as inhibitors of the Plasmodium falciparum dUTPase

scientific article

Differential response of chick liver and brain membranes to short ethanol treatment.

scientific article

Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products

scientific article

Distribution of 3-hydroxy-3-methylglutaryl-CoA reductase in isolated villus and crypt cells of chick duodenum, jejunum and ileum

scientific article published on 01 April 1989

Effect of an Asp80Ala substitution on the binding of dUTP and dUMP to Trypanosoma cruzi dUTPase

scientific article published on 19 March 2007

Embryonic development of mevalonate metabolism by sterol and nonsterol pathways in chick brain and liver

scientific article published in January 1986

Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei.

scientific article published on 29 August 2012

Evaluation of azasterols as anti-parasitics.

scientific article published in October 2006

Evolution of 3-hydroxy-3-methylglutaryl-CoA reductase and microsomal membrane fluidity throughout chick embryo development

scientific article published in January 1985

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase.

scientific article published on 14 August 2010

Exposure of Trypanosoma brucei to an N-acetylglucosamine-binding lectin induces VSG switching and glycosylation defects resulting in reduced infectivity.

scientific article

Expression and characterization of the Trypanosoma cruzi dihydrofolate reductase domain

scientific article published in February 1996

Farnesyl diphosphate synthase is a cytosolic enzyme in Leishmania major promastigotes and its overexpression confers resistance to risedronate.

scientific article published on July 2006

High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.

scientific article

Identification of a residue critical for the excision of 3'-blocking ends in apurinic/apyrimidinic endonucleases of the Xth family.

scientific article published on 30 January 2009

In vitro antiplasmodial and cytotoxic activities of asymmetrical pyridinium derivatives

scientific article

Increased uracil insertion in DNA is cytotoxic and increases the frequency of mutation, double strand break formation and VSG switching in Trypanosoma brucei.

scientific article

Insights into the role of endonuclease V in RNA metabolism in Trypanosoma brucei.

scientific article published on 17 August 2017

Intracellular location of the early steps of the isoprenoid biosynthetic pathway in the trypanosomatids Leishmania major and Trypanosoma brucei.

scientific article

Investigation of acyclic uridine amide and 5'-amido nucleoside analogues as potential inhibitors of the Plasmodium falciparum dUTPase.

scientific article published on 12 July 2013

Kinetic analyses and inhibition studies reveal novel features in peptide deformylase 1 from Trypanosoma cruzi.

scientific article published on 22 December 2011

Kinetic and thermodynamic characterization of dUTP hydrolysis by Plasmodium falciparum dUTPase.

scientific article published on 9 June 2008

Kinetic characterization of squalene synthase from Trypanosoma cruzi: selective inhibition by quinuclidine derivatives

scientific article published on 19 March 2007

Kinetic properties and inhibition of Trypanosoma cruzi 3-hydroxy-3-methylglutaryl CoA reductase.

scientific article published in January 2002

Kinetic properties and inhibition of the dimeric dUTPase-dUDPase from Campylobacter jejuni

scientific article published on 01 February 2009

MDN-0104, an antiplasmodial betaine lipid from Heterospora chenopodii

scientific article

Mevalonate 5-pyrophosphate decarboxylase in isolated villus and crypt cells of chick intestine

scientific article published on 01 April 1988

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

scientific article

New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action.

scientific article

New crystal forms of Trypanosoma cruzi dUTPase

scientific article published on 25 May 2001

Novel 1,2-dihydroquinazolin-2-ones: Design, synthesis, and biological evaluation against Trypanosoma brucei

scientific article published on 11 July 2017

Novel azasterols as potential agents for treatment of leishmaniasis and trypanosomiasis.

scientific article published on August 2004

Novel inhibitors of Leishmanial dihydrofolate reductase.

scientific article published in April 2001

Novel inhibitors of Trypanosoma cruzi dihydrofolate reductase.

scientific article

On the catalytic mechanism of dimeric dUTPases

scientific article

Opening Opportunities for New Drugs Against Neglected Diseases

scientific article published on 01 March 2008

Overexpression of AP endonuclease protects Leishmania major cells against methotrexate induced DNA fragmentation and hydrogen peroxide.

scientific article published on 24 March 2005

Overview of the role of kinetoplastid surface carbohydrates in infection and host cell invasion: prospects for therapeutic intervention

scientific article published on 11 October 2019

Plasmodium falciparum dUTPase: studies on protein stability and binding of deoxyuridine derivatives

scientific article published on 05 May 2007

Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum.

scientific article published on 6 August 2010

Properties of Leishmania major dUTP nucleotidohydrolase, a distinct nucleotide-hydrolysing enzyme in kinetoplastids.

scientific article published in February 2000

Pyridinium-1-yl bisphosphonates are potent inhibitors of farnesyl diphosphate synthase and bone resorption.

scientific article published in April 2005

Pyrimidine requirements in deoxyuridine triphosphate nucleotidohydrolase deficient Trypanosoma brucei mutants.

scientific article published on 29 November 2012

Quantitative role of different embryonic tissues in mevalonate metabolism by sterol and nonsterol pathways. Relationship with enzyme activities of cholesterogenesis

scientific article published in September 1986

Quinuclidine derivatives as potential antiparasitics

scientific article

Regulation of mevalonate 5-pyrophosphate decarboxylase in HeLa cells. Inhibition of enzymatic protein synthesis by serum lipoproteins

scientific article published on 01 July 1997

Relationship between changes in free cholesterol and pyrophosphomevalonate decarboxylase activity during myelination

scientific article published in June 1983

Role of mevalonate-5-pyrophosphate decarboxylase in the regulation of chick intestinal cholesterogenesis

scientific article published in March 1985

SQ109, a new drug lead for Chagas disease

scientific article

Squalene synthase as a target for Chagas disease therapeutics

scientific article

Structural and Kinetic Characterization of Thymidine Kinase from Leishmania major

scientific article

Structural and thermodynamic basis of the inhibition ofLeishmania majorfarnesyl diphosphate synthase by nitrogen-containing bisphosphonates

scientific article

Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase

scientific article

Structures of adenosine kinase from Trypanosoma brucei brucei

scientific article

Studies on the diurnal rhythm of mevalonate metabolism by sterol and nonsterol pathways and of mevalonate-activating enzymes

scientific article published on 01 January 1985

Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases.

scientific article published on 28 July 2017

Surface Glycans: A Therapeutic Opportunity for Kinetoplastid Diseases: (Trends in Parasitology 2017).

scientific article published on 16 October 2017

Synthesis and Evaluation of α-Thymidine Analogues as Novel Antimalarials

scientific article

Synthesis and testing of 5-benzyl-2,4-diaminopyrimidines as potential inhibitors of leishmanial and trypanosomal dihydrofolate reductase

scientific article published in October 2002

Synthesis of sterols by chick brain and liver during embryonic development.

scientific article published in January 1985

The Crystal Structure of the Leishmania major Deoxyuridine Triphosphate Nucleotidohydrolase in Complex with Nucleotide Analogues, dUMP, and Deoxyuridine ⬇️

scientific article

The NTP pyrophosphatase DCTPP1 contributes to the homoeostasis and cleansing of the dNTP pool in human cells

scientific journal article

The crystal structure of Trypanosoma cruzi dUTPase reveals a novel dUTP/dUDP binding fold

scientific article

The crystal structure of a complex of Campylobacter jejuni dUTPase with substrate analogue sheds light on the mechanism and suggests the "basic module" for dimeric d(C/U)TPases

scientific article

The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.

scientific article published on May 1999

Thermodynamic analysis of the binding of 5-fluoro-2'-deoxyuridine 5'-monophosphate to thymidylate synthase over a range of temperatures

scientific article published on 01 September 1995

Thermodynamic characterization of the binding of dCMP to the Asn229Asp mutant of thymidylate synthase

scientific article published on 01 June 1997

Trypanosoma brucei AP endonuclease 1 has a major role in the repair of abasic sites and protection against DNA-damaging agents ⬇️

scientific article published on October 29, 2011

Trypanosoma brucei gambiense adaptation to different mammalian sera is associated with VSG expression site plasticity

scientific article

Trypanosoma cruzi contains a single detectable uracil-DNA glycosylase and repairs uracil exclusively via short patch base excision repair.

scientific article published in September 2004

Trypanosomal dUTPases as potential targets for drug design.

scientific article

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.

scientific article

Validation of Plasmodium falciparum dUTPase as the target of 5'-tritylated deoxyuridine analogues with anti-malarial activity

scientific article published on 03 December 2019

β-Branched acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase

scientific article

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