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List of works by Justin V McCarthy

A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains.

scientific article published on 18 March 2015

Apoptosis induced by Drosophila reaper and grim in a human system. Attenuation by inhibitor of apoptosis proteins (cIAPs).

scientific article published on September 1998

Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways

scientific article

Gamma-secretase-independent role for cadherin-11 in neurotrophin receptor p75 (p75(NTR)) mediated glioblastoma cell migration.

scientific article published on 14 October 2015

Interleukin-1 receptor type 1 is a substrate for gamma-secretase-dependent regulated intramembrane proteolysis.

scientific article

Involvement of presenilins in cell-survival signalling pathways.

scientific article

Loss of Presenilin 2 Function Is Associated with Defective LPS-Mediated Innate Immune Responsiveness.

scientific article published on 18 June 2015

Presenilins are novel substrates for TRAF6-mediated ubiquitination ⬇️

scientific article published on May 21, 2013

RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase

scientific article

Semagacestat, a γ-secretase inhibitor, activates the growth hormone secretagogue (GHS-R1a) receptor

scientific article published on 27 November 2012

Structural and functional characterization of the upstream regulatory region of the human gene encoding prostate apoptosis response factor-4.

scientific article

Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling

scientific article

The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis.

scientific article published on 21 May 2007

γ-Secretase Activity Is Required for Regulated Intramembrane Proteolysis of Tumor Necrosis Factor (TNF) Receptor 1 and TNF-mediated Pro-apoptotic Signaling.

scientific article published on 11 January 2016

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