List of works - Michael G Acker

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

scientific article

BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity

scientific article published on 27 June 2017

Clinical and In Vitro Evidence That Left Ventricular Assist Device-Induced von Willebrand Factor Degradation Alters Angiogenesis

scientific article published on 01 September 2018

Clinical and In Vitro Evidence That Subclinical Hemolysis Contributes to LVAD Thrombosis

scientific article published on 21 September 2017

Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.

scientific article

Development and characterization of a reconstituted yeast translation initiation system.

scientific article

Dual Allosteric Inhibition of SHP2 Phosphatase

scientific article published on 5 January 2018

Generation of Thiocillin Ring Size Variants by Prepeptide Gene Replacement and in Vivo Processing by Bacillus cereus ⬇️

scientific article published on June 15, 2012

Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. ⬇️

scientific article published on December 2009

Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.

scientific article

Inhibition of ADAMTS-13 by Doxycycline Reduces von Willebrand Factor Degradation During Supraphysiological Shear Stress: Therapeutic Implications for Left Ventricular Assist Device-Associated Bleeding

scientific article published on 30 September 2015

Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining.

scientific article

Kinetic analysis of late steps of eukaryotic translation initiation

scientific article published on 19 October 2008

Left Ventricular Assist Device Design Reduces von Willebrand Factor Degradation: A Comparative Study Between the HeartMate II and the EVAHEART Left Ventricular Assist System.

scientific article

Mechanism of ribosomal subunit joining during eukaryotic translation initiation.

scientific article published on August 2008

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation

scientific article

Reconstitution of yeast translation initiation.

scientific article published in January 2007

Reduced continuous-flow left ventricular assist device speed does not decrease von Willebrand factor degradation

scientific article published on 30 January 2016

Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

scientific article published on 30 March 2016

Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.

scientific article

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

scientific article published in Nature Communications

The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome

scientific article

The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models

scientific article published on 16 October 2018

Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.

scientific article

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.

scholarly article

Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b

scientific article published on 12 July 2017

rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.

scientific article

List of works by Michael G Acker

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity

Clinical and In Vitro Evidence That Left Ventricular Assist Device-Induced von Willebrand Factor Degradation Alters Angiogenesis

Clinical and In Vitro Evidence That Subclinical Hemolysis Contributes to LVAD Thrombosis

Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.

Development and characterization of a reconstituted yeast translation initiation system.

Dual Allosteric Inhibition of SHP2 Phosphatase

Generation of Thiocillin Ring Size Variants by Prepeptide Gene Replacement and in Vivo Processing by Bacillus cereus ⬇️

Generation of thiocillin variants by prepeptide gene replacement and in vivo processing by Bacillus cereus. ⬇️

Genetic interception and structural characterization of thiopeptide cyclization precursors from Bacillus cereus.

Inhibition of ADAMTS-13 by Doxycycline Reduces von Willebrand Factor Degradation During Supraphysiological Shear Stress: Therapeutic Implications for Left Ventricular Assist Device-Associated Bleeding

Interaction between eukaryotic initiation factors 1A and 5B is required for efficient ribosomal subunit joining.

Kinetic analysis of late steps of eukaryotic translation initiation

Left Ventricular Assist Device Design Reduces von Willebrand Factor Degradation: A Comparative Study Between the HeartMate II and the EVAHEART Left Ventricular Assist System.

Mechanism of ribosomal subunit joining during eukaryotic translation initiation.

Protein complex interactor analysis and differential activity of KDM3 subfamily members towards H3K9 methylation

Reconstitution of yeast translation initiation.

Reduced continuous-flow left ventricular assist device speed does not decrease von Willebrand factor degradation

Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition

The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome

The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models

Thiazolyl peptide antibiotic biosynthesis: a cascade of post-translational modifications on ribosomal nascent proteins.

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.

Vitamin C induces specific demethylation of H3K9me2 in mouse embryonic stem cells via Kdm3a/b

rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.