List of works - Carine Ali

2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo

scientific article published in October 2004

A Transforming Growth Factor-β Antagonist Unmasks the Neuroprotective Role of This Endogenous Cytokine in Excitotoxic and Ischemic Brain Injury

scientific article published on 01 December 1999

ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function.

scientific article

Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death.

scientific article published on 23 June 2017

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

scientific article published in October 2012

Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact

scientific article published on 02 July 2009

Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin

scientific article published on 16 September 2008

Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory.

scientific article

Antibodies preventing the interaction of tissue-type plasminogen activator with N-methyl-D-aspartate receptors reduce stroke damages and extend the therapeutic window of thrombolysis.

scientific article published on 16 June 2011

Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling

scientific article published on 23 September 2004

Distal occlusion of the middle cerebral artery in mice: are we ready to assess long-term functional outcome?

scientific article published on 09 January 2013

Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation

scientific article published on 16 January 2007

Functional occurrence of the interaction of tissue plasminogen activator with the NR1 Subunit of N-methyl-D-aspartate receptors during stroke

scientific article published on 21 October 2010

GluN2D subunit-containing NMDA receptors control tissue plasminogen activator-mediated spatial memory.

scientific article published in September 2012

HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator

scientific article published on 24 May 2011

High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate

scientific article

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-D-aspartate glutamate receptors improves hemorrhagic stroke outcome

scientific article published on 3 December 2012

Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator.

scientific article

Impacts of tissue-type plasminogen activator (tPA) on neuronal survival

scientific article

Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine against NMDA Receptor-Mediated Excitoxicity in the Brain

scientific article published on 01 June 2000

Longitudinal Molecular Magnetic Resonance Imaging of Endothelial Activation after Severe Traumatic Brain Injury

scientific article published on 30 July 2019

Memantine improves safety of thrombolysis for stroke

scientific article published on 9 August 2012

Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack

scientific article published on 8 November 2016

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

scientific article

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity

scientific article published on 13 November 2009

NURR1 involvement in recombinant tissue-type plasminogen activator treatment complications after ischemic stroke.

scientific article published on 11 December 2014

Neurobehavioral and immunological consequences of prenatal immune activation in rats. Influence of antipsychotics.

scientific article

Neuroprotection and stroke: time for a compromise

scientific article published on 28 August 2007

Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway.

scientific article published on May 2001

Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis

scientific article

Newborn- and adult-derived brain microvascular endothelial cells show age-related differences in phenotype and glutamate-evoked protease release

scientific article

PPACK-Desmodus rotundus salivary plasminogen activator (cDSPAα1) prevents the passage of tissuetype plasminogen activator (rt-PA) across the blood-brain barrier and neurotoxicity

scientific article published on 01 September 2009

Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults

scientific article

Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP.

scientific article published on 24 October 2011

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi

scientific article

Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects

scientific article

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

scientific article published on 5 October 2011

Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis

scientific article

Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism

scientific article published on 12 June 2015

Stroke and the immune system: from pathophysiology to new therapeutic strategies

scientific article published on May 2011

The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo

scientific article

The complexity of tissue-type plasminogen activator: can serine protease inhibitors help in stroke management?

scientific article published in August 2004

The plasminogen activation system in neuroinflammation

scientific article published on 19 October 2015

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

scientific article

The role of plasminogen activators in stroke treatment: fibrinolysis and beyond

scientific article published on 13 November 2018

Tissue plasminogen activator prevents white matter damage following stroke

scientific article

Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors.

scientific article

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

scientific article published on 25 April 2005

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic.

scientific article published on 27 October 2008

Tissue-type plasminogen activator rescues neurones from serum deprivation-induced apoptosis through a mechanism independent of its proteolytic activity

scientific article published on 27 June 2006

Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity.

scientific article

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.

scientific article

Transforming growth factor-beta and ischemic brain injury ⬇️

scientific article published on October 1, 2003

Transforming growth factor-beta signalling in brain disorders

scientific article

Traumatic brain injury: tissue-type plasminogen activator--harmful or beneficial?

scientific article published on 11 September 2012

Understanding the functions of endogenous and exogenous tissue-type plasminogen activator during stroke

scientific article

VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation

scientific article

tPA in the injured central nervous system: different scenarios starring the same actor?

scientific article

List of works by Carine Ali

2,7-Bis-(4-amidinobenzylidene)-cycloheptan-1-one dihydrochloride, tPA stop, prevents tPA-enhanced excitotoxicity both in vitro and in vivo

A Transforming Growth Factor-β Antagonist Unmasks the Neuroprotective Role of This Endogenous Cytokine in Excitotoxic and Ischemic Brain Injury

ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function.

Activation of cell surface GRP78 decreases endoplasmic reticulum stress and neuronal death.

Activation of microglial N-methyl-D-aspartate receptors triggers inflammation and neuronal cell death in the developing and mature brain

Age and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact

Anti-Mullerian-hormone-dependent regulation of the brain serine-protease inhibitor neuroserpin

Anti-NR1 N-terminal-domain vaccination unmasks the crucial action of tPA on NMDA-receptor-mediated toxicity and spatial memory.

Antibodies preventing the interaction of tissue-type plasminogen activator with N-methyl-D-aspartate receptors reduce stroke damages and extend the therapeutic window of thrombolysis.

Arginine 260 of the amino-terminal domain of NR1 subunit is critical for tissue-type plasminogen activator-mediated enhancement of N-methyl-D-aspartate receptor signaling

Distal occlusion of the middle cerebral artery in mice: are we ready to assess long-term functional outcome?

Excitotoxicity in a chronic model of multiple sclerosis: Neuroprotective effects of cannabinoids through CB1 and CB2 receptor activation

Functional occurrence of the interaction of tissue plasminogen activator with the NR1 Subunit of N-methyl-D-aspartate receptors during stroke

GluN2D subunit-containing NMDA receptors control tissue plasminogen activator-mediated spatial memory.

HMGB-1 promotes fibrinolysis and reduces neurotoxicity mediated by tissue plasminogen activator

High t-PA release by neonate brain microvascular endothelial cells under glutamate exposure affects neuronal fate

Immunotherapy blocking the tissue plasminogen activator-dependent activation of N-methyl-D-aspartate glutamate receptors improves hemorrhagic stroke outcome

Impact of alcohol consumption on the outcome of ischemic stroke and thrombolysis: role of the hepatic clearance of tissue-type plasminogen activator.

Impacts of tissue-type plasminogen activator (tPA) on neuronal survival

Ischemia-Induced Interleukin-6 as a Potential Endogenous Neuroprotective Cytokine against NMDA Receptor-Mediated Excitoxicity in the Brain

Longitudinal Molecular Magnetic Resonance Imaging of Endothelial Activation after Severe Traumatic Brain Injury

Memantine improves safety of thrombolysis for stroke

Molecular magnetic resonance imaging discloses endothelial activation after transient ischaemic attack

NMDA receptor activation inhibits alpha-secretase and promotes neuronal amyloid-beta production.

NR2D-containing NMDA receptors mediate tissue plasminogen activator-promoted neuronal excitotoxicity

NURR1 involvement in recombinant tissue-type plasminogen activator treatment complications after ischemic stroke.

Neurobehavioral and immunological consequences of prenatal immune activation in rats. Influence of antipsychotics.

Neuroprotection and stroke: time for a compromise

Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway.

Neurotrophin-3-induced PI-3 kinase/Akt signaling rescues cortical neurons from apoptosis

Newborn- and adult-derived brain microvascular endothelial cells show age-related differences in phenotype and glutamate-evoked protease release

PPACK-Desmodus rotundus salivary plasminogen activator (cDSPAα1) prevents the passage of tissuetype plasminogen activator (rt-PA) across the blood-brain barrier and neurotoxicity

Pharmacological activation/inhibition of the cannabinoid system affects alcohol withdrawal-induced neuronal hypersensitivity to excitotoxic insults

Pituitary adenylate cyclase-activating polypeptide (PACAP) stimulates the expression and the release of tissue plasminogen activator (tPA) in neuronal cells: involvement of tPA in the neuroprotective effect of PACAP.

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi

Recombinant Desmodus rotundus salivary plasminogen activator crosses the blood-brain barrier through a low-density lipoprotein receptor-related protein-dependent mechanism without exerting neurotoxic effects

Selective inhibition of GluN2D-containing N-methyl-D-aspartate receptors prevents tissue plasminogen activator-promoted neurotoxicity both in vitro and in vivo

Smad3-dependent induction of plasminogen activator inhibitor-1 in astrocytes mediates neuroprotective activity of transforming growth factor-beta 1 against NMDA-induced necrosis

Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism

Stroke and the immune system: from pathophysiology to new therapeutic strategies

The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivo

The complexity of tissue-type plasminogen activator: can serine protease inhibitors help in stroke management?

The plasminogen activation system in neuroinflammation

The proteolytic activity of tissue-plasminogen activator enhances NMDA receptor-mediated signaling.

The role of plasminogen activators in stroke treatment: fibrinolysis and beyond

Tissue plasminogen activator prevents white matter damage following stroke

Tissue-type plasminogen activator controls neuronal death by raising surface dynamics of extrasynaptic NMDA receptors.

Tissue-type plasminogen activator crosses the intact blood-brain barrier by low-density lipoprotein receptor-related protein-mediated transcytosis

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic.

Tissue-type plasminogen activator rescues neurones from serum deprivation-induced apoptosis through a mechanism independent of its proteolytic activity

Toward safer thrombolytic agents in stroke: molecular requirements for NMDA receptor-mediated neurotoxicity.

Transforming growth factor alpha-induced expression of type 1 plasminogen activator inhibitor in astrocytes rescues neurons from excitotoxicity.

Transforming growth factor-beta and ischemic brain injury ⬇️

Transforming growth factor-beta signalling in brain disorders

Traumatic brain injury: tissue-type plasminogen activator--harmful or beneficial?

Understanding the functions of endogenous and exogenous tissue-type plasminogen activator during stroke

VEGF modulates NMDA receptors activity in cerebellar granule cells through Src-family kinases before synapse formation

tPA in the injured central nervous system: different scenarios starring the same actor?

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury