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List of works by Tommy N Johansen

3-Pyrazolone analogues of the 3-isoxazolol metabotropic excitatory amino acid receptor agonist homo-AMPA. Synthesis and pharmacological testing

scientific article published on 01 November 1999

3-Substituted phenylalanines as selective AMPA- and kainate receptor ligands.

scientific article published on 16 July 2009

4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues

scientific article published on May 2010

A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure

scientific article

A tetrazolyl-substituted subtype-selective AMPA receptor agonist

scientific article

Aryl- and heteroaryl-substituted phenylalanines as AMPA receptor ligands

scientific article published on 21 June 2017

Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.

scientific article published in May 2005

Design, synthesis and in vitro pharmacology of GluK1 and GluK3 antagonists. Studies towards the design of subtype-selective antagonists through 2-carboxyethyl-phenylalanines with substituents interacting with non-conserved residues in the GluK bindin

scientific article published in October 2014

Design, synthesis and structure-activity relationships of novel phenylalanine-based amino acids as kainate receptors ligands.

scientific article published on 30 September 2016

Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.

scientific article published in March 1998

Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.

scientific article published on 2 August 2007

Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of gamma-aminobutyric acid (GABA) related compounds

scientific article published on July 2006

N-(7-(1H-Imidazol-1-yl)-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl)benzamide, a New Kainate Receptor Selective Antagonist and Analgesic: Synthesis, X-ray Crystallography, Structure-Affinity Relationships, and in Vitro and in Vivo P

scientific article published on 31 October 2019

N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid

scientific article published on 01 January 1996

N1-Substituted Quinoxaline-2,3-diones as Kainate Receptor Antagonists: X-ray Crystallography, Structure-Affinity Relationships, and in Vitro Pharmacology

scientific article published on 23 January 2019

Pharmacological characterization and binding modes of novel racemic and optically active phenylalanine-based antagonists of AMPA receptors.

scientific article published on 8 July 2017

Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.

scientific article

Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist.

scientific article

Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.

scientific article

Structural and pharmacological characterization of phenylalanine-based AMPA receptor antagonists at kainate receptors

scientific article

Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency

scientific article

Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors

scientific article

Synthesis and antitumor effect in vitro and in vivo of substituted 1,3-dihydroindole-2-ones.

scientific article published on October 2010

Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors.

scientific article published in March 2001

Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorophenyl)pentanoic acid.

scientific article published in June 1999

Synthesis and structure-activity studies on acidic amino acids and related diacids as NMDA receptor ligands

scientific article published on 01 September 1994

The anticonvulsant gabapentin (neurontin) does not act through gamma-aminobutyric acid-B receptors.

scientific article published in June 2002

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