List of works - Iain Fraser

3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative Mechanism

scientific article published on 08 September 2018

A Deep Learning Pipeline for Nucleus Segmentation

scientific article published on 03 November 2020

A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events ⬇️

scientific article published on April 15, 1998

A simple method for automatic tracking of actin filaments in the motility assay.

scientific article

A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression

scholarly article

A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses

scientific article published on 08 December 2020

A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs

scientific article

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection

scientific article

Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection

scientific article published on 14 December 2015

Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms

scientific article

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

scientific article

Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA.

scholarly article

Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action

scientific article published on 4 August 2017

Assay Development for Image-Based Quantification of Intracellular Bacterial Replication and Analysis of the Innate Immune Response to Infection.

scientific article

Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.

scientific article

Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2.

scientific article

Commensal-driven immune zonation of the liver promotes host defence

scientific article published on 25 November 2020

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.

scientific article published on 05 January 2016

Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

scientific article published on 21 March 2016

Deciphering signaling outcomes from a system of complex networks.

scientific article

Development of a cell system for siRNA screening of pathogen responses in human and mouse macrophages

scientific article

Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.

scientific article published on 26 May 2016

Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene Expression

scientific article published on 13 June 2018

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

scientific article

Genome-wide siRNA screen of genes regulating the LPS-induced NF-κB and TNF-α responses in mouse macrophages

scientific article published on March 2017

Genome-wide siRNA screen of genes regulating the LPS-induced TNF-α response in human macrophages.

scientific article published on March 2017

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens

scientific article

IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

scientific article published on 06 August 2019

Identification of cAMP-dependent protein kinase holoenzymes in preantral- and preovulatory-follicle-enriched ovaries, and their association with A-kinase-anchoring proteins.

scientific article published in December 1999

Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses

scientific article published on 23 January 2019

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.

scientific article published on 26 May 2013

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88

scientific article

Localization of phospholipid-binding sites of caldesmon

scientific article published on 01 April 1994

Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin

article

Measurement of NF-κB Activation in TLR-Activated Macrophages.

scientific article published in January 2018

Molecular characterisation and stage-specific expression of proliferating cell nuclear antigen (PCNA) from the malarial parasite, Plasmodium falciparum.

scientific article published on January 1993

Multi-Omics Strategies Uncover Host-Pathogen Interactions

scientific article published on 25 March 2019

Navigating the network: signaling cross-talk in hematopoietic cells.

scientific article published on 19 March 2009

Navigating the signalling network in mouse cardiac myocytes

scientific article published in December 2002

Overview of the Alliance for Cellular Signaling

scientific article

Proteome and Secretome Analysis Reveals Differential Post-transcriptional Regulation of Toll-like Receptor Responses

scientific article

Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium

scientific article

Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins.

scientific article

Structure-activity studies of the regulatory interaction of the 10 kilodalton C-terminal fragment of caldesmon with actin and the effect of mutation of caldesmon residues 691-696.

scientific article

Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105

scientific journal article

Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling

scientific article published on 14 January 2014

Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.

scientific article

Systematic Investigation of Multi-TLR Sensing Identifies Regulators of Sustained Gene Activation in Macrophages

scientific article

Systems biology in immunology: a computational modeling perspective.

scientific article

The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis

scientific article published on 27 December 2006

The cAMP Pathway Amplifies Early MyD88-Dependent and Type I Interferon-Independent LPS-Induced Interleukin-10 Expression in Mouse Macrophages

scientific article published on 17 April 2019

The dynamic ADP-ribosylome, phosphoproteome, and interactome in LPS-activated macrophages

scientific article published on 12 June 2020

The inhibitory complex of smooth muscle caldesmon with actin and tropomyosin involves three interacting segments of the C-terminal domain 4

scientific article published on 01 May 1997

The use of RNA interference to analyze protein phosphatase function in mammalian cells

scientific article published on January 2007

Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol

scientific article published on 08 March 2021

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

scientific article published on 5 February 2007

Variability in G-protein-coupled signaling studied with microfluidic devices.

scientific article

List of works by Iain Fraser

3-Aminobenzamide Prevents Concanavalin A-Induced Acute Hepatitis by an Anti-inflammatory and Anti-oxidative Mechanism

A Deep Learning Pipeline for Nucleus Segmentation

A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events ⬇️

A simple method for automatic tracking of actin filaments in the motility assay.

A single lentiviral vector platform for microRNA-based conditional RNA interference and coordinated transgene expression

A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses

A versatile approach to multiple gene RNA interference using microRNA-based short hairpin RNAs

Ablation of the regulatory IE1 protein of murine cytomegalovirus alters in vivo pro-inflammatory TNF-alpha production during acute infection

Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection

Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms

An interactive web-based application for Comprehensive Analysis of RNAi-screen Data

Analysis of C5a-mediated chemotaxis by lentiviral delivery of small interfering RNA.

Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action

Assay Development for Image-Based Quantification of Intracellular Bacterial Replication and Analysis of the Innate Immune Response to Infection.

Burkholderia cenocepacia J2315 escapes to the cytosol and actively subverts autophagy in human macrophages.

Clostridium difficile toxin B differentially affects GPCR-stimulated Ca2+ responses in macrophages: independent roles for Rho and PLA2.

Commensal-driven immune zonation of the liver promotes host defence

Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use.

Corrigendum: An interactive web-based application for Comprehensive Analysis of RNAi-screen Data.

Deciphering signaling outcomes from a system of complex networks.

Development of a cell system for siRNA screening of pathogen responses in human and mouse macrophages

Distinct NF-κB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses.

Dual Roles for Ikaros in Regulation of Macrophage Chromatin State and Inflammatory Gene Expression

Enhanced Functional Genomic Screening Identifies Novel Mediators of Dual Leucine Zipper Kinase-Dependent Injury Signaling in Neurons.

Genome-wide siRNA screen of genes regulating the LPS-induced NF-κB and TNF-α responses in mouse macrophages

Genome-wide siRNA screen of genes regulating the LPS-induced TNF-α response in human macrophages.

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Host gene targets for novel influenza therapies elucidated by high-throughput RNA interference screens

IFN-mediated negative feedback supports bacteria class-specific macrophage inflammatory responses

Identification of cAMP-dependent protein kinase holoenzymes in preantral- and preovulatory-follicle-enriched ovaries, and their association with A-kinase-anchoring proteins.

Immune regulation by glucocorticoids can be linked to cell type-dependent transcriptional responses

Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection.

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88

Localization of phospholipid-binding sites of caldesmon

Mass Spectrometry-based Structural Analysis and Systems Immunoproteomics Strategies for Deciphering the Host Response to Endotoxin

Measurement of NF-κB Activation in TLR-Activated Macrophages.

Molecular characterisation and stage-specific expression of proliferating cell nuclear antigen (PCNA) from the malarial parasite, Plasmodium falciparum.

Multi-Omics Strategies Uncover Host-Pathogen Interactions

Navigating the network: signaling cross-talk in hematopoietic cells.

Navigating the signalling network in mouse cardiac myocytes

Overview of the Alliance for Cellular Signaling

Proteome and Secretome Analysis Reveals Differential Post-transcriptional Regulation of Toll-like Receptor Responses

Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium

Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins.

Structure-activity studies of the regulatory interaction of the 10 kilodalton C-terminal fragment of caldesmon with actin and the effect of mutation of caldesmon residues 691-696.

Suppression of LPS-induced TNF-alpha production in macrophages by cAMP is mediated by PKA-AKAP95-p105

Switching of the relative dominance between feedback mechanisms in lipopolysaccharide-induced NF-κB signaling

Synergistic Ca2+ responses by G{alpha}i- and G{alpha}q-coupled G-protein-coupled receptors require a single PLC{beta} isoform that is sensitive to both G{beta}{gamma} and G{alpha}q.

Systematic Investigation of Multi-TLR Sensing Identifies Regulators of Sustained Gene Activation in Macrophages

Systems biology in immunology: a computational modeling perspective.

The alliance for cellular signaling plasmid collection: a flexible resource for protein localization studies and signaling pathway analysis

The cAMP Pathway Amplifies Early MyD88-Dependent and Type I Interferon-Independent LPS-Induced Interleukin-10 Expression in Mouse Macrophages

The dynamic ADP-ribosylome, phosphoproteome, and interactome in LPS-activated macrophages

The inhibitory complex of smooth muscle caldesmon with actin and tropomyosin involves three interacting segments of the C-terminal domain 4

The use of RNA interference to analyze protein phosphatase function in mammalian cells

Type I IFNs facilitate innate immune control of the opportunistic bacteria Burkholderia cenocepacia in the macrophage cytosol

Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway

Variability in G-protein-coupled signaling studied with microfluidic devices.