List of works - Michael J. Rynkiewicz

A Unique Sugar-binding Site Mediates the Distinct Anti-influenza Activity of Pig Surfactant Protein D

scientific article

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

scientific article published on 15 February 2019

B-Cell Epitopes in GroEL of Francisella tularensis

scientific article

Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti

scientific article

Crystallographic Complexes of Surfactant Protein A and Carbohydrates Reveal Ligand-induced Conformational Change

scientific article

Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop.

scientific article published on 18 July 2017

Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics.

scientific article published on May 2014

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy.

scientific article

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin

scientific article published on 19 August 2015

Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

scientific article

Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity

scientific article

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments

scientific article published on 4 April 2018

Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis

scientific article published on 26 August 2015

Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses.

scientific article published on 13 April 2011

Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus

scientific article published in Journal of Biological Chemistry

Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants.

scientific article published in April 2005

Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D

scientific article

Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo

scientific article

Structural Analysis of a Protective Epitope of the Francisella tularensis O -Polysaccharide

scientific article

Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade ⬇️

scientific article published on November 6, 2001

Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa

scientific article published on 28 July 2006

Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine.

scientific article published on 9 March 2006

The binding sites of monoclonal antibodies to the nonreducing end ofFrancisella tularensis O-antigen accommodate mainly the terminal saccharide

scientific article

The propensity for tropomyosin twisting in the presence and absence of F-actin.

scientific article published on 20 September 2016

The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.

scientific article

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

scientific article published in December 2017

Tropomyosin diffusion over actin subunits facilitates thin filament assembly

scientific article published on 14 January 2016

List of works by Michael J. Rynkiewicz

A Unique Sugar-binding Site Mediates the Distinct Anti-influenza Activity of Pig Surfactant Protein D

A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics

B-Cell Epitopes in GroEL of Francisella tularensis

Crystal structure determination of aristolochene synthase from the blue cheese mold, Penicillium roqueforti

Crystallographic Complexes of Surfactant Protein A and Carbohydrates Reveal Ligand-induced Conformational Change

Differential Ligand Binding Specificities of the Pulmonary Collectins Are Determined by the Conformational Freedom of a Surface Loop.

Discovery of protective B-cell epitopes for development of antimicrobial vaccines and antibody therapeutics.

Distortion of the Actin A-Triad Results in Contractile Disinhibition and Cardiomyopathy.

Electrostatic interaction map reveals a new binding position for tropomyosin on F-actin

Elucidation of Lipid Binding Sites on Lung Surfactant Protein A Using X-ray Crystallography, Mutagenesis, and Molecular Dynamics Simulations

Functional and structural characterization of Francisella tularensis O-antigen antibodies at the low end of antigen reactivity

HCM and DCM cardiomyopathy-linked α-tropomyosin mutations influence off-state stability and crossbridge interaction on thin filaments

Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis

Introduction of N-linked glycans in the lectin domain of surfactant protein D: impact on interactions with influenza A viruses.

Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus

Molecular recognition of the substrate diphosphate group governs product diversity in trichodiene synthase mutants.

Monoclonal antibody-assisted structure-function analysis of the carbohydrate recognition domain of surfactant protein D

Mutagenesis of surfactant protein D informed by evolution and x-ray crystallography enhances defenses against influenza A virus in vivo

Structural Analysis of a Protective Epitope of the Francisella tularensis O -Polysaccharide

Structure of trichodiene synthase from Fusarium sporotrichioides provides mechanistic inferences on the terpene cyclization cascade ⬇️

Synthesis and in vitro biological evaluation of aryl boronic acids as potential inhibitors of factor XIa

Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine.

The binding sites of monoclonal antibodies to the nonreducing end ofFrancisella tularensis O-antigen accommodate mainly the terminal saccharide

The propensity for tropomyosin twisting in the presence and absence of F-actin.

The three-dimensional structure of the ZAP-70 kinase domain in complex with staurosporine: implications for the design of selective inhibitors.

Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function.

Tropomyosin diffusion over actin subunits facilitates thin filament assembly