List of works - Keefe T Chan

A functional genetic screen defines the AKT-induced senescence signaling network

scientific article published on 08 July 2019

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

scientific article published on 26 May 2020

Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.

scientific article

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

scientific article published in September 2016

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

scientific article

Cystathionine β-Synthase in Physiology and Cancer.

scientific article

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

scientific article published on May 2015

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

scientific article

Integrins in cell migration.

scientific article

Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin

scientific article

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.

scientific article

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

scientific article published on June 2012

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

scientific article published on 22 August 2019

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

scientific article published on 18 September 2020

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

scientific article published on 11 November 2020

Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

scientific article published on June 2011

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.

scientific article

List of works by Keefe T Chan

A functional genetic screen defines the AKT-induced senescence signaling network

CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer

Calpain 2 and PTP1B function in a novel pathway with Src to regulate invadopodia dynamics and breast cancer cell invasion.

Combining High-Content Imaging and Phenotypic Classification Analysis of Senescence-Associated Beta-Galactosidase Staining to Identify Regulators of Oncogene-Induced Senescence.

Coronin 1C harbours a second actin-binding site that confers co-operative binding to F-actin

Cystathionine β-Synthase in Physiology and Cancer.

IL2 Inducible T-cell Kinase, a Novel Therapeutic Target in Melanoma

Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling

Integrins in cell migration.

Intravital imaging of a spheroid-based orthotopic model of melanoma in the mouse ear skin

LKB1 loss in melanoma disrupts directional migration toward extracellular matrix cues.

LKB1/STK11 inactivation leads to expansion of a prometastatic tumor subpopulation in melanoma

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Reprogrammed mRNA translation drives resistance to therapeutic targeting of ribosome biogenesis

The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in homologous recombination-proficient high-grade serous ovarian cancer

Unraveling the enigma: progress towards understanding the coronin family of actin regulators.

β2-adrenoceptor signaling regulates invadopodia formation to enhance tumor cell invasion.