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List of works by Javier León

A novel mutation in ADAMTS13 of a child with Upshaw-Schulman Syndrome

scientific article published on 24 July 2014

A novel role of MNT as a negative regulator of REL and the NF-κB pathway

scientific article published on 08 January 2021

Apoptosis and mitotic arrest are two independent effects of the protein phosphatases inhibitor okadaic acid in K562 leukemia cells

scientific article published on 01 June 1999

CM363, a novel naphthoquinone derivative which acts as multikinase modulator and overcomes imatinib resistance in chronic myelogenous leukemia

scientific article

CTCF regulates growth and erythroid differentiation of human myeloid leukemia cells.

scientific article

Cloning and expression in minicells of the determinant of resistance to fosfomycin from the transposon Tn2921

scientific article published on 01 May 1984

Contributions of Myc to tumorigenesis

scientific article

Determination of viability of human cartilage allografts by a rapid and quantitative method not requiring cartilage digestion.

scientific article

Differential expression and phosphorylation of CTCF, a c-myc transcriptional regulator, during differentiation of human myeloid cells

scientific article published on 01 February 1999

Down-regulation of c-Myc and Max genes is associated to inhibition of protein phosphatase 2A in K562 human leukemia cells.

scientific article

Downregulation of hepatic albumin mRNA in response to induced hypercholesterolemia in rabbits

scientific article published on 01 September 1992

Expression of apolipoprotein e in cholesterol-loaded macrophages of extrahepatic tissues during experimental hypercholesterolemia

scientific article published on 01 January 1995

Expression of insulin-like growth factor receptor mRNA in rabbit atherosclerotic lesions

scientific article published on 01 April 1995

Foam cells from aorta and spleen overexpress apolipoprotein E in the absence of hypercholesterolemia

scientific article published on 01 March 1992

Fosfomycin inactivates its target enzyme in Escherichia coli cells carrying a fosfomycin resistance plasmid ⬇️

scientific article published on August 1, 1983

Fosfomycin resistance plasmids do not affect fosfomycin transport into Escherichia coli.

scientific article published on April 1982

Functional phosphorylation sites in the C-terminal region of the multivalent multifunctional transcriptional factor CTCF

scientific article

HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.

scientific article published on 15 January 2009

Hypercholesterolemia induces differential expression of rabbit apolipoprotein A and C genes

article

Identification of a candidate tumor-suppressor gene specifically activated during Ras-induced senescence.

scientific article

Induction of apolipoprotein E expression during erythroid differentiation of human K562 leukemia cells

scientific article published on 01 September 1993

Induction of apolipoprotein E gene expression in human and experimental atherosclerotic lesions

article

Inhibition of cell differentiation: a critical mechanism for MYC-mediated carcinogenesis?

scientific article published on 10 April 2009

Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes

scientific article (publication date: 30 June 2005)

Interferon Induces Up-regulation of Spi-1/PU.1 in Human Leukemia K562 Cells ⬇️

scientific article published on November 26, 1997

Kinetics of myc-max-mad gene expression during hepatocyte proliferation in vivo: Differential regulation of mad family and stress-mediated induction of c-myc.

scientific article published in February 2004

MXD1 localizes in the nucleolus, binds UBF and impairs rRNA synthesis.

scientific article published on 31 August 2016

MYC Oncogene Contributions to Release of Cell Cycle Brakes

scientific article published on 22 March 2019

MYC antagonizes the differentiation induced by imatinib in chronic myeloid leukemia cells through downregulation of p27KIP1 ⬇️

scientific article published on June 18, 2012

MYC in chronic myeloid leukemia: induction of aberrant DNA synthesis and association with poor response to imatinib.

scientific article published on April 2011

MYC oncogene in myeloid neoplasias.

scientific article published on 22 August 2012

Myc Roles in Hematopoiesis and Leukemia ⬇️

scientific article published on June 1, 2010

Myc and cell cycle control.

scientific article published on April 2014

Myc inhibits p27-induced erythroid differentiation of leukemia cells by repressing erythroid master genes without reversing p27-mediated cell cycle arrest

scientific article published on 6 October 2008

Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter

scientific article (publication date: 23 January 2003)

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27

Myeloid leukemia cell growth and differentiation are independent of mitogen-activated protein kinase ERK1/2 activation.

scientific article

NUMB inactivation confers resistance to imatinib in chronic myeloid leukemia cells.

scientific article

Novel triiodophenol derivatives induce caspase-independent mitochondrial cell death in leukemia cells inhibited by Myc.

scientific article published on May 2006

ODZ1 allows glioblastoma to sustain invasiveness through a Myc-dependent transcriptional upregulation of RhoA.

scientific article published on 19 September 2016

PU.1 expression is restored upon treatment of chronic myeloid leukemia patients.

scientific article published on 16 July 2008

Positive autoregulation of ras genes expression in fibroblasts ⬇️

scientific article published on October 27, 1997

SKP2 oncogene is a direct MYC target gene and MYC down-regulates p27(KIP1) through SKP2 in human leukemia cells.

scientific article

Sin3b interacts with Myc and decreases Myc levels

scientific article

Spi-1/PU.1 proto-oncogene induces opposite effects on monocytic and erythroid differentiation of K562 cells

scientific article published on 01 November 1998

Subcellular localization determines the protective effects of activated ERK2 against distinct apoptogenic stimuli in myeloid leukemia cells.

scientific article published on June 2004

Targeting of CTCF to the nucleolus inhibits nucleolar transcription through a poly(ADP-ribosyl)ation-dependent mechanism

scientific article

The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells

scientific article published on 09 January 2020

p21 as a transcriptional co-repressor of S-phase and mitotic control genes

scientific article

p21Cip1 and p27Kip1 induce distinct cell cycle effects and differentiation programs in myeloid leukemia cells.

scientific article published on 3 March 2005

p73 cooperates with Ras in the activation of MAP kinase signaling cascade.

scientific article

p73 plays a role in erythroid differentiation through GATA1 induction.

scientific article published on 9 June 2009

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