List of works by Essam Ghazaly

A synergistic interaction between lapatinib and chemotherapy agents in a panel of cell lines is due to the inhibition of the efflux pump BCRP.

scientific article published on October 2010

Abstract 1885: A comprehensive untargeted UPLC-MS based metabolomic analysis of ASS1 -deficient solid tumor cell lines treated with arginine deiminase

Albendazole and its metabolites in the breast milk of lactating women following a single oral dose of albendazole

scientific article

Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study

scientific article published on 12 September 2018

Application of ProTide technology to gemcitabine: a successful approach to overcome the key cancer resistance mechanisms leads to a new agent (NUC-1031) in clinical development.

scientific article published on 14 February 2014

Arginine deprivation using pegylated arginine deiminase has activity against primary acute myeloid leukemia cells in vivo.

scientific article published on 20 April 2015

Clofarabine, high-dose cytarabine and liposomal daunorubicin in pediatric relapsed/refractory acute myeloid leukemia: a phase IB study.

scientific article published on 17 May 2018

Development and validation of an ultra-high performance LC-MS/MS assay for intracellular SN-38 in human solid tumour cell lines: comparison with a validated HPLC-fluorescence method.

scientific article published on 27 August 2014

Development of HPLC-UV method for rapid and sensitive analysis of topically applied tetracaine: its comparison with a CZE method

scientific article

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer.

scientific article published on 4 January 2016

Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread

scientific article

Inhibition of the Polyamine Synthesis Pathway Is Synthetically Lethal with Loss of Argininosuccinate Synthase 1.

scientific article published on 20 July 2016

Pharmacological factors affecting accumulation of gemcitabine's active metabolite, gemcitabine triphosphate.

scientific article published on 08 June 2017

Phosphoproteomic comparison of Pik3ca and Pten signalling identifies the nucleotidase NT5C as a novel AKT substrate

scientific article published on 6 January 2017

Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging

scientific article published on 27 November 2013

Repression of sphingosine kinase (SK)-interacting protein (SKIP) in acute myeloid leukemia diminishes SK activity and its re-expression restores SK function

scientific article published on 11 March 2020

Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism

scientific article published on 27 November 2017

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