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List of works by Urmi Dhagat

A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.

scientific article

A salicylic acid-based analogue discovered from virtual screening as a potent inhibitor of human 20alpha-hydroxysteroid dehydrogenase.

scientific article published in November 2007

Activation of aldo-keto reductase family member 1B14 (AKR1B14) by bile acids: Activation mechanism and bile acid-binding site

scientific article published on 10 May 2011

Author Correction: EPO does not promote interaction between the erythropoietin and beta-common receptors

scientific article published on 21 May 2019

CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors

scientific article published on 14 December 2015

Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

scientific article

Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362.

scientific article published on 19 February 2014

Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody

scientific article

EPO does not promote interaction between the erythropoietin and beta-common receptors

scientific article published in Scientific Reports

Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant enzyme.

scientific article published on July 2010

Inhibition of 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors

scientific article published on 15 December 2007

Inhibitors of human 20α-hydroxysteroid dehydrogenase (AKR1C1).

scientific article

Molecular determinants for the stereospecific reduction of 3-ketosteroids and reactivity towards all-trans-retinal of a short-chain dehydrogenase/reductase (DHRS4)

scientific article

Role of the β Common (βc) Family of Cytokines in Health and Disease

scientific article

Signalling by the βc family of cytokines

scientific article published on 25 March 2013

Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate

scientific article published in March 2009

Structure-based optimization and biological evaluation of human 20α-hydroxysteroid dehydrogenase (AKR1C1) salicylic acid-based inhibitors.

scientific article published on 17 September 2010

Structure-guided design, synthesis, and evaluation of salicylic acid-based inhibitors targeting a selectivity pocket in the active site of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1).

scientific article published in May 2009

Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme

scientific article

The GM-CSF/IL-3/IL-5 cytokine receptor family: from ligand recognition to initiation of signaling

scientific article

The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities

scientific article published on 12 September 2018

The βc receptor family - Structural insights and their functional implications

scientific article published on 14 May 2015

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