Search filters

List of works by Lionel B Ivashkiv

'-Omics' shed light on B cells in lupus

scientific article published on 01 August 2019

'Tuning' of type I interferon-induced Jak-STAT1 signaling by calcium-dependent kinases in macrophages

scientific article

A novel regulatory role for stromal-derived factor-1 signaling in bone morphogenic protein-2 osteogenic differentiation of mesenchymal C2C12 cells

scientific article published on 17 April 2007

A signal-switch hypothesis for cross-regulation of cytokine and TLR signalling pathways

scientific article published on October 2008

A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis

scientific article

Amplification of IFN-alpha-induced STAT1 activation and inflammatory function by Syk and ITAM-containing adaptors

scientific article published on 3 October 2004

Apoptotic cells inhibit LPS-induced cytokine and chemokine production and IFN responses in macrophages.

scientific article published on 08 January 2007

Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.

scientific article published on 24 September 2010

BET bromodomain inhibition suppresses transcriptional responses to cytokine-Jak-STAT signaling in a gene-specific manner in human monocytes.

scientific article published on December 2014

CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes

scientific article published on 01 January 2022

Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages

scientific article

Can SOCS make arthritis better?

scientific article

Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges

publication published on 11 March 2022

Costimulation of chemokine receptor signaling by matrix metalloproteinase-9 mediates enhanced migration of IFN-alpha dendritic cells

scientific article published on 01 May 2006

Cross-regulation of signaling by ITAM-associated receptors

scientific article published on 19 March 2009

Cross-regulation of signaling pathways by interferon-gamma: implications for immune responses and autoimmune diseases

scientific article published on October 2009

Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation

scientific article published on 14 May 2007

Cutting Edge: EZH2 Promotes Osteoclastogenesis by Epigenetic Silencing of the Negative Regulator IRF8.

scientific article published on 29 April 2016

Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption.

scientific article

Differential interleukin-6/Stat3 signaling as a function of cellular context mediates Ras-induced transformation ⬇️

scientific article published on October 7, 2010

Direct Inhibition of Human RANK+ Osteoclast Precursors Identifies a Homeostatic Function of IL-1β ⬇️

scientific article published on October 8, 2010

Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models.

scientific article published on 13 February 2018

Downregulation of Friend Leukemia Virus Integration 1 as a Feedback Mechanism That Restrains Lipopolysaccharide Induction of Matrix Metalloproteases and Interleukin-10 in Human Macrophages ⬇️

scientific article published on September 29, 2010

Dysregulation of interleukin-10-dependent gene expression in rheumatoid arthritis synovial macrophages.

scientific article

Epigenetic Regulation of Myeloid Cells

scientific article published on June 2016

Epigenetic regulation of macrophage polarization and function

scientific article published on 04 December 2012

Expression and function of semaphorin 3A and its receptors in human monocyte-derived macrophages

scientific article

Expression profiling reveals alternative macrophage activation and impaired osteogenesis in periprosthetic osteolysis

scientific article published on 01 January 2008

FcgammaRIII-dependent inhibition of interferon-gamma responses mediates suppressive effects of intravenous immune globulin

scientific article

Feedback inhibition of osteoclastogenesis during inflammation by IL-10, M-CSF receptor shedding, and induction of IRF8

scientific article

Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.

scientific article published on 23 February 2018

HBEGF macrophages in rheumatoid arthritis induce fibroblast invasiveness

scientific article published on 01 May 2019

Homeostatic role of interferons conferred by inhibition of IL-1-mediated inflammation and tissue destruction

scientific article published on 01 July 2005

How ITAMs inhibit signaling

scientific article published on 19 April 2011

Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis

scientific article published in July 2017

IFN-alpha priming results in a gain of proinflammatory function by IL-10: implications for systemic lupus erythematosus pathogenesis

scientific article

IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways

scientific article

IFN-gamma suppresses IL-10 production and synergizes with TLR2 by regulating GSK3 and CREB/AP-1 proteins.

scientific article

IFN-gamma-primed macrophages exhibit increased CCR2-dependent migration and altered IFN-gamma responses mediated by Stat1

scientific article published on 01 September 2005

IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages.

scientific article published on September 2016

IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling ⬇️

scientific article published on October 25, 2010

IFN-γ selectively suppresses a subset of TLR4-activated genes and enhancers to potentiate macrophage activation

scientific article published on 25 July 2019

IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy

scientific article published on 01 September 2018

IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression

scientific article published on 22 July 2009

IL-27 activates human monocytes via STAT1 and suppresses IL-10 production but the inflammatory functions of IL-27 are abrogated by TLRs and p38

scientific article published on 01 May 2008

ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes

scientific article

Implication of the Association of Fibrinogen Citrullination and Osteoclastogenesis in Bone Destruction in Rheumatoid Arthritis

scientific article published on 20 December 2020

Indirect inhibition of Toll-like receptor and type I interferon responses by ITAM-coupled receptors and integrins.

scientific article

Inflammatory signaling in macrophages: transitions from acute to tolerant and alternative activation states

scientific article published on September 2011

Inhibition of IFN-alpha signaling by a PKC- and protein tyrosine phosphatase SHP-2-dependent pathway

scientific article

Inhibition of IFN-gamma signaling by glucocorticoids

scientific article published on 01 May 2003

Inhibition of IL-6 signaling by a p38-dependent pathway occurs in the absence of new protein synthesis

scientific article published in July 2002

Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors

scientific article

Inhibition of interleukin 10 signaling after Fc receptor ligation and during rheumatoid arthritis

scientific article

Inhibition of osteoclastogenesis and inflammatory bone resorption by targeting BET proteins and epigenetic regulation

scientific article

Insights into rheumatic diseases from next-generation sequencing

scientific article published on 01 June 2019

Insoluble immune complexes are most effective at triggering IL-10 production in human monocytes and synergize with TLR ligands and C5a.

scientific article

Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways

scientific article published on 30 October 2008

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

scientific article published on 30 August 2009

Interferon target-gene expression and epigenomic signatures in health and disease

scientific article published on 19 November 2019

Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.

scientific article

Interferon-γ regulates cellular metabolism and mRNA translation to potentiate macrophage activation

scientific article published on 29 June 2015

Interleukin-10-induced gene expression and suppressive function are selectively modulated by the PI3K-Akt-GSK3 pathway.

scientific article

Interleukin-27 inhibits human osteoclastogenesis by abrogating RANKL-mediated induction of nuclear factor of activated T cells c1 and suppressing proximal RANK signaling.

scientific article published on February 2010

Intravenous Immunoglobulin (IVIG) Attenuates TNF-Induced Pathologic Bone Resorption and Suppresses Osteoclastogenesis by Inducing A20 Expression.

scientific article published on 17 July 2015

Involvement of complement receptor 3 (CR3) and scavenger receptor in macrophage responses to wear debris

scientific article published on 01 November 2006

Kinase inhibitors: a new tool for the treatment of rheumatoid arthritis.

scientific article published on 17 April 2013

Kinetics of IL-10-induced gene expression in human macrophages

scientific article published on January 2005

Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1.

scientific article published on October 2008

Machine learning integration of rheumatoid arthritis synovial histology and RNAseq data identifies three disease subtypes.

scientific article published on 22 February 2018

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

scholarly article by Peter J. Murray et al published August 2014 in Immunity

Macrophage activation and polarization: nomenclature and experimental guidelines

scientific article (publication date: 17 July 2014)

Metabolic-epigenetic coupling in osteoclast differentiation

scientific article published on March 2015

Methods for high-dimensonal analysis of cells dissociated from cyropreserved synovial tissue

scientific article published on 11 July 2018

Modulation of TNF-induced macrophage polarization by synovial fibroblasts.

scientific article

Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling

scientific article

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

scientific article published on 28 July 2011

New mechanisms of action and signaling by TNF-α

scientific article published on 9 February 2012

Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

scientific article

Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages

scientific article published on 25 August 2016

Overview of the biology of type I interferons

scientific article

PTPN22 in autoimmunity: different cell and different way.

scientific article

Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis

scientific article

Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages

scientific article

Prolonged tumor necrosis factor α primes fibroblast-like synoviocytes in a gene-specific manner by altering chromatin.

scientific article published on January 2015

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

scientific article published on 20 October 2014

RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes

scientific article published on 13 February 2016

RBP-J-Regulated miR-182 Promotes TNF-α-Induced Osteoclastogenesis.

scientific article published on 09 May 2016

Regulation of STAT pathways and IRF1 during human dendritic cell maturation by TNF-alpha and PGE2.

scientific article published on 04 August 2008

Regulation of age-associated B cells by IRF5 in systemic autoimmunity.

scientific article published on 26 February 2018

Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors

scientific article published on December 2012

Regulation of interferon and Toll-like receptor signaling during macrophage activation by opposing feedforward and feedback inhibition mechanisms

scientific article published on December 2008

Regulation of macrophage phenotype by long-term exposure to IL-10.

scientific article

Regulation of macrophage-mediated chronic inflammation by JAK inhibitors.

scientific article published on 9 February 2012

Regulation of type I interferon responses

scientific article

Repression of Constitutive and Interferon-gamma-Induced Class II Major Histocompatibility Complex Genes by Cyclic AMP and Prostaglandins

scientific article published on 01 September 1995

Reprogramming of IL-10 activity and signaling by IFN-gamma.

scientific article published on November 2003

Rheumatoid arthritis synoviocyte survival is dependent on Stat3.

scientific article published in December 2002

Role of STAT3 in type I interferon responses. Negative regulation of STAT1-dependent inflammatory gene activation

scientific article published on 29 March 2006

Roles of semaphorins in the immune and hematopoietic system

scientific article published on 13 January 2009

STAT activation during viral infection in vivo: where's the interferon?

scientific article published on August 2010

Selective regulation of IL-10 signaling and function by zymosan

scientific article published on 01 April 2006

Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19

scientific article published in 2022

Sensitization of IFN-γ Jak-STAT signaling during macrophage activation

scientific article published on 12 August 2002

Signaling by STATs

scientific article

Single-cell RNA-seq of rheumatoid arthritis synovial tissue using low-cost microfluidic instrumentation.

scientific article published on 23 February 2018

Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27

scientific article

Suppression of the effector phase of inflammatory arthritis by double-stranded RNA is mediated by type I IFNs

scientific article published on 01 February 2007

Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling

scientific article published on 5 September 2013

Synovial fibroblasts display an uncontrolled inflammatory and tissue destructive response to TNF-α

Systemic lupus erythematosus monocytes are less responsive to interleukin‐10 in the presence of immune complexes ⬇️

scientific article published on January 1, 2011

TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease

scientific article published on 01 November 2005

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

article

TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages

scientific article

TNF biology, pathogenic mechanisms and emerging therapeutic strategies

scientific article

TNF-induced inflammatory genes escape repression in fibroblast-like synoviocytes: transcriptomic and epigenomic analysis

scientific article published on 16 May 2019

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.

scientific article published on 16 January 2012

Targeting cytokines in inflammatory diseases: focus on interleukin-1-mediated autoinflammation

scientific article

The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair

scientific article published on 11 July 2019

The JAK/STAT pathway in rheumatoid arthritis: Pathogenic or protective?

scientific article published on 01 August 2003

The conserved Leu-724 residue is required for both serine phosphorylation and co-activator recruitment for Stat1-mediated transcription activation in response to interferon-gamma

scientific article

The hypoxia-lactate axis tempers inflammation

scientific article published on 01 February 2020

The interferon signature and STAT1 expression in rheumatoid arthritis synovial fluid macrophages are induced by tumor necrosis factor α and counter-regulated by the synovial fluid microenvironment

scientific article published on October 2012

The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate

scientific article

The type I interferon signaling pathway is a target for glucocorticoid inhibition.

scientific article published on 2 August 2010

Tumor Necrosis Factor dynamically regulates the mRNA stabilome in rheumatoid arthritis fibroblast-like synoviocytes

scientific article published on 14 July 2017

Tumor necrosis factor induces GSK3 kinase-mediated cross-tolerance to endotoxin in macrophages

scientific article published on 22 May 2011

Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts

scientific article published on April 2013

Twist mediates suppression of inflammation by type I IFNs and Axl

scientific journal article

Type I interferon modulation of cellular responses to cytokines and infectious pathogens: potential role in SLE pathogenesis

scientific article published on December 2003

Type I interferon: a new player in TNF signaling

scientific article published on 18 February 2010

Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation

scientific article published on 21 August 2017

Use of RNA sequencing to evaluate rheumatic disease patients

scientific article

Wear debris inhibition of anti-osteoclastogenic signaling by interleukin-6 and interferon-gamma. Mechanistic insights and implications for periprosthetic osteolysis

scientific article published in April 2006

iRHOM2 is a critical pathogenic mediator of inflammatory arthritis

scientific article published on 25 January 2013

Paulina is supported by:

About Paulina

Help