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List of works by Peter Kuppen

A basal membrane-like structure surrounding tumour nodules may prevent intraepithelial leucocyte infiltration in colorectal cancer.

scientific article published on 30 January 2003

A systemic antitumor immune response prevents outgrowth of lung tumors after i.v. rechallenge but is not able to prevent growth of experimental liver tumors.

scientific article published in January 2004

Acute-phase response patterns in isolated hepatic perfusion with tumour necrosis factor alpha (TNF-alpha) and melphalan in patients with colorectal liver metastases.

scientific article published in June 1999

Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-γ in vaccinated colorectal cancer patients: a phase I/II clinical trial

scientific article published on 21 November 2012

Administration of BiMAb-retargeted T cells in a rat hepatic metastases colon tumour model results in T-cell tumour infiltration independent of the route of administration

scientific article published on 01 March 2001

Age determines the prognostic role of the cancer stem cell marker aldehyde dehydrogenase-1 in breast cancer

scientific article

Age-dependent clinical prognostic value of histone modifications in colorectal cancer

Allogeneic hematopoietic transplantation and leukemia: a second chance for T cells?

scientific article published on 01 January 2008

Alternatively spliced tissue factor promotes breast cancer growth in a β1 integrin-dependent manner.

scientific article published on 25 June 2013

Alternatively spliced tissue factor synergizes with the estrogen receptor pathway in promoting breast cancer progression.

scientific article

An experimental minimally invasive perfusion technique for the treatment of liver metastases

scientific article published on 01 November 2003

Assessment of DNA methylation status in early stages of breast cancer development ⬇️

scientific article published on May 7, 2013

Biodistribution of lymphokine-activated killer (LAK) cells in Wag rats after hepatic-artery or jugular-vein infusion

scientific article published on 01 September 1992

Biomarkers for early detection of colorectal cancer and polyps: systematic review

scientific article

Biomarkers in precision therapy in colorectal cancer.

scientific article published on 23 August 2013

Breast cancer in elderly compared to younger patients in the Netherlands: stage at diagnosis, treatment and survival in 127,805 unselected patients.

scientific article

CD163 as a Biomarker in Colorectal Cancer: The Expression on Circulating Monocytes and Tumor-Associated Macrophages, and the Soluble Form in the Blood

scientific article published on 18 August 2020

COX2 expression in prognosis and in prediction to endocrine therapy in early breast cancer patients

scientific article published on 01 April 2010

Caspase-3 activity as a prognostic factor in colorectal carcinoma

scientific article published on 01 May 2001

Celecoxib inhibits growth of tumors in a syngeneic rat liver metastases model for colorectal cancer.

scientific article published on 5 February 2008

Characteristics of tumor infiltration by adoptively transferred and endogenous natural-killer cells in a syngeneic rat model: implications for the mechanism behind anti-tumor responses

scientific article published on 01 December 1998

Characterization of three new membrane structures on rat NK cells which are involved in activation of the lytic machinery

scientific journal article

Chromatin status of apoptosis genes correlates with sensitivity to chemo-, immune- and radiation therapy in colorectal cancer cell lines

scientific article published on December 2014

Clinical Relevance of Occult Tumor Cells in Lymph Nodes From Gastric Cancer Patients

scientific article published on 01 September 2005

Clinical applications of the urokinase receptor (uPAR) for cancer patients.

scientific article published on January 2011

Clinical impact of HLA class I expression in rectal cancer. ⬇️

scientific article published on 15 September 2007

Clinical prognostic value of combined analysis of Aldh1, Survivin, and EpCAM expression in colorectal cancer

scientific article

Clinical translation of ex vivo sentinel lymph node mapping for colorectal cancer using invisible near-infrared fluorescence light

scientific article

Co-expression of SNAIL and TWIST determines prognosis in estrogen receptor-positive early breast cancer patients

scientific article published on 28 July 2011

Colorectal cancer vaccines in clinical trials.

scientific article published on June 2011

Combined analysis of HLA class I, HLA-E and HLA-G predicts prognosis in colon cancer patients

Combined analysis of HLA class I, HLA-E and HLA-G predicts prognosis in colon cancer patients.

scientific article

Combined analysis of biomarkers of proliferation and apoptosis in colon cancer: an immunohistochemistry-based study using tissue microarray

article

Combined expression of the non-receptor protein tyrosine kinases FAK and Src in primary colorectal cancer is associated with tumor recurrence and metastasis formation.

scientific article published on 16 June 2008

Comment re: Intratumoral immune reaction in human colorectal cancer

scientific article published on 09 February 2010

Comparison of frequencies and prognostic effect of molecular subtypes between young and elderly breast cancer patients

scientific article published on 8 April 2014

Copy number alterations and allelic ratio in relation to recurrence of rectal cancer

scientific article published on 6 June 2015

Cyclooxygenase 2 expression in rectal cancer is of prognostic significance in patients receiving preoperative radiotherapy

scientific article published on 01 May 2007

Cytoplasmic Overexpression of HER2: a Key Factor in Colorectal Cancer.

scientific article published on 21 February 2013

DNA methylation of apoptosis genes in rectal cancer predicts patient survival and tumor recurrence.

scientific article

Delivery of anticancer drugs via isolated hepatic perfusion: a promising strategy in the treatment of irresectable liver metastases?

scientific article published on April 1998

Detailed examination of lymph nodes improves prognostication in colorectal cancer.

scientific article

Disrupted expression of CXCL5 in colorectal cancer is associated with rapid tumor formation in rats and poor prognosis in patients.

scientific article

Down-regulation of HLA-A expression correlates with a better prognosis in colorectal cancer patients

scientific article published on 01 December 2002

Effect of irradiation on hepatic natural killer cells

scientific article published on 01 June 1994

Effectiveness of isolated liver perfusion with mitomycin C in the treatment of liver tumours of rat colorectal cancer.

scientific article published on July 1991

Electron microscopic observations on the accumulation of large granular lymphocytes (pit cells) and Kupffer cells in the liver of rats treated with continuous infusion of interleukin-2

scientific article published on 01 December 1990

Endogenous natural killer cells do not play a role in antitumor effects induced by interleukin-2 in a syngeneic rat colon tumor model

scientific article published on 01 January 2000

Enhancement of the complement activating capacity of 17-1A mAb to overcome the effect of membrane-bound complement regulatory proteins on colorectal carcinoma

scientific article published on 01 January 2002

Epigenetic silencing of cyclooxygenase-2 affects clinical outcome in gastric cancer

scientific article published on 01 November 2007

Epigenetic status of LINE-1 predicts clinical outcome in early-stage rectal cancer.

scientific article

Establishment and characterization of 7 ovarian carcinoma cell lines and one granulosa tumor cell line: growth features and cytogenetics.

scientific article

Estrogen Receptor Pathway Activity Score to Predict Clinical Response or Resistance to Neoadjuvant Endocrine Therapy in Primary Breast Cancer

scientific article published on 14 November 2019

Evaluation of EphA2 and EphB4 as Targets for Image-Guided Colorectal Cancer Surgery.

scientific article published on 03 February 2017

Evaluation of EphB4 as Target for Image-Guided Surgery of Breast Cancer

scientific article published on 30 July 2020

Experimentally induced liver metastases from colorectal cancer can be prevented by mononuclear phagocyte-mediated monoclonal antibody therapy

scientific article published on 17 June 2010

Expression of HLA class I antigen, aspirin use, and survival after a diagnosis of colon cancer.

scientific article

Expression of cell adhesion molecules and prognosis in breast cancer

scientific article published on 22 November 2012

Expression of uPAR in tumor-associated stromal cells is associated with colorectal cancer patient prognosis: a TMA study

scientific article

Expression profile of saccharide epitope CaMBr1 in normal and neoplastic tissue from dogs, cats, and rats: implication for the development of human-derived cancer vaccines.

scientific article

Ex vivo sentinel node mapping in colon cancer combining blue dye staining and fluorescence imaging.

scientific article published on 25 January 2013

Four-color staining combining fluorescence and brightfield microscopy for simultaneous immune cell phenotyping and localization in tumor tissue sections

scientific article published on 01 May 2005

Functional CD8+ T cells infiltrate into nonsmall cell lung carcinoma.

scientific article published on 22 August 2006

Gene Expression Signature to Improve Prognosis Prediction of Stage II and III Colorectal Cancer

article

HER2 and immunotherapy using monoclonal antibodies in colorectal cancer.

scientific article published in December 2013

HLA-E and HLA-G expression in classical HLA class I-negative tumors is of prognostic value for clinical outcome of early breast cancer patients

scientific article published on 05 November 2010

HLA-G and classical HLA class I expression in primary colorectal cancer and associated liver metastases.

scientific article published on 8 March 2016

HLA-G: A New Immune Checkpoint in Cancer?

scientific article published on 25 June 2020

High mitomycin C concentration in tumour tissue can be achieved by isolated liver perfusion in rats

scientific article published on 01 January 1991

High nuclear expression levels of histone-modifying enzymes LSD1, HDAC2 and SIRT1 in tumor cells correlate with decreased survival and increased relapse in breast cancer patients.

scientific article

High-resolution MALDI-FT-ICR MS imaging for the analysis of metabolites from formalin-fixed, paraffin-embedded clinical tissue samples

scientific article published on 30 June 2015

Histone trimethylation at H3K4, H3K9 and H4K20 correlates with patient survival and tumor recurrence in early-stage colon cancer

scientific article

How does genome sequencing impact surgery?

scientific article published on 24 June 2014

Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study

scientific article published on 05 April 2012

ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

scientific article published on 04 September 2019

Identification of potential HLA-A *0201 restricted CTL epitopes derived from the epithelial cell adhesion molecule (Ep-CAM) and the carcinoembryonic antigen (CEA).

scientific article published on March 1997

Image-guided tumor resection using real-time near-infrared fluorescence in a syngeneic rat model of primary breast cancer ⬇️

scientific article published on September 7, 2010

Immune response against frameshift-induced neopeptides in HNPCC patients and healthy HNPCC mutation carriers

scientific article published on 09 July 2008

Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.

scientific article published on 24 October 2017

Immunohistochemical detection of melphalan-DNA adducts in colon cancer cells in vitro and human colorectal liver tumours in vivo.

scientific article published on May 2004

Immunological subtypes in breast cancer are prognostic for invasive ductal but not for invasive lobular breast carcinoma

scientific article

Increased PTP1B expression and phosphatase activity in colorectal cancer results in a more invasive phenotype and worse patient outcome

scientific article published on March 2016

Increased local cytostatic drug exposure by isolated hepatic perfusion: a phase I clinical and pharmacologic evaluation of treatment with high dose melphalan in patients with colorectal cancer confined to the liver.

scientific article published on May 2000

Increasing the effective concentration of melphalan in experimental rat liver tumours: comparison of isolated liver perfusion and hepatic artery infusion ⬇️

scientific article published on December 1, 1991

Induction of lymphokine-activated killer activity in rat splenocyte cultures: the importance of 2-mercaptoethanol and indomethacin

scientific article published on 01 January 1991

Induction of p53-specific immunity by a p53 synthetic long peptide vaccine in patients treated for metastatic colorectal cancer

scientific article published on 01 February 2009

Interactions between rat colon carcinoma cells and Kupffer cells during the onset of hepatic metastasis.

scientific article

Interleukin-2 activated NK cells do not use the CD95L- and TRAIL-pathways in the rapid induction of apoptosis of rat colon carcinoma CC531s cells.

scientific article published on January 2003

Interleukin-2-activated natural killer cells can induce both apoptosis and necrosis in rat hepatocytes

scientific article published on 01 March 1999

Intraoperative near-infrared fluorescence imaging of colorectal metastases targeting integrin αvβ3 expression in a syngeneic rat model ⬇️

scientific article published on January 6, 2011

Involvement of LFA-1 in hepatic NK cell (pit cell)-mediated cytolysis and apoptosis of colon carcinoma cells

scientific article published on 01 July 1999

Is the presence of interleukin-2 receptor alpha in the serum of colorectal liver metastases patients derived from hepatic natural killer cells?

scientific article published on 01 May 2002

Isolated hepatic melphalan perfusion of colorectal liver metastases: outcome and prognostic factors in 154 patients.

scientific article

Isolated hepatic perfusion with 200 mg melphalan for advanced noncolorectal liver metastases

scientific article published on 10 May 2008

Isolated hepatic perfusion with high-dose melphalan for the treatment of colorectal metastasis confined to the liver

scientific article published on 01 November 2003

Isolated hepatic perfusion with oxaliplatin combined with 100 mg melphalan in patients with metastases confined to the liver: A phase I study.

scientific article

Isolated lung perfusion with melphalan prolongs survival in a rat model of metastatic pulmonary adenocarcinoma

scientific article published on 01 January 1999

Liver and tumour tissue concentrations of TNF-alpha in cancer patients treated with TNF-alpha and melphalan by isolated liver perfusion

scientific article

Locoregional therapies of liver metastases in a rat CC531 coloncarcinoma model results in increased resistance to tumour rechallenge.

scientific article

MHC class I expression protects rat colon carcinoma cells from hepatic natural killer cell-mediated apoptosis and cytolysis, by blocking the perforin/granzyme pathway

scientific article

Magnitude and polarization of P53-specific T-helper immunity in connection to leukocyte infiltration of colorectal tumors.

scientific article

Membrane-bound complement regulatory proteins inhibit complement activation by an immunotherapeutic mAb in a syngeneic rat colorectal cancer model

scientific article published on 01 September 2003

MicroRNA classifier and nomogram for metastasis prediction in colon cancer.

scientific article

NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity.

scientific article published on November 2003

NKG2D ligand tumor expression and association with clinical outcome in early breast cancer patients: an observational study

scientific article

Natural killer cells infiltrating colorectal cancer and MHC class I expression

scientific article published on 01 February 2005

Natural killer cells: from "disturbing" background to central players of immune responses

scientific article published on 01 February 2005

Near-infrared fluorescence imaging in patients undergoing pancreaticoduodenectomy.

scientific article

Near-infrared fluorescence imaging of liver metastases in rats using indocyanine green.

scientific article

Novel avenues in immunotherapies for colorectal cancer

scientific article

Novel intraoperative near-infrared fluorescence camera system for optical image-guided cancer surgery.

scientific article

Nuclear expression of histone deacetylases and their histone modifications predicts clinical outcome in colorectal cancer.

scientific article published on 31 October 2014

Nuclear localization of CXCR4 determines prognosis for colorectal cancer patients

scientific article published on 11 December 2008

Optimization of near-infrared fluorescent sentinel lymph node mapping in cervical cancer patients.

scientific article

PIK3CA kinase domain mutation identifies a subgroup of stage III colon cancer patients with poor prognosis ⬇️

scientific article published on August 10, 2011

Preclinical evaluation of a novel CEA-targeting near-infrared fluorescent tracer delineating colorectal and pancreatic tumors.

scientific article published on 22 June 2015

Prediction in rectal cancer.

scientific article published on April 2012

Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients.

scientific article

Primary tumor classification according to methylation pattern is prognostic in patients with early stage ER-negative breast cancer

scientific article published on 11 April 2011

Prognostic relevance of occult tumour cells in lymph nodes in colorectal cancer.

scientific article published on 18 January 2006

Prognostic value of HLA class I, HLA-E, HLA-G and Tregs in rectal cancer: a retrospective cohort study

scientific article

Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer

scientific article

Prognostic value of tumor-infiltrating dendritic cells in colorectal cancer: role of maturation status and intratumoral localization

scientific article published on 01 April 2005

Promoter methylation and mRNA expression of HLA-G in relation to HLA-G protein expression in colorectal cancer.

scientific article published on 28 May 2016

Rat colon carcinoma cells that survived systemic immune surveillance are less sensitive to NK-cell mediated apoptosis.

scientific article published on January 2003

Rat interleukin-2-activated natural killer (A-NK) cell-mediated lysis is determined by the presence of CD18 on A-NK cells and the absence of major histocompatibility complex class I on target cells

scientific article published on 01 January 1994

Regional administration of natural killer cells in a rat hepatic metastasis model results in better tumor infiltration and anti-tumor response than systemic administration ⬇️

scientific article published on January 19, 1998

Regulatory sequences of H19 and IGF2 genes in DNA-based therapy of colorectal rat liver metastases

scientific article published on 01 March 2005

Reliability of human serum protein profiles generated with C8 magnetic beads assisted MALDI-TOF mass spectrometry.

scientific article published in November 2005

Remodeling of the actin cytoskeleton of target hepatocytes and NK cells during induction of apoptosis.

scientific article published in June 2001

Role of NK cells in adoptive immunotherapy of metastatic colorectal cancer in a syngeneic rat model.

scientific article

Secreted and membrane-associated matrix metalloproteinases of IL-2-activated NK cells and their inhibitors

scientific article published on 01 June 2000

Sialyl Lewis X expression and lymphatic microvessel density in primary tumors of node-negative colorectal cancer patients predict disease recurrence

scientific article published on 06 August 2008

Socioeconomic differences in survival among breast cancer patients in the Netherlands not explained by tumor size ⬇️

scientific article published on November 13, 2010

Soluble factors produced by macrophages/monocytes inhibit lymphokine-activated killer activity in rat splenocyte cultures

scientific article published on 01 January 1994

Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer

scientific article published on 22 November 2011

Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer.

scientific article published on 14 February 2012

Stromal Targets for Fluorescent-Guided Oncologic Surgery

scientific article

T cell responses in colorectal cancer patients: evidence for class II HLA-restricted recognition of shared tumor-associated antigens.

scientific article published in December 2000

Targeting Glycans and Heavily Glycosylated Proteins for Tumor Imaging

scientific article published on 21 December 2020

The Molecular and Functional Characteristics of HLA-G and the Interaction with Its Receptors: Where to Intervene for Cancer Immunotherapy?

scientific article published on 17 November 2020

The clinical prognostic value of molecular intrinsic tumor subtypes in older breast cancer patients: A FOCUS study analysis.

scientific article published on 24 November 2015

The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery

scientific article published on 14 April 2011

The clinical value of HER-2 overexpression and PIK3CA mutations in the older breast cancer population: a FOCUS study analysis.

scientific article published on 11 March 2016

The development of novel mouse monoclonal antibodies against the CC531 rat colon adenocarcinoma

scientific article published on 01 January 2000

The homeobox gene MEIS1 is methylated in BRAF (p.V600E) mutated colon tumors

scientific article

The immunological consequences of photodynamic treatment of cancer, a literature review

scientific article

The infiltration of experimentally induced lung metastases of colon carcinoma CC531 by adoptively transferred interleukin-2-activated natural killer cells in Wag rats

scientific article published on 01 February 1994

The number and distribution of hepatic natural killer cells (pit cells) in normal rat liver: an immunohistochemical study

scientific article published on 01 June 1995

The phenotypic heterogeneity of human natural killer cells: presence of at least 48 different subsets in the peripheral blood

scientific article published on 01 February 2001

The predictive value of HLA class I tumor cell expression and presence of intratumoral Tregs for chemotherapy in patients with early breast cancer

scientific article published on 09 February 2010

The prognostic value of apoptotic and proliferative markers in breast cancer.

scientific article published on 6 November 2013

The prognostic value of the apoptosis pathway in colorectal cancer: a review of the literature on biomarkers identified by immunohistochemistry

scientific article published on 04 July 2013

The simultaneous ex vivo detection of low-frequency antigen-specific CD4+ and CD8+ T-cell responses using overlapping peptide pools.

scientific article

Tumor Heterogeneity and Immunotherapy of Cancer ⬇️

scientific article published on June 1, 1995

Tumor LINE-1 Methylation Level in Association with Survival of Patients with Stage II Colon Cancer.

scientific article published on 27 December 2016

Tumor immune subtypes distinguish tumor subclasses with clinical implications in breast cancer patients.

scientific article

Tumor-stroma ratio in the primary tumor is a prognostic factor in early breast cancer patients, especially in triple-negative carcinoma patients

scientific article published on 02 April 2010

Tumour immunotherapy: the adjuvant treatment of the 21st century?

scientific article published in June 2000

Validation of the 12-gene colon cancer recurrence score as a predictor of recurrence risk in stage II and III rectal cancer patients.

scientific article published on 26 September 2014

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