List of works by Christine Pirker

A human model of epithelial to mesenchymal transition to monitor drug efficacy in hepatocellular carcinoma progression

scientific article published on March 2011

Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression

scientific article

Aggressiveness of human melanoma xenograft models is promoted by aneuploidy-driven gene expression deregulation

scientific article

Altered membrane rigidity via enhanced endogenous cholesterol synthesis drives cancer cell resistance to destruxins.

scientific article published on 22 May 2018

Anticancer metal drugs and immunogenic cell death.

scientific article published on 16 June 2016

Bacterial ghosts as adjuvant to oxaliplatin chemotherapy in colorectal carcinomatosis

scientific article published on 16 February 2018

CD44 drives aggressiveness and chemoresistance of a metastatic human osteosarcoma xenograft model

scientific article

Chronic arsenic trioxide exposure leads to enhanced aggressiveness via Met oncogene addiction in cancer cells

scientific article published on 28 March 2016

Cytogenetic and comparative genomic hybridization findings in four cases of breast cancer after neoadjuvant chemotherapy.

scientific article

DNA damage, somatic aneuploidy, and malignant sarcoma susceptibility in muscular dystrophies

scientific article

DR-01NOVEL PEDIATRIC EPENDYMOMA MODELS SHOW HIGH CHEMOTHERAPY-RESISTANCE AND HYPERACTIVATION OF ABC-TRANSPORTERS.

scientific article published in November 2014

Dynamics of CRISPR/Cas9-mediated genomic editing of the AXL locus in hepatocellular carcinoma cells.

scientific article published on 13 December 2017

Dysregulated Expression of the MicroRNA miR-137 and Its Target YBX1 Contribute to the Invasive Characteristics of Malignant Pleural Mesothelioma.

scientific article published on 4 November 2017

EGFR is not a major driver for osteosarcoma cell growth in vitro but contributes to starvation and chemotherapy resistance.

scientific article published on 2 November 2015

Epigenetic down-regulation of integrin α7 increases migratory potential and confers poor prognosis in malignant pleural mesothelioma.

scientific article published on 26 May 2015

FGF2 and EGF induce epithelial-mesenchymal transition in malignant pleural mesothelioma cells via a MAPKinase/MMP1 signal.

scientific article published in April 2018

FGF5 is expressed in melanoma and enhances malignancy in vitro and in vivo.

scientific article published on 23 September 2017

Fibroblast growth factor receptor 4: a putative key driver for the aggressive phenotype of hepatocellular carcinoma.

scientific article

Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.

scientific article published on October 2014

Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition

scientific article

Impact of terminal dimethylation on the resistance profile of α-N-heterocyclic thiosemicarbazones

scientific article published on 15 March 2012

Intrathoracic solitary fibrous tumor - an international multicenter study on clinical outcome and novel circulating biomarkers

scientific article published on 2 October 2017

Intrinsic fluorescence of the clinically approved multikinase inhibitor nintedanib reveals lysosomal sequestration as resistance mechanism in FGFR-driven lung cancer.

scientific article published on 7 September 2017

Loss of CUL4A expression is underlying cisplatin hypersensitivity in colorectal carcinoma cells with acquired trabectedin resistance

scientific article published on 17 January 2017

Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling.

scientific article published on 02 September 2016

MAP kinase activity supported by BRAF (V600E) mutation rather than gene amplification is associated with ETV1 expression in melanoma brain metastases

scientific article

Major vault protein supports glioblastoma survival and migration by upregulating the EGFR/PI3K signalling axis

scientific article

Malignant predominantly minigemistocytic glioma in two infants: a distinctive glioma variant?

scientific article published on 01 April 2007

Metal Drugs and the Anticancer Immune Response

scientific article published on 29 November 2018

Multidrug-resistant cancer cells are preferential targets of the new antineoplastic lanthanum compound KP772 (FFC24).

scientific article

Multiple chromosomal abnormalities in human liver (pre)neoplasia

scientific article published on 01 April 2004

New 5-Aryl-1H-imidazoles display in vitro antitumor activity against apoptosis-resistant cancer models, including melanomas, through mitochondrial targeting.

scientific article published on 20 August 2013

New cellular tools reveal complex epithelial-mesenchymal interactions in hepatocarcinogenesis

scientific article

Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo

scientific article published on 03 May 2018

Opposing Roles of JNK and p38 in Lymphangiogenesis in Melanoma.

scientific article published on 29 January 2016

Overexpression of Aurora-A in primary cells interferes with S-phase entry by diminishing Cyclin D1 dependent activities

scientific article published on 16 March 2011

Overexpression of the human major vault protein in astrocytic brain tumor cells

scientific article

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis

scientific article

Promoter methylation patterns of ABCB1, ABCC1 and ABCG2 in human cancer cell lines, multidrug-resistant cell models and tumor, tumor-adjacent and tumor-distant tissues from breast cancer patients.

scientific article published on 28 September 2016

Response of experimental malignant melanoma models to the pan-Aurora kinase inhibitor VE-465.

scientific article published in December 2010

SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors

scientific article published on April 2004

Sensitivity of Melanoma Cells to EGFR and FGFR Activation but Not Inhibition is Influenced by Oncogenic BRAF and NRAS Mutations.

scientific article published on 9 March 2015

Sensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis.

scientific article published on 14 July 2017

Seven novel and stable translocations associated with oncogenic gene expression in malignant melanoma.

scientific article

Simultaneous blockade of the epidermal growth factor receptor/mammalian target of rapamycin pathway by epidermal growth factor receptor inhibitors and rapamycin results in reduced cell growth and survival in biliary tract cancer cells

scientific article

Subcellular Duplex DNA and G-Quadruplex Interaction Profiling of a Hexagonal PtII Metallacycle

scientific article published on 08 May 2019

Synergistic effect of Sorafenib and Sunitinib with Enzastaurin, a selective protein kinase C inhibitor in renal cell carcinoma cell lines

scientific article

Synergistic effects of erlotinib and everolimus on bronchial carcinoids and large-cell neuroendocrine carcinomas with activated EGFR/AKT/mTOR pathway

scientific article

TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma

scientific article published on 01 November 2018

Telomerase- and alternative telomere lengthening-independent telomere stabilization in a metastasis-derived human non-small cell lung cancer cell line: effect of ectopic hTERT.

scientific article published on April 2006

The major vault protein is responsive to and interferes with interferon-gamma-mediated STAT1 signals

scientific article published on 17 January 2006

The metastatic microenvironment: Claudin-1 suppresses the malignant phenotype of melanoma brain metastasis.

scientific article

Trabectedin Is Active against Malignant Pleural Mesothelioma Cell and Xenograft Models and Synergizes with Chemotherapy and Bcl-2 Inhibition In Vitro

scientific article published on 10 August 2016

Triapine-mediated ABCB1 induction via PKC induces widespread therapy unresponsiveness but is not underlying acquired triapine resistance.

scientific article

Vemurafenib resistance signature by proteome analysis offers new strategies and rational therapeutic concepts.

scientific article

Whole genome amplification for CGH analysis: Linker-adapter PCR as the method of choice for difficult and limited samples

scientific article published on September 2004

[11C]Erlotinib PET cannot detect acquired erlotinib resistance in NSCLC tumor xenografts in mice.

scientific article

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