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List of works by Roger L Nation

A Novel Chemical Biology Approach for Mapping of Polymyxin Lipopeptide Antibody Binding Epitopes

scientific article published on 29 March 2016

A palliative cancer care flexible education program for Australian community pharmacists

scientific article

A secondary mode of action of polymyxins against Gram-negative bacteria involves the inhibition of NADH-quinone oxidoreductase activity

scientific article published on 30 October 2013

A simple method for the assay of colistin in human plasma, using pre-column derivatization with 9-fluorenylmethyl chloroformate in solid-phase extraction cartridges and reversed-phase high-performance liquid chromatography.

scientific article

A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

scientific article published on 25 March 2022

Activity of colistin combined with doripenem at clinically relevant concentrations against multidrug-resistant Pseudomonas aeruginosa in an in vitro dynamic biofilm model.

scientific article published on 15 May 2014

Agents of Last Resort: Polymyxin Resistance.

scientific article published on June 2016

Aminoglycoside Concentrations Required for Synergy with Carbapenems against Pseudomonas aeruginosa Determined via Mechanistic Studies and Modeling

scientific article published on 11 September 2017

An in vivo assessment of the tobramycin/ticarcillin interaction in cystic fibrosis patients

scientific article published on October 1993

Anthelmintic closantel enhances bacterial killing of polymyxin B against multidrug-resistant Acinetobacter baumannii

scientific article published on 16 December 2015

Antibiograms of multidrug-resistant clinical Acinetobacter baumannii: promising therapeutic options for treatment of infection with colistin-resistant strains

scientific article published on 17 July 2007

Antimicrobial Activity and Toxicity of the Major Lipopeptide Components of Polymyxin B and Colistin: Last-line Antibiotics against Multidrug-Resistant Gram-negative Bacteria

scientific article published on 04 September 2015

Assessing medication knowledge of Australian palliative cancer care patients and caregivers and their interactions with pharmacists

scientific article published on 01 September 2009

Atomic force microscopy investigation of the morphology and topography of colistin-heteroresistant Acinetobacter baumannii strains as a function of growth phase and in response to colistin treatment

scientific article published on 28 September 2009

Cellular Uptake and Localization of Polymyxins in Renal Tubular Cells Using Rationally Designed Fluorescent Probes

scientific article

Clinical utility of Aspergillus galactomannan and PCR in bronchoalveolar lavage fluid for the diagnosis of invasive pulmonary aspergillosis in patients with haematological malignancies

scientific article published on 29 March 2014

Clinically relevant plasma concentrations of colistin in combination with imipenem enhance pharmacodynamic activity against multidrug-resistant Pseudomonas aeruginosa at multiple inocula

scientific article

Colistin and Polymyxin B Dosage Regimens against Acinetobacter baumannii: Differences in Activity and the Emergence of Resistance

scientific article published on 11 April 2016

Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance

scientific article

Colistin and polymyxin B: peas in a pod, or chalk and cheese?

scientific article

Colistin methanesulfonate is an inactive prodrug of colistin against Pseudomonas aeruginosa.

scientific article

Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production

scientific article

Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1,6-N-acetylglucosa

scientific article published on 24 October 2011

Colistin: how should it be dosed for the critically ill?

scientific article

Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections

scientific article

Combinatorial pharmacodynamics of polymyxin B and tigecycline against heteroresistant Acinetobacter baumannii

scientific article published on 12 July 2016

Comparative pharmacodynamics of four different carbapenems in combination with polymyxin B against carbapenem-resistant Acinetobacter baumannii

scientific article published on 20 September 2016

Comparison of once-, twice- and thrice-daily dosing of colistin on antibacterial effect and emergence of resistance: studies with Pseudomonas aeruginosa in an in vitro pharmacodynamic model.

scientific article published on 28 January 2008

Critical Need for Clarity in Polymyxin B Dosing

scientific article published on 24 April 2017

Defining the dosage units for colistin methanesulfonate: urgent need for international harmonization.

scientific article published on December 2006

Design and Evaluation of Novel Polymyxin Fluorescent Probes

scientific article published on 11 November 2017

Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions

scientific article

Determination of naloxone in blood by high-performance liquid chromatography

scientific article published on 01 December 1983

Developing an anion host for lipid A binding and antibacterial activity

scientific article published on 18 March 2010

Development and validation of a liquid chromatography-mass spectrometry assay for polymyxin B in bacterial growth media.

scientific article published on 24 January 2014

Different surface charge of colistin-susceptible and -resistant Acinetobacter baumannii cells measured with zeta potential as a function of growth phase and colistin treatment

scientific article

Disposition of betamethasone in parturient women after intramuscular administration

scientific article

Dosing guidance for intravenous colistin in critically-ill patients

scientific article published on 23 December 2016

Drug release from nanomedicines: Selection of appropriate encapsulation and release methodology.

scientific article

Drug-binding energetics of human α-1-acid glycoprotein assessed by isothermal titration calorimetry and molecular docking simulations.

scientific article

Effect of colistin exposure and growth phase on the surface properties of live Acinetobacter baumannii cells examined by atomic force microscopy

scientific article

Effect of cyclophosphamide administration on the activity and relative content of hepatic P4502D1 in rat

scientific article published on 01 November 1995

Effect of ketoprofen and its enantiomers on the renal disposition of methotrexate in the isolated perfused rat kidney.

scientific article

Effect of racemic ibuprofen dose on the magnitude and duration of platelet cyclo-oxygenase inhibition: relationship between inhibition of thromboxane production and the plasma unbound concentration of S(+)-ibuprofen. ⬇️

scientific article published on February 1991

Effects of albumin on the disposition of morphine and morphine-3-glucuronide in the rat isolated perfused liver

scientific article published on 01 February 1997

Emergence of High-Level Colistin Resistance in an Acinetobacter baumannii Clinical Isolate Mediated by Inactivation of the Global Regulator H-NS

scientific article published on 26 June 2018

Emergence of polymyxin B resistance influences pathogenicity in Pseudomonas aeruginosa mutators

scientific article

Enantioselective pharmacodynamics of the nonsteroidal antiinflammatory drug ketoprofen: in vitro inhibition of human platelet cyclooxygenase activity

scientific article published on January 1, 1992

Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus

scientific article published on 21 October 2014

Gelofusine Ameliorates Colistin-Induced Nephrotoxicity

scientific article published on 18 September 2017

Hepatic disposition of electrophilic acyl glucuronide conjugates.

scientific article

High-Dose Ampicillin-Sulbactam Combinations Combat Polymyxin-Resistant Acinetobacter baumannii in a Hollow-Fiber Infection Model

scientific article published on 4 January 2017

High-intensity meropenem combinations with polymyxin B: new strategies to overcome carbapenem resistance in Acinetobacter baumannii

scientific article published on 15 September 2016

High-performance liquid chromatographic method for simple and rapid determination of linezolid in human plasma.

scientific article published in August 2006

High-performance liquid chromatographic method for the simultaneous determination of lidocaine and its N-dealkylated metabolites in plasma

scientific article published on 01 March 1979

Hospital costs, length of stay and mortality attributable to invasive scedosporiosis in haematology patients.

scientific article published on 29 May 2012

Imaging the distribution of polymyxins in the kidney

scientific article

Influence of octanoic acid on the reversible protein binding of ketorolac enantiomers to human serum albumin (HSA): comparative liquid chromatographic studies using a HSA chiral stationary phase

scientific article published on 01 December 1994

Inhibition of placental P-glycoprotein: impact on indinavir transfer to the foetus.

scientific article published on 17 December 2007

Insertion sequence ISAba11 is involved in colistin resistance and loss of lipopolysaccharide in Acinetobacter baumannii.

scientific article

International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of Americ

scientific article published on 01 January 2019

Lack of effect of co-trimoxazole on the pharmacokinetics of orally administered theophylline

scientific article published on 01 November 1989

Leaching of 2-(2-hydroxyethylmercapto) benzothiazole into contents of disposable syringes

scientific article published on 01 October 1981

Leaching of a contaminant into the contents of disposable syringes

scientific article published on 01 April 1981

Lipopolysaccharide-deficient Acinetobacter baumannii shows altered signaling through host Toll-like receptors and increased susceptibility to the host antimicrobial peptide LL-37.

scientific article published on 17 December 2012

Loading-washout studies of the stereoselective sinusoidal uptake of (R)- and (s)-2-phenylpropionyl acyl glucuronide

scientific article published on 01 October 2006

Low doses of colistimethate: Don't rush in!

scientific article published on 16 December 2016

Major pathways of polymyxin-induced apoptosis in rat kidney proximal tubular cells

scientific article

Making sure the residents get their tablets: medication administration in care homes for older people

scientific article published on 01 October 2006

Management of meningitis due to antibiotic-resistant Acinetobacter species

scientific article published on April 2009

Marked enantioselective protein binding in humans of ketorolac in vitro: elucidation of enantiomer unbound fractions following facile synthesis and direct chiral HPLC resolution of tritium-labelled ketorolac

scientific article published on 01 January 1994

Measuring polymyxin uptake by renal tubular cells: is BODIPY-polymyxin B an appropriate probe?

scientific article published on October 2014

Metabolism and urinary excretion of benzhexol in humans

scientific article published on 01 March 1978

Methionine Ameliorates Polymyxin-Induced Nephrotoxicity by Attenuating Cellular Oxidative Stress.

scientific article published on 23 October 2017

Molecular basis for the increased polymyxin susceptibility of Klebsiella pneumoniae strains with under-acylated lipid A.

scientific article

Nephrotoxicity of Polymyxins: Is There Any Difference between Colistimethate and Polymyxin B?

scientific article published on 19 December 2016

New Polymyxin B Dosing Strategies To Fortify Old Allies in the War against KPC-2-Producing Klebsiella pneumoniae.

scientific article published on 6 February 2017

New dosing strategies for an old antibiotic: pharmacodynamics of front-loaded regimens of colistin at simulated pharmacokinetics in patients with kidney or liver disease

scientific article published on 16 December 2013

Novel approach to optimize synergistic carbapenem-aminoglycoside combinations against carbapenem-resistant Acinetobacter baumannii

scientific article

Novel rate-area-shape modeling approach to quantify bacterial killing and regrowth for in vitro static time-kill studies

scientific article

Old polymyxins are back: is resistance close?

scientific article published on 01 September 2006

Optimization and evaluation of piperacillin plus tobramycin combination dosage regimens against Pseudomonas aeruginosa for patients with altered pharmacokinetics via the hollow-fiber infection model and mechanism-based modeling

scientific article published on 20 February 2018

Optimization of Synergistic Combination Regimens against Carbapenem- and Aminoglycoside-Resistant Clinical Pseudomonas aeruginosa Isolates via Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling

scientific article

Optimization of a meropenem plus tobramycin combination dosage regimen against hypermutable and non-hypermutable Pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model.

scientific article published on 5 February 2018

Optimization of dosing regimens of intravenous colistin in patients with cystic fibrosis: What data are required?

scientific article published on 08 July 2019

Optimizing Polymyxin Combinations Against Resistant Gram-Negative Bacteria

scientific article

Optimizing use of colistin and polymyxin B in the critically ill.

scientific article published on December 2007

Paradoxical Effect of Polymyxin B: High Drug Exposure Amplifies Resistance in Acinetobacter baumannii

scientific article published on 11 April 2016

Personalizing Polymyxin B Dosing Using an Adaptive Feedback Control Algorithm.

scientific article published on 14 May 2018

Pharmacodynamics of colistin and fosfomycin: a 'treasure trove' combination combats KPC-producing Klebsiella pneumoniae

scientific article published on 21 April 2017

Pharmacodynamics of dose-escalated 'front-loading' polymyxin B regimens against polymyxin-resistant mcr-1-harbouring Escherichia coli

scientific article published on 15 May 2017

Pharmacoeconomic evaluation of fluconazole, posaconazole and voriconazole for antifungal prophylaxis in patients with acute myeloid leukaemia undergoing first consolidation chemotherapy

scientific article published on 13 March 2013

Pharmacokinetic/pharmacodynamic investigation of colistin against Pseudomonas aeruginosa using an in vitro model

scientific article

Pharmacokinetic/toxicodynamic analysis of colistin-associated acute kidney injury in critically ill patients

scientific article published on 11 September 2017

Pharmacokinetics of betamethasone in healthy adults after intravenous administration

scientific article published on 01 January 1983

Pharmacokinetics of colistin methanesulphonate and colistin in rats following an intravenous dose of colistin methanesulphonate.

scientific article

Pharmacokinetics of intravenous polymyxin B in critically ill patients.

scientific article published in November 2008

Pharmacokinetics of meperidine in man ⬇️

scientific article published on 01 April 1976

Pharmacokinetics of novel antimicrobial cationic peptides NAB 7061 and NAB 739 in rats following intravenous administration

scientific article published on 10 September 2009

Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats.

scientific article published on 12 January 2017

Pharmacokinetics/pharmacodynamics of colistin and polymyxin B: are we there yet?

scientific article published on 18 October 2016

Pharmacokinetics/pharmacodynamics of systemically administered polymyxin B against Klebsiella pneumoniae in mouse thigh and lung infection models

scientific article published on 14 November 2017

Physicochemical aspects of the coformulation of colistin and azithromycin using liposomes for combination antibiotic therapies

scientific article published on 21 March 2013

Plasma concentrations of propranolol and 4-hydroxypropranolol during chronic oral propranolol therapy ⬇️

scientific article published on August 1, 1979

Plasma level of chlormethiazole and two metabolites after oral administration to young and aged human subjects

scientific article published on 01 October 1977

Polymyxin B and Fosfomycin Thwart KPC-producing Klebsiella pneumoniae in the Hollow Fibre Infection Model.

scientific article published on 24 February 2018

Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategies

scientific article published on 3 August 2016

Polymyxin Combinations Combat Escherichia coli Harboring mcr-1 and blaNDM-5: Preparation for a Postantibiotic Era.

scientific article

Polymyxin Resistance in Acinetobacter baumannii: Genetic Mutations and Transcriptomic Changes in Response to Clinically Relevant Dosage Regimens.

scientific article published on 19 May 2016

Polymyxin combinations: pharmacokinetics and pharmacodynamics for rationale use.

scientific article published on January 2015

Polymyxin-resistant, carbapenem-resistant Acinetobacter baumannii is eradicated by a triple combination of agents that lack individual activity

scientific article published on 28 February 2017

Polymyxins and analogues bind to ribosomal RNA and interfere with eukaryotic translation in vitro.

scientific article published on 18 September 2013

Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients

scientific article

Population pharmacokinetics of colistin methanesulfonate in rats: achieving sustained lung concentrations of colistin for targeting respiratory infections.

scientific article published on 5 August 2013

Precaution in use of high-pressure liquid chromatographic simultaneous plasma procainamide and N-acetylprocainamide determination

scientific article published on April 1, 1979

Preliminary clinical study of the effect of ascorbic acid on colistin-associated nephrotoxicity

scientific article published on 23 March 2015

Probing the penetration of antimicrobial polymyxin lipopeptides into gram-negative bacteria

scientific article

Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: targeting advantage of inhalational administration.

scientific article published on 18 February 2014

Quantitation of Polymyxin-Lipopolysaccharide Interactions Using an Image-Based Fluorescent Probe.

scientific article published on 09 January 2016

Relationship between trough plasma and epithelial lining fluid concentrations of voriconazole in lung transplant recipients.

scientific article published on July 2013

Renal excretion mechanisms of the antiviral nucleoside analogue AM 188 in the rat isolated perfused kidney.

scientific article published in January 2004

Renal secretion of the antiviral nucleoside analog AM188 is inhibited by probenecid, p-aminohippuric acid, and cimetidine in the isolated perfused rat kidney.

scientific article

Reply to Pai

scientific article published on 18 September 2013

Reverse engineering the antigenic architecture of the haemagglutinin from influenza H5N1 clade 1 and 2.2 viruses with fine epitope mapping using monoclonal antibodies ⬇️

scientific article published on November 3, 2012

Significant accumulation of polymyxin in single renal tubular cells: a medicinal chemistry and triple correlative microscopy approach

scientific article

Simple method for the assay of linezolid in Brain Heart Infusion broth by high-performance liquid chromatography.

scientific article published in January 2004

Stereoselective drug disposition: potential for misinterpretation of drug disposition data.

scientific article

Stereoselective interactions of ketoprofen glucuronides with human plasma protein and serum albumin ⬇️

scientific article published on July 22, 1992

Structure, Function, and Biosynthetic Origin of Octapeptin Antibiotics Active against Extensively Drug-Resistant Gram-Negative Bacteria.

scientific article published on 23 January 2018

Structure--activity relationships of polymyxin antibiotics

scientific article

Structure-activity relationships for the binding of polymyxins with human α-1-acid glycoprotein

scientific article

Substantial Targeting Advantage Achieved by Pulmonary Administration of Colistin Methanesulfonate in a Large-Animal Model.

scientific article

Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae.

scientific article

Synergistic activity of colistin and rifampin combination against multidrug-resistant Acinetobacter baumannii in an in vitro pharmacokinetic/pharmacodynamic model

scientific article published on 28 May 2013

Synergistic killing of NDM-producing MDR Klebsiella pneumoniae by two 'old' antibiotics-polymyxin B and chloramphenicol

scientific article

Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents

scientific article published on 01 June 2015

Synthesis of Norbornane Bisether Antibiotics via Silver-mediated Alkylation

scientific article published in January 2015

Teaching 'old' polymyxins new tricks: new-generation lipopeptides targeting gram-negative 'superbugs'.

scientific article

The combination of colistin and doripenem is synergistic against Klebsiella pneumoniae at multiple inocula and suppresses colistin resistance in an in vitro pharmacokinetic/pharmacodynamic model

scientific article

The disposition of morphine and morphine-3-glucuronide in the isolated perfused rat liver: effects of altered perfusate flow rate.

scientific article published in May 1996

The effect of old age on the disposition and antinociceptive response of morphine and morphine-6β-glucuronide in the rat ⬇️

scientific article published on June 1, 1997

The first total synthesis and solution structure of a polypeptin, PE2, a cyclic lipopeptide with broad spectrum antibiotic activity.

scientific article published in August 2017

The influence of renal function on the enantioselective pharmacokinetics and pharmacodynamics of ketoprofen in patients with rheumatoid arthritis.

scientific article

The influence of renal function on the renal clearance of morphine and its glucuronide metabolites in intensive‐care patients ⬇️

scientific article published on July 1, 1992

The pharmacokinetics of chlormethiazole following intravenous administration in the aged

scientific article published on January 1, 1976

The placental transfer of betamethasone

scientific article published on 01 October 1980

The role of perceptions of clinicians in their adoption of a web-based antibiotic approval system: Do perceptions translate into actions?

scientific article published in January 2008

The single-point method of dosage prediction: pharmacokinetic basis and method optimization

scientific article published on 01 July 1982

The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model

scientific article

Transcriptomic Analysis of the Activity of a Novel Polymyxin against Staphylococcus aureus

scientific article published on 27 July 2016

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii

scientific article published on 30 March 2017

Updated US and European Dose Recommendations for Intravenous Colistin: How Do They Perform?

scientific article published on 25 November 2015

Use of high-performance liquid chromatography to study the pharmacokinetics of colistin sulfate in rats following intravenous administration

scientific article

Utility of bronchoalveolar lavage fluid galactomannan alone or in combination with PCR for the diagnosis of invasive aspergillosis in adult hematology patients: a systematic review and meta-analysis

scientific article published on 25 June 2013

fAUC/MIC is the most predictive pharmacokinetic/pharmacodynamic index of colistin against Acinetobacter baumannii in murine thigh and lung infection models.

scientific article

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