List of works - Clemens Kreutz

A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β.

scientific article published on October 2016

A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens.

scientific article

Addressing parameter identifiability by model-based experimentation.

scientific article published in March 2011

An easy and efficient approach for testing identifiability

scientific article published on 22 January 2018

BRAF V600E Mutations in Nevi and Melanocytic Tumors of Uncertain Malignant Potential

scientific article published on 12 July 2018

Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity

scientific article published on 12 May 2022

Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes

scientific article published in May 2012

Cause and cure of sloppiness in ordinary differential equation models. ⬇️

scientific article published on 11 August 2014

Combination of immunosuppressive drugs leaves specific "fingerprint" on gene expression in vitro.

scientific article published in June 2009

Comprehensive estimation of input signals and dynamics in biochemical reaction networks.

scientific article published on September 2012

Computational processing and error reduction strategies for standardized quantitative data in biological networks

scientific article

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice

scientific article published on 24 April 2020

Data-based identifiability analysis of non-linear dynamical models

scientific article

Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems

scientific article

Dealing with prognostic signature instability: a strategy illustrated for cardiovascular events in patients with end-stage renal disease

scientific article

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.

scientific article

Driving the Model to Its Limit: Profile Likelihood Based Model Reduction

scientific article

Experimental design for parameter estimation of gene regulatory networks

scientific article

Gene profiling of polycystic kidneys.

scientific article

Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays.

scientific article

Guidelines for benchmarking of optimization-based approaches for fitting mathematical models

scientific article published on 16 December 2019

Hepatocyte Ploidy Is a Diversity Factor for Liver Homeostasis.

scientific article published on 31 October 2017

Host cell responses induced by hepatitis C virus binding.

scientific article published on June 2006

Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells

scientific article

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

scientific article published on 01 October 2020

Joining forces of Bayesian and frequentist methodology: a study for inference in the presence of non-identifiability

scientific article published on 31 December 2012

L1 regularization facilitates detection of cell type-specific parameters in dynamical systems.

scientific article

Lessons learned from quantitative dynamical modeling in systems biology

scientific article

Likelihood based observability analysis and confidence intervals for predictions of dynamic models

scientific article

MeDIP coupled with a promoter tiling array as a platform to investigate global DNA methylation patterns in AML cells.

scientific article

Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells.

scientific article

Network topology and parameter estimation: from experimental design methods to gene regulatory network kinetics using a community based approach

scientific article

PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2.

scientific article published on 3 May 2014

Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C

scientific article published on 22 May 2020

Profile likelihood-based analyses of infectious disease models

scientific article published in January 2017

Quantitative data generation for systems biology: the impact of randomisation, calibrators and normalisers.

scientific article

Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations

scientific article

Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression

scientific article published on 12 December 2017

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

scientific article

Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates prefibrotic primary myelofibrosis from essential thrombocythemia.

scientific article published on 13 May 2013

Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models

scientific article published on 28 May 2015

TSSi--an R package for transcription start site identification from 5' mRNA tag data.

scientific article

Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions

scientific article

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.

scientific article published on 26 October 2010

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

scientific article published on 20 April 2015

[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis].

scientific article

cDNA microarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain

scientific article published on 20 September 2007

List of works by Clemens Kreutz

A Thymic Epithelial Stem Cell Pool Persists throughout Ontogeny and Is Modulated by TGF-β.

A novel approach for reliable microarray analysis of microdissected tumor cells from formalin-fixed and paraffin-embedded colorectal cancer resection specimens.

Addressing parameter identifiability by model-based experimentation.

An easy and efficient approach for testing identifiability

BRAF V600E Mutations in Nevi and Melanocytic Tumors of Uncertain Malignant Potential

Benchmarking of analysis strategies for data-independent acquisition proteomics using a large-scale dataset comprising inter-patient heterogeneity

Caspase-3 feeds back on caspase-8, Bid and XIAP in type I Fas signaling in primary mouse hepatocytes

Cause and cure of sloppiness in ordinary differential equation models. ⬇️

Combination of immunosuppressive drugs leaves specific "fingerprint" on gene expression in vitro.

Comprehensive estimation of input signals and dynamics in biochemical reaction networks.

Computational processing and error reduction strategies for standardized quantitative data in biological networks

Conditional deletion of Nedd4-2 in lung epithelial cells causes progressive pulmonary fibrosis in adult mice

Data-based identifiability analysis of non-linear dynamical models

Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems

Dealing with prognostic signature instability: a strategy illustrated for cardiovascular events in patients with end-stage renal disease

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range.

Driving the Model to Its Limit: Profile Likelihood Based Model Reduction

Experimental design for parameter estimation of gene regulatory networks

Gene profiling of polycystic kidneys.

Genome-wide analysis of DNA copy number changes and LOH in CLL using high-density SNP arrays.

Guidelines for benchmarking of optimization-based approaches for fitting mathematical models

Hepatocyte Ploidy Is a Diversity Factor for Liver Homeostasis.

Host cell responses induced by hepatitis C virus binding.

Identification of Cell Type-Specific Differences in Erythropoietin Receptor Signaling in Primary Erythroid and Lung Cancer Cells

Identification of Interleukin1β as an Amplifier of Interferon alpha-induced Antiviral Responses

Joining forces of Bayesian and frequentist methodology: a study for inference in the presence of non-identifiability

L1 regularization facilitates detection of cell type-specific parameters in dynamical systems.

Lessons learned from quantitative dynamical modeling in systems biology

Likelihood based observability analysis and confidence intervals for predictions of dynamic models

MeDIP coupled with a promoter tiling array as a platform to investigate global DNA methylation patterns in AML cells.

Microarray analysis reveals influence of the sesquiterpene lactone parthenolide on gene transcription profiles in human epithelial cells.

Network topology and parameter estimation: from experimental design methods to gene regulatory network kinetics using a community based approach

PI3K-p110-alpha-subtype signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2.

Phosphoproteomics identifies dual-site phosphorylation in an extended basophilic motif regulating FILIP1-mediated degradation of filamin-C

Profile likelihood-based analyses of infectious disease models

Quantitative data generation for systems biology: the impact of randomisation, calibrators and normalisers.

Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations

Resolving the Combinatorial Complexity of Smad Protein Complex Formation and Its Link to Gene Expression

Structural and practical identifiability analysis of partially observed dynamical models by exploiting the profile likelihood

Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates prefibrotic primary myelofibrosis from essential thrombocythemia.

Summary of the DREAM8 Parameter Estimation Challenge: Toward Parameter Identification for Whole-Cell Models

TSSi--an R package for transcription start site identification from 5' mRNA tag data.

Theoretical and experimental analysis links isoform-specific ERK signalling to cell fate decisions

Transcription factors ETF, E2F, and SP-1 are involved in cytokine-independent proliferation of murine hepatocytes.

USP18 lack in microglia causes destructive interferonopathy of the mouse brain

[Differential diagnosis of myeloproliferative neoplasms. Quantitative NF-E2 immunohistochemistry for differentiating between essential thrombocythemia and primary myelofibrosis].

cDNA microarray analysis of adaptive changes after renal ablation in a sclerosis-resistant mouse strain