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List of works by Raquel Álvarez-Velilla

A pentapeptide signature motif plays a pivotal role in Leishmania DNA topoisomerase IB activity and camptothecin sensitivity

scientific article published on 18 September 2012

First evidence of intraclonal genetic exchange in trypanosomatids using two Leishmania infantum fluorescent transgenic clones

scientific article (publication date: September 2014)

Gimatecan and other camptothecin derivatives poison Leishmania DNA-topoisomerase IB leading to a strong leishmanicidal effect.

scientific article published in March 2013

Identification and characterization of the regions involved in the nuclear translocation of the heterodimeric leishmanial DNA topoisomerase IB.

scientific article

Indotecan (LMP400) and AM13-55: two novel indenoisoquinolines show potential for treating visceral leishmaniasis

scientific article

Infrared fluorescent imaging as a potent tool for in vitro, ex vivo and in vivo models of visceral leishmaniasis

scientific article (publication date: March 2015)

Leishmania donovani: proteasome-mediated down-regulation of methionine adenosyltransferase

scientific article published on 01 August 2011

Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB.

scientific article published on 22 December 2015

Role of trypanosomatid's arginase in polyamine biosynthesis and pathogenesis

scientific article published on 20 October 2011

Synthesis of marine α-methoxylated fatty acid analogs that effectively inhibit the topoisomerase IB from Leishmania donovani with a mechanism different from that of camptothecin

scientific article published on 30 September 2013

Target-based vs. phenotypic screenings in Leishmania drug discovery: A marriage of convenience or a dialogue of the deaf?

scientific article

Trypanosomatids see the light: recent advances in bioimaging research

scientific article published on 22 September 2014

Trypanosomatids topoisomerase re-visited. New structural findings and role in drug discovery

scientific article

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