Search filters

List of works by Peter J Cullen

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

scientific article

A defect in the retromer accessory protein, SNX27, manifests by infantile myoclonic epilepsy and neurodegeneration

scientific article published on 17 April 2015

A heterodimeric SNX4:SNX7 SNX-BAR autophagy complex coordinates ATG9A trafficking for efficient autophagosome assembly

scientific article published on 08 June 2020

A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer

scientific article

A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer

scientific article

Actin-dependent endosomal receptor recycling

scientific article published on 15 September 2018

Acute inactivation of retromer and ESCPE-1 leads to time-resolved defects in endosomal cargo sorting

scientific article published on 03 August 2020

Analyzing the role of the putative inositol 1,3,4,5-tetrakisphosphate receptor GAP1IP4BP in intracellular Ca2+ homeostasis.

scientific article

Atypical parkinsonism-associated retromer mutant alters endosomal sorting of specific cargo proteins.

scientific article published on August 2016

Bridging the GAP in inositol 1,3,4,5-tetrakisphosphate signalling.

scientific article published in December 1998

CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway

scientific article

Calcium signalling: the ups and downs of protein kinase C

scientific article published on 01 September 2003

Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins

scientific article (publication date: June 2001)

Clathrin is not required for SNX-BAR-retromer-mediated carrier formation.

scientific article published on 26 September 2012

Coincidence detection in phosphoinositide signaling.

scientific article

Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing

scientific article published on January 2004

Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1IP4BP and GAP1m result from the GAP1IP4BP PH domain directing plasma membrane targeting.

scientific article published in December 1997

Electroporation can cause artefacts due to solubilization of cations from the electrode plates. Aluminum ions enhance conversion of inositol 1,3,4,5-tetrakisphosphate into inositol 1,4,5-trisphosphate in electroporated L1210 cells.

scientific article published on August 1991

Endosomal Retrieval of Cargo: Retromer Is Not Alone

scientific article published on 30 July 2018

Engineering the phosphoinositide-binding profile of a class I pleckstrin homology domain.

scientific article published on 28 July 2003

Epigenetic silencing of a Ca(2+)-regulated Ras GTPase-activating protein RASAL defines a new mechanism of Ras activation in human cancers.

scholarly article

GAP1 family members constitute bifunctional Ras and Rap GTPase-activating proteins

scientific article published on 23 January 2006

GAP1IP4BP contains a novel group I pleckstrin homology domain that directs constitutive plasma membrane association.

scientific article

GFP fusion proteins to study signaling in live cells

scientific article published on 01 January 2004

Heparin inhibits the inositol 1,4,5-trisphosphate-induced Ca2+ release from rat liver microsomes

scientific article published on 01 February 1988

IP3 3-kinase opposes NGF driven neurite outgrowth

scientific article (publication date: 2012)

Identification of a Ras GTPase-activating protein regulated by receptor-mediated Ca2+ oscillations

scientific article

Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling

scientific article

Inositol 1,3,4,5-tetrakisphosphate and Ca2+ homoeostasis: the role of GAPIIP4BP ⬇️

scientific article published on August 1, 1997

Inositol 1,3,4,5-tetrakisphosphate binding sites in neuronal and non-neuronal tissues. Properties, comparisons and potential physiological significance ⬇️

scientific article published on November 15, 1992

Inositol 1,3,4,5-tetrakisphosphate controls proapoptotic Bim gene expression and survival in B cells

scientific article

Inositol phosphates - whither bound? Intracellular signalling.

scientific article published on May 1996

Insulin-dependent translocation of ARNO to the plasma membrane of adipocytes requires phosphatidylinositol 3-kinase ⬇️

scientific article published on April 9, 1998

Integration of calcium and Ras signalling.

scientific article

Intracellular membrane traffic at high resolution.

scientific article

Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1

scientific article published on 25 August 2020

Membrane Curvature: The Power of Bananas, Zeppelins and Boomerangs

scientific article published on 01 June 2007

Membrane association, localization and topology of rat inositol 1,4,5-trisphosphate 3-kinase B: implications for membrane traffic and Ca2+ homoeostasis.

scientific article published on June 1997

Membrane targeting: what a difference a G makes

scientific article published on 01 November 2000

Membrane-associated cargo recycling by tubule-based endosomal sorting.

scientific article published on 15 March 2014

Modulation of Ins(2,4,5)P3-stimulated Ca2+ mobilization by Ins(1,3,4,5)P4: enhancement by activated G-proteins, and evidence for the involvement of a GAP1 protein, a putative Ins(1,3,4,5)P4 receptor ⬇️

scientific article published on May 1, 1998

Molecular basis for SNX-BAR-mediated assembly of distinct endosomal sorting tubules

scientific article

Molecular cloning and functional characterization of a human homologue of centaurin-alpha

scientific article

Molecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins

scientific article published on 01 October 2019

Molecular modelling and site-directed mutagenesis of the inositol 1,3,4,5-tetrakisphosphate-binding pleckstrin homology domain from the Ras GTPase-activating protein GAP1IP4BP

scientific article published on July 2000

Neuropilin-1 is a host factor for SARS-CoV-2 infection

scientific article published on 20 October 2020

Parkinson's disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

scientific journal article

Peter Cullen: nexins have it sorted

scientific article published on May 2014

Phosphoinositides and the regulation of tubular-based endosomal sorting

scientific article published on 01 August 2011

Phosphoinositides in the mammalian endo-lysosomal network

scientific article

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

scientific article

Purification and characterization of an Ins(1,3,4,5)P4 binding protein from pig platelets: possible identification of a novel non-neuronal Ins(1,3,4,5)P4 receptor

scientific article published on January 1995

Recent advances in retromer biology

scientific article

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

scientific article published on 11 September 2017

Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation.

scientific article published on 21 July 2014

Retromer and sorting nexins in endosomal sorting

scientific article

Retromer associates with the cytoplasmic amino-terminus of polycystin-2

scientific article published on 06 June 2018

Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation

scientific article

Retromer- and WASH-dependent sorting of nutrient transporters requires a multivalent interaction network with ANKRD50.

scientific article published on December 2016

Retromer: a master conductor of endosome sorting

scientific article

SNX-BAR proteins in phosphoinositide-mediated, tubular-based endosomal sorting.

scientific article

SNX15 links clathrin endocytosis to the PtdIns3P early endosome independently of the APPL1 endosome.

scientific article

SNX17 protects integrins from degradation by sorting between lysosomal and recycling pathways

scientific article published on 9 April 2012

SNX27-Retromer directly binds ESCPE-1 to transfer cargo proteins during endosomal recycling

scientific article published on 13 April 2022

SNX3-retromer requires an evolutionary conserved MON2:DOPEY2:ATP9A complex to mediate Wntless sorting and Wnt secretion

scientific article published in Nature Communications

SNX4 coordinates endosomal sorting of TfnR with dynein-mediated transport into the endocytic recycling compartment

scientific article

SNX–BAR‐Mediated Endosome Tubulation is Co‐ordinated with Endosome Maturation ⬇️

scientific article published on October 31, 2011

Sequence-dependent cargo recognition by SNX-BARs mediates retromer-independent transport of CI-MPR.

scientific article

Sorting nexin-1 defines an early phase of Salmonella-containing vacuole-remodeling during Salmonella infection

scientific article published on 27 May 2008

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides

scientific article

Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport

scientific article

Sorting nexin-21 is a scaffold for the endosomal recruitment of huntingtin

scientific article published on 10 September 2018

Sorting nexins provide diversity for retromer-dependent trafficking events ⬇️

scientific article published on December 22, 2011

Specificity of the purified inositol (1,3,4,5) tetrakisphosphate-binding protein from porcine platelets

scientific article published on 01 January 1995

Structural and Functional Analysis of the Putative Inositol 1,3,4,5-Tetrakisphosphate Receptors GAP1IP4BPand GAP1m ⬇️

scientific article published on September 8, 1998

Structural insights into the architecture and membrane interactions of the conserved COMMD proteins

scientific article published on 01 August 2018

Studying the spatial and temporal regulation of Ras GTPase-activating proteins

scientific article published on 01 January 2006

TFEB controls retromer expression in response to nutrient availability

scientific article published on 06 November 2019

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage

scientific article published on 01 April 1989

Thapsigargin, a novel molecular probe for studying intracellular calcium release and storage. 1989.

scientific article published in December 1994

The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport

scientific article

The Phosphatidylinositol 3,4,5-trisphosphate (PI(3,4,5)P3) Binder Rasa3 Regulates Phosphoinositide 3-kinase (PI3K)-dependent Integrin αIIbβ3 Outside-in Signaling.

scientific article

The ability of GAP1IP4BP to function as a Rap1 GTPase-activating protein (GAP) requires its Ras GAP-related domain and an arginine finger rather than an asparagine thumb.

scientific article

The emerging role of retromer in neuroprotection

scientific article published on 8 April 2017

The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade.

scientific article

The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.

scientific article

The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation

scientific article (publication date: 13 December 2002)

The retromer coat complex coordinates endosomal sorting and dynein-mediated transport, with carrier recognition by the trans-Golgi network

scientific article

The retromer complex

scientific article

The retromer component sorting nexin-1 is required for efficient retrograde transport of Shiga toxin from early endosome to the trans Golgi network.

scientific article

To degrade or not to degrade: mechanisms and significance of endocytic recycling

scientific article published on 01 November 2018

Will the real IP4 receptor please stand up?

scientific article published on 01 August 1993

Paulina is supported by:

About Paulina

Help