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List of works by Steven Wiley

A general system for studying protein-protein interactions in Gram-negative bacteria

scientific article published in July 2008

A steady state model for analyzing the cellular binding, internalization and degradation of polypeptide ligands ⬇️

scientific article published on August 1, 1981

A systems perspective of heterocellular signaling.

scientific article published on 26 October 2018

Achieving Molecular Selectivity in Imaging Using Multiphoton Raman Spectroscopy Techniques ⬇️

scientific article published on November 1, 2001

Affinity regulates spatial range of EGF receptor autocrine ligand binding

scientific article published on October 2002

Amphiregulin acts as an autocrine growth factor in two human polarizing colon cancer lines that exhibit domain selective EGF receptor mitogenesis.

scientific article published on June 1999

An analysis pipeline for the inference of protein-protein interaction networks

scientific article published in January 2009

An enzymatic method for radiolabeling vertebrate vitellogenin

scientific article published on 01 August 1984

An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells

scientific article

An integrated model of epidermal growth factor receptor trafficking and signal transduction

scientific article

Assay of growth factor stimulation of fluid-phase endocytosis

scientific article published on 01 January 1987

Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo

scientific article published on 09 September 2013

Autocrine epidermal growth factor signaling stimulates directionally persistent mammary epithelial cell migration ⬇️

scientific article published on December 24, 2001

Autocrine loops with positive feedback enable context-dependent cell signaling

scientific article published in March 2002

Basic fibroblast growth factor regulates persistent ERK oscillations in premalignant but not malignant JB6 cells.

scientific article published on 17 December 2009

Blazing Signature Filter: a library for fast pairwise similarity comparisons

scientific article published on 11 June 2018

Carrier-Assisted Single-Tube Processing Approach for Targeted Proteomics Analysis of Low Numbers of Mammalian Cells

scientific article published on 28 December 2018

Cell surface receptors for signal transduction and ligand transport: a design principles study.

scientific article

Changes in translational efficiency is a dominant regulatory mechanism in the environmental response of bacteria.

scientific article published on 30 September 2013

Characterization and improvement of RNA-Seq precision in quantitative transcript expression profiling.

scientific article

Cholesterol dictates the freedom of EGF receptors and HER2 in the plane of the membrane

scientific article

Computational modeling of the EGF-receptor system: a paradigm for systems biology

scientific article

Conservation of protein abundance patterns reveals the regulatory architecture of the EGFR-MAPK pathway

scientific article published on 12 July 2016

Coregulation of Terpenoid Pathway Genes and Prediction of Isoprene Production in Bacillus subtilis Using Transcriptomics

scientific article

Coregulation of epidermal growth factor receptor/human epidermal growth factor receptor 2 (HER2) levels and locations: quantitative analysis of HER2 overexpression effects

scientific article published on 01 March 2003

Decoding Signal Processing at the Single-Cell Level

scientific article published on 01 December 2017

Differential postendocytotic compartmentation in Xenopus oocytes is mediated by a specifically bound ligand

scientific article published on 01 November 1980

EGF-receptor-mediated mammary epithelial cell migration is driven by sustained ERK signaling from autocrine stimulation

scientific article

Effect of epidermal growth factor receptor internalization on regulation of the phospholipase C-gamma1 signaling pathway

scientific article published on March 1999

Enabling high-throughput data management for systems biology: the Bioinformatics Resource Manager

scientific article

Endocytic Relay as a Potential Means for Enhancing Ligand Transport through Cellular Tissue Matrices: Analysis and Possible Implications for Drug Delivery

scientific article published on January 1996

Endocytosis and lysosomal targeting of epidermal growth factor receptors are mediated by distinct sequences independent of the tyrosine kinase domain

scientific article published on 01 March 1995

Engineering dynamics of growth factors and other therapeutic ligands

scientific article

Engineering epidermal growth factor for enhanced mitogenic potency

scientific article published on December 1996

ErbB-2 amplification inhibits down-regulation and induces constitutive activation of both ErbB-2 and epidermal growth factor receptors.

scientific article published on March 1999

Escape of autocrine ligands into extracellular medium: experimental test of theoretical model predictions

scientific article published in March 1998

FRET measurements between small numbers of molecules identifies subtle changes in receptor interactions

Facile carrier-assisted targeted mass spectrometric approach for proteomic analysis of low numbers of mammalian cells

scientific article published on 06 August 2018

Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library

scientific article

Functional independence of the epidermal growth factor receptor from a domain required for ligand-induced internalization and calcium regulation

scientific article

Functional reconstitutional of the human epidermal growth factor receptor system in Xenopus oocytes

scientific article

Genomes to Life "Center for Molecular and Cellular Systems": a research program for identification and characterization of protein complexes

scientific article published on January 2002

Global modulation of the epidermal growth factor receptor is triggered by occupancy of only a few receptors. Evidence for a binary regulatory system in normal human fibroblasts.

scientific article

HER/ErbB receptor interactions and signaling patterns in human mammary epithelial cells

scientific article

HER2-Mediated Effects on EGFR Endosomal Sorting: Analysis of Biophysical Mechanisms ⬇️

scientific article published on October 1, 2003

High speed method for in situ multispectral image registration.

scientific article published in April 2007

How low can you go?

scientific article published on 04 January 2018

Identification of Proteins in Human Cytomegalovirus (HCMV) Particles: the HCMV Proteome

scientific article published in December 2004

Identification of proteins in human cytomegalovirus (HCMV) particles: the HCMV proteome

scientific article published on October 2004

Improving RNA-Seq Precision with MapAl

scientific article published on 2 April 2012

Induced autocrine signaling through the epidermal growth factor receptor contributes to the response of mammary epithelial cells to tumor necrosis factor alpha

scientific article published on 20 February 2004

Inference of interactions in cyanobacterial-heterotrophic co-cultures via transcriptome sequencing

scientific article published on 29 April 2014

Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics

scientific article

Integrating Multiple Types of Data for Signaling Research: Challenges and Opportunities ⬇️

scientific article published on February 15, 2011

Internalized epidermal growth factor receptors participate in the activation of p21(ras) in fibroblasts

scientific article

Investigating the correspondence between transcriptomic and proteomic expression profiles using coupled cluster models

scientific article

Ligand accumulation in autocrine cell cultures

scientific article

Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor.

scientific article published on December 1991

Ligand-induced transformation by a noninternalizing epidermal growth factor receptor

scientific article published on February 1990

Metalloprotease-mediated ligand release regulates autocrine signaling through the epidermal growth factor receptor

scientific article published on May 1999

Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological response

scientific article

Molecular/cell engineering approach to autocrine ligand control of cell function.

scientific article published on May 1995

Multiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells.

scientific article

Mutational removal of the Thr669 and Ser671 phosphorylation sites alters substrate specificity and ligand-induced internalization of the epidermal growth factor receptor

scientific article

Network analysis of epidermal growth factor signaling using integrated genomic, proteomic and phosphorylation data

scientific article

New methods for the purification of vertebrate vitellogenin

scientific article published on 01 August 1979

News

scientific article published on 01 June 2005

Open questions: the disrupted circuitry of the cancer cell

scientific article

Oscillatory dynamics of the extracellular signal-regulated kinase pathway

scientific article published on December 2010

Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells

scientific article

Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation

scientific article published on November 1990

Postendocytic trafficking of epidermal growth factor-receptor complexes is mediated through saturable and specific endosomal interactions.

scientific article published on June 1994

Predicting Species-Resolved Macronutrient Acquisition during Succession in a Model Phototrophic Biofilm Using an Integrated 'Omics Approach

scientific article

Publisher Correction: Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt

scientific article published on 03 September 2020

Quantitative Assessment of Autocrine Cell Loops

scientific article published on 01 January 1999

Quantitative analysis of HER2-mediated effects on HER2 and epidermal growth factor receptor endocytosis: distribution of homo- and heterodimers depends on relative HER2 levels

scientific article published on 9 April 2003

Quantitative analysis of the EGF receptor autocrine system reveals cryptic regulation of cell response by ligand capture

scientific article published on 01 June 2001

Quantitative analysis of the endocytic system involved in hormone-induced receptor internalization

scientific article published on September 1990

Rapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor

scientific article

Ratiometric assay of epidermal growth factor receptor tyrosine kinase activation

scientific article published on 01 January 2000

Real-time quantitative measurement of autocrine ligand binding indicates that autocrine loops are spatially localized

scientific article

Receptor downregulation and desensitization enhance the information processing ability of signalling receptors

scientific article

Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

scientific article published on 21 October 2020

Receptor-mediated endocytosis in Xenopus oocytes. I. Characterization of the vitellogenin receptor system

scientific article published on 01 March 1987

Receptor-mediated endocytosis in Xenopus oocytes. II. Evidence for two novel mechanisms of hormonal regulation.

scientific article published on March 1987

Regulation of postendocytic trafficking of the epidermal growth factor receptor through endosomal retention

scientific article published on April 1994

Removal of the membrane-anchoring domain of epidermal growth factor leads to intracrine signaling and disruption of mammary epithelial cell organization

scientific article

Role of intrinsic protein tyrosine kinase in function and metabolism of the epidermal growth factor receptor

scientific article

Science Signaling Podcast for 12 July 2016: Adaptor proteins limit signaling

scientific article published on 12 July 2016

Self-organization of polarized cell signaling via autocrine circuits: computational model analysis

scientific article

Sensitive targeted quantification of ERK phosphorylation dynamics and stoichiometry in human cells without affinity enrichment

scientific article

Should software hold data hostage?

scientific article published in August 2004

Simple protein complex purification and identification method for high-throughput mapping of protein interaction networks

scientific article published on 01 March 2005

Smad signaling dynamics: insights from a parsimonious model

scientific article published on 9 September 2008

Spatial range of autocrine signaling: modeling and computational analysis

scientific article

Specific factors are required for kinase-dependent endocytosis of insulin receptors

scientific article

Statistically inferring protein-protein associations with affinity isolation LC-MS/MS assays.

scientific article published on 11 August 2007

Structural aspects of the epidermal growth factor receptor required for transmodulation of erbB-2/neu

scientific article published on 01 March 1997

Structure of the EGF receptor transactivation circuit integrates multiple signals with cell context

scientific article published on 10 May 2010

Studies on engineered autocrine systems: requirements for ligand release from cells producing an artificial growth factor

scientific article published in January 1995

Surfactant-assisted one-pot sample preparation for label-free single-cell proteomics

scientific article published on 01 March 2021

Targeted Quantification of Phosphorylation Dynamics in the Context of EGFR-MAPK Pathway.

scientific article

The Oocyte as an Endocytic Cell ⬇️

scientific article published on 01 January 1983

The dynamic expression of the epidermal growth factor receptor and epidermal growth factor ligand family in a differentiating intestinal epithelial cell line

scientific article

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

scientific article published on January 1997

The heparin-binding domain of HB-EGF mediates localization to sites of cell-cell contact and prevents HB-EGF proteolytic release.

scientific article

The mammary epithelial cell secretome and its regulation by signal transduction pathways

scientific article published in January 2008

The membrane-anchoring domain of epidermal growth factor receptor ligands dictates their ability to operate in juxtacrine mode

scientific article

The role of tyrosine kinase activity in endocytosis, compartmentation, and down-regulation of the epidermal growth factor receptor.

scientific article published on June 1991

Trafficking and proteolytic release of epidermal growth factor receptor ligands are modulated by their membrane-anchoring domains

scientific article published on 01 January 2000

Trafficking of the ErbB receptors and its influence on signaling

scientific article

Transcriptomic and proteomic signatures of stemness and differentiation in the colon crypt

scientific article published on 19 August 2020

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