List of works - Christopher J Squire

2-Ethylthio-9-methyl-1,4-dihydroacridine-1,4-dione and 9-methyl-2-(4-tolylthio)-1,4-dihydroacridine-1,4-dione

scientific article published on 15 April 1999

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

scientific article published on 22 April 2017

Activation domain-dependent degradation of somatic Wee1 kinase

scientific article published on 28 December 2009

Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in α-isopropylmalate synthase from Mycobacterium tuberculosis

scientific article published on 13 March 2013

Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin

scientific article

Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed

scientific article published in December 2015

Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B.

scientific article published on 16 June 2017

Chemical synthesis of γ-secretase activating protein using pseudoglutamines as ligation sites

scientific article published on 01 January 2015

Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis ⬇️

scientific article published on September 30, 2011

Complexes of DNA with minor groove binders: crystallographic studies ⬇️

1998 doctoral thesis by Christopher John Squire at University of Auckland

Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3

scientific article published in 2012

Crystal and NMR Structures of a Peptidomimetic β-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides

scientific article published on 2 November 2017

Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding

scientific article

Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis

scientific article published on 21 May 2004

Defining the potassium binding region in an apple terpene synthase

scientific article

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).

scientific article published on 6 November 2013

Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis

scientific article

Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability

scientific article published on 16 February 2017

Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system

scientific article

Harnessing ester bond chemistry for protein ligation.

scientific article published on 13 January 2017

High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon

scientific article

In vitro studies with methylproamine: a potent new radioprotector

scientific article published in February 2004

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance

scientific article published on 20 July 2018

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.

scientific article

Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2

scientific article

Poxviral ankyrin proteins

scientific article

Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis

scientific article published on 20 March 2014

Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily

scientific article

Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding

scientific article

Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria

scientific article

Structure and function of GlmU fromMycobacterium tuberculosis

scientific article

Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation

scientific article

Structure of AKR1C3 with 3-phenoxybenzoic acid bound

scientific article published in April 2012

Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).

scientific article

Structure of the first parallel DNA quadruplex-drug complex

scientific article (publication date: 9 April 2003)

Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery

scientific article

Structures of the dimerization domains of the Escherichia coli disulfide-bond isomerase enzymes DsbC and DsbG

scientific article published in April 2007

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

scientific article

Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases

scientific article

TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure

scientific article published on 14 January 2019

The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition

scientific article published in March 2015

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster

scientific article published on 16 July 2019

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages

scientific article published in July 2012

Total Chemical Synthesis of an Orf Virus Protein, ORFV002, an Inhibitor of the Master Gene Regulator NF-κB.

scientific article published on March 2014

Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

scientific article published on 28 January 2003

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs

scientific article published on 23 June 2021

List of works by Christopher J Squire

2-Ethylthio-9-methyl-1,4-dihydroacridine-1,4-dione and 9-methyl-2-(4-tolylthio)-1,4-dihydroacridine-1,4-dione

2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors

Activation domain-dependent degradation of somatic Wee1 kinase

Amino-acid substitutions at the domain interface affect substrate and allosteric inhibitor binding in α-isopropylmalate synthase from Mycobacterium tuberculosis

Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin

Binding mode of the breakthrough inhibitor AZD9291 to epidermal growth factor receptor revealed

Bioinspired Total Synthesis and Stereochemical Revision of the Fungal Metabolite Pestalospirane B.

Chemical synthesis of γ-secretase activating protein using pseudoglutamines as ligation sites

Cloning, expression, purification, crystallization and preliminary X-ray studies of the C-terminal domain of Rv3262 (FbiB) from Mycobacterium tuberculosis ⬇️

Complexes of DNA with minor groove binders: crystallographic studies ⬇️

Crystal Structures of Three Classes of Non-Steroidal Anti-Inflammatory Drugs in Complex with Aldo-Keto Reductase 1C3

Crystal and NMR Structures of a Peptidomimetic β-Turn That Provides Facile Synthesis of 13-Membered Cyclic Tetrapeptides

Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding

Crystallization and preliminary X-ray analysis of alpha-isopropylmalate synthase from Mycobacterium tuberculosis

Defining the potassium binding region in an apple terpene synthase

Discovery and characterisation of hydrazines as inhibitors of the immune suppressive enzyme, indoleamine 2,3-dioxygenase 1 (IDO1).

Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis

Engineering a Lys-Asn isopeptide bond into an immunoglobulin-like protein domain enhances its stability

Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system

Harnessing ester bond chemistry for protein ligation.

High-resolution crystal structure of plant carboxylesterase AeCXE1, from Actinidia eriantha, and its complex with a high-affinity inhibitor paraoxon

In vitro studies with methylproamine: a potent new radioprotector

MCR-1: a promising target for structure-based design of inhibitors to tackle polymyxin resistance

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes.

Minor groove binding of a bis-quaternary ammonium compound: the crystal structure of SN 7167 bound to d(CGCGAATTCGCG)2

Poxviral ankyrin proteins

Preparation of truncated orf virus entry fusion complex proteins by chemical synthesis

Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily

Removal of the C-terminal regulatory domain of α-isopropylmalate synthase disrupts functional substrate binding

Self-generated covalent cross-links in the cell-surface adhesins of Gram-positive bacteria

Structure and function of GlmU fromMycobacterium tuberculosis

Structure and inhibition of the human cell cycle checkpoint kinase, Wee1A kinase: an atypical tyrosine kinase with a key role in CDK1 regulation

Structure of AKR1C3 with 3-phenoxybenzoic acid bound

Structure of Escherichia coli UDP-N-acetylmuramoyl:L-alanine ligase (MurC).

Structure of the first parallel DNA quadruplex-drug complex

Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery

Structures of the dimerization domains of the Escherichia coli disulfide-bond isomerase enzymes DsbC and DsbG

Synthesis and structure-activity relationships of N-6 substituted analogues of 9-hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of Wee1 and Chk1 checkpoint kinases

Synthesis and structure-activity relationships of soluble 8-substituted 4-(2-chlorophenyl)-9-hydroxypyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones as inhibitors of the Wee1 and Chk1 checkpoint kinases

TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure

The 1.65 Å resolution structure of the complex of AZD4547 with the kinase domain of FGFR1 displays exquisite molecular recognition

The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster

The high-resolution crystal structure of a parallel intermolecular DNA G-4 quadruplex/drug complex employing syn glycosyl linkages

Total Chemical Synthesis of an Orf Virus Protein, ORFV002, an Inhibitor of the Master Gene Regulator NF-κB.

Trapping HIV-1 reverse transcriptase before and after translocation on DNA.

Validating TDP1 as an Inhibition Target for the Development of Chemosensitizers for Camptothecin-Based Chemotherapy Drugs