List of works - Kazuhiko Arima

A cross-talk between RNA splicing and signaling pathway alters Fas gene expression at post-transcriptional level: alternative splicing of Fas mRNA in the leukemic U937 cells.

scientific article published in September 2005

A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies.

scientific article published in June 2009

A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis.

scientific article published on 13 March 2009

Accuracy of spinal curvature assessed by a computer-assisted device and anthropometric indicators in discriminating vertebral fractures among individuals with back pain

scientific article published on 14 March 2014

Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis

scientific article published on 27 February 2012

Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells

scientific article published in December 2003

Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women

scientific article published on 11 November 2020

Association between the hemoglobin levels and hypertension in relation to the BMI status in a rural Japanese population: the Nagasaki Islands Study

scientific article published on 01 January 2014

Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older

scientific article

Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan.

scientific article published on 26 November 2015

Association of vertebral compression fractures with physical performance measures among community-dwelling Japanese women aged 40 years and older

scientific article

Associations between renal impairment and anemia in older, rural Japanese men: the Nagasaki Island study

scientific article

Branched‐chain amino acid deficiency stabilizes insulin‐induced vascular endothelial growth factor mRNA in hepatocellular carcinoma cells ⬇️

scientific article published on October 1, 2012

Characterization of peripheral natural killer cells in primary Sjögren’s syndrome: Impaired NK cell activity and low NK cell number

scientific article published on 01 May 2006

Clinical outcomes in the first year of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome.

scientific article published on 20 June 2016

Combination of MRI-detected bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability of early rheumatoid arthritis

scientific article published on 02 September 2014

Confirmation of effectiveness of tocilizumab by ultrasonography and magnetic resonance imaging in biologic agent-naïve early-stage rheumatoid arthritis patients

scientific article published on 13 November 2013

Contribution of an adenine to guanine single nucleotide polymorphism of the matrix metalloproteinase-13 (MMP-13) -77 promoter region to the production of anticyclic citrullinated peptide antibodies in patients with HLA-DRB1*shared epitope-negative r

scientific article published on 26 November 2010

Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism.

scientific article published in August 2010

Cutaneous vasculitis induced by TNF inhibitors: a report of three cases

scientific article published on 08 October 2009

Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drugs shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors

scientific article published on 06 September 2011

Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndrome.

scientific article published on October 2005

Determination of the Subset of Sjögren’s Syndrome with Articular Manifestations by Anticyclic Citrullinated Peptide Antibodies

scientific article published on 01 January 2009

Different expression levels of TNF receptors on the rheumatoid synovial macrophages derived from surgery and a synovectomy as detected by a new flow cytometric analysis

scientific article published on July 2009

Direct infection of primary salivary gland epithelial cells by human T lymphotropic virus type I in patients with Sjögren's syndrome

scientific article

Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases

scientific article published on 3 February 2015

Early prediction of rheumatoid arthritis by serological variables and magnetic resonance imaging of the wrists and finger joints: results from prospective clinical examination.

scientific article published on January 2006

Efficacy and safety of mizoribine by one single dose administration for patients with rheumatoid arthritis.

scientific article published on 15 October 2010

Epidemiology of Kienböck's disease in middle-aged and elderly Japanese women

scientific article published on 01 January 2015

Examination of IgM Rheumatoid Factor (IgM-RF) and Anti-cyclic Citrullinated Peptide Antibody (Anti-CCP Ab) in Japanese Patients with Palindromic Rheumatism

scientific article published on 18 July 2006

Falls are associated with stroke, arthritis and multiple medications among community-dwelling elderly persons in Japan.

scientific article published in January 2013

Free thyroxine (FT4) and anemia in relation to drinking status of Japanese men: the Nagasaki islands study.

scientific article published on 28 May 2013

Height and drinking status in relation to risk of anemia in rural adult healthy Japanese men: the Nagasaki Islands study

scientific article

Hemoglobin as a possible biochemical index of hypertension-induced vascular damage.

scientific article published on 28 January 2016

High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion.

scientific article published on 15 May 2009

High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome.

scientific article published on 17 November 2011

Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene

scientific article published on 01 October 2000

Infliximab is Effective for Takayasu Arteritis Refractory to Glucocorticoid and Methotrexate

scientific article published on 03 April 2006

La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity.

scientific article

Long-term follow-up of adalimumab monotherapy for rheumatoid arthritis in Japanese patients: a report of six cases

scientific article published on 18 January 2011

Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.

scientific article

Magnetic Resonance Imaging Bone Edema at Enrollment Predicts Rapid Radiographic Progression in Patients with Early RA: Results from the Nagasaki University Early Arthritis Cohort

scientific article published in May 2016

Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis: comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaacetic acid-e

scientific article published on 28 December 2011

Membraneous glomerulonephritis and non-Hodgkin's lymphoma in a patient with primary Sjögren's syndrome.

scientific article

Mental health problems and influencing factors in Japanese women 4 months after delivery

scientific article

Nakajo-Nishimura syndrome

scientific article

Prediction of DAS28-CRP remission in patients with rheumatoid arthritis treated with tacrolimus at 6 months by baseline variables

scientific article published in January 2009

Prediction of DAS28-ESR remission at 6 months by baseline variables in patients with rheumatoid arthritis treated with etanercept in Japanese population.

scientific article

Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus.

scientific article published on 30 December 2015

Presence of ultrasound subclinical synovitis and increment of serum vascular endothelial growth factor in a patient with rheumatoid arthritis achieved in sustained clinical remission by treatment with adalimumab and methotrexate

scientific article published on 18 February 2014

Prevalence of lumbar spondylosis and its association with low back pain among community-dwelling Japanese women

scientific article

Proinflammatory Cytokines Synergistically Enhance the Production of Chemokine Ligand 20 (CCL20) from Rheumatoid Fibroblast-like Synovial Cells in vitro and Serum CCL20 Is Reduced in vivo by Biologic Disease-modifying Antirheumatic Drugs

scientific article published on 01 October 2009

Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice ⬇️

scientific article published on June 1, 2012

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome.

scientific article

RS3PE syndrome presenting as vascular endothelial growth factor associated disorder

scientific article

Reduction in serum levels of substance P in patients with rheumatoid arthritis by etanercept, a tumor necrosis factor inhibitor

scientific article published on 29 December 2010

Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro-apoptotic stimuli.

scientific article published in February 2005

Regulation of disease susceptibility and mononuclear cell infiltration into the labial salivary glands of Sjögren's syndrome by monocyte chemotactic protein-1.

scientific article published on 12 May 2010

Relationship Between Urinary Cross-Linked N-Telopeptide of Type-I Collagen and Heel Stiffness Index Measured by Quantitative Ultrasound in Middle-Aged and Elderly Men

scientific article

Relationship between adult height and body weight and risk of carotid atherosclerosis assessed in terms of carotid intima-media thickness: the Nagasaki Islands study

scientific article

Relationship between bone turnover markers and the heel stiffness index measured by quantitative ultrasound in post-menopausal Japanese women

scientific article published on 01 June 2019

Risk factors of adverse events during treatment in elderly patients with rheumatoid arthritis: an observational study

scientific article published on 10 April 2014

Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach.

scientific article published on 6 June 2012

Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-gamma through JAK/STAT pathway by translational regulation.

scientific article published in April 2006

Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population: The Nagasaki Islands study

scientific article published on 27 January 2014

Successful treatment of Schnitzler syndrome with cyclosporine

scientific article published on 06 March 2014

Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine.

scientific article published on 26 June 2010

Successful treatment of refractory neuro-Behcet's disease with infliximab: a case report to show its efficacy by magnetic resonance imaging, transcranial magnetic stimulation and cytokine profile.

scientific article published on January 2007

Successful treatment using tacrolimus (FK506) in a patient with TNF receptor-associated periodic syndrome (TRAPS) complicated by monocytic fasciitis

scientific article

Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics.

scientific article published on 3 October 2009

Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis

scientific article published on 22 March 2014

The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM.

scientific article

The presence of anti-cyclic citrullinated peptide antibody is associated with magnetic resonance imaging detection of bone marrow oedema in early stage rheumatoid arthritis.

scientific article published on January 2006

Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration

scholarly article by Junko Kita et al published 30 September 2011 in Modern Rheumatology

Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration

scientific article published on 30 September 2011

Twenty-four-week follow-up examination of a leukocytapheresis therapy in rheumatoid arthritis

scientific article published on 01 January 2006

Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion.

scientific article

Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.

scientific article published in May 2015

Usefulness of chair stand time as a surrogate of gait speed in diagnosing sarcopenia.

scientific article

Vitamin K deficiency, evaluated with higher serum ucOC, was correlated with poor bone status in women

scientific article published on 10 April 2020

List of works by Kazuhiko Arima

A cross-talk between RNA splicing and signaling pathway alters Fas gene expression at post-transcriptional level: alternative splicing of Fas mRNA in the leukemic U937 cells.

A prediction rule for disease outcome in patients with undifferentiated arthritis using magnetic resonance imaging of the wrists and finger joints and serologic autoantibodies.

A significantly impaired natural killer cell activity due to a low activity on a per-cell basis in rheumatoid arthritis.

Accuracy of spinal curvature assessed by a computer-assisted device and anthropometric indicators in discriminating vertebral fractures among individuals with back pain

Adiponectin relation to skin changes and dyslipidemia in systemic sclerosis

Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells

Association between self-reported walking speed and calcaneal stiffness index in postmenopausal Japanese women

Association between the hemoglobin levels and hypertension in relation to the BMI status in a rural Japanese population: the Nagasaki Islands Study

Association of Physical Performance and Pain With Fear of Falling Among Community-Dwelling Japanese Women Aged 65 Years and Older

Association of maternal pre-pregnancy weight, weight gain during pregnancy, and smoking with small-for-gestational-age infants in Japan.

Association of vertebral compression fractures with physical performance measures among community-dwelling Japanese women aged 40 years and older

Associations between renal impairment and anemia in older, rural Japanese men: the Nagasaki Island study

Branched‐chain amino acid deficiency stabilizes insulin‐induced vascular endothelial growth factor mRNA in hepatocellular carcinoma cells ⬇️

Characterization of peripheral natural killer cells in primary Sjögren’s syndrome: Impaired NK cell activity and low NK cell number

Clinical outcomes in the first year of remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome.

Combination of MRI-detected bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability of early rheumatoid arthritis

Confirmation of effectiveness of tocilizumab by ultrasonography and magnetic resonance imaging in biologic agent-naïve early-stage rheumatoid arthritis patients

Contribution of an adenine to guanine single nucleotide polymorphism of the matrix metalloproteinase-13 (MMP-13) -77 promoter region to the production of anticyclic citrullinated peptide antibodies in patients with HLA-DRB1*shared epitope-negative r

Contribution of anti-CCP antibodies, proximal interphalangeal joint involvement, HLA-DRB1 shared epitope, and PADI4 as risk factors for the development of rheumatoid arthritis in palindromic rheumatism.

Cutaneous vasculitis induced by TNF inhibitors: a report of three cases

Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drugs shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors

Detection of apoptosis-specific autoantibodies directed against granzyme B-induced cleavage fragments of the SS-B (La) autoantigen in sera from patients with primary Sjögren's syndrome.

Determination of the Subset of Sjögren’s Syndrome with Articular Manifestations by Anticyclic Citrullinated Peptide Antibodies

Different expression levels of TNF receptors on the rheumatoid synovial macrophages derived from surgery and a synovectomy as detected by a new flow cytometric analysis

Direct infection of primary salivary gland epithelial cells by human T lymphotropic virus type I in patients with Sjögren's syndrome

Distinguishing the cerebrospinal fluid cytokine profile in neuropsychiatric systemic lupus erythematosus from other autoimmune neurological diseases

Early prediction of rheumatoid arthritis by serological variables and magnetic resonance imaging of the wrists and finger joints: results from prospective clinical examination.

Efficacy and safety of mizoribine by one single dose administration for patients with rheumatoid arthritis.

Epidemiology of Kienböck's disease in middle-aged and elderly Japanese women

Examination of IgM Rheumatoid Factor (IgM-RF) and Anti-cyclic Citrullinated Peptide Antibody (Anti-CCP Ab) in Japanese Patients with Palindromic Rheumatism

Falls are associated with stroke, arthritis and multiple medications among community-dwelling elderly persons in Japan.

Free thyroxine (FT4) and anemia in relation to drinking status of Japanese men: the Nagasaki islands study.

Height and drinking status in relation to risk of anemia in rural adult healthy Japanese men: the Nagasaki Islands study

Hemoglobin as a possible biochemical index of hypertension-induced vascular damage.

High serum cartilage oligomeric matrix protein determines the subset of patients with early-stage rheumatoid arthritis with high serum C-reactive protein, matrix metalloproteinase-3, and MRI-proven bone erosion.

High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome.

Identification of a novel gene encoding a PrP-like protein expressed as chimeric transcripts fused to PrP exon 1/2 in ataxic mouse line with a disrupted PrP gene

Infliximab is Effective for Takayasu Arteritis Refractory to Glucocorticoid and Methotrexate

La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity.

Long-term follow-up of adalimumab monotherapy for rheumatoid arthritis in Japanese patients: a report of six cases

Lupus Nephritis IgG Induction of Calcium/Calmodulin-Dependent Protein Kinase IV Expression in Podocytes and Alteration of Their Function.

Magnetic Resonance Imaging Bone Edema at Enrollment Predicts Rapid Radiographic Progression in Patients with Early RA: Results from the Nagasaki University Early Arthritis Cohort

Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis: comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaacetic acid-e

Membraneous glomerulonephritis and non-Hodgkin's lymphoma in a patient with primary Sjögren's syndrome.

Mental health problems and influencing factors in Japanese women 4 months after delivery

Nakajo-Nishimura syndrome

Prediction of DAS28-CRP remission in patients with rheumatoid arthritis treated with tacrolimus at 6 months by baseline variables

Prediction of DAS28-ESR remission at 6 months by baseline variables in patients with rheumatoid arthritis treated with etanercept in Japanese population.

Predictors of clinical outcomes in patients with neuropsychiatric systemic lupus erythematosus.

Presence of ultrasound subclinical synovitis and increment of serum vascular endothelial growth factor in a patient with rheumatoid arthritis achieved in sustained clinical remission by treatment with adalimumab and methotrexate

Prevalence of lumbar spondylosis and its association with low back pain among community-dwelling Japanese women

Proinflammatory Cytokines Synergistically Enhance the Production of Chemokine Ligand 20 (CCL20) from Rheumatoid Fibroblast-like Synovial Cells in vitro and Serum CCL20 Is Reduced in vivo by Biologic Disease-modifying Antirheumatic Drugs

Prophylactic and therapeutic efficacies of a selective inhibitor of the immunoproteasome for Hashimoto's thyroiditis, but not for Graves' hyperthyroidism, in mice ⬇️

Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome.

RS3PE syndrome presenting as vascular endothelial growth factor associated disorder

Reduction in serum levels of substance P in patients with rheumatoid arthritis by etanercept, a tumor necrosis factor inhibitor

Regulation of alternative splicing of caspase-2 through an intracellular signaling pathway in response to pro-apoptotic stimuli.

Regulation of disease susceptibility and mononuclear cell infiltration into the labial salivary glands of Sjögren's syndrome by monocyte chemotactic protein-1.

Relationship Between Urinary Cross-Linked N-Telopeptide of Type-I Collagen and Heel Stiffness Index Measured by Quantitative Ultrasound in Middle-Aged and Elderly Men

Relationship between adult height and body weight and risk of carotid atherosclerosis assessed in terms of carotid intima-media thickness: the Nagasaki Islands study

Relationship between bone turnover markers and the heel stiffness index measured by quantitative ultrasound in post-menopausal Japanese women

Risk factors of adverse events during treatment in elderly patients with rheumatoid arthritis: an observational study

Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach.

Significant inhibition of TRAIL-mediated fibroblast-like synovial cell apoptosis by IFN-gamma through JAK/STAT pathway by translational regulation.

Subclinical carotid atherosclerosis and hyperuricemia in relation to renal impairment in a rural Japanese population: The Nagasaki Islands study

Successful treatment of Schnitzler syndrome with cyclosporine

Successful treatment of chronic lupus myocarditis with prednisolone and mizoribine.

Successful treatment of refractory neuro-Behcet's disease with infliximab: a case report to show its efficacy by magnetic resonance imaging, transcranial magnetic stimulation and cytokine profile.

Successful treatment using tacrolimus (FK506) in a patient with TNF receptor-associated periodic syndrome (TRAPS) complicated by monocytic fasciitis

Switching to the anti-interleukin-6 receptor antibody tocilizumab in rheumatoid arthritis patients refractory to antitumor necrosis factor biologics.

Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis

The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM.

The presence of anti-cyclic citrullinated peptide antibody is associated with magnetic resonance imaging detection of bone marrow oedema in early stage rheumatoid arthritis.

Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration

Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration

Twenty-four-week follow-up examination of a leukocytapheresis therapy in rheumatoid arthritis

Ultrasonographic examination of rheumatoid arthritis patients who are free of physical synovitis: power Doppler subclinical synovitis is associated with bone erosion.

Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.

Usefulness of chair stand time as a surrogate of gait speed in diagnosing sarcopenia.