List of works - Shaun Lott

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis

scientific journal article

Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2

scientific journal article

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

scientific article

The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device

scientific article published on 26 September 2013

A flexible and economical medium-throughput strategy for protein production and crystallization

scientific article

The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase

scientific journal article

The TB structural genomics consortium: providing a structural foundation for drug discovery.

scientific article

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation

scientific article

Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin

scientific journal article

A new Gateway vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis

scientific article published on 14 September 2007

3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity

scientific article published on 7 December 2011

High throughput crystallography of TB drug targets.

scientific article published on June 2007

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes

scientific journal article

Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

scientific article

The TB Structural Genomics Consortium: a decade of progress

scientific article published on 17 January 2011

Using secretion to solve a solubility problem: high-yield expression in Escherichia coli and purification of the bacterial glycoamidase PNGase F.

scientific article published in February 2002

Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga

scientific article

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

scientific article

The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate

scientific journal article

A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel

scientific article published in February 2002

Identification of extracellular siderophores and a related peptide from the endophytic fungus Epichloë festucae in culture and endophyte-infected Lolium perenne.

scientific article published on 22 December 2011

Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis

scientific article

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation

scientific article

Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif

scientific article published in August 2013

The potential impact of structural genomics on tuberculosis drug discovery

scientific article

A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

scientific article

The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis

scientific article

Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis.

scientific article published in February 2009

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

scientific article

The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition

scientific article

Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site.

scientific article published on 29 October 2012

Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis

scientific article published on 24 March 2005

Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

scientific article

Prediction of the substrate for nonribosomal peptide synthetase (NRPS) adenylation domains by virtual screening

scientific article published on 11 September 2015

Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation

scientific article

Protein structure prediction and analysis as a tool for functional genomics

scientific article published in January 2003

The cloning, expression and crystallisation of a thermostable arginase.

scientific article published in May 1996

Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis

scientific article

Structure of HisF, a histidine biosynthetic protein from Pyrobaculum aerophilum

scientific article

The gamma-subunit of the principal G-protein from squid (Loligo forbesi) photoreceptors contains a novel N-terminal sequence

scientific article

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis

scientific article

Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.

scientific article published on 24 December 2004

The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.

scientific article

Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis.

scientific article published on 21 July 2014

Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site

scientific article

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

scientific article published on 01 August 2018

Mycobacterial MenJ: An Oxidoreductase Involved in Menaquinone Biosynthesis

scientific article published on 27 August 2018

The mechanism of fluorinated anthranilate-induced growth inhibition in Mycobacterium tuberculosis

scientific article published on 26 November 2018

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

scientific article published on 26 April 2019

Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: using structural genomics tools for a challenging target

scientific article published on 15 August 2010

List of works by Shaun Lott

A highly conserved transcriptional repressor controls a large regulon involved in lipid degradation in Mycobacterium smegmatis and Mycobacterium tuberculosis

Cholesterol utilization in mycobacteria is controlled by two TetR-type transcriptional regulators: kstR and kstR2

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

The BC component of ABC toxins is an RHS-repeat-containing protein encapsulation device

A flexible and economical medium-throughput strategy for protein production and crystallization

The structure of MbtI from Mycobacterium tuberculosis, the first enzyme in the biosynthesis of the siderophore mycobactin, reveals it to be a salicylate synthase

The TB structural genomics consortium: providing a structural foundation for drug discovery.

Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation

Crystal Structure of AhpE from Mycobacterium tuberculosis, a 1-Cys peroxiredoxin

A new Gateway vector and expression protocol for fast and efficient recombinant protein expression in Mycobacterium smegmatis

3D structure of the Yersinia entomophaga toxin complex and implications for insecticidal activity

High throughput crystallography of TB drug targets.

The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes

Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

The TB Structural Genomics Consortium: a decade of progress

Using secretion to solve a solubility problem: high-yield expression in Escherichia coli and purification of the bacterial glycoamidase PNGase F.

Structural analysis of Chi1 Chitinase from Yen-Tc: the multisubunit insecticidal ABC toxin complex of Yersinia entomophaga

Inhibition studies of Mycobacterium tuberculosis salicylate synthase (MbtI)

The crystal structure of TrpD, a metabolic enzyme essential for lung colonization by Mycobacterium tuberculosis, in complex with its substrate phosphoribosylpyrophosphate

A single WW domain is the predominant mediator of the interaction between the human ubiquitin-protein ligase Nedd4 and the human epithelial sodium channel

Identification of extracellular siderophores and a related peptide from the endophytic fungus Epichloë festucae in culture and endophyte-infected Lolium perenne.

Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis

Interaction of serum- and glucocorticoid regulated kinase 1 (SGK1) with the WW-domains of Nedd4-2 is required for epithelial sodium channel regulation

Structure and dynamics of human Nedd4-1 WW3 in complex with the αENaC PY motif

The potential impact of structural genomics on tuberculosis drug discovery

A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography

The structure and unusual protein chemistry of hypoxic response protein 1, a latency antigen and highly expressed member of the DosR regulon in Mycobacterium tuberculosis

Making sense of a missense mutation: characterization of MutT2, a Nudix hydrolase from Mycobacterium tuberculosis, and the G58R mutant encoded in W-Beijing strains of M. tuberculosis.

The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.

The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition

Synthesis and evaluation of M. tuberculosis salicylate synthase (MbtI) inhibitors designed to probe plasticity in the active site.

Crystallization and preliminary X-ray crystallographic analysis of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Mycobacterium tuberculosis

Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex

Prediction of the substrate for nonribosomal peptide synthetase (NRPS) adenylation domains by virtual screening

Crystal structure of a truncated mutant of glucose-fructose oxidoreductase shows that an N-terminal arm controls tetramer formation

Protein structure prediction and analysis as a tool for functional genomics

The cloning, expression and crystallisation of a thermostable arginase.

Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis

Structure of HisF, a histidine biosynthetic protein from Pyrobaculum aerophilum

The gamma-subunit of the principal G-protein from squid (Loligo forbesi) photoreceptors contains a novel N-terminal sequence

Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis

Crystallization and preliminary X-ray crystallographic analysis of MbtI, a protein essential for siderophore biosynthesis in Mycobacterium tuberculosis.

The structure of an ancient conserved domain establishes a structural basis for stable histidine phosphorylation and identifies a new family of adenosine-specific kinases.

Crystal structure of PhnF, a GntR-family transcriptional regulator of phosphate transport in Mycobacterium smegmatis.

Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

Mycobacterial MenJ: An Oxidoreductase Involved in Menaquinone Biosynthesis

The mechanism of fluorinated anthranilate-induced growth inhibition in Mycobacterium tuberculosis

Cryo-EM structures of the pore-forming A subunit from the Yersinia entomophaga ABC toxin

Expression and purification of an adenylation domain from a eukaryotic nonribosomal peptide synthetase: using structural genomics tools for a challenging target