List of works - Isabel Mérida

A Blk-p190RhoGAP signaling module downstream of activated Gα13 functionally opposes CXCL12-stimulated RhoA activation and cell invasion

scientific article

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex

scientific article

A new role of diacylglycerol kinase alpha on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes

scientific article published on 22 August 2006

A phospho-oligosaccharide mimics the effect of insulin to inhibit isoproterenol-dependent phosphorylation of phospholipid methyltransferase in isolated adipocytes

scientific article published on 01 November 1987

A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse

scientific article published on 21 May 2015

Activation of partially purified rat liver lipid methyltransferase by phosphorylation

scientific article published in August 1984

Analysis of the inhibitor binding to the nucleoside site of phosphorylase

scientific article published in 1984

Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells

scientific article

Cell surface CD28 levels define four CD4+ T cell subsets: abnormal expression in rheumatoid arthritis.

scientific article published on May 2001

Changes in the balance between mitogenic and antimitogenic lipid second messengers during proliferation, cell arrest, and apoptosis in T-lymphocytes.

scientific article

Conformational changes required in the human growth hormone receptor for growth hormone signaling.

scientific article published on April 1997

Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors

scientific article published on 22 June 2019

Diacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8+ T Cells with Broad Antitumor Capacity.

scientific article

Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway.

scientific article

Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development.

scientific article published in April 2002

Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes

scientific article

Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression.

scientific article published on January 2009

Diacylglycerol kinase control of protein kinase C

scientific article published on 18 April 2019

Diacylglycerol kinase α inactivation is an integral component of the costimulatory pathway that amplifies TCR signals.

scientific article

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.

scientific article

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

scientific article

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.

scientific article published on 21 September 2011

Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes

scientific article published on 01 November 2020

Diacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells.

scientific article published on 20 December 2016

Diacylglycerol kinase ζ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse

scientific article published on 14 April 2020

Diacylglycerol kinase ζ: at the crossroads of lipid signaling and protein complex organization.

scientific article

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

scientific article

Diacylglycerol kinases in cancer.

scientific article

Diacylglycerol kinases: at the hub of cell signalling

scientific article

Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation

scientific article published on 7 November 2013

Diacylglycerol, when simplicity becomes complex.

scientific article published on 8 December 2006

Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

scientific article

Different phosphorylated forms of an insulin-sensitive glycosylphosphatidylinositol from rat hepatocytes

scientific article published on 01 August 1988

Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2.

scientific article published on April 1995

Dual role of ceramide in the control of apoptosis following IL-2 withdrawal.

scientific article

Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity

scientific article (publication date: 16 August 2002)

Editorial: Diacylglycerol Kinase Signalling.

scientific article published on 21 September 2017

Effects of alloxan on S-adenosylmethionine metabolism in the rat liver

scientific article published in July 1986

Enterotoxin septic shock protection and deficient T helper 2 cytokine production in growth hormone transgenic mice

scientific article published on 01 October 1996

Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.

scientific article

Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension

scientific article published on 02 January 2001

Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells

scientific article published in Journal of Biological Chemistry

FoxO-dependent regulation of diacylglycerol kinase α gene expression

scientific article

Glucose transport and antilipolysis are differentially regulated by the polar head group of an insulin-sensitive glycophospholipid

scientific article

Identification of insulin-like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3

scientific article published on 01 October 1997

Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol.

scientific article

Inhibition by insulin of glucagon-dependent phospholipid methyltransferase phosphorylation in rat hepatocytes

scientific article published on 01 April 1987

Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol

scientific article (publication date: 11 June 1999)

Interleukin-2 stimulates a late increase in phosphatidic acid production in the absence of phospholipase D activation.

scientific article published on August 1998

Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway

scientific article published in Journal of Biological Chemistry

Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis

scientific article

Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes.

scientific article published on September 1996

Membrane translocation of protein kinase Ctheta during T lymphocyte activation requires phospholipase C-gamma-generated diacylglycerol

scientific article published on 8 May 2003

Modulation by the ratio S-adenosylmethionineS-adenosylhomocysteine of cyclic AMP-dependent phosphorylation of the 50 kDa protein of rat liver phospholipid methyltransferase

scientific article published in December 1985

Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid

scientific article

Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation

scientific article

Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells

scientific article

Phospholipid methyltransferase phosphorylation by intact hepatocytes: Effect of glucagon

scientific article published in August 1985

Predominant contribution of DGKζ over DGKα in the control of PKC/PDK-1-regulated functions in T cells.

scientific article

Protein and lipid kinase activation cascades in interleukin-2 receptor signalling.

scientific article published in October 1993

Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes

scientific article

Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling

scientific article

Protooncogene-encoded protein kinases in interleukin-2 signal transduction.

scientific article

Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions

scientific article published on 28 April 2015

Regulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid products

scientific journal article

Regulation of interleukin 2-dependent growth responses by glycosylphosphatidylinositol molecules

scientific article

Role of diacylglycerol kinase alpha in the attenuation of receptor signaling

scientific article

Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells

scientific article published on 02 October 2007

SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes

scientific article published on 27 November 2017

Shaping up the membrane: diacylglycerol coordinates spatial orientation of signaling.

scientific article published on 27 July 2011

Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse

scientific article

T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation

scientific article (publication date: 15 March 2003)

T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells

scientific article

The identification of phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and its regulation by interleukin-2.

scientific article

The membrane proximal segment of the IL-2 receptor beta-chain acidic region is essential for IL2-dependent protein tyrosine kinase activation

scientific article published on 01 April 1994

The role of diacylglycerol kinase activation and phosphatidate accumulation in interleukin-2-dependent lymphocyte proliferation.

scientific article published on July 1993

The serine-rich cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation.

scientific article published on March 1993

Transcriptional Activity of FOXO Transcription Factors Measured by Luciferase Assays

scientific article published on 01 January 2019

Translocation dynamics of sorting nexin 27 in activated T cells ⬇️

scientific article published on February 8, 2011

Vasopressin-stimulated phosphorylation of rat liver phospholipid methyltransferase in isolated hepatocytes

scientific article published on 17 February 1986

c-Abl Tyrosine Kinase Regulates Serum-induced Nuclear Export of Diacylglycerol Kinase α by Phosphorylation at Tyr-218 ⬇️

scientific article published on December 23, 2011

List of works by Isabel Mérida

A Blk-p190RhoGAP signaling module downstream of activated Gα13 functionally opposes CXCL12-stimulated RhoA activation and cell invasion

A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex

A new role of diacylglycerol kinase alpha on the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes

A phospho-oligosaccharide mimics the effect of insulin to inhibit isoproterenol-dependent phosphorylation of phospholipid methyltransferase in isolated adipocytes

A role for novel lipid interactions in the dynamic recruitment of SNX27 to the T-cell immune synapse

Activation of partially purified rat liver lipid methyltransferase by phosphorylation

Analysis of the inhibitor binding to the nucleoside site of phosphorylase

Beta2-chimaerin provides a diacylglycerol-dependent mechanism for regulation of adhesion and chemotaxis of T cells

Cell surface CD28 levels define four CD4+ T cell subsets: abnormal expression in rheumatoid arthritis.

Changes in the balance between mitogenic and antimitogenic lipid second messengers during proliferation, cell arrest, and apoptosis in T-lymphocytes.

Conformational changes required in the human growth hormone receptor for growth hormone signaling.

Diacylglycerol Kinase Malfunction in Human Disease and the Search for Specific Inhibitors

Diacylglycerol Kinase ζ Limits Cytokine-dependent Expansion of CD8+ T Cells with Broad Antitumor Capacity.

Diacylglycerol is required for the formation of COPI vesicles in the Golgi-to-ER transport pathway.

Diacylglycerol kinase alpha activity promotes survival of CD4+ 8+ double positive cells during thymocyte development.

Diacylglycerol kinase alpha regulates the secretion of lethal exosomes bearing Fas ligand during activation-induced cell death of T lymphocytes

Diacylglycerol kinase alpha, from negative modulation of T cell activation to control of cancer progression.

Diacylglycerol kinase control of protein kinase C

Diacylglycerol kinase α inactivation is an integral component of the costimulatory pathway that amplifies TCR signals.

Diacylglycerol kinase α promotes 3D cancer cell growth and limits drug sensitivity through functional interaction with Src.

Diacylglycerol kinase α regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes

Diacylglycerol kinase ζ controls diacylglycerol metabolism at the immunological synapse.

Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes

Diacylglycerol kinase ζ limits the polarized recruitment of diacylglycerol-enriched organelles to the immune synapse in T cells.

Diacylglycerol kinase ζ promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse

Diacylglycerol kinase ζ: at the crossroads of lipid signaling and protein complex organization.

Diacylglycerol kinase-ζ regulates mTORC1 and lipogenic metabolism in cancer cells through SREBP-1

Diacylglycerol kinases in cancer.

Diacylglycerol kinases: at the hub of cell signalling

Diacylglycerol metabolism attenuates T-cell receptor signaling and alters thymocyte differentiation

Diacylglycerol, when simplicity becomes complex.

Diacylglycerol-dependent binding recruits PKCtheta and RasGRP1 C1 domains to specific subcellular localizations in living T lymphocytes.

Different phosphorylated forms of an insulin-sensitive glycosylphosphatidylinositol from rat hepatocytes

Differential effect of rapamycin and cyclosporin A in proliferation in a murine T cell line expressing either intermediate or high affinity receptor for IL-2.

Dual role of ceramide in the control of apoptosis following IL-2 withdrawal.

Dynamics of diacylglycerol kinase zeta translocation in living T-cells. Study of the structural domain requirements for translocation and activity

Editorial: Diacylglycerol Kinase Signalling.

Effects of alloxan on S-adenosylmethionine metabolism in the rat liver

Enterotoxin septic shock protection and deficient T helper 2 cytokine production in growth hormone transgenic mice

Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.

Evidence for the involvement of diacylglycerol kinase in the activation of hypoxia-inducible transcription factor 1 by low oxygen tension

Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells

FoxO-dependent regulation of diacylglycerol kinase α gene expression

Glucose transport and antilipolysis are differentially regulated by the polar head group of an insulin-sensitive glycophospholipid

Identification of insulin-like growth factor-binding protein-1 as a potential physiological substrate for human stromelysin-3

Importance of chroman ring and tyrosine phosphorylation in the subtype-specific translocation and activation of diacylglycerol kinase alpha by D-alpha-tocopherol.

Inhibition by insulin of glucagon-dependent phospholipid methyltransferase phosphorylation in rat hepatocytes

Interleukin-2 causes an increase in saturated/monounsaturated phosphatidic acid derived from 1,2-diacylglycerol and 1-O-alkyl-2-acylglycerol

Interleukin-2 stimulates a late increase in phosphatidic acid production in the absence of phospholipase D activation.

Intermediate Affinity Interleukin-2 Receptor Mediates Survival via a Phosphatidylinositol 3-Kinase-dependent Pathway

Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis

Linomide prevents the lethal effect of anti-Fas antibody and reduces Fas-mediated ceramide production in mouse hepatocytes.

Membrane translocation of protein kinase Ctheta during T lymphocyte activation requires phospholipase C-gamma-generated diacylglycerol

Modulation by the ratio S-adenosylmethionineS-adenosylhomocysteine of cyclic AMP-dependent phosphorylation of the 50 kDa protein of rat liver phospholipid methyltransferase

Modulation of the mammalian target of rapamycin pathway by diacylglycerol kinase-produced phosphatidic acid

Phosphatidic acid generation through interleukin 2 (IL-2)-induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation

Phosphoinositide binding by the SNX27 FERM domain regulates its localization at the immune synapse of activated T-cells

Phospholipid methyltransferase phosphorylation by intact hepatocytes: Effect of glucagon

Predominant contribution of DGKζ over DGKα in the control of PKC/PDK-1-regulated functions in T cells.

Protein and lipid kinase activation cascades in interleukin-2 receptor signalling.

Protein kinase D1/2 is involved in the maturation of multivesicular bodies and secretion of exosomes in T and B lymphocytes

Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling

Protooncogene-encoded protein kinases in interleukin-2 signal transduction.

Redundant and specialized roles for diacylglycerol kinases α and ζ in the control of T cell functions

Regulation of diacylglycerol kinase alpha by phosphoinositide 3-kinase lipid products

Regulation of interleukin 2-dependent growth responses by glycosylphosphatidylinositol molecules

Role of diacylglycerol kinase alpha in the attenuation of receptor signaling

Role of the diacylglycerol kinase alpha-conserved domains in membrane targeting in intact T cells

SNX27 links DGKζ to the control of transcriptional and metabolic programs in T lymphocytes

Shaping up the membrane: diacylglycerol coordinates spatial orientation of signaling.

Sorting nexin 27 interactome in T-lymphocytes identifies zona occludens-2 dynamic redistribution at the immune synapse

T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation

T cell receptor-dependent tyrosine phosphorylation of beta2-chimaerin modulates its Rac-GAP function in T cells

The identification of phosphatidylinositol 3,5-bisphosphate in T-lymphocytes and its regulation by interleukin-2.

The membrane proximal segment of the IL-2 receptor beta-chain acidic region is essential for IL2-dependent protein tyrosine kinase activation

The role of diacylglycerol kinase activation and phosphatidate accumulation in interleukin-2-dependent lymphocyte proliferation.

The serine-rich cytoplasmic domain of the interleukin-2 receptor beta chain is essential for interleukin-2-dependent tyrosine protein kinase and phosphatidylinositol-3-kinase activation.

Transcriptional Activity of FOXO Transcription Factors Measured by Luciferase Assays

Translocation dynamics of sorting nexin 27 in activated T cells ⬇️