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List of works by Thierry Chardès

35th Annual Meeting of the European Association for the Study of Diabetes

article

A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment

scientific article published on 15 April 2021

A constitutive nitric oxide synthase modulates insulin secretion in the INS-1 cell line

scientific article

A neuronal isoform of nitric oxide synthase expressed in pancreatic beta-cells controls insulin secretion

scientific article published in June 2001

A peptide mimetic of an anti-CD4 monoclonal antibody by rational design

scientific article published on 01 July 2003

A recombinant human monoclonal anti-R7V antibody as a potential therapy for HIV infected patients in failure of HAART.

scientific article

A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions

scientific article published on 18 February 2019

Amplification of the secretory IgA response to Toxoplasma gondii using cholera toxin

scientific article published on 01 July 1991

An auristatin-based antibody-drug conjugate targeting HER3 enhances the radiation response in pancreatic cancer

scientific article published on 01 April 2019

Anti-HER2 vaccines: new prospects for breast cancer therapy

scientific article

Anti-HER3 domain 1 and 3 antibodies reduce tumor growth by hindering HER2/HER3 dimerization and AKT-induced MDM2, XIAP, and FoxO1 phosphorylation.

scientific article published on March 2013

Anti-Müllerian hormone (AMH) autocrine signaling promotes survival and proliferation of ovarian cancer cells

scientific article published on 26 January 2021

Anti-digoxin scFv fragments expressed in bacteria and in insect cells have different antigen binding properties

scientific article

Antibody responses to Toxoplasma gondii in sera, intestinal secretions, and milk from orally infected mice and characterization of target antigens

scientific article published on May 1990

Application of the Spot method to the identification of peptides and amino acids from the antibody paratope that contribute to antigen binding

scientific article published in September 2002

Biasing HER4 Tyrosine Kinase Signaling with Antibodies: Induction of Cell Death by Antibody-Dependent 4ICD Trafficking

scientific article published on 16 May 2020

Biological activities on T lymphocytes of a baculovirus-expressed chimeric recombinant IgG1 antibody with specificity for the CDR3-like loop on the D1 domain of the CD4 molecule.

scientific article published on 19 January 2006

CD4 ligation excludes the Carma1-Bcl10-MALT1 complex from GM1-positive membrane rafts in CD3/CD28 activated T cells

scientific article published on 29 March 2011

Cellular and humoral recognition of Toxoplasma gondii P30 antigen and its cleavage fragments

scientific article published on 01 January 1992

Directed mutagenesis in region 713-720 of human thyroperoxidase assigns 713KFPED717 residues as being involved in the B domain of the discontinuous immunodominant region recognized by human autoantibodies

scientific article published on 18 May 2004

Efficient CD4 binding and immunosuppressive properties of the 13B8.2 monoclonal antibody are displayed by its CDR-H1-derived peptide CB1.

scientific article

Efficient amplification and direct sequencing of mouse variable regions from any immunoglobulin gene family

scientific article published on June 1999

Epitopic analysis of the Toxoplasma gondii major surface antigen SAG1

scientific article published on 01 July 1994

Evidence for two discontinuous regions on the thyrotropin receptor involved in the binding of the monoclonal antibody 34A.

scientific article

Examination of HER3 targeting in cancer using monoclonal antibodies

scientific article

HER3 as biomarker and therapeutic target in pancreatic cancer: new insights in pertuzumab therapy in preclinical models

scientific article

ITCH-dependent proteasomal degradation of c-FLIP induced by the anti-HER3 antibody 9F7-F11 promotes DR5/caspase 8-mediated apoptosis of tumor cells

scientific article published on 23 August 2019

Immunological characterization of a 17-kDa antigen from Cryptosporidium parvum recognized early by mucosal IgA antibodies.

scientific article published in November 1992

Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

scientific article published on 04 February 2019

In pancreatic carcinoma, dual EGFR/HER2 targeting with cetuximab/trastuzumab is more effective than treatment with trastuzumab/erlotinib or lapatinib alone: implication of receptors' down-regulation and dimers' disruption

scientific article published in February 2012

In vitro antitumoral activity of baculovirus-expressed chimeric recombinant anti-CD4 antibody 13B8.2 on T-cell lymphomas

scientific article published on February 2007

Local and systemic cellular immunity following oral infection of mice with Toxoplasma gondii cysts

scientific article published on 01 January 1992

Localization of the discontinuous immunodominant region recognized by human anti-thyroperoxidase autoantibodies in autoimmune thyroid diseases

scientific article published on 24 December 2002

Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects

scientific article published on 25 May 2016

Mapping of B epitopes in GRA4, a dense granule antigen of Toxoplasma gondii and protection studies using recombinant proteins administered by the oral route

scientific article published in April 1998

Mapping the paratope of anti-CD4 recombinant Fab 13B8.2 by combining parallel peptide synthesis and site-directed mutagenesis

scientific article

Molecular cloning of GRA4, a Toxoplasma gondii dense granule protein, recognized by mucosal IgA antibodies

scientific article

Monoclonal antibody 667 recognizes the variable region A motif of the ecotropic retrovirus CasBrE envelope glycoprotein and inhibits Env binding to the viral receptor

scientific article

Mucosal and systemic cellular immune responses induced by Toxoplasma gondii antigens in cyst orally infected mice

scientific article published on 01 March 1993

Mucosal immune response in toxoplasmosis

scientific article

Mucosal vaccination against toxoplasmosis

scientific article published on 01 January 1995

Neuregulin 1 Allosterically Enhances the Antitumor Effects of the Noncompeting Anti-HER3 Antibody 9F7-F11 by Increasing Its Binding to HER3.

scientific article published on 15 May 2017

Oral immunization with Toxoplasma gondii antigens in association with cholera toxin induces enhanced protective and cell-mediated immunity in C57BL/6 mice.

scientific article

PIN-bodies: a new class of antibody-like proteins with CD4 specificity derived from the protein inhibitor of neuronal nitric oxide synthase.

scientific article

Peritoneal macrophages from C57BL/6 mice orally immunized with Toxoplasma gondii antigens in association with cholera toxin possess an enhanced ability to inhibit parasite multiplication

scientific article published on 01 October 1995

Pertinence of kappa and lambda recombinant antibodies directed against thyroid peroxidase in thyroid autoimmune disease.

scientific article

Preclinical validation of AXL receptor as a target for antibody-based pancreatic cancer immunotherapy

scientific article

Production and characterization of monoclonal antibodies against human thyroglobulin

scientific article

Production and partial characterization of anti-Candida monoclonal antibodies

scientific article published on 01 March 1986

Protection against Chlamydia psittaci in mice conferred by Lyt-2+ T cells

scientific article published on October 1992

Protein inhibitor of neuronal nitric oxide synthase (PIN) is a new regulator of glucose-induced insulin secretion

scientific journal article

Recombinant anti-CD4 antibody 13B8.2 blocks membrane-proximal events by excluding the Zap70 molecule and downstream targets SLP-76, PLC gamma 1, and Vav-1 from the CD4-segregated Brij 98 detergent-resistant raft domains

scientific article published on 01 July 2007

Synthetic peptides derived from the variable regions of an anti-CD4 monoclonal antibody bind to CD4 and inhibit HIV-1 promoter activation in virus-infected cells

scientific article

Targeting the NRG1/HER3 pathway in tumor cells and cancer-associated fibroblasts with an anti-neuregulin 1 antibody inhibits tumor growth in pre-clinical models of pancreatic cancer

scientific article published in September 2018

The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation

scientific article published on 18 May 2016

The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells

scientific article

The chimeric mouse-human anti-CD4 Fab 13B8.2 expressed in baculovirus inhibits both antigen presentation and HIV-1 promoter activation

scientific article

The human Müllerian inhibiting substance type II receptor as immunotherapy target for ovarian cancer. Validation using the mAb 12G4.

scientific article

The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases

scientific article (publication date: June 2002)

The lipid-modulating effects of a CD4-specific recombinant antibody correlate with ZAP-70 segregation outside membrane rafts

scientific article published on 24 July 2010

Thyroid peroxidase autoantibodies obtained from random single chain FV libraries contain the same heavy/light chain combinations as occur in vivo.

scientific article published in November 2001

Time-resolved fluorescence resonance energy transfer (TR-FRET) to analyze the disruption of EGFR/HER2 dimers: a new method to evaluate the efficiency of targeted therapy using monoclonal antibodies

scientific article

Toxoplasma gondii oral infection induces specific cytotoxic CD8 alpha/beta+ Thy-1+ gut intraepithelial lymphocytes, lytic for parasite-infected enterocytes.

scientific article published on November 1994

Vaccination with human anti-trastuzumab anti-idiotype scFv reverses HER2 immunological tolerance and induces tumor immunity in MMTV.f.huHER2(Fo5) mice. ⬇️

scientific article

[Mimicking polyclonal immune response in therapy: from combination of two monoclonal antibodies to oligoclonal antibody-based mixtures]

scientific article published on 01 December 2019

[The HER3/ERBB3 receptor: the dark side of the ERBB planet].

scientific article

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